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Seizure: the Journal of the British Epilepsy Association

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https://read.qxmd.com/read/31416672/corrigendum-to-febrile-seizures-are-they-truly-benign-longitudinal-analysis-of-risk-factors-and-future-risk-of-afebrile-epileptic-seizure-based-on-the-national-sample-cohort-in-south-korea-2002-2013-seizure-64-january-2019-77-83
#1
Yoo Jin Choi, Joonghee Kim, Jae Yun Jung, Hyuksool Kwon, Joong Wan Park, Young Ho Kwak, Do Kyun Kim, Jin Hee Lee
No abstract text is available yet for this article.
August 12, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31401499/rasmussen-s-encephalitis-presenting-as-progressive-parietal-dysfunction-sans-seizures
#2
Divyani Garg, Ayush Agarwal, Deepa Dash, Swati Mahajan, Rajesh Kumar Singh, Rohit Bhatia, Manjari Tripathi
No abstract text is available yet for this article.
August 2, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31386963/peripapillary-retinal-nerve-fibre-layer-thinning-in-genetic-generalized-epilepsy
#3
Jesús González de la Aleja, Maripaz Guerrero-Molina, Rosa Ana Saíz-Díaz, Francisco López-Muñoz, Isidoro Raga-Martínez, Jesús Hernández-Gallego, Patricia Navarrete-Chamorro, Francisco Javier Povedano-Montero
PURPOSE: The purpose of this study was to compare the peripapillary retinal nerve fibre layer (RNFL) between patients with genetic generalized epilepsy (GGE) and healthy controls. METHODS: This prospective observational study was conducted on adults aged 18-60 years. The study group comprised 26 consecutive patients who met the inclusion criteria and 26 healthy age- and sex-matched healthy adults. Peripapillary RNFL thickness was measured by spectral domain optical coherence tomography...
August 1, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31401500/dissecting-the-phenotypic-and-genetic-spectrum-of-early-childhood-onset-generalized-epilepsies
#4
Soo Yeon Kim, Se Song Jang, Jong-Il Kim, Hunmin Kim, Hee Hwang, Ji Eun Choi, Jong-Hee Chae, Ki Joong Kim, Byung Chan Lim
PURPOSE: Although the genetic and clinical aspects of epilepsy with myoclonic-atonic seizures (MAE) and early onset absence epilepsy (EOAE) have been investigated thoroughly, other early childhood-onset generalized epilepsies that share clinical features with MAE and EOAE have not been characterized. In this study, we aimed to delineate the genetic and phenotypic spectrum of early childhood-onset generalized epilepsies, including MAE and EOAE. METHODS: We recruited 61 patients diagnosed with MAE, EOAE, genetic epilepsy with febrile seizure plus (GEFS+) and unclassified generalized epilepsies that shared seizure onset age and seizure types...
July 31, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31382137/epilepsy-in-china-factors-influencing-marriage-status-and-fertility
#5
Sisi Li, Jiani Chen, Ammar Taha Abdullah Abdulaziz, Yadong Liu, Xuran Wang, Mintao Lin, Yingjie Qin, Xu Liu, Dong Zhou
PURPOSE: To investigate the current status of marriage and fertility of patients with epilepsy (PWE) and characterize its influencing factors. METHODS: A total of 1,823 adult patients (males age 22 years or older, females age 20 years or older) were included in this study. Data concerning sociodemographic and clinical characteristics were collected. Descriptive analyses, followed by univariate and multivariate logistic regression analyses were utilized to examine factors associated with marriage and fertility of PWE...
July 26, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31375336/cognitive-outcome-of-pediatric-epilepsy-surgery-across-ages-and-different-types-of-surgeries-a-monocentric-1-year-follow-up-study-in-306-patients-of-school-age
#6
C Helmstaedter, K Beeres, C E Elger, S Kuczaty, J Schramm, C Hoppe
OBJECTIVE: The neuropsychological outcome of pediatric epilepsy surgery has been reported before, but only few studies compared different major types of surgery in differentially located epilepsies. METHODS: Neuropsychological performance of 306 children and adolescents (ages 6-17 years) were assessed before and one year after epilepsy surgery. Individual impairments, changes into and out of impairment, as well as intraindividually meaningful positive or negative changes were examined...
July 26, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31369919/a-de-novo-heterozygous-missense-bscl2-variant-in-2-siblings-with-intractable-developmental-and-epileptic-encephalopathy
#7
Ana Fernández-Marmiesse, Sofía Sánchez-Iglesias, Alejandra Darling, María M O'Callaghan, Raúl Tonda, Cristina Jou, David Araújo-Vilar
PURPOSE: We present the case of 2 siblings with profound refractory epilepsy and neurological regression that began at the ages of 3 and 6 months. Diagnosis remained elusive despite extensive metabolic and genetic workups, including use of a targeted next-generation sequencing panel for epilepsy genes. METHODS: Whole-exome sequencing was performed for the 2 siblings and their unaffected parents, in addition to fibroblast cell culture, RNA extraction and reverse-transcription, and cDNA PCR...
