Journals Seizure : the Journal of the B...

Seizure : the Journal of the British Epilepsy Association
Ting Zhao, Hong-Jian Li, Hui-Lan Zhang, Ji-Rong Feng, Jing Yu, Ke-Fang Sun, Jie Feng, Yan Sun, Lu-Hai Yu
OBJECTIVE: This study was the first to evaluate the effect of CYP3A4 gene polymorphisms on the plasma concentration and effectiveness of perampanel (PER) in Chinese pediatric patients with epilepsy. METHODS: We enrolled 102 patients for this investigation. The steady-state concentration was determined after patients maintained a consistent PER dosing regimen for at least 21 days. Plasma PER concentrations were measured using liquid chromatography-tandem mass spectrometry...
July 8, 2024: Seizure: the Journal of the British Epilepsy Association
J Idowu, C Meades, J H Cross, A Muggeridge, M Lakhanpaul, K Robinson, L B Sherar, N Pearson, C Reilly
PURPOSE: To describe the prevalence and associated factors of mental health problems in secondary school-aged (11-16 years) children with epilepsy and their primary caregivers compared to a control group without epilepsy. METHODS: Children with epilepsy (n = 60), controls (n = 49), and caregivers (n = 60 epilepsy and n = 49 control group) completed a measure of the child's mental health (Strengths and Difficulties Questionnaire; SDQ). Primary caregivers in both groups completed a measure of their own mental health (Depression, Anxiety, and Stress Scale-21; DASS-21)...
July 4, 2024: Seizure: the Journal of the British Epilepsy Association
Sangeeth T A, Ajay Asranna, Raghavandra Kenchaiah, Ravindranadh C Mundlamuri, Viswanathan Lg, Sanjib Sinha
BACKGROUND: The analysis of EEG demands expertise and keen observation to distinguish epileptiform discharges from benign epileptiform variants (BEVs), a frequent source of erroneous interpretation. The prevalence of BEVs varies based on geographical, racial, and ethnic characteristics. However, most data on BEVs originates from Western populations, and additional studies on different cohorts would enrich the existing literature. METHODS: We reviewed EEGs from our institutional database to study the prevalence of benign epileptiform variants and analyzed their frequency, topography, and other characteristics...
July 3, 2024: Seizure: the Journal of the British Epilepsy Association
Angelo Pascarella, Lucia Manzo, Edoardo Ferlazzo
Brain aging is associated with a decline in cognitive performance, motor function and sensory perception, even in the absence of neurodegeneration. The underlying pathophysiological mechanisms remain incompletely understood, though alterations in neurogenesis, neuronal senescence and synaptic plasticity are implicated. Recent years have seen advancements in neurophysiological techniques such as electroencephalography (EEG), magnetoencephalography (MEG), event-related potentials (ERP) and transcranial magnetic stimulation (TMS), offering insights into physiological and pathological brain aging...
July 2, 2024: Seizure: the Journal of the British Epilepsy Association
Tian-Yi Cui, Han Wu, Chong-Yang Tang, Xiong-Fei Wang, Tian-Fu Li, Jian Zhou
OBJECTIVE: To summarize the surgical outcomes of genetically refractory epilepsy and identify prognostic factors for these outcomes. METHODS: A literature search of the PubMed, Web of Science, and Embase databases for relevant studies, published between January 1, 2002 and December 31, 2023, was performed using specific search terms. All studies addressing surgical outcomes and follow-up of genetically refractory epilepsy were included. All statistical analyses were performed using STATA software (StataCorp LLC, College Station, TX, USA)...
June 29, 2024: Seizure: the Journal of the British Epilepsy Association
Christoph Kaiser, Walter Kipp, Nolbert Gumisiriza, George Asaba
PURPOSE: To assess long-term mortality and causes of death in children with nodding syndrome, an epileptic disorder of sub-Sahara Africa. METHODS: Ten children with nodding syndrome were followed over 24 years. The mortality rate was determined as the number of deaths per 1000 person-years of observation. The standard mortality ratio (SMR) was calculated as the number of observed deaths divided by the number of expected deaths in the general population. Patients were started on phenobarbital and treatment response was monitored during the first 20 months of follow-up...
June 26, 2024: Seizure: the Journal of the British Epilepsy Association
Vineet Punia, Sakhi Bhansali, Carolyn Tsai
The unique patho-clinical entity of late-onset epilepsy (LOE), distinguished by its distinct natural history, from its onset to the prognosis it portends, necessitates specialized care. We lack a universally accepted definition, but LOE is typically identified as epilepsy onset after the age of 60 or 65. Unlike epilepsy in younger individuals, LOE is almost by default focal in origin, secondary to acquired etiologies, and presents unique diagnostic and management challenges due to its atypical semiology, higher comorbidity burden, frailty, and increased risks of subsequent stroke and dementia...
