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Journals Clinical and Experimental Hype...

Clinical and Experimental Hypertension : CHE

https://read.qxmd.com/read/37439538/association-between-composite-dietary-antioxidant-index-and-hypertension-insights-from-nhanes
#41
JOURNAL ARTICLE
Mingyue Wu, Jiayi Si, Yihai Liu, Lina Kang, Biao Xu
AIM: The association between composite dietary antioxidant index (CDAI) and hypertension remains unknown. Our study was to investigate the association of CDAI with hypertension in general adults. METHODS: A total of 21 526 participants were enrolled from the National Health and Nutrition Examination Surveys (NHANES). The CDAI was calculated from the intake of six dietary antioxidants. Multivariable logistic regressions were performed to explore the associations between CDAI and the prevalence of hypertension...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37395230/ketogenic-diet-inhibits-neointimal-hyperplasia-by-suppressing-oxidative-stress-and-inflammation
#42
JOURNAL ARTICLE
Xuefei Xu, Limin Xie, Lili Chai, Xiaoming Wang, Jinhu Dong, Jipei Wang, Pengwei Yang
OBJECTIVE: Neointimal hyperplasia is the primary mechanism underlying atherosclerosis and restenosis after percutaneous coronary intervention. Ketogenic diet (KD) exerts beneficial effects in various diseases, but whether it could serve as non-drug therapy for neointimal hyperplasia remains unknown. This study aimed to investigate the effect of KD on neointimal hyperplasia and the potential mechanisms. METHODS AND RESULTS: Carotid artery balloon-injury model was employed in adult Sprague-Dawley rats to induce neointimal hyperplasia...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37395203/ginsenoside-rh2-mitigates-myocardial-damage-in-acute-myocardial-infarction-by-regulating-pyroptosis-of-cardiomyocytes
#43
JOURNAL ARTICLE
Hong Peng, Li Chen, Yi Deng, Xin Liao, Yi Yang
BACKGROUND: Acute myocardial infarction (AMI) is one of the most important causes of mortality among patients with cardiovascular disease. Ginsenoside Rh2 plays a protective role in cardiovascular diseases. Furthermore, pyroptosis reportedly participates in regulating the occurrence and development of AMI. However, whether ginsenoside Rh2 contributes to mitigating AMI by regulating cardiomyocyte pyroptosis remains unknown. METHODS: In the present study, we established an AMI model in rats...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37366048/association-between-renal-surface-nodularity-and-increased-adverse-vascular-event-risk-in-patients-with-arterial-hypertension
#44
JOURNAL ARTICLE
Jiule Ding, Jie Chen, Jun Zhou, Zhenxing Jiang, Dehui Xiang, Wei Xing
OBJECTIVE: To explore the association of renal surface nodularity (RSN) with the increased adverse vascular event (AVE) risk in patients with arterial hypertension. METHODS: This cross-sectional study included patients with arterial hypertension aged 18-60 years who underwent contrasted computed tomography (CT) of kidney from January 2012 to December 2020. The subjects were classified into AVE or not (non-AVE) matched with age (≤5 years) and sex...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37358045/the-relationship-between-circadian-rhythm-of-blood-pressure-and-vascular-dysfunction-in-essential-hypertension
#45
JOURNAL ARTICLE
Yancui Sun, Ying Zhang, Fei Liu, Xiaojie Liu, Tesfaldet H Hidru, Xiaolei Yang, Yinong Jiang
OBJECTIVE: This study aimed to explore whether circadian rhythm of blood pressure is associated with brachial-ankle pulse wave velocity (baPWV) and brachial artery flow-mediated dilation (FMD) in patients with essential hypertension. METHOD: This cross-sectional study included 4,217 patients with essential hypertension who completed 24-hour ambulatory blood pressure monitoring, baPWV, and FMD. BaPWV and FMD were measured to evaluate arterial stiffness and endothelial dysfunction...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37358029/relationship-between-ambulatory-arterial-stiffness-index-and-the-severity-of-angiographic-atherosclerosis-in-patients-with-h-type-hypertension-and-coronary-artery-disease
#46
JOURNAL ARTICLE
Li Dong, Jing Liu, Yan Qin, Wen-Juan Yang, Liang Nie, Hua-Ning Liu, Qing-Hua Hu, Yu Sun, Wen-Yan Cao
