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Journals Seizure : the Journal of the B...

Seizure : the Journal of the British Epilepsy Association

https://read.qxmd.com/read/38368830/which-psychogenic-nonepileptic-seizure-pnes-patients-are-more-likely-to-be-treated-with-anti-seizure-medications
#1
JOURNAL ARTICLE
Ronen Spierer, Moshe Herskovitz
BACKGROUND: The average time for psychogenic nonepileptic seizures (PNES) diagnosis is about 7.5 years. Many patients receive inadequate treatment and sometimes even life-threatening treatments such as tracheal intubation during this time. PURPOSE: To determine the risk factors for misdiagnosis of PNES as Epilepsy. METHODS: The medical records of patients who underwent video-electroencephalogram (EEG) monitoring were reviewed retrospectively...
February 13, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38367318/clinical-observation-and-analysis-of-rash-caused-by-lacosamide-in-children-with-epilepsy
#2
JOURNAL ARTICLE
Yingying Guo, Yu Liu, Dan Li, Xueying Wang, Shaoping Huang, Lin Yang
PURPOSE: To draw clinical attention to rashes caused by lacosamide. METHODS: This retrospective analysis included patients admitted to the Department of Pediatrics, Second Affiliated Hospital of Xi'an Jiaotong University between January 2021 and September 2023. We focused on patients who developed rashes after lacosamide treatment and analyzed all patients who exhibited rashes after lacosamide treatment to analyze the risk factors. RESULTS: In total, 190 patients received lacosamide, of whom four developed allergies (2...
February 13, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38342044/maladaptive-personality-traits-in-patients-with-epilepsy-and-psychogenic-non-epileptic-seizures
#3
JOURNAL ARTICLE
G Kustov, D Zhuravlev, M Zinchuk, S Popova, O Tikhonova, A Yakovlev, F Rider, A Guekht
OBJECTIVE: We aimed to evaluate the sociodemographic, clinical, and psychological characteristics associated with psychogenic non-epileptic seizures (PNES) in patients with epilepsy, with particular emphasis on the personality profile assessed from a dimensional perspective. METHODS: The cohort study included 77 consecutive inpatients with active epilepsy aged 36-55 years; 52 (67.5%) were female. The presence of PNES was confirmed by video-EEG monitoring. All patients underwent the Mini-International Neuropsychiatric Interview to diagnose psychiatric disorders...
February 9, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38354598/efficacy-of-pharmacological-treatments-for-dravet-syndrome-systematic-review-and-network-meta-analysis
#4
REVIEW
Dujiang Xia, Peng Zhang, Yankun Chen, Xi Liu, Yangmei Chen
BACKGROUND: Numerous anti-seizure medications (ASMs) have been developed to treat Dravet syndrome (DS). This network meta-analysis aimed to comprehensively analyse the efficacy of ASMs in DS patients, especially in non-seizure-free patients after treatment. METHODS: PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure databases were searched. The treatment efficacy was assessed by the percentage reduction in monthly convulsive seizure frequency (MCSF) from baseline or individuals who achieved at least a 50 % or 75 % reduction from baseline in convulsive seizure frequency (CSF)...
February 7, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38342043/triphasic-waves-in-covid-19-patients-going-further
#5
LETTER
Moisés León-Ruiz, Julián Benito-León, Carlos Castañeda-Cabrero
No abstract text is available yet for this article.
February 7, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38354597/us-generic-antiseizure-medication-supply-chain-observations-from-analysis-of-us-government-databases
#6
JOURNAL ARTICLE
Pradeep Javarayee, Jennifer Meylor, Shamshad Shahrukh, Shannon Pollock, Rene Andrade-Machado, Jeetendra Sah, Hema Patel
BACKGROUND: Generic drug manufacturing has shifted away from the U.S. in the last few decades. The medication supply chain, from manufacturers to resellers, has become increasingly globalized and complex. This has led to bottlenecks in their manufacture resulting in medication shortages. Review of this process as it pertains to antiseizure medications (ASM) shows gaps in our comprehension of its complexities. Understanding these processes will be essential for preventing medication shortages...
