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Journals British Journal of Biomedical ...

British Journal of Biomedical Science

https://read.qxmd.com/read/38895586/case-report-the-conundrum-of-what-to-pick-antibiotic-susceptibility-variability-in-burkholderia-cenocepacia-in-cystic-fibrosis-implications-for-antibiotic-susceptibility-testing-and-treatment
#1
JOURNAL ARTICLE
John E Moore, John McCaughan, Jacqueline C Rendall, Beverley C Millar
Within cystic fibrosis microbiology, there is often mismatch between the antibiotic susceptibility result of an isolated bacterial pathogen and the clinical outcome, when the patient is treated with the same antibiotic. The reasoning for this remains largely elusive. Antibiotic susceptibility to four antibiotics (ceftazidime, meropenem, minocycline and trimethoprim-sulfamethoxazole) was determined in consecutive isolates ( n = 11) from an adult cystic fibrosis patient, over a 63 month period. Each isolate displayed its own unique resistotype...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38868755/supporting-the-biomedical-science-ug-project-research-journey-through-staff-student-partnerships
#2
JOURNAL ARTICLE
S Veuger, L Cookson, H Creighton, S Gallaher, S Racey, M Ridley, I Robson
Introduction: Developing research skills enhances graduate attributes and student employability. The UG research project is coined the pedagogy of the 21st century but the diversity of supervisory styles is a source of student perceived inequality of experience. The goal of this study was to provide structure and support to undergraduate (UG) biomedical science research students and supervisors by co-creating research informed resources that are accessible, engaging and student centred. We asked 1) How do UG students experience research supervision? 2) What approaches do supervisors use to support UG project students? 3) How do students as partners benefit from being involved in pedagogical research? Materials and Methods: In Stage One, 3 UG student research partners co-developed questionnaires and followed these up with semi-structured interviews...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38868754/faecal-immunochemical-test-fit-sensitivity-a-five-year-audit
#3
JOURNAL ARTICLE
Eddie Cole, Deepa Narayanan, Ree Nee Tiam, John Shepherd, Mark O R Hajjawi
Introduction: Colorectal cancer has a high prevalence and mortality rate in the United Kingdom. Cancerous colorectal lesions often bleed into the gastrointestinal lumen. The faecal immunochemical test (FIT) detects haemoglobin (Hb) in the faeces of patients and is used as a first line test in the diagnosis of colorectal cancer. Materials and Methods: A retrospective audit of all FIT performed and all colorectal cancers diagnosed in the Hull and East Riding of Yorkshire counties of the United Kingdom (population approximately 609,300) between 2018 and 2022 was conducted...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38854458/embedding-assessment-literacy-can-enhance-graduate-attribute-development-in-a-biomedical-sciences-curriculum
#4
JOURNAL ARTICLE
Kevin A Robertson, Kirsty J Hughes, Susan M Rhind
This paper describes the successful implementation of an assessment literacy strategy within a Biomedical Sciences degree. Teaching was aligned with an assessment literacy framework and aimed to prepare undergraduates for a literature comprehension assessment. Students were introduced to the assessment purpose and an adapted Miller's pyramid model illustrated how the assessment contributed to competency development during their degree. Students read primary research papers and answered questions relating to the publications...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38650738/case-report-of-a-hidden-intruder-extremely-rare-presentation-of-hydatidosis-as-a-nuchal-tumoural-mass
#5
Dragoș F Voicu, Constantin Popazu, Delia Mihaela Râșnoveanu, Daniela Mihalache, Alexandra Toma
Introduction: The parasitic tapeworm impersonated by the larvae of Echinococcus granulosus represents the aetiology of the hydatid pathology. The predilect site of invasion is the liver, but there are other cases of different localization all over the body, regardless of the type of invaded tissue. Soft tissue hydatidosis can be a real challenge for the clinician in terms of the diagnosis, and it might generate various complications such as anaphylactic shock. The aim of the present work is to illustrate a unique case of primary hydatidosis located in the nuchal region...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38605981/andragogy-in-practice-applying-a-theoretical-framework-to-team-science-training-in-biomedical-research
