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Clinical and Experimental Hypertension: CHE

Farzaneh Farajian-Mashhadi, Fatemeh Eskandari, Mahnaz Rezaei, Farzaneh Eskandari, Darya Najafi, Batool Teimoori, Maryam Moradi-Sharbabak, Saeedeh Salimi
PURPOSE: Vitamin D deficiency may be a main causative agent in the pathogenesis of preeclampsia (PE). The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta. Therefore, we evaluated the potential relationship between maternal and placental VDR polymorphisms and the predisposition to PE in an Iranian population. METHODS: This case-control study surveyed 152 PE and 160 normotensive pregnant women...
April 20, 2019: Clinical and Experimental Hypertension: CHE
Xiaoxia Zhang, Lingling Huang, Xin Peng, Yixian Xie, Xinyu Bao, Junxuan Huang, Peixi Wang
Backgroud and Purpose: Hypertension has been regarded as one of the most common chronic diseases reported in different studies, and handgrip strength is a good indicatorof anindividual's overall health. However, few studies have concentrated on investigating the relationship between hypertension and handgrip strength, especially for the middle-aged and elderly population in the community. Therefore, the purpose of this study was to explore the association of handgrip strength with the risk of hypertension. METHODS: A cross-sectional study was conducted using a multi-instrument questionnaire...
April 19, 2019: Clinical and Experimental Hypertension: CHE
Xianping Lv, Xueying Li, Xueli Dai, Mengchun Liu, Cuijiao Wu, Weiqing Song, Jingli Wang, Xiaoyan Ren, Yan Cai
OBJECTIVES: The involvement of oxidative stress in the pathophysiology of preeclampsia (PE) has been already suggested. In this present study, we aimed to investigate the association of the genetic frequency of heme oxygense-1 (HMOX1) polymorphism with PE in Chinese Han women. METHODS: We researched the genetic distribution of rs2071746 polymorphism in HMOX1 by the TaqMan allelic discrimination real-time PCR between 1235 PE patients and 1720 healthy women. RESULTS: We found there were't significant differences in the distribution of HMOX1 rs2071746 polymorphism in PE compared to the control group (rs2071746, genotype χ2 = 0...
April 12, 2019: Clinical and Experimental Hypertension: CHE
Yosuke Takamiya, Keisuke Okamura, Kazuyuki Shirai, Tetsu Okuda, Kunihisa Kobayashi, Hidenori Urata
OBJECTIVE: We purpose to confirm the effect of teneligliptin (Tenelia), a selective dipeptidyl peptidase-4 (DPP-4) inhibitor, on glycemic control and non-glucose risk factors for macroangiopathy, including blood pressure, lipid metabolism, and body weight. METHODS: In a prospective, multicenter, open-label, observational study, teneligliptin (20 mg/day) was administered to type 2 diabetic patients with poor glycemic control (HbA1c ≥ 6.5% to <10%) at our hospitals...
April 11, 2019: Clinical and Experimental Hypertension: CHE
Vaishali Kasture, Surabhi Dalvi, Mayur Swamy, Anvita Kale, Sadhana Joshi
BACKGROUND: Early (EOP) and late onset (LOP) preeclampsia are two subtypes of preeclampsia. This study examines the effect of maternal omega-3 fatty acids and vitamin E supplementation in a rat model of preeclampsia. METHOD: Pregnant Wistar rats were assigned to control; EOP; LOP; EOP+omega-3 fatty acid supplementation+vitamin E and LOP+omega-3 fatty acid supplementation+vitamin E. L-Nitroarginine methylester was used to induce preeclampsia. Blood Pressure (BP) was recorded during pregnancy and dams were dissected at d14 and d20 of gestation...
April 9, 2019: Clinical and Experimental Hypertension: CHE
Jin Gong, Qunfang Xie, Ying Han, Bingying Chen, Lieyou Li, Guoxiang Zhou, Tingjun Wang, Liangdi Xie
BACKGROUND: Subjects with metabolic syndrome showed increased risk of cardiovascular events. We investigated the relationship between components of metabolic syndrome and arterial stiffness in Chinese hypertensives. METHOD: 680 subjects (aged 58.44 ± 11.67 years, male 63.53%, hypertension 65.00%) were divided into five groups based on the number of known components of metabolic syndrome (MSCs) according to the criteria of 2010 Chinses Guidelines for Prevention and Management of Hypertension (0MSCs: n= 86; 1MSCs: n= 153; 2MSCs: n= 201; 3MSCs: n= 148; 4/5MSCs: n= 92...
April 9, 2019: Clinical and Experimental Hypertension: CHE
Lin Meng, Xiaoxue Bai, Yan Zheng, Dongmei Chen, Yang Zheng
AIM: We explored the role of histone modification in the association of depression-hypertension by comparing norepinephrine transporter (NET) gene levels in different depression-hypertensive patients. Then, we analyzed the expression of NET correlation with inflammatory cytokines to provide a new direction for detecting the association mechanism between depression and hypertension. METHODS: NE expression levels in serum of diverse groups were detected by enzyme-linked immunosorbent assay...