July 25, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31419720/convulsive-status-epilepticus-due-to-different-evolutionary-stages-of-neurocysticercosis-solitary-cyticercus-granuloma-low-cyst-load-and-single-calcific-lesion-in-an-endemic-country-clinical-profile
#8
Jagarlapudi M K Murthy, Devdutt Suresh Deshmukh
PURPOSE: The aims of the study were: (a) to evaluate the clinical profile of convulsive status epilepticus (CSE) due to different evolutionary stages of neurocysticercosis (NCC), solitary cysticercus granuloma, low cyst load and single calcific lesion in an endemic country; (b) to evaluate the response of CSE to antiepileptic drugs; and (c) to evaluate long-term outcomes METHODS: A retrospective review of case records of patients with CSE due to different evaluative stages of NCC seen over a period of 18 years...
July 24, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31386961/efficacy-of-statin-therapy-in-post-stroke-seizure-prophylaxis-clues-from-an-observational-study-of-routine-secondary-prevention-treatment
#9
Yuxiang Li, Bei Zhang, Lu Zhang, Dandan Xie, Yi Li
PURPOSE: To confirm that statin use can reduce the risk of post-stroke seizures (PSS), and to further investigate the association between the details of specific statin therapy, including the initial time, types, doses, courses, and the risk of PSS. METHODS: Patients with newly-onset ischemic stroke and no history of epilepsy before stroke were enrolled. After an average of 2 years follow-up, with the aim of establishing a PSS diagnosis, logistic regression was utilized to assess the association between specific statin therapy and the risk of PSS...
July 24, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31386962/parasagittal-hemispherotomy-in-hemispheric-polymicrogyria-with-electrical-status-epilepticus-during-slow-sleep-indications-results-and-follow-up
#10
Martine Fohlen, Georg Dorfmüller, Sarah Ferrand-Sorbets, Nathalie Dorison, Mathilde Chipaux, Delphine Taussig
PURPOSE: Polymicrogyria (PMG), although the most common brain malformation, represents a low percentage among patients operated on for epilepsy. In cases of hemispheric PMG, electrical status epilepticus during slow sleep (ESESS) may occur leading to an aggravation of the neurological condition and a risk of drug resistance. In such cases, surgical treatment can be offered. METHODS: From a population of 230 children who underwent hemispherotomy for epilepsy, we retrospectively reviewed the patients with unilateral PMG and drug-resistant ESESS focusing on clinical charts, electrophysiological data and post-surgical outcome...
July 23, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31382136/high-dose-prednisone-therapy-for-infantile-spasms-and-late-onset-epileptic-spasms-in-china-the-addition-of-topiramate-provides-no-benefit
#11
Zhaoshi Yi, Huaping Wu, Xiongying Yu, Jian Zha, Hui Chen, Yong Chen, Jianmin Zhong
PURPOSE: To compare the clinical efficacy of high-dose prednisone monotherapy and the combination of hormone and moderate-dose topiramate (TPM) therapy in children with infantile spasms (IS) and late-onset epileptic spasms (ES), and to evaluate whether the addition of TPM would provide more benefits for patients. METHODS: All patients were assigned to receive either high-dose prednisone alone (the maximum doses was 60 mg a day) or high-dose prednisone with TPM (the moderate doses was 5 mg/kg/day)...
July 17, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31344659/impact-of-knowledge-attitudes-and-sociocultural-factors-on-school-enrollment-of-children-with-epilepsy-in-gabon
#12
Euloge Ibinga, Michel Druet-Cabanac, Marc Harris Dassi Tchoupa Revegue, Jean Engohang-Ndong, Ulrick Bisvigou, Simon Jonas Ategbo, Pierre-Marie Preux, Edgard Brice Ngoungou
PURPOSE: Perceptions, beliefs and culture influence attitude towards epilepsy in sub-Saharan Africa. Misconceptions on epilepsy contribute to the persistence of negative attitudes in children with epilepsy particularly on their school enrollment. The aim of the study was to assess knowledge, attitudes, and sociocultural factors affecting schooling of children with epilepsy in Gabon. METHODS: Teachers and health workers from two urban and four rural localities of Gabon were assessed using a self-administered questionnaire...
July 16, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31352161/jeavons-syndrome-in-a-family-with-glut1-deficiency-syndrome
#13
Priyanka Madaan, Prashant Jauhari, Biswaroop Chakrabarty, Sheffali Gulati
No abstract text is available yet for this article.
July 15, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31325818/study-of-the-hippocampal-internal-architecture-in-temporal-lobe-epilepsy-using-7-t-and-3-t-mri
#14
Yiwei Zhang, Yuelei Lv, Hui You, Wanchen Dou, Bo Hou, Lin Shi, Zhentao Zuo, Weiyu Mao, Feng Feng
PURPOSE: To compare the hippocampal internal architecture (HIA) between 3 and 7 Tesla (T) magnetic resonance imaging (MRI) in patients with temporal lobe epilepsy (TLE), and to investigate the relationship between HIA and hippocampal volume, and postoperative outcomes. MATERIALS AND METHODS: Thirty-nine TLE patients were recruited with 3 and 7 T MRI scans and a semi-quantitative assessment of the HIA was performed. Differences in HIA scores between 3 and 7 T MRI were evaluated...
