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Seizure: the Journal of the British Epilepsy Association

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https://read.qxmd.com/read/31121549/establishment-of-low-cost-epilepsy-surgery-centers-in-resource-poor-setting
#1
Anis Jukkarwala, Neeraj N Baheti, Amit Dhakoji, Bhagwati Salgotra, Girish Menon, Aditya Gupta, Sanjay Prakash, Chaturbhuj Rathore
PURPOSE: To prospectively assess the feasibility of establishing low cost epilepsy surgery programs in resource poor settings. METHOD: We started epilepsy surgery centers in Tier 2 and Tier 3 cities in India in private hospitals. This model is based on the identifying and operating ideal epilepsy surgery candidates on the basis of clinical history, interictal and ictal video-EEG data, and 1.5 T MRI without other investigations and without regular involvement of other specialists...
May 14, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31121547/latencies-to-first-interictal-epileptiform-discharges-in-different-seizure-types-during-video-eeg-monitoring
#2
Guray Koc, Gulin Morkavuk, Efdal Akkaya, Omer Karadas, Alev Leventoglu, Bulent Unay, Zeki Gokcil
PURPOSE: Interictal epileptiform discharges (IEDs) have high diagnostic value concerning patients with epilepsy and the instances of obtaining IEDs increase with longer recording times. However, the merit of a single, extended electroencephalography (EEG) recording in detecting IEDs has not been substantiated. We aimed to determine the optimal duration of an EEG required to diagnose epilepsy in different seizure types. METHODS: Overall, 84 patients-29 with generalised onset epilepsy and 55 with focal onset epilepsy-were evaluated...
May 14, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31112829/infantile-epilepsy-with-multifocal-myoclonus-caused-by-tbc1d24-mutations
#3
Jing Zhang, Jiaoyang Chen, Qi Zeng, Liping Zhang, Xiaojuan Tian, Xiaoling Yang, Zhixian Yang, Ye Wu, Xiru Wu, Yuehua Zhang
PURPOSE: To summarize the clinical features and neuroimaging changes of epilepsy associated with TBC1D24 mutations. METHODS: Genetic testing was conducted in all epilepsy patients without acquired risk factors for epilepsy. Epilepsy patients identified with TBC1D24 compound heterozygous mutations by next-generation sequencing (NGS) epilepsy panel or whole exome sequencing (WES) were enrolled. The enrolled patients were followed up to summarize the clinical features...
May 13, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31103792/auras-in-psychogenic-nonepileptic-seizures
#4
Ali A Asadi-Pooya, Zahra Bahrami
PURPOSE: The aim of this study was to investigate the frequency and characteristics of auras in patients with psychogenic nonepileptic seizures (PNES) and to characterize the patients' historical and clinical risk factors that may be associated with such manifestations. METHODS: In this retrospective database study, all patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 until 2018, were studied...
May 13, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31102827/a-novel-variant-in-scn1a-gene-associated-with-dravet-syndrome
#5
Baps Pathirana, D Hettiarachchi, N F Neththikumara, P D Ratnayake, Vhw Dissanayake
No abstract text is available yet for this article.
May 10, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31112828/knowledge-attitudes-and-practice-towards-epilepsy-among-medical-staff-in-southern-china-does-the-level-of-hospitals-make-a-difference
#6
Ke Yang, Yue He, Bo Xiao, Jing Wang, Li Feng
PURPOSE: To assess knowledge, attitudes, and practice (KAP) toward epilepsy among medical staff from different levels of hospitals in Southern China. METHOD: An adapted and structured questionnaire was administered to medical personnel from tertiary (n = 451) and basic-level (n = 448) hospitals in Southern China. The questionnaire comprised of three domains which consisted of 6 items for awareness, 12 items for knowledge and a 14 item scale for attitudes...
May 8, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31082694/olfactory-stimulus-induced-temporal-lobe-seizures-in-limbic-encephalitis
#7
Federica Avorio, Alessandra Morano, Martina Fanella, Jinane Fattouch, Mariarita Albini, Luca M Basili, Emanuele Cerulli Irelli, Giacomo Fisco, Mario Manfredi, Anna T Giallonardo, Carlo Di Bonaventura
No abstract text is available yet for this article.
May 6, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31072785/corrigendum-to-does-age-affect-response-to-quinidine-in-patients-with-kcnt1-mutations-report-of-three-new-cases-and-review-of-the-literature-seizure-55-february-2018-1-3
#8
Elie Abdelnour, William Gallentine, Marie McDonald, Monisha Sachdev, Yong-Hui Jiang, Mohamad A Mikati
No abstract text is available yet for this article.