#6
JOURNAL ARTICLE
Jacqueline M Knapke, Laura Hildreth, Jennifer R Molano, Stephanie M Schuckman, Jason T Blackard, Megan Johnstone, Elizabeth J Kopras, M K Lamkin, Rebecca C Lee, John R Kues, Angela Mendell
This study is the first to apply the theoretical principles of Malcolm Knowles' theory of andragogy to evaluate data collected from learners who participated in team science training workshops in a biomedical research setting. Briefly, andragogy includes six principles: the learner's self-concept, the role of experience, readiness to learn, orientation to learning, the learner's need to know, and intrinsic motivation. Using an embedded study design, the primary focus was on qualitative data, with quantitative data complementing the qualitative findings...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38566933/double-immunohistochemical-labelling-of-prame-and-melan-a-in-slow-mohs-biopsy-margin-assessment-of-lentigo-maligna-and-lentigo-maligna-melanoma
#7
JOURNAL ARTICLE
R Salih, F Ismail, G E Orchard
Introduction: Lentigo maligna (LM) and lentigo maligna melanoma (LMM) predominantly affect the head and neck areas in elderly patients, presenting as challenging ill-defined pigmented lesions with indistinct borders. Surgical margin determination for complete removal remains intricate due to these characteristics. Morphological examination of surgical margins is the key form of determining successful treatment in LM/LMM and underpin the greater margin control provided through the Slow Mohs micrographic surgery (SMMS) approach...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38501148/assessing-the-efficacy-of-active-learning-to-support-student-performance-across-undergraduate-programmes-in-biomedical-science
#8
JOURNAL ARTICLE
D J Lees-Murdock, D Khan, R Irwin, J Graham, V Hinch, B O'Hagan, S McClean
Introduction: Active learning is a useful tool to enhance student engagement and support learning in diverse educational situations. We aimed to assess the efficacy of an active learning approach within a large interprofessional first year Medical Cell Biology module taken by six healthcare programmes across the School of Biomedical Sciences at Ulster University, United Kingdom. Materials and methods: An active learning approach was developed for weekly formative assessment using Smartwork to design a weekly interactive multiple-choice quiz to reinforce key concepts specifically for each lecture...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38481978/the-role-and-limitations-of-the-reference-interval-within-clinical-chemistry-and-its-reliability-for-disease-detection
#9
REVIEW
Nathan E Timbrell
Reference intervals (RIs) are a range of values that are supplied alongside laboratory measurements for comparison to allow interpretation of this data. Historically, RIs were referred to as the normal range. However, the perception of what is normal can lead to confusion in clinicians and unnecessary emotional distress in patients. RIs can be acquired using several methods. Laboratories may quote published studies or derive their own using established direct or indirect methods. Alternatively, laboratories may verify RIs provided by assay manufacturers using in-house studies...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38450253/genetic-variants-associated-with-response-to-platinum-based-chemotherapy-in-non-small-cell-lung-cancer-patients-a-field-synopsis-and-meta-analysis
#10
JOURNAL ARTICLE
Hilary Sito, Mohamad Ayub Khan Sharzehan, Md Asiful Islam, Shing Cheng Tan
Background: Publications on the associations of genetic variants with the response to platinum-based chemotherapy (PBC) in NSCLC patients have surged over the years, but the results have been inconsistent. Here, a comprehensive meta-analysis was conducted to combine eligible studies for a more accurate assessment of the pharmacogenetics of PBC in NSCLC patients. Methods: Relevant publications were searched in PubMed, Scopus, and Web of Science databases through 15 May 2021. Inclusion criteria for eligible publications include studies that reported genotype and allele frequencies of NSCLC patients treated with PBC, delineated by their treatment response (sensitive vs...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38444562/measuring-the-impact-of-incorporating-case-study-presentations-into-applied-biomedical-science-placement-workshops-for-trainee-biomedical-scientists