June 26, 2024: Seizure: the Journal of the British Epilepsy Association
Isha Puntambekar, Fenglai Xiao, Robert Shortman, Matthias Koepp
INTRODUCTION: About 25 % of new-onset epilepsies are diagnosed after age 65. Late-onset epilepsy (LOE) is predicted to become a major healthcare problem in the next 15 years as the global population increases and ages. Neurodegenerative disorders account for 10-20 % of LOE, while over 20 % of these patients have an unknown etiology. Established diagnostic tools such as FDG-PET and novel biomarkers of neurodegeneration including amyloid and tau PET hold a lot of promise in diagnosing and ruling out neurodegenerative disorders in these patients...
June 25, 2024: Seizure: the Journal of the British Epilepsy Association
Kristina Malmgren
The highly heterogeneous population of elderly with epilepsy continues to increase as the incidence of epilepsy rises with increasing life expectancy. There are many aspects to consider in the treatment of elderly with epilepsy, e g comorbidities and the complexity of polypharmacy. The literature on quality-of-life (QoL) and patient-centered outcomes in elderly in general as well as in elderly with epilepsy is limited, most of the existing studies report results from quality-of-life surveys. No such QoL questionnaires have, however, in the validation process explored issues specific to the elderly...
June 25, 2024: Seizure: the Journal of the British Epilepsy Association
G Marinella, F Pascarella, A Vetro, A Bonuccelli, F Pochiero, A Santangelo, M G Alessandrì, R Pasquariello, A Orsini, R Battini
UNLABELLED: Familial hyperlysinemia is a rare autosomal recessive disorder due to defects of the AASS (α-aminoadipate δ-semialdehyde synthase) gene, which encodes for a bifunctional enzyme. Two types of hyperlysinemia have been identified namely type 1, due to the deficit of the alfa-ketoglutarate activity, and type 2, due to the deficit of the saccharopine dehydrogenase activity. METHODS: To better characterize the phenotypic spectrum of familial hyperlysinemia type 1, we conducted a systematic review of cases in the literature following PRISMA guidelines...
June 24, 2024: Seizure: the Journal of the British Epilepsy Association
Seline W Hepsø, Maya Lee, Kristoffer Noszka, Yvonne Myrtvedt Wollertsen, Gunhild Holmaas, Erle Kristensen, Tom Eichele, Marte-Helene Bjork, Silja T Griffiths, Omar Hikmat
PURPOSE: Refractory (RSE) and super-refractory status epilepticus (SRSE) are serious medical emergencies whose long-term outcomes depend on the timeliness of their management. Population-based clinical and epidemiological data on these conditions are sparse. We aimed to provide a detailed description of the epidemiology and clinical course of RSE and SRSE in children and adolescents and identify potential prognostic biomarkers. METHODS: In this retrospective population-based study, patients aged one month to 18 years who fulfilled the RSE/SRSE diagnostic criteria and were admitted to the intensive care unit of Haukeland University Hospital from 2012 to 2021 were considered eligible...
June 24, 2024: Seizure: the Journal of the British Epilepsy Association
Chris Tailby, Jodie E Chapman, Remy Pugh, Annette Holth Skogan, Christoph Helmstaedter, Graeme D Jackson
Epilepsy is an inherently dynamic disease and neuropsychology plays a key role in the formulation, monitoring and management of the condition. Teleneuropsychology provides an opportunity for neuropsychology to increase its accessibility, reach and efficiency, using focussed assessments to target epilepsy relevant domains at critical timepoints in the disease trajectory. Neuropsychologists working with epilepsy have, however, been comparatively slow to adopt telehealth methods. Here we review recent developments in teleneuropsychology, with particular reference to applications and considerations in Late Onset Epilepsy...
June 23, 2024: Seizure: the Journal of the British Epilepsy Association
Lu Gao, Xianjun Li, Huanfa Li, Hua Zhang, Xiaohong Liu, Jian Yang
PURPOSE: To investigate glymphatic function by Virchow-Robin space (VRS) counts and volume in patients with newly diagnosed self-limited epilepsy with centrotemporal spikes (SeLECTS) and evaluate its relationship with structural connectivity and cognitive impairment. METHODS: Thirty-two children with SeLECTS and thirty-two age- and sex-matched typically developing (TD) children were enrolled in this study. VRS counts and volume were quantified. Structural networks were constructed and the topological metrics were analyzed...