May 6, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31121548/evaluation-for-epilepsy-surgery-why-do-patients-not-proceed-to-operation
#9
Johan Weber, Cecilia Gustafsson, Kristina Malmgren, Moa Strandberg, Ûmran Can, Maria Compagno Strandberg, Eva Kumlien
PURPOSE: To investigate the reasons for not proceeding to surgery in patients undergoing presurgical evaluation for epilepsy. METHODS: A retrospective cohort study of 401 consecutive patients who were evaluated for but did not proceed to surgery for epilepsy between 1990 and 2016 at three Swedish epilepsy surgery centers was performed. Reasons for not proceeding to surgery were categorized as inconclusive investigation, seizure onset within eloquent cortex, evidence of multiple seizure foci, infrequent seizures, risk of postoperative severe cognitive decline, patient or caregiver declining surgery or invasive investigation, severe psychiatric or somatic comorbidity, patient death during evaluation and complications during the evaluation...
May 5, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31101405/dc-shifts-high-frequency-oscillations-ripples-and-fast-ripples-in-relation-to-the-seizure-onset-zone
#10
REVIEW
Somin Lee, Naoum P Issa, Sandra Rose, James X Tao, Peter C Warnke, Vernon L Towle, Wim van Drongelen, Shasha Wu
Efforts to improve epilepsy surgery outcomes have led to increased interest in the study of electroencephalographic oscillations outside the conventional EEG bands. These include fast activity above the gamma band, known as high frequency oscillations (HFOs), and infraslow activity (ISA) below the delta band, sometimes referred to as direct current (DC) or ictal baseline shifts (IBS). HFOs in particular have been extensively studied as potential biomarkers for epileptogenic tissue in light of evidence showing that resection of brain tissue containing HFOs is associated with good surgical outcomes...
May 3, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31056410/corrigendum-to-seizure-like-episodes-and-eeg-abnormalities-in-patients-with-long-qt-syndrome-seizure-61-2018-214-220
#11
Alba González, Dag Aurlien, Pål G Larsson, Ketil Berg Olsen, Iselin T Dahl, Thor Edvardsen, Kristina H Haugaa, Erik Taubøll
No abstract text is available yet for this article.
May 2, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31079028/effect-of-brivaracetam-on-the-anger-levels-of-epilepsy-patients-a-prospective-open-labelled-controlled-study
#12
Manuel Toledo, Laura Abraira, Gonzalo Mazuela, Manuel Quintana, Sonia Cazorla, Estevo Santamarina
PURPOSE: The rate of brivaracetam-related behavioural adverse events is a current focus of discussion. This study aims to assess the effect of brivaracetam on anger levels in patients with epilepsy, adjusted by mood symptoms, history of psychiatric disorders and seizure response. METHOD: Prospective analysis of 37 patients assessed for anger levels (STAXI-2), depression-anxiety (HADS) and quality of life (QOLIE-10) before adjunctive brivaracetam treatment and reassessed 3-6 months later...
May 1, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31077960/long-term-epilepsy-after-early-post-stroke-status-epilepticus
#13
Laura Abraira, Manuel Toledo, Lorena Guzmán, María Sueiras, Manuel Quintana, Elena Fonseca, Javier Salas-Puig, Jose Alvarez-Sabín, Estevo Santamarina
PURPOSE: The risk of developing epilepsy at long term after post-stroke status epilepticus (PSSE) is unknown. We aimed to evaluate post-stroke epilepsy (PSE) after early-onset PSSE and its associated factors. METHOD: All consecutive patients with early-onset PSSE and no history of epilepsy admitted to our hospital between February 2011 and April 2017 were included. We analysed status epilepticus (SE) and stroke-related factors in relation to the development of PSE...
May 1, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31075750/vitamin-d-abnormalities-and-bone-turn-over-analysis-in-children-with-epilepsy-in-the-western-cape-of-south-africa
#14
Edward Kija, Barry E Gidal, Alexander Shapson-Coe, Shihaam Cader, George van der Watt, Steve Delport, Jo M Wilmshurst
PURPOSE: The effects of antiseizure medications (ASMs) on bone metabolism is inconsistent. Most studies are in high income settings and none from sub-Saharan Africa. METHODS: A hospital based cross-sectional study in a paediatric epilepsy service with a comparison group assessed vitamin D metabolism. RESULTS: Seventy-five children with epilepsy and 75 comparison group were recruited. Median age for children with epilepsy was 9 years (range 1-17 years) and controls 3 years (range 1-12 years)...
April 29, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31054491/a-call-for-better-information-about-epilepsy-the-patients-perspective-an-online-survey
#15
Oliver Henning, Kristin A Alfstad, Karl O Nakken, Morten I Lossius
PURPOSE: For people with epilepsy (PWE), insufficient information and knowledge about the disease might have a negative influence on outcome and lead to poorer quality of life. In contrast, good information may increase empowerment and reduce stigma. This study investigated whether Norwegian PWE want information about different epilepsy-related issues, whether they actually obtain the information that they seek, and the extent to which they are satisfied with the information they receive...