April 7, 2019: Clinical and Experimental Hypertension: CHE
Shiran Alagacone, Emanuele Verga, Roberto Verdolini, Shaik Mohammed Saifullah
BACKGROUND: Previous studies have already shown a link between vitamin D deficiency and hypertension. The impact of vitamin D deficiency in resistant hypertension is currently unknown. This study examined whether an association between the two entities exists. METHOD: We analysed 2953 known hypertensive subjects surveyed by NHANES (National Health and Nutrition Examination Survey) among the United States population between 2003 and 2006. Subjects were categorized as having either resistant hypertension or hypertension based on the number of anti-hypertensives in use and their overall blood pressure control...
April 2, 2019: Clinical and Experimental Hypertension: CHE
Haiying Wang, Taimei Zhou, Huiying He, Rong Peng, Sujie Wang, Xinglin Jiang
Hypertension is a complex disease that partially influenced by genetic factors. Up till now, the association between the rs651821 in apolipoprotein A5 (APOA5) gene and hypertension remains unknown. This study was undertaken to investigate the relationship between the APOA5 rs651821 and hypertension in Tongdao Dong population. A total of 274 participants were involved in this study (135 hypertensive patients and 139 nonhypertensive adults). The single nucleotide polymorphism (SNP) was genotyped by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP)...
March 30, 2019: Clinical and Experimental Hypertension: CHE
Mitsuru Ohishi, Takuo Yoshida, Nobuhiro Nishigaki, Akinori Oh, Yukio Shimasaki
The number of patients with heart failure (HF) is rapidly increasing. Although hypertension is related to onset of HF, antihypertensive treatment status for these patients has not been fully examined. We conducted a claims-based study to discern the treatment status of Japanese hypertensive patients with HF. Two Japanese databases (2008-2016) from acute care hospitals and health insurance societies were used to analyze prescription rates for antihypertensive drug class or category of diuretics in all hypertensive patients and the subset of patients with HF...
March 26, 2019: Clinical and Experimental Hypertension: CHE
Derya Demirtas, Hilmi Erdem Sumbul, Abdullah Orhan Demirtas, Yahya Kemal Icen, Erdinc Gulumsek, Hasan Koca, Örsan Deniz Urgun, Mevlut Koc
INTRODUCTION: There is not enough data on the effects of primary hyperparathyroidism (pHPT) on morning blood pressure surge (MBPS) in the literature. We aimed to determine whether there was any change in MBPS value in patients with hypertensive pHPT and to determine the parameters related to MBPS. METHOD: 80 patients with newly diagnosed pHPT with hypertension (HT) and 80 controls with newly diagnosed hypertension were included. Routine laboratory examinations and ambulatory blood pressure monitoring (ABPM) were performed in all patients...
March 21, 2019: Clinical and Experimental Hypertension: CHE
Akiyo Sasaki-Otomaru, Kotaro Yamasue, Osamu Tochikubo, Kyoko Saito, Masahiko Inamori
This study aimed to examine the associations between home blood pressure (HBP) and sleep and activity assessed using data obtained via a wristwatch-type pulsimeter with accelerometer (Pulsense®) using original software. We recruited 28 elderlies and 40 employees aged 24-81 years who were not on hypotensive agents and sleeping drugs. Sleep, activity, and HBP were measured consecutively over a 5-7-day period. Body mass index (BMI), base heart rate (HR0 ), and age showed significant correlation with HBP in a simple and multiple linear regression analysis...
March 19, 2019: Clinical and Experimental Hypertension: CHE
Carlos Leonardo Figueiredo Machado, Cíntia Ehlers Botton, Clarissa Müller Brusco, Lucinéia Orsolin Pfeifer, Eduardo Lusa Cadore, Ronei Silveira Pinto
The aim of the present study was to evaluate the effects of 12 weeks of muscle power training (MPT) on casual blood pressure (BP) (before and after each training session) and resting BP (pre- and post-training program) in type 2 diabetes mellitus (T2DM) elderly. METHODS: Twelve T2DM elderly individuals (68.75 ± 7.83 years), non-insulin-dependents participated in the present study and performed the MPT program twice a week. Casual BP was measured before and after training sessions, and resting BP was measured 48 h before the first and 48 h after the last training session...
March 14, 2019: Clinical and Experimental Hypertension: CHE
Sebastian Völz, Linda C Lundblad, Bert Andersson, Jonas Multing, Bengt Rundqvist, Mikael Elam
BACKGROUND: The impact of renal denervation (RDN) on muscle sympathetic nerve activity (MSNA) at rest remains controversial. Mental stress (MS) induces transient changes in sympathetic nerve activity, heart rate (HR) and blood pressure (BP). It is not known whether RDN modifies these changes. PURPOSE: The main objective was to assess the effect of RDN on MSNA and BP alterations during MS. METHODS: In 14 patients (11 included in analysis) with resistant hypertension multi-unit MSNA, BP (Finometer ®) and HR were assessed at rest and during forced arithmetics at baseline and 6 months after RDN...
