journal
https://read.qxmd.com/read/38385680/zilebesiran-a-promising-antihypertensive-therapy-inhibiting-angiotensinogen-synthesis
#1
JOURNAL ARTICLE
Rida S Khan, William H Frishman
Systemic hypertension is one of the most common noncommunicable diseases globally, with over one billion people affected. Despite the widespread use of numerous antihypertensive drugs, it is estimated that only a fifth of diagnosed patients achieve adequate blood pressure control. For this reason, the pursuit for novel antihypertensive therapies is ongoing. Zilebesiran, an siRNA designed to target the liver, is the newest potential addition to the renin-angiotensin-aldosterone system-inhibiting drugs. This subcutaneous injection post-transcriptionally silences the AGT gene responsible for the synthesis of angiotensinogen...
February 22, 2024: Cardiology in Review
https://read.qxmd.com/read/38385663/the-rising-use-of-e-cigarettes-unveiling-the-health-risks-and-controversies
#2
JOURNAL ARTICLE
Parth Sheth, Fena Mehta, Gurusha Jangid, F N U Anamika, Bhupinder Singh, Sai Gautham Kanagala, Rohit Jain
The use of e-cigarettes has tremendously increased in recent times due to the widespread availability of e-cigarettes in diverse flavors, reduced cost compared to regular cigarettes, and misconception of being comparatively safe, which have led to around 2.55 million US middle and high school students smoking e-cigarettes. These devices use a nicotine-rich liquid, which is aerosolized electronically, producing vapors that may also include hazardous chemicals and heavy metals. E-cigarettes are associated with e-cigarette or vaping-associated lung injury, which presents as an acute respiratory ailment mirroring various pulmonary diseases...
February 22, 2024: Cardiology in Review
https://read.qxmd.com/read/38363130/image-and-clinical-characteristics-of-the-right-coronary-artery-originating-from-the-left-coronary-sinus-a-database-review
#3
JOURNAL ARTICLE
Mingyuan Yuan, Jiani Zhang
This article systematically explores the imaging and clinical characteristics of a relatively rare cardiac anomaly: the right coronary artery originating from the left coronary sinus. Through a comprehensive analysis of existing literature, this study aims to provide a comprehensive understanding of the prevalence, diagnostic methods, and potential clinical implications of this anatomical variation. Anatomical classification is introduced, along with clinical imaging diagnostic methods, including coronary angiography, computed tomography, and magnetic resonance imaging...
February 16, 2024: Cardiology in Review
https://read.qxmd.com/read/38353563/a-personalized-cell-based-therapy-for-ischemic-heart-failure-with-reduced-ejection-fraction-safety-and-feasibility-outcomes-of-the-roll-in-cohort-of-the-cardiamp-cell-therapy-trial-and-review-of-similar-trials
#4
JOURNAL ARTICLE
Jared M Feldman, William H Frishman, Wilbert S Aronow
CardiAMP Cell Therapy for Heart Failure trial is a prospective, multicenter, randomized, controlled, double-blinded trial that has been granted breakthrough designation by the United States Food and Drug Administration. This trial evaluates clinical outcomes of intramyocardial delivery of a high dose of autologous bone marrow mononuclear cells in chronic postmyocardial infarction heart failure patients. This trial represents the first attempt to personalize marrow-derived cell-based therapy for the treatment of ischemic heart failure with reduced ejection fraction...
February 16, 2024: Cardiology in Review
https://read.qxmd.com/read/38358290/safety-and-efficacy-of-bone-marrow-and-adipose-tissue-derived-mesenchymal-stem-cells-for-the-treatment-of-ischemic-stroke-a-systematic-review
#5
JOURNAL ARTICLE
Leila Afshar Hezarkhani, Kazhal Veysi, Adibeh Rahmani, Nader Salari, Razie Hasheminezhad, Vahideh Nasr, Masoud Mohammadi
Neurological diseases, including ischemic stroke, are considered a big challenge for public health due to their high prevalence and lack of definitive and effective treatments. Addressing these issues requires innovative therapeutic approaches and among the limited methods available, stem cells have shown promise in improving central nervous system repair by enhancing myelin regeneration and neuronal recovery. To advance this field of research, this systematic review aims to assess the safety and effectiveness of mesenchymal stem cells (MSCs) derived from both bone marrow and adipose tissue for the treatment of ischemic stroke...