OBJECTIVE: To investigate coronary artery disease (CAD) and its correlation with the ambulatory arterial stiffness index (AASI) in patients with H-type hypertension (essential hypertension combined with hyper-homocysteinemia) and coronary heart disease (CHD). METHODS: Patients with essential hypertension and CHD who were undergoing coronary angiography were enrolled. The general clinical data, biochemical indicators, ambulatory blood pressure monitoring results and coronary angiography results of the selected patients were collected, and the AASI and Gensini scores were calculated...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37337968/seasonal-variation-in-diurnal-blood-pressure-pattern
#47
JOURNAL ARTICLE
Xinyue Du, Lingli Wang, Wenyi He, Xin Fu, Yingjiao Zhang, Wei Zhou, Yuying Han, Guolan Deng
AIMS: To explore the relationship between diurnal blood pressure (BP) pattern and season. METHODS: A total of 6765 eligible patients (average age 57.35 ± 15.53 years; male 51.8%; hypertensives 68.8%) from 1 October 2016 to 6 April 2022 were enrolled, who were divided into four dipper groups, dipper, non-dipper, riser, and extreme-dipper, according to the diurnal BP pattern calculated using their ambulatory BP monitoring data. The season which the patient was in was determined by the time of ambulatory BP monitoring examination...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37337964/the-impact-of-timing-of-fixed-dose-triple-antihypertensive-combinations-on-ambulatory-blood-pressure-monitoring-parameters
#48
RANDOMIZED CONTROLLED TRIAL
Cigdem Ileri, Zekeriya Dogan, Beste Ozben, Latife Bircan, Aycan Acet, Taner Sen
INTRODUCTION: Re-establishing "dipping" physiology significantly reduces cardiovascular events. The aim was to investigate the effect of timing of fixed dose triple antihypertensive combinations on blood pressure (BP) control. METHODS: One hundred sixteen consecutive patients (62.7 ± 10.7 years, 38 men) with grade II hypertension were randomized into four groups. Group 1 and Group 2 patients were given angiotensin converting enzyme inhibitor-based triple antihypertensive pills to be taken in the morning or evening, respectively while Group 3 and Group 4 patients were given angiotensin receptor blocker (ARB) based triple antihypertensive pills to be taken in the morning or evening, respectively...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37337961/determinants-of-self-rated-health-among-elderly-patients-with-hypertension-a-cross-sectional-analysis-based-on-the-chinese-longitudinal-healthy-longevity-survey
#49
JOURNAL ARTICLE
Yang Zhou, Yanjing Huang, Aohua Zhang, Guige Yin, Hongjuan Hu
BACKGROUND: The total number of elderly patients with hypertension in China has been increasing year by year, it is necessary to adopt simple and valid measures to evaluate the health status of elderly patients with hypertension to reduce the heavy burden faced by this group. METHOD: This study is a cross-sectional analysis. Participants aged at least 65 years were included. Self-Rated Health (SRH) assessment of respondents was classified into two groups: participants who responded as "very good" and "good" were considered as having good SRH, and participants who answered as "average," "poor," and "very poor" were considered as having poor SRH...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37326510/central-venous-catheter-as-a-novel-approach-to-postoperative-thrombolysis-in-patients-with-acute-iliofemoral-deep-venous-thrombosis
#50
JOURNAL ARTICLE
Biyun Teng, Fenghe Li, Xuehu Wang, Hao Tian, Yu Zhao, Qiu Zeng
BACKGROUND AND AIMS: Percutaneous mechanical thrombectomy (PMT) along with postoperative thrombolysis (POT) has been the standard treatment for acute iliofemoral deep venous thrombosis (IFDVT). However, commonly used catheter directed thrombolysis (CDT) approaches for POT carry certain disadvantages, including the need for a sheath, inferior comfortability, and catheter-related complications. Therefore, we propose a new simplified method of POT using a central venous catheter (CVC). METHODS: The retrospective study analyzed patients with IFDVT who underwent POT using CVC from January 2020 to August 2021...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37183711/sestrin2-levels-in-patients-with-anxiety-and-depression-myocardial-infarction-was-up-regulated-and-suppressed-inflammation-and-ferroptosis-by-lkb1-mediated-ampk-activation