February 5, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38330750/epileptiform-electroencephalogram-discharges-increase-seizure-recurrence-risk-in-patients-with-acute-symptomatic-seizure-due-to-a-structural-brain-lesion
#7
JOURNAL ARTICLE
Laia Grau-López, Belén Flores-Pina, Marta Jiménez, Jaime Carbonell, Jordi Ciurans, Eva Chies, Olga Fagundez, Alejandra Fumanal, Juan Luis Becerra
OBJECTIVE: The risk factors for seizure recurrence after acute symptomatic seizure due to a structural brain lesion are not well established. The aim of this study was to analyze possible associations between demographic, clinical, and electroencephalographic variables and epilepsy development in patients with acute symptomatic seizure due to an acute structural brain lesion. METHODS: We designed an observational prospective study of patients with acute symptomatic seizure due to an acute structural brain lesion (hemorrhagic stroke, ischemic stroke, traumatic brain injury, or meningoencephalitis) who underwent EEG during their initial admission between January 2015 and January 2020...
February 4, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38364333/clinical-analysis-of-pafah1b1-gene-variants-in-pediatric-patients-with-epilepsy
#8
JOURNAL ARTICLE
Wei-Xing Feng, Xiao-Fei Wang, Yun Wu, Xing-Meng Li, Shu-Hua Chen, Xiao-Hui Wang, Zi-Han Wang, Fang Fang, Chun-Hong Chen
PURPOSE: PAFAH1B1, also known as LIS1, is associated with type I lissencephaly in humans, which is a severe developmental brain disorder believed to result from abnormal neuronal migration. Our objective was to characterize the genotypes and phenotypes of PAFAH1B1-related epilepsy. METHODS: We conducted a comprehensive analysis of the medical histories, magnetic resonance imaging findings, and video-electroencephalogram recordings of 11 patients with PAFAH1B1 variants at the Neurology Department of Beijing Children's Hospital from June 2017 to November 2022...
February 2, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38330751/efficacy-of-vagus-nerve-stimulation-in-managing-drug-resistant-absence-epilepsy-syndromes
#9
JOURNAL ARTICLE
Caitlin Wessel, Feride Un Candan, Paya Yazdan Panah, Samir Karia, Jeetendra Sah, Ian Mutchnick, Cemal Karakas
PURPOSE: Around 11% of patients with absence epilepsy develop drug-resistant absence epilepsy (DRAE), and are at increased risk for developing psychiatric and neurologic comorbidities. Current therapeutic options for DRAE are limited. The purpose of this study was to assess the efficacy of vagus nerve stimulation (VNS) in treating DRAE. METHODS: Our institution maintains a database of patients who received VNS between 2010 and 2022. We identified DRAE patients who were <18 years of age at seizure onset, were electro-clinically diagnosed with an absence epilepsy syndrome (childhood absence, juvenile absence, or Jeavons Syndrome) by an epileptologist, and had normal brain imaging...
February 2, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38325220/early-discontinuation-of-ambulatory-veeg-among-individuals-with-intellectual-disabilities-a-retrospective-chart-review
#10
JOURNAL ARTICLE
Ewan S Nurse, Nicholas Winterling, Mark J Cook
OBJECTIVE: This retrospective chart review aims to quantify the rate of patients with intellectual disability (ID) accessing an Australian ambulatory EEG service, and understand the clinical implications of discontinuing studies prematurely. METHODS: Electronic records of referrals, patient monitoring notes, and EEG reports were accessed retrospectively. Each referral was assessed to determine whether the patient had an ID. For each study where patients were discharged prematurely, the outcomes of their EEG report were assessed and compared between the ID and non-ID groups...
