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Journals Clinical and Experimental Hype...

Clinical and Experimental Hypertension : CHE

https://read.qxmd.com/read/37939250/calcitriol-reverses-age-related-hypertension-via-downregulating-renal-ap1-at-1-r-pathway-through-regulating-mitochondrial-function
#21
JOURNAL ARTICLE
Ruifang Hua, Baixiong Liu, Wenxiu He, Huilin Zhang, Yong Liu, Qiang Xie, Linjun Zhou, Fang Pei
BACKGROUND: The vitamin D level in the blood is associated with the incidence of hypertension. The present study investigated whether or not calcitriol, an active form of vitamin D, reverses age-related hypertension. METHODS: Young (3-month-old) and aged (12-month-old) C57BL/6 male mice were administered with or without calcitriol at 150 ng/kg per day by oral gavage for 8 weeks. Blood pressure was measured by tail-cuff plethysmography and telemetry, and superoxide production in renal tissue was assessed by fluorescence imaging, and the protein expression of AP1/AT1 R signaling pathway was examined by Western blot...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37902269/tyg-index-is-a-predictor-of-all-cause-mortality-during-the-long-term-follow-up-in-middle-aged-and-elderly-with-hypertension
#22
JOURNAL ARTICLE
Jie Pang, Linyan Qian, Xiaoru Che, Ping Lv, Qiang Xu
BACKGROUND: The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there has been a lack of studies exploring the specific relationship between the TyG index and all-cause and cardiovascular mortality among middle-aged and elderly with hypertension. METHODS: A total of 3,614 participants with hypertension were enrolled from the National Health and Nutrition Examination Survey. The TyG index was calculated using the formula log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37899350/cdn1163-alleviates-serca2-dysfunction-induced-pulmonary-vascular-remodeling-by-inhibiting-the-phenotypic-transition-of-pulmonary-artery-smooth-muscle-cells
#23
JOURNAL ARTICLE
Weimin Yu, Qian Zhang, Yixiang Qiu, Hui Chen, Xiaoyang Huang, Li Xiao, Gang Xu, Siqi Li, Pingping Hu, Xiaoyong Tong
BACKGROUND AND PURPOSE: Substitution of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads to activated inositol requiring enzyme 1 alpha (IRE1α) and spliced X-box binding protein 1 (XBP1s) pathway accelerating cell proliferation of pulmonary artery smooth muscle cells (PASMCs) followed by significant pulmonary vascular remodeling resembling human pulmonary hypertension. Based on this knowledge, we intend to investigate other potential mechanisms involved in SERCA2 dysfunction-induced pulmonary vascular remodeling...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37879890/rgs10-inhibits-proliferation-and-migration-of-pulmonary-arterial-smooth-muscle-cell-in-pulmonary-hypertension-via-akt-mtorc1-signaling
#24
JOURNAL ARTICLE
Sheng Hu, Yijie Zhang, Chenming Qiu, Ying Li
Objective: Excessive proliferation and migration of pulmonary arterial smooth muscle cell (PASMC) is a core event of pulmonary hypertension (PH). Regulators of G protein signaling 10 (RGS10) can regulate cellular proliferation and cardiopulmonary diseases. We demonstrate whether RGS10 also serves as a regulator of PH. Methods: PASMC was challenged by hypoxia to induce proliferation and migration. Adenovirus carrying Rgs10 gene (Ad-Rgs10) was used for external expression of Rgs10. Hypoxia/SU5416 or MCT was used to induce PH...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37871163/visceral-fat-and-its-dynamic-change-are-associated-with-renal-damage-evidence-from-two-cohorts
#25
JOURNAL ARTICLE
Mengyue Lin, Shiwan Wu, Xiulian Deng, Yequn Chen, Xuerui Tan
BACKGROUND AND AIMS: To evaluate the association of Chinese visceral adiposity index (CVAI) and its dynamic trends with risk of renal damage, and to compare its prediction performance with that of other obesity indices. METHODS AND RESULTS: A community-based population with 23 905 participants from Shantou city was included in the cross-sectional analysis. A total of 9,778 individuals from two separated cohort were included in the longitudinal portion. Five patterns of CVAI change were predefined (low-stable, decreasing, moderate, increasing, and persistent-high)...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37848382/mg53-alleviates-hypoxia-reoxygenation-induced-cardiomyocyte-injury-by-succinylation-and-ubiquitination-modification