April 27, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31054490/the-landscape-of-early-infantile-epileptic-encephalopathy-in-a-consanguineous-population
#16
Marwan Nashabat, Xena S Al Qahtani, Salwa Almakdob, Waleed Altwaijri, Duaa M Ba-Armah, Khalid Hundallah, Amal Al Hashem, Saeed Al Tala, Sateesh Maddirevula, Fowzan S Alkuraya, Brahim Tabarki, Majid Alfadhel
PURPOSE: Epileptic encephalopathies (EE), are a group of age-related disorders characterized by intractable seizures and electroencephalogram (EEG) abnormalities that may result in cognitive and motor delay. Early infantile epileptic encephalopathies (EIEE) manifest in the first year of life. EIEE are highly heterogeneous genetically but a genetic etiology is only identified in half of the cases, typically in the form of de novo dominant mutations. METHOD: This is a descriptive retrospective study of a consecutive series of patients diagnosed with EIEE from the participating hospitals...
April 27, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31048270/impact-of-antiepileptic-drugs-for-seizure-prophylaxis-on-short-and-long-term-functional-outcomes-in-patients-with-acute-intracerebral-hemorrhage-a-meta-analysis-and-systematic-review
#17
Brian Spoelhof, Julian Sanchez-Bautista, Andres Zorrilla-Vaca, Peter W Kaplan, Salia Farrokh, Marek Mirski, Brin Freund, Lucia Rivera-Lara
PURPOSE: The purpose of this analysis is to assess the effect of antiepileptics (AEDs) on seizure prevention and short and long term functional outcomes in patients with acute intracerebral hemorrhage. METHOD: The meta-analysis was conducted using the PRISMA guidelines. A literature search was performed of the PubMed, the Cochrane Library, and EMBASE databases. Search terms included "Anticonvulsants", "Intracerebral Hemorrhage", and related subject headings...
April 25, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31035234/a-very-rare-form-of-autosomal-dominant-progressive-myoclonus-epilepsy-caused-by-a-novel-variant-in-the-prickle1-gene
#18
Hussein Algahtani, Fahad Al-Hakami, Mohammed Al-Shehri, Bader Shirah, Mohammad H Al-Qahtani, Angham Abdulrahman Abdulkareem, Muhammad Imran Naseer
PURPOSE: Progressive myoclonus epilepsy (PME) comprises a group of heterogeneous disorders defined by the combination of action myoclonus, epileptic seizures, and progressive neurologic deterioration. Neurologic deterioration may include progressive cognitive decline, ataxia, neuropathy, and myopathy. A number of genes have been identified to cause either isolated PME or diseases that manifest PME. We report a Saudi family with a very rare form of autosomal dominant PME. METHODS: We included two patients from Saudi Arabia with a presumptive clinical diagnosis of PME...
April 19, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31048271/the-efficacy-of-a-pharmacist-implemented-educational-treatment-programme-for-people-with-epilepsy-a-report-of-a-randomised-controlled-trial
#19
Unyime Eshiet, Jegbefume Okonta, Chinwe Ukwe
PURPOSE: To evaluate the efficacy of a pharmacist implemented educational treatment programme in improving knowledge and perception of epilepsy among people with the condition. METHOD: A randomized controlled study was conducted on patients with epilepsy recruited from the medical and neurology out-patient clinics of two tertiary hospitals. Patients in the intervention group were offered an educational treatment programme implemented by a clinical pharmacist. The impact of the educational intervention was evaluated by using an epilepsy knowledge scale and the brief illness perception questionnaire...
April 15, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31026743/perampanel-for-the-treatment-of-epilepsy-longitudinal-actuarial-analysis-and-dose-responses-based-on-monthly-outcomes
#20
Ioannis Stavropoulos, Walter Louden, Cathy Queally, Jane Adcock, Maggie Tristram, Marcus Neale, Nicholas Moran, Lorena Flores L, Lina Nashef, Mark P Richardson, Charlie Bell, Sean Slaght, Julia Aram, Niki Rayner, Robert Powell, Alison Mead, Arjune Sen, Robert Elwes
PURPOSE: To explore the retention rates and the efficacy and tolerability of perampanel (PER) by using monthly real life data for a period of 12 months. METHODS: Longitudinal outcomes of (PER) usage were assessed using actuarial statistics in an observational nonrandomised multicentre study of 181 people with epilepsy (PWE) refractory to first and second line drugs. Graded seizure outcomes, toxicity and the dose of PER were recorded for each month. RESULTS: PWE were followed for a mean of 15...
April 15, 2019: Seizure: the Journal of the British Epilepsy Association
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