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Journals Clinical and Experimental Hype...

Clinical and Experimental Hypertension : CHE

https://read.qxmd.com/read/38615327/relationship-between-triglyceride-glucose-index-and-new-onset-hypertension-in-general-population-a-systemic-review-and-meta-analysis-of-cohort-studies
#1
REVIEW
Changqiang Yang, Yue Song, Peijian Wang
BACKGROUND: The triglyceride-glucose (TyG) index is an alternative biomarker for insulin resistance that may be connected to incident hypertension. We performed the meta-analysis to clarify the connection between TyG index and new-onset hypertension in the general population. METHODS: We recruited cohort studies that assessed the association between TyG index and the risk of hypertension in the general population by searching the databases of PubMed, EMBASE, and Web of Science (SCI) from their inception dates until July 18, 2023...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38527024/omentin-1-ameliorates-pulmonary-arterial-hypertension-by-inhibiting-endoplasmic-reticulum-stress-through-ampk%C3%AE-signaling
#2
JOURNAL ARTICLE
Xinyu Deng, Hao Luo, Jing He, Wang Deng, Daoxin Wang
BACKGROUND: Endothelial dysfunction of the pulmonary artery contributes to hypoxia-induced pulmonary arterial hypertension (PAH). Omentin-1, as a novel adipocytokine, plays an important protective role against cardiovascular diseases. However, the effect and underlying mechanisms of omentin-1 against PAH remain unclear. METHODS: PAH was induced in SD (Sprague & Dawley) rats via a low-oxygen chamber for 4 weeks. Hemodynamic evaluation was undertaken using a PowerLab data acquisition system, and histopathological analysis was stained with hematoxylin and eosin (H&E)...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38525833/-chicoric-acid-advanced-paqr3-ubiquitination-to-ameliorate-ferroptosis-in-diabetes-nephropathy-through-the-relieving-of-the-interaction-between-paqr3-and-p110%C3%AE-pathway
#3
JOURNAL ARTICLE
Weiwei Zhang, Yong Liu, Jiajun Zhou, Teng Qiu, Haitang Xie, Zhichen Pu
PURPOSE: This study aimed to examine the impact of CA on DN and elucidate its underlying molecular mechanisms of inflammation. METHODS: We fed C57BL/6 mice injected with streptozotocin to induce diabetes. In addition, we stimulated NRK-52E cells with 20 mmol/L d-glucose to mimic the diabetic condition. RESULTS: Our findings demonstrated that CA effectively reduced blood glucose levels, and improved DN in mice models. Additionally, CA reduced kidney injury and inflammation in both mice models and in vitro models...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38507311/emodin-ameliorates-myocardial-fibrosis-in-mice-by-inactivating-the-ros-pi3k-akt-mtor-axis
#4
JOURNAL ARTICLE
Wei Huang, Peiting Zhou, Xinyun Zou, Yunchuan Liu, Longfu Zhou, Yaolei Zhang
BACKGROUND: Emodin is a traditional medicine that has been shown to exert anti-inflammatory and anti-oxidative effects. Previous research has indicated that emodin can alleviate myocardial remodeling and inhibit myocardial hypertrophy and fibrosis. However, the mechanism by which emodin affects myocardial fibrosis (MF) has not yet been elucidated. METHODS: Fibroblasts were treated with ANGII, and a mouse model of MF was established by ligation of the left anterior descending coronary artery...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38488417/association-between-cbs-gene-t833c-g919a-and-844ins68-polymorphisms-in-the-8th-exon-region-and-coronary-artery-disease-a-meta-analysis
#5
REVIEW
Zijiang Zhu, Yuhan Geng, Long Ma, Keying Yao, Ruitong Chang, Yongming Ma, Jialong Li
BACKGROUND: Several studies indicate that the cystathionine β-synthase (CBS) gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region may be correlated with coronary artery disease (CAD) susceptibility, but the results have been inconsistent and inconclusive. Thus, a meta-analysis was conducted to provide a comprehensive estimate of these associations. METHODS: On the basis of searches in the PubMed, EMBASE, Cochrane Library, Wanfang, VIP, and CNKI databases, we selected 14 case - control studies including 2123 cases and 2368 controls for this meta-analysis...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38471134/chronic-exercise-improves-renal-at-1-and-etb-receptor-functions-via-modulating-grk4-expression-in-obese-zucker-rats