March 14, 2019: Clinical and Experimental Hypertension: CHE
Diogo Nóbrega Catelas, Maria Paula Serrão, Patricio Soares-Da-Silva
BACKGROUND AND OBJECTIVE: Evaluate the activity of dopamine-β-hydroxylase (DβH) as well as the effect of the DβH inhibitor nepicastat upon enzyme activity and levels of dopamine (DA) and norepinephrine (NE) in the rat left ventricle, kidney, and adrenal glands. METHODS: DβH assay consisted of the enzymatic hydroxylation of tyramine into octopamine, and DA and NE tissues levels were quantified by HPLC-ED. RESULTS: Nepicastat (30 mg/kg, p...
March 1, 2019: Clinical and Experimental Hypertension: CHE
Miki Imamura, Kei Asayama, Yukiya Sawanoi, Toshikazu Shiga, Kanako Saito, Takayoshi Ohkubo
OBJECTIVE: For repeated measurements of blood pressure (BP) using the auscultatory method, current guidelines recommend intervals of 1-2 minutes; however, evidence to support this recommendation is insufficient. In the present study, the effects of intervals among repeated BP measurements using the auscultatory method were evaluated. METHODS: Systolic and diastolic BPs were measured using the auscultatory method in 37 participants. The measurements were repeated 5 times each at intervals of 15, 30, 60, 90, and 120 seconds...
February 27, 2019: Clinical and Experimental Hypertension: CHE
Daole Yan, Gang Li, Yaozhong Zhang, Yinglong Liu
OBJECTIVE:  To investigate the effects of angiotensin-converting enzyme 2 (ACE2) activation on pulmonary arterial cell apoptosis during pulmonary vascular remodeling associated with pulmonary arterial hypertension (PAH) and to elucidate potential mechanisms related to Hippo signaling. METHODS: PAH model was developed by injecting monocrotaline combined with left pneumonectomy using Sprague-Dawley rat. Then, resorcinolnaphthalein (Res; ACE2 activator), MLN-4760 (ACE2 inhibitor), A-779 (Mas inhibitor), and 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino) benzenesulfonamide (XMU-MP-1; MST1/2 inhibitor) were administered via continuous subcutaneous or intraperitoneal injection for 3 weeks...
February 26, 2019: Clinical and Experimental Hypertension: CHE
Muserref Hosaf, Sedat Abusoglu, Ahmet Avci, Kenan Demir, Ali Unlu, Duygu Eryavuz, Gulsum Abusoglu
Asymmetric dimethylarginine, symmetric dimethylarginine, and L-monomethylarginine are originated from the subsequent proteolytic catalysis of methylated arginine residues on different proteins and inhibit the endogenous nitric oxide generation. The changes in total methylarginine load (Asymmetric dimethylarginine plus symmetric dimethylarginine plus L-monomethylarginine) may contribute to hypertension. The aim of this study was to determine serum methylarginine concentrations in patients with masked hypertension and determine the association between these biomarkers and blood pressure measurements...
February 22, 2019: Clinical and Experimental Hypertension: CHE
Shunsuke Kiuchi, Shinji Hisatake, Takayuki Kabuki, Takashi Oka, Shintaro Dobashi, Takahiro Fujii, Takanori Ikeda
BACKGROUND: It is unclear that the difference in efficacy of tolvaptan (TLV) on the length of hospital stay for both heart failure (HF) preserved ejection fraction (EF) (HFpEF) and reduced EF (HFrEF) patients. METHODS: We investigated 369 patients who were hospitalized with HF from February 2011 to June 2016 and initiated TLV. Patients who died in hospital, transferred hospital or clinical scenario 4 or 5 were excluded. Finally, we analyzed 108 patients with HFpEF and 96 patients with HFrEF...
February 22, 2019: Clinical and Experimental Hypertension: CHE
Xiaojie Yuan, Tingcai Wang, Jie Gao, Yunchao Wang, Yajun Chen, Kanakaraju Kaliannan, Xiaochun Li, Jing Xiao, Tianyou Ma, Lei Zhang, Zhongjun Shao
BACKGROUND: Hypertension (HTN), dyslipidemia and hyperhomocysteinemia (HHcy) are risk factors for cardiovascular disease (CVD). METHODS: Hypertensive Chinese subjects (n = 228) were enrolled. MTHFR C667T, MTHFR A1298C, MTR A2756G, and MTRR A66G genotypes were determined. Unconditional logistic regression was performed to determine the associations of serum Hcy status and genotypes with HTN and dyslipidemia. RESULTS: The mean age of hypertensive adults was 65...
February 20, 2019: Clinical and Experimental Hypertension: CHE
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