#11
JOURNAL ARTICLE
Amreen Bashir, Kathryn Dudley, Karan Singh Rana, Kayleigh Wilkins, Ross Pallett
Introduction: Successfully completing the Institute of Biomedical Science (IBMS) registration portfolio is essential to becoming a Health and Care Professions Council (HCPC) registered Biomedical Scientist. In the West Midlands, a unique collaboration between four universities (Aston, Wolverhampton, Coventry, and Keele) and local NHS Trusts supports student placements and portfolio development. The universities support Training Officers in delivering components of the registration portfolio through the delivery of eight combined placement workshops...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38434675/the-one-health-concept
#12
REVIEW
Sarah J Pitt, Alan Gunn
The concept of One Health has been developed as the appreciation that human health is intricately connected to those of other animals and the environment that they inhabit. In recent years, the COVID-19 pandemic and noticeable effects of climate change have encouraged national and international cooperation to apply One Health strategies to address key issues of health and welfare. The United Nations (UN) Sustainable Development Goals have established targets for health and wellbeing, clean water and sanitation, climate action, as well as sustainability in marine and terrestrial ecosystems...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38283642/a-landscape-view-of-the-female-genital-tract-microbiome-in-healthy-controls-and-women-with-reproductive-health-conditions-associated-with-ectopic-pregnancy
#13
REVIEW
Hui En Teh, Cheng Khee Pung, Valliammai Jayanthi Thirunavuk Arasoo, Polly Soo Xi Yap
Disruption of the female genital microbiome is associated with several pregnancy complications, including miscarriage, preterm onset of labour, and tubal pregnancy. Ectopic pregnancy is a known cause of maternal morbidity and mortality, but early diagnosis and treatment of ectopic pregnancy remain a challenge. Despite growing established associations between genital microbiome and female reproductive health, few studies have specifically focused on its link with ectopic pregnancy. Therefore, the current review aims to provide a comprehensive account of the female genital microbiome in healthy and fertile women compared to those in ectopic pregnancy and its associated risk factors...
2023: British Journal of Biomedical Science
https://read.qxmd.com/read/38162586/group-assessments-to-help-build-online-learning-communities-in-biomedical-science-distance-learning-programmes
#14
JOURNAL ARTICLE
Beverley C Millar, Harriet Purkis, John E Moore, Stephen McClean, Colm J Lowery
Introduction: Biomedical Science distance learning courses offer flexibility in study while in employment. Asynchronous and self-learning approaches are common within such courses and often student-student interaction is limited. The aims of this study were to establish learning communities, develop confidence in participating in online teamwork and foster an appreciation of transferable skills including digital capabilities through remote group activities. Materials and Methods: Two cohorts of students ( n = 20/ n = 21) were enrolled in a microbiology module of an IBMS accredited MSc distance learning course...
2023: British Journal of Biomedical Science
https://read.qxmd.com/read/38094711/a-cytomegalovirus-cmv-case-study-to-promote-interprofessional-learning-ipl-between-audiology-and-biomedical-science-students-in-higher-education
#15
JOURNAL ARTICLE
Amreen Bashir, Ross Pallett, Karan Singh Rana, Saira Hussain
Modern and effective patient care requires specialist healthcare professionals working together. Interprofessional learning (IPL) seeks to provide opportunities for different healthcare disciplines to learn with, from and about each other. This study focused on the delivery and evaluation of a cytomegalovirus (CMV) case study workshop to facilitate IPL between two Health and Care Professions Council (HCPC) regulated courses: Biomedical Science and Audiology. The 2 h online workshop consisted of 1) defining the roles, responsibilities and skills of the two healthcare professions, 2) the structure of the Biomedical Science and Audiology departments, 3) routes to HCPC registration, 4) core curriculum of both degree programmes and 5) interpreting interdisciplinary data related to a CMV patient case...