#6
JOURNAL ARTICLE
Jingjing Lu, Zhengsheng Li, Yinan Yang, Fangning Wei
BACKGROUND: Physical activity has profound benefits on health, especially in patients with cardiovascular and metabolic disease. Exercise training can reduce oxidative stress, improve renal function, and thus lower blood pressure. However, the effect of exercise training on angiotensin II type 1 receptors (AT1 R) and endothelin subtype B receptors (ETBR)-mediated diuresis and natriuresis in obese Zucker rats is unclear. METHODS: Lean and obese Zucker rats were exercised or placed on a nonmoving treadmill for 8 weeks...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38471132/causal-relationship-between-iron-status-and-preeclampsia-eclampsia-a-mendelian-randomization-analysis
#7
JOURNAL ARTICLE
Xiaofeng Yang, Jiachun Wei, Lu Sun, Qimei Zhong, Xiaoxuan Zhai, Ya Chen, Shujuan Luo, Chunyan Tang, Lan Wang
BACKGROUND: Preeclampsia/eclampsia is a severe pregnancy-related disorder associated with hypertension and organ damage. While observational studies have suggested a link between maternal iron status and preeclampsia/eclampsia, the causal relationship remains unclear. The aim of this study was to investigate the genetic causality between iron status and preeclampsia/eclampsia using large-scale genome-wide association study (GWAS) summary data and Mendelian randomization (MR) analysis...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38346228/a-smartwatch-sphygmomanometer-based-model-for-predicting-short-term-new-onset-hypertension-in-individuals-with-high-normal-blood-pressure-a-cohort-study
#8
JOURNAL ARTICLE
Yuqi Liu, Zhonghua Lv, Shanshan Zhou, Zihao Fu, Yifei Wang, Li Yi, Xiaolong Li, Ying Wang, Shunying Hu, Zhirui Zhou, Yundai Chen
OBJECTIVES: The objective was to utilize a smartwatch sphygmomanometer to predict new-onset hypertension within a short-term follow-up among individuals with high-normal blood pressure (HNBP). METHODS: This study consisted of 3180 participants in the training set and 1000 participants in the validation set. Participants underwent both ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM) using a smartwatch sphygmomanometer. Multivariable Cox regressions were used to analyze cumulative events...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38281072/exploration-and-validation-of-signature-genes-and-immune-associations-in-septic-cardiomyopathy
#9
JOURNAL ARTICLE
Zhengbo Zhao, Xiaojing Wang, Fangyan Tan, Han Liu, Wan Chen, Jing Wang, Songbai Deng, Jianlin Du
An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis of sepsis. In our research, we aimed to identify signature genes and their immune connections in septic cardiomyopathy. By analyzing the mouse myocardial transcriptome from sepsis induced by cecum ligation and puncture (CLP), we identified four distinct k-means clusters. Further analysis of human myocardial datasets using Weighted Gene Co-expression Network Analysis (WGCNA) revealed a strong correlation between the MEturquoise module and septic cardiomyopathy (cor = 0...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38270079/optimizing-the-aldosterone-to-renin-ratio-cut-off-for-screening-primary-aldosteronism-based-on-cardiovascular-risk-a-collaborative-study
#10
JOURNAL ARTICLE
Chunxue He, Ruolin Li, Jun Yang, Hang Shen, Yue Wang, Xiangjun Chen, Wenjin Luo, Qinglian Zeng, Linqiang Ma, Ying Song, Qingfeng Cheng, Zhihong Wang, Fei-Fei Wu, Qifu Li, Shumin Yang, Jinbo Hu
OBJECTIVES: Aldosterone-to-renin ratio (ARR) based screening is the first step in the diagnosis of primary aldosteronism (PA). However, the guideline-recommended ARR cutoff covers a wide range, from the equivalent of 1.3 to 4.9 ng·dl-1 /mIU∙l-1 . We aimed to optimize the ARR cutoff for PA screening based on the risk of cardiovascular diseases (CVD). METHODS: Longitudinally, we included hypertensive participants from the Framingham Offspring Study (FOS) who attended the sixth examination cycle and followed up until 2014...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38264971/the-positive-association-between-the-atherogenic-index-of-plasma-and-the-risk-of-new-onset-hypertension-a-nationwide-cohort-study-in-china
