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Journals Hypertension Research : Offici...

Hypertension Research : Official Journal of the Japanese Society of Hypertension

https://read.qxmd.com/read/38789539/mineralocorticoid-receptor-overactivation-in-diabetes-mellitus-role-of-o-glcnac-modification
#21
REVIEW
Rie Jo, Hiroshi Itoh, Hirotaka Shibata
Hypertension is a significant risk factor for microangiopathy and cardiovascular complications in diabetic patients. The efficacy of mineralocorticoid receptor (MR) antagonists in impeding the advancement of diabetic nephropathy, along with the reduction in active renin concentration observed in diabetic retinopathy, strongly implies the involvement of MR overactivation in diabetic complications. This review provides a comprehensive review of various mechanisms proposed for MR overactivation in diabetes mellitus...
May 24, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38789538/blood-pressure-reduction-with-empagliflozin-in-japanese-patients-with-type-2-diabetes-and-cardiovascular-diseases-a-post-hoc-sub-analysis-of-the-placebo-controlled-randomized-emblem-trial
#22
JOURNAL ARTICLE
Atsushi Tanaka, Michio Shimabukuro, Hiroki Teragawa, Hisako Yoshida, Yosuke Okada, Toshinari Takamura, Isao Taguchi, Shigeru Toyoda, Hirofumi Tomiyama, Shinichiro Ueda, Yukihito Higashi, Koichi Node
Detailed effect of sodium-glucose cotransporter 2 inhibitors on blood pressure (BP) in Japanese patients with type 2 diabetes (T2D) at a high risk of cardiovascular disease (CVD) is not fully understood. In this post-hoc sub-analysis of placebo-controlled randomized EMBLEM trial for Japanese patients with T2D and CVD, 105 participants (empagliflozin N = 52, placebo N = 53) were included, and office systolic/diastolic BPs and mean arterial pressure (MAP) over 24 weeks were estimated using mixed-effects models for repeated measures...
May 24, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38783146/the-relationship-between-sglt2-and-systemic-blood-pressure-regulation
#23
REVIEW
Priscilla Ahwin, Diana Martinez
The sodium-glucose cotransporter 2 (SGLT2) is a glucose transporter that is located within the proximal tubule of the kidney's nephrons. While it is typically associated with the kidney, it was later identified in various areas of the central nervous system, including areas modulating cardiorespiratory regulation like blood pressure. In the kidney, SGLT2 functions by reabsorbing glucose from the nephron's tubule into the bloodstream. SGLT2 inhibitors are medications that hinder the function of SGLT2, thus preventing the absorption of glucose and allowing for its excretion through the urine...
May 23, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38783145/associations-and-attributable-burden-between-risk-factors-and-all-cause-and-cause-specific-mortality-at-different-ages-in-patients-with-hypertension
#24
JOURNAL ARTICLE
Qiao Jin, Jie Mei, Yu Chit Wong, Cindy Lo Kuen Lam, Eric Yuk Fai Wan
It remains unclear the age-specific associations of risk factors with deaths and mortality burden attributable across age. In a territory-wide retrospective cohort, 1,012,228 adults with hypertension were identified. Comorbidities including diabetes, chronic kidney disease (CKD), cardiovascular disease (CVD), heart failure, and cancer, and risk factors including current smoking and suboptimal control of blood pressure (BP), glucose and low-density lipoprotein cholesterol were defined. Associations of comorbidities/risk factors with all-cause and cause-specific mortality across age groups (18-54, 55-64, 65-74, and ≥75 years) were assessed...
May 23, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38783144/cardiopulmonary-deconditioning-and-plasma-volume-loss-are-not-sufficient-to-provoke-orthostatic-hypertension
#25
JOURNAL ARTICLE
J-N Hoenemann, S Moestl, L de Boni, F Hoffmann, M Arz, L Berger, D Pesta, K Heusser, E Mulder, S M C Lee, B R Macias, J Tank, J Jordan
Orthostatic hypertension, defined by an increase of systolic blood pressure (SBP) of ≥20 mmHg upon standing, harbors an increased cardiovascular risk. We pooled data from two rigorously conducted head-down tilt bedrest studies to test the hypothesis that cardiopulmonary deconditioning and hypovolemia predispose to orthostatic hypertension. With bedrest, peak VO2 decreased by 6 ± 4 mlO2 /min/kg (p < 0.0001) and plasma volume by 367 ± 348 ml (p < 0...