#51
JOURNAL ARTICLE
Yufeng Qian, Lian Chen, Beibei Gao, Xianhua Ye
Although great progress has been made in the diagnosis and treatment of acute myocardial infarction (AMI) in recent years, its morbidity and mortality are still relatively high. In this study, we explain that the function of Sestrin2 gene in Anxiety and Depression Myocardial infarction and its possible mechanism. 26 patients with Anxiety and Depression Myocardial infarction (ADMI) and 26 normal volunteers were collected from our hospital. All mice anaesthetized using 50 mg/kg of pentobarbital sodium and the left anterior descending arteries (LAD) were ligated to induce myocardial infarction...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37183710/microrna-98-inhibition-accelerates-the-development-of-atherosclerosis-via-regulation-of-dysfunction-of-endothelial-cell
#52
JOURNAL ARTICLE
Huai Yu, Hui Cao, Hang Yu
BACKGROUND: Atherosclerosis has been recognized as a chronic inflammation initiated by dysfunction of endothelial cell that contributes to the increased morbidity and mortality of severe cardiovascular events. The reported important role of microRNA-98 (miR-98) in regulation of endothelial cell behaviors prompt us to hypothesize that miR-98 could be involved in the process of atherosclerosis. METHODS AND RESULTS: The current research showed the miR-98 expression was gradually down-regulated in atherosclerotic mouse arteries isolated from ApoE ablation mice subjected to high fat diet...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37165667/neutrophil-and-monocyte-ratios-to-high-density-lipoprotein-cholesterol-as-biomarkers-in-non-dipping-hypertension
#53
JOURNAL ARTICLE
Yaqin Zhang, Yanju Ding, Wen Jiang
OBJECTIVE: To investigate the level and significance of neutrophils to high-density lipoprotein cholesterol ratio (NHR) and monocytes to high-density lipoprotein cholesterol ratio (MHR) in patients with non-dipping hypertension. METHODS: A total of 228 patients were retrospectively enrolled in the study. They were divided into the dipping hypertension group ( n  = 76), the non-dipping hypertension group ( n  = 77) and the control group ( n  = 75) according to 24-h ambulatory blood pressure monitoring system (ABPM) recordings...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37161316/age-creatinine-and-ejection-fraction-acef-score-as-predictive-values-for-late-non-valvular-atrial-fibrillation-recurrence-after-radiofrequency-ablation
#54
JOURNAL ARTICLE
Yan Luo, Yan Tang, Wenchao Huang, Shiqiang Xiong, Yu Long, Hanxiong Liu
The clinical risk factors associated with late recurrence in patients with non-valvular atrial fibrillation (AF) (NVAF) undergoing radiofrequency catheter ablation (RFCA) remain unknown. Furthermore, the current prognostic risk score system is commonly used in such patients as a noninvasive method to assess late AF recurrence. According to recent research, the Age, creatinine, and ejection fraction (ACEF) score is a useful risk score for cardiovascular morbidity and mortality. As a result, we hypothesized that pre-ablation ACEF score could be used to assess late recurrence in patients with NVAF...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37154169/fgfr2-modulates-the-akt-nrf2-are-signaling-pathway-to-improve-angiotensin-ii-induced-hypertension-related-endothelial-dysfunction
#55
JOURNAL ARTICLE
Kun Jiao, Ping Su, Yongling Li
BACKGROUND: Fibroblast growth factor receptor (FGFR)2 expression was decreased in hypertension patients while its role in hypertension was not explored. This experiment aimed to investigate the expression ofFGFR2 in angiotensin II (Ang II)-induced human umbilical vein endothelial cells (HUVECs) and the role of FGFR2 in improving AngII-induced hypertension-related endothelial dysfunction. METHODS: AngII-induced HUVECs simulated the hypertension model in vitro. The expression of FGFR2 in Ang II-induced HUVECs and transfected HUVECswas detected by RT-qPCR and western blot...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37154151/association-analysis-of-mthfr-rs1801133-and-rs1801131-and-mtrr-rs1801394-gene-polymorphisms-towards-the-development-of-hypertension-in-the-bai-population-from-yunnan-china