July 9, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31326720/clinical-outcomes-of-closed-loop-vagal-nerve-stimulation-in-patients-with-refractory-epilepsy
#15
Michal Tzadok, Amit Harush, Andrea Nissenkorn, Yaacov Zauberman, Zeev Feldman, Bruria Ben-Zeev
PURPOSE: The AspireSR® is a vagal nerve stimulation (VNS) device that operates as a closed-loop system, delivering an automatic stimulation in response to an ictal heart rate increase that serves as a predictor for an imminent seizure. Our purpose is to assess the outcome of the AspireSR® in a patient population managed in a pediatric neurology unit. METHODS: The records of patients who underwent transplantation during 2015-2017 and are continuously followed in one pediatric-epilepsy clinic, were retrospectively analyzed...
July 8, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31325820/burden-in-caregivers-of-adults-with-epilepsy-in-asian-families
#16
Siew-Tim Lai, Wan-Yen Tan, Monica Chen-Mun Wo, Kheng-Seang Lim, Sherrini Bazir Ahmad, Chong-Tin Tan
PURPOSE: The literature on caregiver burden tends to focus on children and teenagers with epilepsy and less on adults. As caregiving is a dynamic, complex process across the trajectories, this study aims to examine the factors associated with caregiving burden in those caring for adults with epilepsy. METHOD: This is a cross-sectional, survey-based study in which participants responded to questionnairesregarding perceived burden (ZBI), quality of life (IEQoL), psychological distress (DASS-21), family functioning (FAD) and perceived social support (MSPSS)...
July 8, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31325819/automated-spectrographic-seizure-detection-using-convolutional-neural-networks
#17
Peter Z Yan, Fei Wang, Nathaniel Kwok, Baxter B Allen, Sotirios Keros, Zachary Grinspan
PURPOSE: Non-convulsive seizures are common in critically ill patients, and delays in diagnosis contribute to increased morbidity and mortality. Many intensive care units employ continuous EEG (cEEG) for seizure monitoring. Although cEEG is continuously recorded, it is often reviewed intermittently, which may delay seizure diagnosis and treatment. This may be mitigated with automated seizure detection. In this study, we develop and evaluate convolutional neural networks (CNN) to automate seizure detection on EEG spectrograms...
July 8, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31302303/trends-in-sodium-valproate-prescriptions-among-children-aged-0-to-14-years-between-2010-and-2016-a-study-based-on-the-french-national-health-insurance-database
#18
Elisabeth Polard, Adeline Degremont, Caroline Rault, Béranger Le Nautout, Emmanuel Oger, Arnaud Biraben, Emmanuel Nowak
PURPOSE: After a huge campaign of information on the teratogenic risk of sodium valproate (VPA) having taken place in France we aimed to evaluate the trend of its prescriptions in young epileptic girls. METHOD: Using the French National Health Insurance Database we searched for patients aged 0-14 years being supplied an antiepileptic drug (AED) between 2010 and 2016. RESULTS: 113,362 children received at least one AED, 61,259 boys and 52,103 girls...
July 8, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31323445/ct-perfusion-and-eeg-patterns-in-patients-with-acute-isolated-aphasia-in-seizure-related-stroke-mimics
#19
Paolo Manganotti, Giovanni Furlanis, Miloš Ajčević, Paola Polverino, Paola Caruso, Mariana Ridolfi, Roberta Antea Pozzi-Mucelli, Maria Assunta Cova, Marcello Naccarato
PURPOSE: Isolated speech impairment is one of the most challenging clinical manifestations of stroke mimic (SM). We aimed to investigate perfusional and EEG pattern of isolated aphasia to better differentiate between vascular and epileptic etiology in emergency settings. METHOD: We retrospectively analyzed 481 cases with acute focal neurological symptoms admitted to our Stroke Unit. The patients showing isolated aphasia and confirmed ischemic infarction or SM with seizure etiology on follow-up were included for subsequent analysis of clinical, neuroimaging, and EEG data...
July 4, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/31310965/valproate-utilisation-trends-among-girls-and-women-from-2013-to-2018
#20
Kristijonas Puteikis, Irma Medžiaušaitė, Rūta Mameniškienė
PURPOSE: To evaluate the change in the number of female valproate users in Lithuania from 2013 to 2018 and determine the presumed impact of two distinct European Medicines Agency (EMA) regulatory interventions on the observed trend. METHOD: An interrupted time series analysis was performed using reimbursement data from the National Health Register Fund to detect changes in user trends after a selected regulatory event in time. RESULTS: The absolute number of female patients under 50 using valproate is seen decreasing over time...
July 4, 2019: Seizure: the Journal of the British Epilepsy Association
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