February 15, 2024: Cardiology in Review
https://read.qxmd.com/read/38358268/emerging-therapies-for-treatment-resistant-hypertension-a-review-of-lorundrostat-and-related-selective-aldosterone-synthase-inhibitors
#6
JOURNAL ARTICLE
Jared M Feldman, William H Frishman, Wilbert S Aronow
The target-hypertension (Target-HTN) trial investigated the efficacy and safety of lorundrostat, an aldosterone synthase inhibitor, as an antihypertensive. Cohort 1 of the trial includes patients with suppressed plasma renin activity and elevated aldosterone levels. Lorundrostat doses of 100 mg and 50 mg daily significantly decreased systolic blood pressure compared to the placebo group. Cohort 2 also demonstrated a reduction in systolic blood pressure with the 100 mg daily dose of lorundrostat...
February 15, 2024: Cardiology in Review
https://read.qxmd.com/read/38349172/complexities-of-coexisting-cardiac-amyloidosis-and-coronary-artery-disease-a-contemporary-review-of-diagnostic-and-treatment-approaches
#7
JOURNAL ARTICLE
Yahui Lu, Geng Bai, Weiding Wang, Guangping Li
Cardiac amyloidosis (CA) represents an emerging challenge in cardiovascular medicine, with notable clinical overlaps and diagnostic complexities when coexisting with coronary artery disease (CAD). This integrative review navigates the intricate terrain of CA and CAD, elucidating epidemiology, clinical presentations, and diagnostic considerations. Examining both immunoglobulin light chain amyloidosis (AL) and transthyretin amyloidosis, we underscore their shared demographic associations, diagnostic intricacies, and potential diagnostic confounders with CAD...
February 13, 2024: Cardiology in Review
https://read.qxmd.com/read/38349134/the-association-and-utility-of-left-ventricular-end-diastolic-pressure-in-predicting-the-development-of-and-in-managing-contrast-induced-nephropathy-in-patients-undergoing-coronary-angiography
#8
JOURNAL ARTICLE
Gaspar Del Rio-Pertuz, Natnicha Leelaviwat, Poemlarp Mekraksakit, Juthipong Benjanuwattra, Kenneth Nugent
Contrast-induced nephropathy (CIN) is a significant complication in patients undergoing coronary angiography, and its development is associated with increased morbidity and mortality. Left ventricular end-diastolic pressure (LVEDP) provides one index of left heart filling status. An elevated LVEDP can reflect volume overload or abnormal diastolic function and indicates a cardiac disorder. Data on the association between an elevated LVEDP and CIN are limited and have had conflicting results. We systematically searched the databases PubMed, Embase, and Scopus for full-text articles from database inception to May 2022...
February 13, 2024: Cardiology in Review
https://read.qxmd.com/read/38334419/titin-the-missing-link-in-cardiac-physiology
#9
JOURNAL ARTICLE
Jude ElSaygh, Anas Zaher, Stephen J Peterson, Manish A Parikh, William H Frishman
Titin, an extraordinary protein known for its colossal size and multifaceted roles, is a cornerstone in the structural and functional dynamics of striated muscle tissues, including the heart and skeletal muscles. Its sheer enormity, with a molecular weight exceeding 3000 kDa, is paralleled only by the immense influence it exerts on muscle physiology. This review will delve into the remarkable structural organization of Titin and the genetics of this molecule, including the common mutations resulting in various cardiomyopathies...
February 9, 2024: Cardiology in Review
https://read.qxmd.com/read/38334371/innovations-in-aortic-valve-replacement-a-comprehensive-overview-of-the-intuity-rapid-deployment-valve
#10
JOURNAL ARTICLE
Abdulaziz M Alaklabi, Saleha Abdul Rab, Belal N Sabbah, Ahmed Essam Maklad, Aleksander Dokollari, Jef Van den Eynde, Michel Pompeu Sa, Arian Arjomandi Rad, Muhammad Rauf Ahsan, Ali Fatehi Hassanabad
Rapid deployment/sutureless (RDS) valves have recently emerged as an innovative surgical solution, providing an alternative to traditional methods of surgical aortic valve replacement (SAVR) by eliminating the need for suture placement and tying. This innovation leads to a reduction in aortic crossclamp and cardiopulmonary bypass times, enhancing the efficiency of the procedure. Among the 2 available RDS valves, the Edwards Intuity valve in particular has been demonstrated to be a particularly promising substitute in the field of SAVR...
