Louisa Stern, Lukas Fabian Boehme, Mara Rebecca Goetz, Christine Nitschke, Anastasios Giannou, Tao Zhang, Cenap Güngör, Matthias Reeh, Jakob Robert Izbicki, Ralf Fliegert, Anne Hausen, Nathalia Giese, Thilo Hackert, Masha Y Niv, Stefan Heinrich, Matthias Martin Gaida, Tarik Ghadban
Bitter taste receptors (T2Rs) are G protein‑coupled receptors originally detected in the gustatory system. More recently, T2Rs have been shown to be expressed in extra‑oral cells eliciting non‑gustatory functions. Emerging evidence has suggested a potential role for T2R signaling in diverse pathophysiological conditions, including cancer. -The aim of the present study was to evaluate the expression of T2R14 in pancreatic ductal adenocarcinoma (PDAC) and to assess its involvement in the anticancer effects induced by apigenin, a natural ligand of T2R14...
January 2023: International Journal of Oncology