#11
JOURNAL ARTICLE
Yue Yuan, Jing Shi, Wei Sun, Xiangqing Kong
BACKGROUND: The atherogenic index of plasma (AIP) is a novel metabolic biomarker of atherosclerosis. Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chinese population. METHODS: Prospective data were obtained from 3150 participants aged ≥ 18 years in the China Health and Nutrition Survey from 2009 to 2015. The AIP is a logarithmically transformed ratio of triglycerides to high-density lipoprotein cholesterol in molar concentration...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38230680/research-hotspots-and-trends-regarding-micrornas-in-hypertension-a-bibliometric-analysis
#12
REVIEW
Yu Sun, Qingxin Shang
To investigate the research levels, hotspots, and development trends regarding microRNAs in hypertension, this study conducted a visual analysis of studies on miRNA in hypertension based on the Web of Science core collection database using CiteSpace and VOSviewer analysis software along with literature from 2005-2023 as information data. Using citation frequency, centrality, and starting year as metrics, this study analyzed the research objects. It revealed the main research bodies and hotspots and evaluated the sources of literature and the distribution of knowledge from journals and authors...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38147409/inhibition-of-dyrk1a-attenuates-vascular-remodeling-in-pulmonary-arterial-hypertension-via-suppressing-stat3-pim-1-nfat-pathway
#13
JOURNAL ARTICLE
Cong Lan, Guangyao Fang, Chenming Qiu, Xiuchuan Li, Fengyuan Yang, Yongjian Yang
Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response to hypoxia, both in vivo and in vitro ...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38010958/the-long-non-coding-rna-malat1-functions-as-a-competing-endogenous-rna-to-regulate-vascular-remodeling-by-sponging-mir-145-5p-hk2-in-hypertension
#14
JOURNAL ARTICLE
Jiangyong Yang, Guojun Jiang, Ling Huang, Zhongyi Liu, Rengui Jiang, Gang Cao, Jun Cao, Hengqing Zhu, Lemei Chen, Xiaoming Chen, Fang Pei
Long non-coding RNAs (LncRNAs) have been found to play a regulatory role in the pathophysiology of vascular remodeling-associated illnesses through the lncRNA-microRNA (miRNA) regulation axis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is thought to be involved in proliferation, migration, apoptosis, and calcification of vascular smooth muscle cells (VSMCs). The purpose of this study was to investigate the regulatory role of MALAT1 on vascular remodeling in hypertension. Our data indicate that the expression of MALAT1 is significantly upregulated in hypertensive aortic smooth muscle...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37983187/baseline-and-longitudinal-cardiovascular-health-using-life-s-essential-8-metrics-with-the-risk-of-incident-hypertension
#15
JOURNAL ARTICLE
Xue Tian, Jingxuan Feng, Shuohua Chen, Yijun Zhang, Xiaoli Zhang, Qin Xu, Penglian Wang, Shouling Wu, Anxin Wang
OBJECTIVE: The quantification of cardiovascular health (CVH) was updated by the American Heart Association recently by using the "Life's Essential 8" (LE8) score. We aimed to investigate the associations of baseline and longitudinal CVH status measured by the new LE8 score (except for blood pressure) with the risk of hypertension. METHODS: A total of 52 990 participants with complete data on LE8 metrics and without hypertension were enrolled from the Kailuan study, Tangshan, China...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37970663/canagliflozin-ameliorates-hypobaric-hypoxia-induced-pulmonary-arterial-hypertension-by-inhibiting-pulmonary-arterial-smooth-muscle-cell-proliferation
#16
JOURNAL ARTICLE
Luxun Tang, Qi Cai, Xiao Wang, Xiaoyu Li, Xiuchuan Li, Lianglong Chen, Yongjian Yang
