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British Journal of Biomedical Science

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https://read.qxmd.com/read/30700210/clinicopathological-impact-of-anti-smooth-muscle-antibodies-in-patients-with-nonalcoholic-fatty-liver-disease
#1
Hatem Elalfy, Mohamed Abd El-Maksoud, Sally Abed, Mohammed Abd El Aziz, Ayman Z Elsamanoudy, Salwa Abo-Khair, Mie A Mohamed, Wagdi Elkashef, Khaled Zalata, Raghda Farag, Mona Arafa
INTRODUCTION: Previous studies examining the prevalence of serum autoantibodies in patients with NAFLD reported a wide range of prevalence rates depending on the threshold values used for an abnormal titer. We aimed to evaluate the association of anti-smooth muscle antibodies (ASMAbs) with pathological changes including liver fibrosis in NAFLD patients. PATIENTS AND METHODS: 124 patients were enrolled and classifed on ASMAbs positive (>1/40) or negative (= or <1/40)...
January 31, 2019: British Journal of Biomedical Science
https://read.qxmd.com/read/30691359/the-association-of-hepatic-fat-percentage-with-selected-anthropometric-and-biochemical-parameters-at-3-tesla-magnetic-resonance-imaging
#2
A Al-Radaideh, R Tayyem, K Al-Fayomi, N Nimer, A Almomani, S Alhajjaj, L Agraib, N Hijjawi
BACKGROUND AND AIM: This relatively comprehensive and multi-parametric study was conducted to investigate any association between hepatic fat percentage (HFP) values measured using high-field MRI, anthropometric and biochemical measurements in a group of disease-free adults. METHODS: Abdominal MRI, anthropometric and biochemical measurements were determined in 167 healthy subjects. HFP values were derived from the MRI, whilst routine lipids, leptin, resistin, IL6 and adiponectin were measured by routine methods...
January 29, 2019: British Journal of Biomedical Science
https://read.qxmd.com/read/30633636/lactobacillus-casei-suppresses-hfq-gene-expression-in-escherichia-coli-o157-h7
#3
S Mahdavi, A Isazadeh
Introduction Escherichia coli O157:H7 infection causes dysentery and hemolytic-uremic syndrome (HUS). It is often contracted by intake of contaminated water or food. This bacterium encodes the sRNA chaperone hfq, which is important in growth and virulence. It has been shown that hfq is a global regulator of virulence genes, so with control of this gene with drugs or probiotics we could control the disease. The aim of this study was the effect of Lactobacillus casei on hfq gene expression levels in E. coli O157:H7 by Q-PCR method...
January 11, 2019: British Journal of Biomedical Science
https://read.qxmd.com/read/30628543/bmp4-circulating-levels-and-promoter-rs17563-polymorphism-in-risk-prediction-of-idiopathic-male-infertility
#4
F Eslaminejadi, F Mashayekhi, M A Osalou, S T Sasani, Z Salehi
INTRODUCTION: Bone morphogenetic proteins (BMPs) play an important role in the survival and proliferation of murine germ cells during embryonic development and the regulation of postnatal primordial germ cells migration. We hypothesised a link between BMP4 promoter (rs17563) gene polymorphism and its circulating levels with idiopathic male infertility. METHODS: One hundred idiopathic infertile men and 126 fertile men were recruited. DNA was extracted from peripheral blood and genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP)...
January 10, 2019: British Journal of Biomedical Science
https://read.qxmd.com/read/30616430/inverse-relationship-between-helicobacter-pylori-cagg-pathogenicity-island-and-risk-of-gastric-ulcer
#5
S Z Bakhti, N Raei, S Latifi-Navid, S Zahri, A Yazdanbod
No abstract text is available yet for this article.
January 8, 2019: British Journal of Biomedical Science
https://read.qxmd.com/read/30569830/a-single-nucleotide-polymorphism-in-tlr4-is-linked-with-the-risk-of-hiv-1-infection
#6
S Vidyant, A Chatterjee, T N Dhole
INTRODUCTION: Toll-like receptors (TLRs) are pattern recognition receptors that play a role in innate immunity. Mounting evidence shows that single-nucleotide polymorphisms (SNPs) in TLRs link to various infectious diseases, including human immunodeficiency virus (HIV). We hypothesised links between two TLR4 SNPs (rs4986790 leading to Asp299Gly and rs4986791 leading to Thr399Ile) and HIV. MATERIALS AND METHODS: We recruited 160 HIV-1 seropositive patients, who were further divided on disease severity based on CD4 count (stage I, II, and III), and 270 age and sex matched healthy HIV-1 seronegative (HSN) individuals...