February 9, 2024: Cardiology in Review
https://read.qxmd.com/read/38334977/coronavirus-disease-2019-covid-19-in-heart-transplant-recipients-and-anti-sars-cov-2-monoclonal-antibodies-experience-lessons-learnt-and-future-challenges
#11
JOURNAL ARTICLE
Rohan Kapur, Kenji Okumura, Suguru Ohira, Ameesh Isath, Aditya Gandhi, Marina Keller, Rajat Nog, Alan Gass, David Spielvogel, Steven Lansman, Abhay Dhand
Solid organ transplant recipients (SOTRs), including heart transplant (HT) recipients, infected with Coronavirus disease 2019 (COVID-19) are at higher risk of hospitalization, mechanical ventilation, or death when compared with general population. Advances in diagnosis and treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have reduced COVID-19-related mortality rates from ~30% in the early pandemic to <3% in 2022 among HT recipients. We performed a retrospective chart review including adult HT recipients at Westchester Medical Center from January 1, 2020 to December 10, 2022, who received anti-SARS-CoV-2 monoclonal antibodies (mAbs) for treatment of mild-to-moderate COVID-19, and those who received tixagevimab/cilgavimab for preexposure prophylaxis...
February 8, 2024: Cardiology in Review
https://read.qxmd.com/read/38323875/evaluating-the-efficacy-of-interatrial-shunt-devices-in-heart-failure-with-preserved-ejection-fraction-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Mohamed Riad Abouzid, Karim Ali
Heart failure with preserved ejection fraction (HFpEF) is a prevalent and challenging condition with limited therapeutic options. This meta-analysis aims to assess the feasibility and effectiveness of interatrial shunt devices (IASD) in the treatment of HFpEF, focusing on key hemodynamic parameters and clinical outcomes. Six clinical trials, encompassing 324 patients, were included in this analysis. The results showed a significant reduction in pulmonary capillary wedge pressure (PCWP) at rest after IASD implantation, with a mean difference of 1...
February 7, 2024: Cardiology in Review
https://read.qxmd.com/read/38323874/postcardiac-injury-syndrome-after-cardiac-surgery-an-evidence-based-review
#13
JOURNAL ARTICLE
Muhammad Hamza Tahir, Sidra Sohail, Daniyal Shahid, Iqbal Hussain, Jahanzeb Malik, Syeda Iqra, Maria Faraz
Postcardiac injury syndrome (PCIS) serves as a comprehensive term encompassing a spectrum of conditions, namely postpericardiotomy syndrome, postmyocardial infarction (MI) related pericarditis (Dressler syndrome), and post-traumatic pericarditis stemming from procedures like percutaneous coronary intervention or cardiac implantable electronic device placement. These conditions collectively give rise to PCIS, triggered by cardiac injury affecting pericardial or pleural mesothelial cells, leading to subsequent inflammation syndromes spanning from uncomplicated pericarditis to substantial pleural effusion...
February 7, 2024: Cardiology in Review
https://read.qxmd.com/read/38323873/cardiopulmonary-resuscitation-education-in-united-states-schools-shortcomings-and-future-directions
#14
JOURNAL ARTICLE
Harris Z Whiteson, Matthew B Weiss, William H Frishman
Cardiopulmonary resuscitation (CPR) is a lifesaving procedure that is performed during a cardiac arrest. CPR consists of chest compressions, rescue breaths, and the usage of an automated external defibrillator (AED) based on availability. Performance of CPR can greatly increase the chances of survival by enabling the manual perfusion of vital organs in lieu of the heart's normal function. Despite extensive studies demonstrating the efficacy and necessity of CPR in an emergency, most of the public across the United States is ill-equipped and/or educated on how to perform it...
February 7, 2024: Cardiology in Review
https://read.qxmd.com/read/38305409/management-of-hypertension-in-patients-with-polycystic-ovarian-syndrome-a-mini-review
#15
JOURNAL ARTICLE
Amin Liaghatdar, Sadegh Mazaheri-Tehrani, Mohammad Fakhrolmobasheri
Polycystic ovarian syndrome (PCOS) is a common problem among young women. It is characterized mainly by hyperandrogenism features, such as hirsutism, menstrual problems, and anovulation. Diagnosis is based on the existence of 2 items out of, oligo-ovulation, hyperandrogenism features, and ultrasounds findings. Cardiovascular complications such as hypertension are a prevalent serious condition in these patients which is mainly predisposed by the high levels of androgens, and insulin resistance. High blood pressure should be controlled well to prevent the progression of other serious conditions...