February 1, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38308906/epileptic-tissue-localization-using-graph-based-networks-in-the-high-frequency-oscillation-range-of-intracranial-electroencephalography
#11
JOURNAL ARTICLE
Christos Stergiadis, Dimitrios Kazis, Manousos A Klados
PURPOSE: High frequency oscillations (HFOs) are an emerging biomarker of epilepsy. However, very few studies have investigated the functional connectivity of interictal iEEG signals in the frequency range of HFOs. Here, we study the corresponding functional networks using graph theory, and we assess their predictive value for automatic electrode classification in a cohort of 20 drug resistant patients. METHODS: Coherence-based connectivity analysis was performed on the iEEG recordings, and six different local graph measures were computed in both sub-bands of the HFO frequency range (80-250 Hz and 250-500 Hz)...
January 29, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38308907/long-term-outcome-of-treatment-na%C3%A3-ve-patients-with-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis-a-retrospective-study-in-a-single-center
#12
JOURNAL ARTICLE
Soomi Cho, Hye Jeong Lee, Sue Hyun Lee, Kyung Min Kim, Min Kyung Chu, Joonho Kim, Kyoung Heo
PURPOSE: This study aimed to describe long-term treatment outcomes of treatment-naïve patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). METHODS: A retrospective review was conducted of treatment-naïve patients with MTLE-HS who visited the Yonsei Epilepsy Clinic from April 2000 to April 2022 and were followed up for at least 2 years. Seizure freedom (SF) was defined as no seizures or auras only for >1 year, and complete SF was defined as no seizures including auras for >1 year...
January 27, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38335875/clinical-characteristics-seizure-control-and-delivery-outcomes-in-pregnant-women-with-focal-and-generalized-epilepsies
#13
JOURNAL ARTICLE
Melikova Shahla, Mammadbayli Aytan
OBJECTIVE: To prospectively investigate the course of epilepsy and assess seizure control during pregnancy in women with focal epilepsy (FE) compared with generalized epilepsy (GE), to ascertain the effects of epilepsy and its types on delivery and neonatal outcomes, and to compare adverse outcomes between pregnancies complicated by epilepsy and normal pregnancies. METHODS: 124 pregnant women with epilepsy (WWE) were enrolled in a prospective study. Obstetric and neonatal outcomes were compared with those of 277 healthy women in the control group...
January 26, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38301485/ketamine-in-the-treatment-of-refractory-and-super-refractory-status-epilepticus-experience-from-two-centres
#14
JOURNAL ARTICLE
Manuel García-Ruiz, Pablo Mayo Rodríguez, Luca Palliotti, Clara Lastras, María Romeral-Jiménez, Irene García Morales, Cándido Pardo Rey, Marc Rodrigo-Gisbert, Daniel Campos-Fernández, Estevo Santamarina, Beatriz Parejo Carbonell
PURPOSE: There is insufficient evidence on the management of refractory status epilepticus (RSE) and super-RSE (SRSE). Ketamine is a N-methyl-d-aspartate receptor antagonist in the treatment of these entities. Our objectives were to study the effectiveness and safety of ketamine in the treatment of adult patients with RSE and SRSE, to determine the factors that can influence the response to ketamine, and to explore its use in patients without mechanical ventilation. METHODS: Adult patients who had received intravenous ketamine for the treatment of RSE or SRSE at Hospital Universitario Clínico San Carlos (Madrid, Spain) or Hospital Universitari Vall d'Hebron (Barcelona, Spain) from 2017 to 2023 were retrospectively analysed...
January 22, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38302348/a-rare-syndrome-microcephaly-diabetes-mellitus-and-epilepsy-due-to-homozygous-trmt10a-mutation
#15
JOURNAL ARTICLE
Firdevs Ezgi Uçan Tokuç, Meltem Korucuk, Tarkan Kalkan, Fatma Genç
No abstract text is available yet for this article.