#26
JOURNAL ARTICLE
Yan Wang, Hongying Zhou, Jin Wu, Shanshan Ye
BACKGROUND: Mitsugumin 53 (MG53) is a membrane repair factor that is associated with acute myocardial infarction. This study aimed to investigate the effects of MG53 on cardiomyocyte injury and the posttranslational modification of MG53. METHODS: Cardiomyocyte injury was evaluated by enzyme-linked immunosorbent assay and flow cytometry. The succinylation and ubiquitination levels of MG53 were examined by immunoprecipitation (IP) and western blot. The relationship between MG53 and KAT3B or SIRT7 was assessed by co-IP and immunofluorescence...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37842909/associations-between-central-pulse-pressure-microvascular-endothelial-function-and-fluid-overload-in-peritoneal-dialysis-patients
#27
JOURNAL ARTICLE
Seoyon Koh, Seung-Jung Kim, Shina Lee
BACKGROUND: Microcirculatory endothelial dysfunction is a complex phenomenon that contributes to the development of cardiovascular disease. However, the relationship between microcirculatory endothelial dysfunction and macrovascular disease remains incompletely understood. Fluid overload is a risk factor for cardiovascular mortality in patients undergoing peritoneal dialysis. Therefore, we investigated the effects of chronic fluid overload on both the microcirculation and macrocirculation in these patients...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37817460/tip60-mediates-stress-induced-hypertension-via-promoting-glutamate-dmpfc-to-vca1-release
#28
JOURNAL ARTICLE
Ying Wang, Min Xia, Jincheng Lu, Tianyu Wang, Xuan Zhang, Michael Ntim, Bin Wang
Hypertension is well-known to be influenced by genetic and environmental factors. Managing stress is one of the non-pharmacologic approaches to treating hypertension. It is, therefore, imperative to unravel the molecular mechanism by which stress conditions influence hypertension. In this study, TIP60 expressions in human blood samples and cell lines, glutamatedmPFC- to - vCA1 release, and receptor expressions in the Stress-induced hypertension mice were determined using western blotting, CSF (obtained by microdialysis), and ELISA...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37805984/body-roundness-index-improves-the-predictive-value-of-cardiovascular-disease-risk-in-hypertensive-patients-with-obstructive-sleep-apnea-a-cohort-study
#29
JOURNAL ARTICLE
Xintian Cai, Shuaiwei Song, Junli Hu, Qing Zhu, Wenbo Yang, Jing Hong, Qin Luo, Xiaoguang Yao, Nanfang Li
BACKGROUND: Obesity, especially visceral obesity, plays an important role in the progression of cardiovascular disease (CVD). The body roundness index (BRI) is a new measure of obesity that is considered to reflect visceral obesity more comprehensively than other measures. This study aims to evaluate the relationship between BRI and CVD risk in hypertensive patients with obstructive sleep apnea (OSA) and explore its superiority in predicting CVD. METHODS: The Cox proportional hazards model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CVD...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37805983/accumulated-exposure-to-high-non-high-density-lipoprotein-cholesterol-increases-the-risk-of-cardiovascular-diseases-in-hypertensive-individuals-an-11-year-prospective-cohort-study
#30
JOURNAL ARTICLE
Weiqiang Wu, Yanjuan Chen, Kuangyi Wu, Huancong Zheng, Guanzhi Chen, Xianxuan Wang, Zegui Huang, Zefeng Cai, Zhiwei Cai, Zhichao Chen, Yulong Lan, Shuohua Chen, Shouling Wu, Youren Chen