#56
JOURNAL ARTICLE
Yongxin Liu, Chunping Xu, Yuqing Wang, Caiting Yang, Genyuan Pu, Le Zhang, Zhuang Wang, Pengyan Tao, Shenghe Hu, Mingming Lai
OBJECTIVE: Hypertension is one of the leading causes of human death and disability. MTHFR and MTRR regulate folate metabolism and are closely linked to hypertension, although the relationship is inconsistent among different ethnic groups. The present study aims to investigate the effects of MTHFR C677T (rs1801133), MTHFR A1298C (rs1801131), and MTRR A66G (rs1801394) polymorphisms on hypertension susceptibility in the Bai nationality of the Yunnan Province, China. METHODS: This case-control study included 373 hypertensive patients and 240 healthy controls from the Chinese Bai population...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37154141/folic-acid-enhances-the-cardiovascular-protective-effect-of-amlodipine-in-renal-hypertensive-rats-with-elevated-homocysteine
#57
JOURNAL ARTICLE
Li Li, Xiaohui Tong, Zebin Ma, Lei Lv, Haipeng Liu, Guang Liang Chen
OBJECTIVES: To investigate the actions of amlodipine-folic acid (amlodipine-FA) preparation on hypertension and cardiovascular in renal hypertensive rats with hyperhomocysteinemia (HHcy), so as to provide experimental basis for clinical research of amlodipine folic acid tablets. METHODS: Rats model of renal hypertension with HHcy were established. The rats were randomly divided into groups of model, amlodipine, folic acid (FA) and amlodipine-FA of various dosages...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37149883/ghrelin-improves-endothelial-function-and-reduces-blood-pressure-in-ang-ii-induced-hypertensive-mice-role-of-ampk
#58
JOURNAL ARTICLE
Juan Deng, Yuan Hu, Yindi Zhang, Fadong Yu
BACKGROUND: Endothelial dysfunction is a major pathophysiology observed in hypertension. Ghrelin, a key regulator of metabolism, has been shown to play protective roles in cardiovascular system. However, whether it has the effect of improving endothelial function and lowering blood pressure in Ang II-induced hypertensive mice remains unclear. METHODS: In this study, hypertension was induced by continuous infusion of Ang II with a subcutaneous osmotic pumps and ghrelin (30 μg/kg/day) was intraperitoneal injection for 4 weeks...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37144334/inhibition-of-endoplasmic-reticulum-stress-restores-the-balance-of-renal-ras-components-and-lowers-blood-pressure-in-the-spontaneously-hypertensive-rats
#59
JOURNAL ARTICLE
Jun Zhu, Anjing Shao, Chunyan Wang, Chensi Zeng, Hongyong Wang
BACKGROUND: Endoplasmic reticulum (ER) stress has been shown to play a critical role in the pathogenesis of hypertension. However, the underlying mechanisms for lowering blood pressure (BP) by suppressing ER stress remain unclear. Here, we hypothesized that inhibition of ER stress could restore the balance between RAS components and lower BP in spontaneously hypertensive rats (SHRs). METHODS: Wistar-Kyoto (WKY) rats and SHRs received vehicle or 4-PBA, an ER stress inhibitor, in the drinking water for 4 weeks...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37139811/inflammation-is-associated-with-incident-hypertension-in-patients-with-axial-spondyloarthritis-a-longitudinal-cohort-study
#60
JOURNAL ARTICLE
Lin-Hong Shi, Steven H Lam, Ho So, Crystal Y Chan, Tena K Li, Cheuk-Chun Szeto, Lai-Shan Tam
OBJECTIVES: To elucidate the risk factors for the development of incident hypertension (IHT) in patients with axial spondyloarthritis (axSpA). METHODS: We conducted a retrospective cohort study in axSpA patients who were recruited from 2001 to 2019 from a university clinic in Hong Kong. Patients with HT and/or anti-hypertensive drug use at baseline were excluded. They were followed until the end of 2020. The outcome was IHT, defined by a diagnosis and a prescription for an antihypertensive drug...
December 31, 2023: Clinical and Experimental Hypertension: CHE
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