June 22, 2024: Seizure: the Journal of the British Epilepsy Association
Attila Rácz, Daniel S Galvis-Montes, Valeri Borger, Albert J Becker, Julika Pitsch
The aim of the present study was to review the current knowledge on the neuropathological spectrum of late onset epilepsies. Several terms including 'neuropathology*' AND 'late onset epilepsy' (LOE) combined with distinct neuropathological diagnostic terms were used to search PubMed until November 15, 2023. We report on the relevance of definitional aspects of LOE with implications for the diagnostic spectrum of epilepsies. The neuropathological spectrum in patients with LOE is described and includes vascular lesions, low-grade neuroepithelial neoplasms and focal cortical dysplasias (FCD)...
June 19, 2024: Seizure: the Journal of the British Epilepsy Association
Qi Liu, Qingya Zhao, Qianqian Ji, Xiaogang Lv, Xiaoping Huang, Xiaowei Xu, Yiqiang Zhan
PURPOSE: The analysis of long-term trends of mortality from epilepsy has not been conducted, which is crucial for estimating the future burden of epilepsy. We therefore aimed to investigate the long-term trends of mortality from epilepsy in the United States from 1979 to 2021. METHODS: The cause-of-death and demographic data were from the National Center for Health Statistics (1979-2021) and population estimates were from the US Census Bureau. We used the joinpoint regression model to analyze secular trends in the mortality of epilepsy spanning from 1979 to 2021...
June 19, 2024: Seizure: the Journal of the British Epilepsy Association
Yu Zhang, Haijiao Wang, Ling Liu
PURPOSE: This systematic review and meta-analysis examined the risk factors for suicide-related events (SRE) in patients with epilepsy (PWE). METHODS: The PubMed, Embase, Cochrane Online Library, and databases were searched for relevant articles published from 1946 to August 30, 2022. The quality of the extracted articles was assessed using the Newcastle-Ottawa scale. Subsequently, a meta-analysis of PWE was performed to calculate the random-effects pooled odds ratios (ORs) for studies investigating the association between suicide and its associated risk factors...
June 19, 2024: Seizure: the Journal of the British Epilepsy Association
Elsa Tillberg, Jonas K E Persson
PURPOSE: The purpose of this study was to describe intellectual disability and its association with epilepsy and brain imaging, in a population-based group of children with hemiplegic (unilateral) cerebral palsy, previously investigated and published in 2020. MATERIALS AND METHODS: Forty-seven children of school age in northern Stockholm, fulfilling the Surveillance of Cerebral Palsy in Europe-criteria of hemiplegic (unilateral spastic) cerebral palsy, were invited to participate in the study...
June 15, 2024: Seizure: the Journal of the British Epilepsy Association
Yao-Lun Yang, Hsiu-Fen Lee, Ching-Shiang Chi, Chi-Ren Tsai, Pei-Yu Wu, Shu-Ning Liu
OBJECTIVE: To analyze cerebellar atrophy in genetic epileptic encephalopathies (EEs). METHODS: This research included a retrospective cohort study conducted from January 2016 to December 2023 and a systematic review on cerebellar atrophy in genetic EEs. Pediatric individuals who were diagnosed with EEs based on electroclinical features, carried causative gene variants, and exhibited cerebellar atrophy were recruited. Electroclinical features, neuroimaging findings, and causative variants of eligible individuals were analyzed...
June 15, 2024: Seizure: the Journal of the British Epilepsy Association
Zheng Yin, Pei Li
BACKGROUND: Individual susceptibility to sodium valproate (VPA)-induced tremors may be due to genetic polymorphisms in the gene encoding the uridine diphosphate glucuronosyltransferase (UGT) enzyme, which affec the drug's clinical efficacy and cause toxic side effects. This study aimed to investigate the association between UGT1A6 polymorphisms and VPA-induced tremors in patients with epilepsy. METHODS: In total, 128 patients with epilepsy were enrolled. Patients with epilepsy who received VPA were divided into tremor and non-tremor groups...
June 14, 2024: Seizure: the Journal of the British Epilepsy Association
Suncica Lah, George Karapetsas, Alice Winsor, Linda Gonzalez, Anna Mandalis, Mark Pertini, Michael Gascoigne
AIM: In children and adolescents with epilepsy (CAWE), disturbed sleep and functional difficulties are frequently present, but their relationship is unclear. In this scoping review we aimed to explore associations between sleep and functional outcomes in CAWE. METHOD: We registered the protocol with open science framework and conducted the review according to the PRISMA Extension for Scoping Reviews. We searched Medline, Embase, PsycINFO and PubMed for original studies reporting on relations between sleep and functional outcomes (adaptive/quality of life, behavioural/mood, cognitive & academic) in CAWE...
June 13, 2024: Seizure: the Journal of the British Epilepsy Association
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