May 23, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38778172/immunological-insights-into-hypertension-unraveling-triggers-and-potential-therapeutic-avenues
#26
REVIEW
Brandon G Shokoples, Pierre Paradis, Ernesto L Schiffrin
Hypertension remains the leading cause of morbidity and mortality worldwide. Despite its prevalence, the development of novel antihypertensive therapies has only recently accelerated, with novel agents not yet commercialized, leaving a substantial proportion of individuals resistant to existing treatments. The intricate pathophysiology of hypertension is now understood to involve chronic low-grade inflammation, which places the immune system in the spotlight as a potential target for new therapeutics. This review explores the factors that initiate and sustain an immune response in hypertension, offering insights into potential targets for new treatments...
May 22, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38778171/hypotensive-effects-of-exercise-training-are-postmenopausal-women-with-hypertension-non-responders-or-responders
#27
JOURNAL ARTICLE
Marina Lívia Venturini Ferreira, Alex Castro, Silas Gabriel de Oliveira Nunes, Marcus Vinícius Mattos Abreu Dos Santos, Cláudia Regina Cavaglieri, Hirofumi Tanaka, Mara Patrícia Traina Chacon-Mikahil
We tested the hypothesis that increasing the exercise dose or changing the exercise mode would augment hypotensive effects when traditional aerobic exercise training failed to produce it in postmenopausal women. Sixty-five postmenopausal women with essential hypertension were randomly allocated into the continuous aerobic training (CAT) and non-exercising control (CON) groups. CAT group cycled at moderate intensity 3 times a week for 12 weeks. Individuals who failed to decrease systolic blood pressure (BP) were classified as non-responders (n = 34) and performed an additional 12 weeks of exercise training with either increasing the exercise dose or changing the exercise mode...
May 22, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38778170/the-salt-sensitivity-of-drd4-null-mice-is-associated-with-the-upregulations-of-sodium-transporters-in-kidneys
#28
JOURNAL ARTICLE
Mingzhuo Zhang, Mingda Liu, Weiwan Wang, Zhiyun Ren, Ping Wang, Ying Xue, Xiaoyan Wang
To explore the mechanism of the hypertension in dopamine receptor-4 (Drd4) null mice, we determined the salt sensitivity and renal sodium transport proteins in Drd4-/- and Drd4+/+ mice with varied salt diets. On normal NaCl diet (NS), mean arterial pressures (MAP, telemetry) were higher in Drd4-/- than Drd4+/+ ; Low NaCl diet (LS) tended to decrease MAP in both strains; high NaCl diet (HS) elevated MAP with sodium excretion decreased and pressure-natriuresis curve shifted to right in Drd4-/- relative to Drd4+/+ mice...
May 22, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38773338/does-daily-self-monitoring-of-urinary-sodium-to-potassium-ratio-decrease-salt-intake
#29
EDITORIAL
Michihiro Satoh, Tomoko Muroya, Hirohito Metoki
No abstract text is available yet for this article.
May 21, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38773337/another-step-forward-in-the-introduction-of-aortic-systolic-blood-pressure-assessment-into-clinical-practice
#30
EDITORIAL
Athanase D Protogerou, Elpida Athanasopoulou, Antonios A Argyris
No abstract text is available yet for this article.
May 21, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38773336/pharmacological-stimulation-of-the-parasympathetic-system-a-promising-means-of-cardioprotection-in-heart-failure
#31
EDITORIAL
Fedor Simko, Tomas Baka
No abstract text is available yet for this article.
May 21, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769138/adrenomedullin-improved-endothelial-dysfunction-via-receptor-akt-pathway-in-rats-with-obesity-related-hypertension
#32
JOURNAL ARTICLE
Si-Yu Liu, Qian Wang, Hong Zhou, Ning Tong, Rui Chang, Fang-Zheng Wang, Ping Guo, Xin Li, Ye-Bo Zhou, Zhen-Zhen Li
Obesity-related hypertension (OH) is accompanied by obvious endothelial dysfunction, which contributes to increased peripheral vascular resistance and hypertension. Adrenomedullin (ADM), a multifunctional active peptide, is elevated in obese humans. The OH rats induced by high fat diet (HFD) for 28 weeks and the human umbilical vein endothelial cells (HUVECs)-treated by palmitic acid (PA) were used to investigate the effects of ADM on endothelial dysfunction and the underlying mechanisms. Vascular reactivity was assessed using mesenteric arteriole rings, and the protein expression levels were examined by Western blot analysis...