Pulmonary arterial hypertension (PAH) is a disease with a high mortality and few treatment options to prevent the development of pulmonary vessel remodeling, pulmonary vascular resistance, and right ventricular failure. Canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, is originally used in diabetes patients which could assist the glucose excretion and decrease blood glucose. Recently, a few studies have reported the protective effect of SGLT2 inhibitor on monocrotaline-induced PAH. However, the effects of canagliflozin on hypobaric hypoxia-induced PAH as well as its mechanism still unclear...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37963203/circusp9x-mir-599-stim1-axis-regulates-proliferation-and-migration-in-vascular-smooth-muscle-cells-induced-by-oxidized-low-density-lipoprotein
#17
REVIEW
Hui-Lin Hu, Hui-Xiu Zheng, Na Yuan, Chang-Lin Zhai, Hao Chen, Hai-Hua Pan, Gang Qian
Circular RNAs (circRNAs) regulate the function of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) progression. We aimed to explore the role of circUSP9X in oxidized low-density lipoprotein (ox-LDL)-induced VSMCs. Cell proliferation was assessed using cell counting kit-8 and EDU assays. Cell migration was evaluated using Transwell and wound healing assays. The interaction between circUSP9X or STIM1 and miR-599 was analyzed using dual-luciferase reporter and RNA pull-down assays. Their levels were examined using quantitative real-time PCR...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37963199/follistatin-like-1-protects-endothelial-function-in-the-spontaneously-hypertensive-rat-by-inhibition-of-endoplasmic-reticulum-stress-through-ampk-dependent-mechanism
#18
JOURNAL ARTICLE
Hanwen Liu, Yanwen Li, Maogang Li, Linghai Xie, Feng Li, Runmei Pan, Fang Pei
OBJECTIVE: Endothelial dysfunction is a critical initiating factor in the development of hypertension and related complications. Follistatin-like 1 (FSTL1) can promote endothelial cell function and stimulates revascularization in response to ischemic insult. However, it is unclear whether FSTL1 has an effect on ameliorating endothelial dysfunction in spontaneously hypertensive rats (SHRs). METHODS: Wistar Kyoto (WKY) and SHRs were treated with a tail vein injection of vehicle (1 mL/day) or recombinant FSTL1 (100 μg/kg body weight/day) for 4 weeks...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37943619/thrombospondin-2-is-a-novel-biomarker-of-essential-hypertension-and-associated-with-nocturnal-na-excretion-and-insulin-resistance
#19
JOURNAL ARTICLE
Xiaoxin Zhou, Longlong Zhang, Xiaoqian Lin, Xi Chen, Hong Liu, Xiaoli Yuan, Qiuxia Zhao, Weiwei Wang, Xun Lei, Pedro A Jose, Chunyan Deng, Jian Yang
BACKGROUND: Thrombospondins (TSPs) play important roles in several cardiovascular diseases. However, the association between circulating (plasma) thrombospondin 2 (TSP2) and essential hypertension remains unclear. The present study was aimed to investigate the association of circulating TSP2 with blood pressure and nocturnal urine Na+ excretion and evaluate the predictive value of circulating TSP2 in subjects with hypertension. METHODS AND RESULTS: 603 newly diagnosed essential hypertensive subjects and 508 healthy subjects were preliminarily screened, 47 healthy subjects and 40 newly diagnosed essential hypertensive subjects without any chronic diseases were recruited...
December 31, 2023: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/37939250/calcitriol-reverses-age-related-hypertension-via-downregulating-renal-ap1-at-1-r-pathway-through-regulating-mitochondrial-function
#20
JOURNAL ARTICLE
Ruifang Hua, Baixiong Liu, Wenxiu He, Huilin Zhang, Yong Liu, Qiang Xie, Linjun Zhou, Fang Pei
BACKGROUND: The vitamin D level in the blood is associated with the incidence of hypertension. The present study investigated whether or not calcitriol, an active form of vitamin D, reverses age-related hypertension. METHODS: Young (3-month-old) and aged (12-month-old) C57BL/6 male mice were administered with or without calcitriol at 150 ng/kg per day by oral gavage for 8 weeks. Blood pressure was measured by tail-cuff plethysmography and telemetry, and superoxide production in renal tissue was assessed by fluorescence imaging, and the protein expression of AP1/AT1 R signaling pathway was examined by Western blot...
December 31, 2023: Clinical and Experimental Hypertension: CHE
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