December 20, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30421643/tlr3-and-tlr4-snp-variants-in-the-liver-disease-resulting-from-hepatitis-b-virus-and-hepatitis-c-virus-infection
#7
I Sghaier, S Zidi, L Mouelhi, E Ghazoueni, E Brochot, W Y Almawi, B Y Loueslati
BACKGROUND: Chronic infection with hepatitis B (HBV) and C virus (HCV) is linked with a pro-inflammatory state, predisposing to cirrhosis and liver cancer, particularly hepatocellular carcinoma (HCC). A role for Toll-like receptor (TLR) signalling in hepatocarcinogenesis was recently documented. We hypothesised a link TLR3 and TLR4 polymorphisms and HCC, as surrogates for the significance of TLR signalling in the promotion and initiation of HCC. MATERIALS AND METHODS: We recruited 174 HCV-infected patients, 100 HBV-infected patients and 360 healthy control subjects...
January 2019: British Journal of Biomedical Science
https://read.qxmd.com/read/30392460/clinical-diagnostic-significance-of-prealbumin-cholinesterase-and-retinol-binding-protein-in-liver-cirrhosis-combined-with-encephalopathy
#8
L Tan, Y Meng, T Zeng, Q Wang, T Long, S Wu, X Guan, H Fu, W Zheng, Y Tian, J Chen, J Yu, Y Wu, H Li, L Cao
OBJECTIVE: Hepatic encephalopathy is a common consequence of liver cirrhosis, but diagnosis can be difficult as it is based on clinical criteria alone. We hypothesised that serum prealbumin, cholinesterase and retinol binding protein (RBP) can help support the diagnosis of hepatic encephalopathy. METHODS: We enrolled 306 cirrhotic patients (110 with encephalopathy), 100 chronic hepatitis B patients and 50 healthy controls, measuring routine liver function tests (ALT, AST, GGT, ALP, and bilirubin), albumin, prothrombin time, prealbumin, cholinesterase and RBP by routine methods...
January 2019: British Journal of Biomedical Science
https://read.qxmd.com/read/30430908/the-severity-of-nafld-is-associated-with-the-risk-of-urolithiasis
#9
Shaoyou Qin, Jiangbin Wang, Changyu Zhou, Yonggui Zhang, Yan Xu, Xu Wang, Song Wang
BACKGROUND AND AIMS: Population-based studies suggest a strong association between the presence of nonalcoholic fatty liver disease (NAFLD) and an increased risk of urolithiasis. However, the available information on the association of the severity of NAFLD with urolithiasis is limited. We hypothesised a link between the severity of NAFLD and the risk of urolithiasis. METHODS: We recruited 1527 adult patients with NAFLD who completed a comprehensive health checkup...
November 15, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30406733/influence-of-single-nucleotide-polymorphism-in-il-27-and-il-33-genes-on-breast-cancer
#10
Nazila Fathi Maroufi, Milad Matin, Nushin Ghanbari, Afshin Khorrami, Zahra Amini, Saba Haj Azimian, Alireza Isazadeh, Sina Taefehshokr, Nima Taefehshokr, Behzad Baradaran
No abstract text is available yet for this article.
November 8, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30406716/genetic-polymorphism-of-glial-cell-derived-neurotrophic-factor-gdnf-in-male-infertility
#11
S Shabani, F Mashayekhi, S S Shahangian, Z Salehi
No abstract text is available yet for this article.
November 8, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30379116/nitrosative-stress-and-cytokines-are-linked-with-the-severity-of-sepsis-and-organ-dysfunction
#12
S Kumar, E Gupta, V K Srivastava, S Kaushik, J Saxena, L K Goyal, S Mehta, A Jyoti
OBJECTIVE: An imbalance in oxidant-antioxidant status may impact the severity of sepsis. We hypothesised links between nitrosative stress and pro-inflammatory cytokines and their correlation with the severity of sepsis and associated organ dysfunction. METHODS: The hypothesis was tested in 110 patients with sepsis (in whom a disease severity score (APACHE II) and assessment of organ failure score (SOFA) were determined) and 55 healthy volunteers. Neutrophil inducible nitric oxide synthase (iNOS) expressions at mRNA and protein levels were estimated by real-time PCR and immuno-precipitation followed by Western blotting, respectively...
October 31, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30175654/association-of-genetic-polymorphisms-of-chemokines-and-their-receptors-with-clearance-or-persistence-of-hepatitis-c-virus-infection
#13
M El-Bendary, M Neamatallah, H Elalfy, T Besheer, M El-Setouhy, M M Youssef, M Zein, D Elhammady, A Hegazy, G Esmat
BACKGROUND: Polymorphisms of certain genes may have an effect on either persistence of infection or spontaneous clearance of hepatitis C virus (HCV). We hypothesized that one or more variants of chemokines (CCL2 and CCL5) and chemokine receptors (CC chemokine receptor type 2 [CCR2]) genes are associated with the susceptibility to HCV infection. METHODS: We recruited 1460 patients with chronic HCV (CHC), 108 subjects with spontaneous virus clearance (SVC) and 1446 individuals as a healthy control group...