May 21, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769140/gut-bacteria-derived-extracellular-vesicles-and-hypertension
#33
EDITORIAL
Kento Kitada
No abstract text is available yet for this article.
May 20, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769139/taking-action-for-controlling-high-blood-pressure-challenges-in-the-real-world
#34
EDITORIAL
Toshiki Maeda
No abstract text is available yet for this article.
May 20, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769137/preoperative-blood-urea-nitrogen-to-serum-albumin-ratio-for-prediction-of-in-hospital-mortality-in-patients-who-underwent-emergency-surgery-for-acute-type-a-aortic-dissection
#35
JOURNAL ARTICLE
Qingsong Wu, Jian Zheng, Jianling Lin, Linfeng Xie, Mirong Tang, Meng Ke, Liangwan Chen
The study aimed to assess the predictive value of blood urea nitrogen (BUN)-to-albumin ratio (BA-R) for in-hospital mortality in patients undergoing emergency surgery for acute type A aortic dissection (ATAAD). Patients who were diagnosed with ATAAD and underwent emergency surgery within 48 hours of onset at our hospital between January 2015 and December 2021 were included in this study. The primary endpoint of this study was postoperative in-hospital mortality (POIM). The data of the survivors and non-survivors were retrospectively compared analyses...
May 20, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769136/microrna-based-electrochemical-biosensor-for-early-detection-of-pulmonary-arterial-hypertension
#36
LETTER
Ashikha Shirin Usman Pp, Durairaj Sekar
No abstract text is available yet for this article.
May 20, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769135/geriatric-nutritional-risk-index-is-associated-with-adverse-outcomes-in-patients-with-hypertension-the-fukushima-cohort-study
#37
JOURNAL ARTICLE
Kenichi Tanaka, Hiroshi Kimura, Hiroki Ejiri, Hirotaka Saito, Kimio Watanabe, Sakumi Kazama, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama
Malnutrition is reportedly associated with adverse clinical outcomes in various populations. However, associations between nutritional status and adverse outcomes in patients with hypertension have not been sufficiently elucidated. We therefore aimed to investigate the impact of nutritional status as evaluated by the Geriatric Nutritional Risk Index (GNRI) on adverse outcomes in patients with hypertension. We conducted a retrospective cohort study of 1588 hypertensive patients enrolled in the Fukushima Cohort Study...
May 20, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769134/amelioration-of-gait-and-balance-disorders-by-rosuvastatin-is-associated-with-changes-in-cerebrovascular-reactivity-in-older-patients-with-hypertensive-treatment
#38
JOURNAL ARTICLE
Junyi Ge, Xiaofei Qin, Xinyi Yu, Peilin Li, Yanli Yao, Hua Zhang, Huajing Song, Zhendong Liu
To investigate the effect of rosuvastatin on gait and balance disorder progression and elucidate the role of cerebrovascular reactivity (CVR) on this effect. From April 2008 to November 2010, 943 hypertensive patients aged ≥60 years were enrolled from the Shandong area of China. Patients were randomized into rosuvastatin and placebo groups. Gait, balance, CVR, fall and stroke were assessed. During an average 72 months of follow-up, the decreasing trends for step length, step speed, and Berg balance scale scores and the increasing trends for step width and chair rising test were slower in the rosuvastatin group when compared to the placebo group...
May 20, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769133/chatgpt-and-bing-and-home-blood-pressure-monitoring-hbpm-knowledge
#39
LETTER
Hinpetch Daungsupawong, Viroj Wiwanitkit
No abstract text is available yet for this article.
May 20, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38769132/enhancing-healthcare-with-ethical-considerations-in-artificial-intelligence
#40
LETTER
Zahra Karbasi, Michaeel Motaghi Niko, Maryam Zahmatkeshan
No abstract text is available yet for this article.
May 20, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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