February 2, 2024: Cardiology in Review
https://read.qxmd.com/read/38305253/milvexian-a-focus-on-a-new-oral-anticoagulant-that-targets-factor-xia-for-thromboembolism-prophylaxis
#16
JOURNAL ARTICLE
Joseph Birchansky, William H Frishman
Drugs that target factor XI and/or XIa have been evaluated as alternatives to existing anticoagulants, in light of studies that indicate that a decrease in Factor XI/XIa levels or activity may result in a lower risk of thrombosis without a significant increase in bleeding risk. Milvexian is an investigational small-molecule factor XIa inhibitor that has recently completed phase 2 clinical trials. Preclinical studies were suggestive of its potential to prevent arterial and venous thrombosis. It was well-tolerated in healthy participants, as well as in participants with mild or moderate hepatic impairment and moderate or severe renal impairment...
February 2, 2024: Cardiology in Review
https://read.qxmd.com/read/38299850/low-carbohydrate-ketogenic-diet-and-coronary-artery-disease-a-brief-review-of-the-limited-evidence-between-them
#17
JOURNAL ARTICLE
Josef Kusayev, David Weininger, William H Frishman, Wilbert S Aronow
Nowadays there is a lot of interest among the general population regarding the ketogenic diet (KD) and its health benefits. Most people following this diet have a reduced intake of carbohydrates which gets replaced by calories coming from fat and protein. Even though KD has shown some limited health benefits, there is no consensus on long-term effects and cardiovascular safety profile, especially the relation of KD to coronary artery disease (CAD). This concern comes predominantly from increased fat intake in KD and other similar diets with decreased carbohydrate intake...
February 1, 2024: Cardiology in Review
https://read.qxmd.com/read/38299806/transvenous-compared-with-leadless-pacemakers-a-meta-analysis-comparing-tp-versus-lp
#18
JOURNAL ARTICLE
Shady Habboush, Ahmed Elmoursi, Ahmed F Gadelmawla, Amr T Masoud, Mohamed Khalil, Hesham Sheashaa, Nooraldin Merza, Ahmed T Massoud
This study aims to compare the effectiveness of leadless pacemakers (LPs) and transvenous pacemakers and to examine the safety of both methods. We included patients undergoing single-chamber pacemaker implantation, either LP or TVP. Our outcomes were successful implantation rate, major complication, vascular injury, tamponade, and pneumothorax. We performed a double-arm analysis comparing LP versus TVP, with risk ratio (RR) and 95% confidence interval. A total of 10 studies were included in this meta-analysis...
February 1, 2024: Cardiology in Review
https://read.qxmd.com/read/38294226/pitavastatin-in-the-prevention-of-cardiovascular-disease-in-people-living-with-hiv-a-review
#19
JOURNAL ARTICLE
Harris Z Whiteson, Maddison Drogy, Grant Eickel, William H Frishman
HIV is associated with a wide array of pathophysiologic mechanisms that ultimately contribute to mortality. While HIV is traditionally known as a disease that attacks the immune system, it is now established that infection with HIV can cause cardiovascular disease (CVD). Through inflammation, atherogenesis, interactions with antiretroviral therapy/highly-active antiretroviral therapy (ART/HAART), and other mechanisms, HIV is an independent risk factor for the development of CVD. The treatment of the CVD risks associated with HIV is complicated, especially due to interactions with hyperlipidemic drugs and ART/HAART...
January 31, 2024: Cardiology in Review
https://read.qxmd.com/read/38294225/pharmacological-update-and-emerging-treatments-of-pulmonary-hypertension
#20
JOURNAL ARTICLE
Shazli Khan, Sukhbir Randhawa, Haris Patail, Yaakov Spira, William H Frishman, Wilbert S Aronow, Gregg M Lanier
Pulmonary hypertension (PH) is defined as elevated pressures in the pulmonary artery and is associated with significant morbidity and mortality. The World Health Organization classifies PH into 5 distinct groups based on underlying etiology, pathology, and modality of treatment. Therapeutic approach may be challenging due to the extensive spectrum of causes and underlying mechanisms mediating PH. The 5 groups include pulmonary arterial hypertension (group 1), PH secondary to left heart disease (group 2), PH secondary to chronic lung disease (group 3), chronic thromboembolic pulmonary hypertension (group 4), and PH due to miscellaneous causes (group 5)...
January 31, 2024: Cardiology in Review
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