BACKGROUND: The relationship of cumulative non high-density lipoprotein-cholesterol (Cum-non-HDL-C) concentration with the risk of cardiovascular disease (CVD) in individuals with hypertension remains unclear. METHODS: In total 27 234 participants for whom three consecutive total cholesterol and HDL-C concentrations were available, and who did not have CVD, comprising 13 617 with hypertension and 13 617 without from 2006 to 2010. Participants were placed into four groups according to Cum-non-HDL-C...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37652577/mediating-effect-of-subclinical-inflammation-on-the-process-of-morning-hypertension-leading-to-atrial-fibrillation-in-community-based-older-adults
#31
JOURNAL ARTICLE
Jinping Li, Zhibo Hu, Liming Hou, Peilin Li, Ruizhen Yang, Yuanli Dong, Hua Zhang, Yuqi Guo, Weike Liu, Zhendong Liu
BACKGROUND: The impacts and mechanisms of morning hypertension (MHT) on the risk of new-onset atrial fibrillation (AF) in the elderly have not been clarified. We aimed to investigate an association between MHT and new-onset AF and explore a mediating effect of subclinical inflammation on this association. METHODS: From 2008 to 2010, 1789 older adults aged ≥60 years were recruited in Shandong area, China. Morning blood pressure (BP) was assessed using 24-hour ambulatory BP monitoring...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37641972/effect-of-grk4-on-renal-gastrin-receptor-regulation-in-hypertension
#32
JOURNAL ARTICLE
Xuewei Xia, Yongchun Zeng, Zhuxin Li, Hao Luo, Wei Wang, Yanji He, Bingjun Lu, Jingwen Guo, Ken Chen, Xiang Xu
OBJECTIVE: To investigate whether GRK4 regulates the phosphorylation and function of renal CCKBR. METHODS: GRK4 A142V transgenic mice were used as an animal model of enhanced GRK4 activity, and siRNA was used to silence the GRK4 gene to investigate the regulatory effect of GRK4 on CCKBR phosphorylation and function. Finally, the co-localization and co-connection of GRK4 and CCKBR in RPT cells were observed by laser confocal microscopy and immunoprecipitation to explore the mechanism of GRK4 regulating CCKBR...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37639695/a-propensity-score-matched-comparison-of-blood-pressure-lowering-in-essential-hypertension-patients-treated-with-antihypertensive-chinese-herbal-medicine-comparing-the-real-world-registry-data-vs-randomized-controlled-trial
#33
RANDOMIZED CONTROLLED TRIAL
Xinxing Lai, Zhenghao Fang, Zhenyu Dong, Shengxian Wu, Xiaohua Zhou, Ying Gao
BACKGROUND: Randomized controlled trials have demonstrated that Songling Xuemaikang capsule (SXC) is effective in blood pressure (BP) lowering for essential hypertension. However, the effectiveness of SXC in real-world clinical practice remains unknown. We aimed to investigate whether the BP-lowering effectiveness of SXC in the real-world practice setting is comparable to the efficacy of the intervention in a randomized controlled trial. METHODS: We included 1325 patients treated with SXC monotherapy from a real-world registry and 300 from the SXC-BP trial...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37552638/comprehensive-viewpoints-on-heart-rate-variability-at-high-altitude
#34
REVIEW
Jun Hou, Keji Lu, Peiwen Chen, Peng Wang, Jing Li, Jiali Yang, Qing Liu, Qiang Xue, Zhaobing Tang, Haifeng Pei
OBJECTIVES: Hypoxia is a physiological state characterized by reduced oxygen levels in organs and tissues. It is a common clinicopathological process and a major cause of health problems in highland areas.  Heart rate variability (HRV) is a measure of the balance in autonomic innervation to the heart. It provides valuable information on the regulation of the cardiovascular system by neurohumoral factors, and changes in HRV reflect the complex interactions between multiple systems...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37551155/nuts-consumption-and-hypertension-risks-in-children-a-mediating-role-of-circulating-lipid-metabolites
#35
JOURNAL ARTICLE
Liu Qin, Yanling Ren, Lan Chen, Ye Feng, Shunqing Luo, Ping Zhang, Wei Zhang, Xiaohua Liang
BACKGROUND: Although nuts play an important role in preventing cardiovascular disease, the metabolic cues by which nuts regulate blood pressure have not been fully understood.Aims:We conducted a nested case-control study in a prospective cohort study of Southwest China children to explore the potential lipid metabolites related to the relationship between nut dietary and blood pressure. METHODS: Forty-three hypertension cases and 53 controls serum samples were obtained for lipidomic data analysis using a liquid chromatography mass spectrometry platform...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37503669/influence-of-blood-pressure-variations-during-hemodialysis-on-the-prognosis-of-dialysis-patients