October 29, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30092718/snp-rs10800708-within-the-kif14-mirna-binding-site-is-linked-with-breast-cancer
#14
A Shasttiri, M Rostamian Delavar, M Baghi, M Dehghani Ashkezari, K Ghaedi
No abstract text is available yet for this article.
October 26, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30295133/british-journal-of-biomedical-science-in-2018-what-have-we-learned
#15
Andrew Blann
In 2018 the British Journal of Biomedical Science published one guideline (in reproductive science) and 40 research articles in the various disciplines the comprise biomedical science. The latter were 24 original articles and 16 'In Brief' short reports. Of these, 23 are of note to only one of the sub-disciplines (seven each to biochemists and microbiologists, six to cell pathologists, and one each to cytologists, immunologists and reproductive scientists). Reflecting the increasing complexity of laboratory science, thirteen papers crossed one boundary (three papers each relevant to biochemists and immunologists, and to haematologists and biochemists), whilst four papers were relevant to three or more disciplines...
October 8, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30269656/a-functional-genetic-variant-in-gas5-lncrna-rs145204276-modulates-p27-kip1-expression-and-confers-risk-for-gastric-cancer
#16
Keyvan Aminian, Farhad Mashayekhi, Laleh Mirzanejad, Zivar Salehi
OBJECTIVE: There has been extensive progress in the identification of single nucleotide polymorphisms (SNPs) affecting susceptibility to gastric cancer in recent years. We hypothesised a functional polymorphism (rs145204276) in GAS5 lncRNA (growth arrest specific transcript 5 long noncoding RNA) in gastric cancer that may modulate the p27Kip1 protein level. MATERIAL AND METHODS: We recruited 130 gastric cancer cases and 230 age and sex matched healthy control subjects...
October 1, 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30211669/role-of-variants-rs5030717-and-rs5030718-of-tlr4-in-the-risk-prediction-of-nephropathy-hypertension-and-dyslipidaemia-in-type-2-diabetes-mellitus
#17
S A Abbas, S T Raza, S S Mir, Z Siddiqi, A Zaidi, Z H Zaidi, F Mahdi
BACKGROUND: Type 2 diabetes mellitus describes a metabolic disorder characterised by prolonged elevated blood glucose that brings a risk of developing microvascular and macrovascular disease. Several factors, such as dysregulation of the Toll-like receptor 4 (TLR-4), are reputed to contribute to the multiple pathophysiological disturbances responsible for impaired glucose homeostasis. We hypothesised that variants rs5030717 and rs5030718 of TLR4 are associated with diabetic nephropathy, hypertension and dyslipidaemia...
October 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30105943/bpi-anca-in-chronic-obstructive-pulmonary-disease-with-pulmonary-pseudomonas-aeruginosa-colonisation-a-novel-indicator-of-poor-prognosis
#18
Y Tian, T Zeng, L Tan, Y Wu, J Yu, J Huang, Z Pei
No abstract text is available yet for this article.
October 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30079841/serum-leptin-and-homeostasis-model-assessment-ir-as-novel-predictors-of-early-liver-fibrosis-in-chronic-hepatitis-b-virus-infection
#19
N Mousa, A Abdel-Razik, T Sheta, W Shabana, S Zakaria, M Awad, M Abd Elsalam, N El-Wakeel, W Elkashef, N Effat, A Elgamal, A G Deiab, W Eldars
BACKGROUND: The relationship between hepatitis B virus (HBV) infection, leptin and insulin resistance remains unclear. We hypothesised links between serum leptin and insulin resistance in non-diabetic patients with chronic viral hepatitis B infection and their relation to liver fibrosis. METHODS: We recruited 190 untreated patients with chronic HBV infection and 72 healthy controls. Serum leptin, fasting glucose, insulin, liver function tests (LFTs), C-peptide and Homeostasis model assessment-IR (HOMA-IR) were measured/calculated by ELISA and standard techniques...
October 2018: British Journal of Biomedical Science
https://read.qxmd.com/read/30058458/prognostic-significance-of-soluble-major-histocompatibility-complex-class-i-related-chain-a-smica-in-gastric-cancer
#20
P Zhao, D Chen, H Cheng
No abstract text is available yet for this article.
October 2018: British Journal of Biomedical Science
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