2023: British Journal of Biomedical Science
https://read.qxmd.com/read/38074463/diagnostic-techniques-in-autoimmune-blistering-diseases
#16
REVIEW
John B Mee
Autoimmune blistering diseases (AIBD) comprise a heterogeneous group of uncommon disorders of the skin and mucous membranes, characterised by antibodies targeting structural proteins within epithelial tissue and the underlying basement membrane. There can be significant overlap in clinical presentation of these diseases and accurate diagnosis relies on the detection and characterisation of relevant autoantibodies. Immunofluorescence provides the gold-standard diagnostic tool for these diseases, identifying both tissue-bound autoantibodies in biopsy material using direct immunofluorescence and circulating antibodies in serum through indirect immunofluorescence...
2023: British Journal of Biomedical Science
https://read.qxmd.com/read/38034850/retrospective-analysis-of-allergen-distribution-dynamics-in-central-taiwan
#17
JOURNAL ARTICLE
Yu-Wei Tseng, Tze-Kiong Er
Introduction: Allergy is a type Ⅰ hypersensitivity reaction to certain substances (allergens) such as environmental factors, food and drugs. Allergies are a significant public health issue, and therefore, understanding the distribution patterns of allergens in specific regions is important. This study aimed to retrospectively analyse allergen distribution patterns in Central Taiwan over a 5 years period (2018-2022). Methods: Data of patients who had allergen sensitization testing using the OPTIGEN® Allergen-Specific IgE Assay from the 1st of January 2018 to the 31st of December 2022 were reviewed retrospectively...
2023: British Journal of Biomedical Science
https://read.qxmd.com/read/37849690/gamification-in-biomedical-science-education-the-successful-implementation-of-resimion-a-scenario-based-learning-tool
#18
JOURNAL ARTICLE
Jennifer E May, Elizabeth Anderson, Dan Clark, Jonathon Hull
Introduction: Scenario-based learning and gamification have many advantages in comparison to traditional didactic teaching methods, including development of many higher-level skills such as analysis and evaluation. It is hoped that these simulations provide a real-world experience in a format accessible to students. Integration of these tools into teaching excelled during the COVID-19 pandemic, an event that completely changed education and initiated the greatest advancement in digital learning to date. We discuss our experiences using Resimion, a novel scenario-based learning tool that was adapted to biomedical science, both for teaching and assessment...
2023: British Journal of Biomedical Science
https://read.qxmd.com/read/37822354/transcriptional-response-of-burkholderia-cenocepacia-h111-to-severe-zinc-starvation
#19
JOURNAL ARTICLE
James Paul Barnett
Burkholderia cenocepacia is an opportunistic pathogen that is primarily associated with severe respiratory infections in people with cystic fibrosis. These bacteria have significant intrinsic resistance to antimicrobial therapy, and there is a need for more effective treatments. Bacterial zinc uptake and homeostasis systems are attractive targets for new drugs, yet our understanding of how bacteria acquire and utilise zinc remains incomplete. Here we have used RNA-sequencing and differential gene expression analysis to investigate how B...
2023: British Journal of Biomedical Science
https://read.qxmd.com/read/37822353/the-use-of-cd200-in-the-differential-diagnosis-of-b-cell-lymphoproliferative-disorders
#20
JOURNAL ARTICLE
Hanaan Kareem Al-Zubaidi, Stephen Fôn Hughes
Background: B-Cell Lymphoproliferative Disorders (B-LPDs) are a group of heterogenous disorders characterised by the accumulation of B-cells in peripheral blood, bone marrow, lymph nodes and spleen. They have a variable disease course and outcome and many share similar features making differential diagnosis challenging. Therefore, accurate diagnosis is fundamental in particular for determining treatment options. Immunophenotyping by flow cytometry plays a crucial role in the diagnosis of B-LPDs. However, overlapping immunophenotyping patterns exist and the use of novel monoclonal antibodies has become increasingly important in immunophenotyping analysis...
2023: British Journal of Biomedical Science
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