#36
JOURNAL ARTICLE
Yuko Ohta, Masayo Fukuhara, Ritsuko Fujisawa, Maki Kanesaki, Hiroshi Tsuruta, Hidetoshi Nakamura, Yuhei Kawano
The prognosis of dialysis patients is poorer than that of the general population. The relationship between dialysis patients' blood pressure (BP) and mortality is controversial. We investigated the relationships between mortality and ( i ) pre-dialysis BP and ( ii ) BP variation during hemodialysis in maintenance dialysis patients.We retroactively analyzed the cases of the 284 patients on hemodialysis (mean age 68 ± 13 years old) who had been regularly followed at Kokura Daiichi Hospital, Japan in 2018...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37477238/prognostic-implications-of-machine-learning-derived-echocardiographic-phenotypes-in-community-hypertensive-patients
#37
JOURNAL ARTICLE
Anping Cai, Zhou Dan, Yingling Zhou, Yinqing Feng, Zhiqiang Nie
BACKGROUND: Echocardiogram is commonly used to evaluate cardiac remodeling in hypertension (HTN). However, study on echocardiographic phenotypes and their prognostic implications in HTN is limited. OBJECTIVE: We aimed to evaluate the prognostic implications echocardiographic phenotypes in community hypertensive patients. METHOD: A total of 1881 community hypertensive patients without overt cardiovascular disease and severe renal disease (mean age 62...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37454306/anthocyanin-attenuates-high-salt-induced-hypertension-via-inhibiting-the-hyperactivity-of-the-sympathetic-nervous-system
#38
JOURNAL ARTICLE
Chunmei Xu, Jun Zhu, Guangyuan Gong, Li Guo, Ye Zhang, Ziyue Zhang, Chunlan Ma
BACKGROUND: Anthocyanin plays a protective role in cardiovascular disease through antioxidant effect. Whether anthocyanin can reduce salt-induced hypertension and the related mechanisms remain unclear. METHODS: Chronic infusion of vehicle (artificial cerebrospinal fluid, aCSF, 0.4 μL/h) or anthocyanin (10 mg/kg, 0.4 μL/h) into bilateral paraventricular nucleus (PVN) of Sprague-Dawley rats was performed. Then, the rats were fed a high salt diet (8% NaCl, HS) or normal salt diet (0...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37439538/association-between-composite-dietary-antioxidant-index-and-hypertension-insights-from-nhanes
#39
JOURNAL ARTICLE
Mingyue Wu, Jiayi Si, Yihai Liu, Lina Kang, Biao Xu
AIM: The association between composite dietary antioxidant index (CDAI) and hypertension remains unknown. Our study was to investigate the association of CDAI with hypertension in general adults. METHODS: A total of 21 526 participants were enrolled from the National Health and Nutrition Examination Surveys (NHANES). The CDAI was calculated from the intake of six dietary antioxidants. Multivariable logistic regressions were performed to explore the associations between CDAI and the prevalence of hypertension...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37395230/ketogenic-diet-inhibits-neointimal-hyperplasia-by-suppressing-oxidative-stress-and-inflammation
#40
JOURNAL ARTICLE
Xuefei Xu, Limin Xie, Lili Chai, Xiaoming Wang, Jinhu Dong, Jipei Wang, Pengwei Yang
OBJECTIVE: Neointimal hyperplasia is the primary mechanism underlying atherosclerosis and restenosis after percutaneous coronary intervention. Ketogenic diet (KD) exerts beneficial effects in various diseases, but whether it could serve as non-drug therapy for neointimal hyperplasia remains unknown. This study aimed to investigate the effect of KD on neointimal hyperplasia and the potential mechanisms. METHODS AND RESULTS: Carotid artery balloon-injury model was employed in adult Sprague-Dawley rats to induce neointimal hyperplasia...
December 31, 2023: Clinical and Experimental Hypertension: CHE
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