January 19, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38277927/impact-of-copy-number-variants-in-epilepsy-plus-neurodevelopment-disorders
#16
JOURNAL ARTICLE
Sofia João, Rita Quental, Joel Pinto, Carolina Almeida, Helena Santos, Sofia Dória
INTRODUCTION: Epilepsy, a neurological disorder characterized by recurring unprovoked seizures due to excessive neuronal excitability, is primarily attributed to genetic factors, accounting for an estimated 70 % of cases. Array-comparative genomic hybridization (aCGH) is a crucial genetic test for detecting copy number variants (CNVs) associated with epilepsy. This study aimed to analyze a cohort of epilepsy patients with CNVs detected through aCGH to enhance our understanding of the genetic underpinnings of epilepsy...
January 19, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38262122/atn1-related-infantile-developmental-and-epileptic-encephalopathy-responding-to-ketogenic-diet
#17
JOURNAL ARTICLE
Yi Xie, Tangfeng Su, Yan Liu, Sanqing Xu
BACKGROUND: Research has shown gene ATN1 to be associated with the nuclear receptor signaling. Its mutations in an evolutionarily conserved histidine-rich motif may cause CHEDDA, short for congenital hypotonia, epilepsy, developmental delay and digital anomalies, a recently identified neurodevelopmental syndrome that could evolve into developmental and epileptic encephalopathy (DEE). Up to date, there have been reported less than 20 cases, whose clinical features and treatment are worth in-depth exploring...
January 19, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38308908/efficacy-and-safety-of-perampanel-as-the-first-add-on-therapy-for-children-with-epilepsy-a-real-world-multicenter-prospective-observational-study
#18
JOURNAL ARTICLE
Jiahui Mai, Hua Li, Yinghui He, Tieshuan Huang, Caimei Lin, Song Lan, Xiaohua Xiao, Suli He, Xinguo Lu, Li Chen, Bing Li, Xufeng Luo, Han Wang, Jianxiang Liao, Dezhi Cao
OBJECTIVE: Perampanel (PER) is a new anti-seizure medication (ASM) with a novel mechanism of action. This study aimed to determine the efficacy and safety of PER when added to monotherapy in children and adolescents (age, 4-18 years) with epilepsy. METHOD: A multicenter prospective observational study was performed on children and adolescents (age, 4-18 years) with epilepsy who did not respond to ASM monotherapy between July 2021 and October 2022. PER was used as the first add-on therapy for the enrolled patients...
January 16, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38237316/purified-cannabidiol-as-add-on-therapy-in-children-with-treatment-resistant-infantile-epileptic-spasms-syndrome
#19
JOURNAL ARTICLE
Gabriela Reyes Valenzuela, Adolfo Gallo, Agustin Calvo, Santiago Chacón, Lorena Fasulo, Santiago Galicchio, Javier Adi, Pablo Sebastian Fortini, Roberto Caraballo
OBJECTIVE: The aim of this study was to assess efficacy, safety, and tolerability of highly purified cannabidiol oil (CBD) as add-on therapy for the treatment of a series of patients with infantile epileptic spasms syndrome (IESS) who were resistant to antiseizure medications and ketogenic dietary therapy. MATERIAL AND METHODS: We conducted a retrospective analysis of the medical records of 28 infants with treatment-resistant IESS aged 6 to 21 months who received highly purified CBD between July 2021 and June 2023...
January 15, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38232648/impact-of-variant-subtype-on-electro-clinical-phenotype-of-dravet-syndrome-a-south-indian-cohort-study
#20
JOURNAL ARTICLE
S Krishna, Alfiya Fasaludeen, Manna Jose, Moinak Banerjee, Soumya Sundaram, Ashalatha Radhakrishnan, Ramshekhar N Menon
OBJECTIVE: We aimed to compare the electroclinical correlates of truncating and missense variants of SCN1A variants in children with Dravet syndrome (DS) and to determine phenotypic features in relation to variants identified and seizure outcomes. METHODS: A single center prospective study was carried out on a South Indian cohort. Patients below 18 years of age who met the clinical criteria for DS who had undergone genetic testing and completed a minimum of one year follow up were included...
January 14, 2024: Seizure: the Journal of the British Epilepsy Association
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