journal
https://read.qxmd.com/read/38990003/direct-oral-anticoagulants-exhibit-lower-risks-of-mortality-and-bleeding-compared-to-vitamin-k-antagonists-in-atrial-fibrillation-patients-on-chronic-hemodialysis-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Aman Goyal, Surabhi Maheshwari, Laveeza Fatima, Binish Javed, Sawai Singh Rathore, Gauranga Mahalwar
This meta-analysis aimed to assess the outcomes of patients with atrial fibrillation undergoing chronic hemodialysis, comparing the effectiveness of direct oral anticoagulants (DOACs) and vitamin K antagonists. A systematic search was conducted across various databases including PubMed, Embase, and Google Scholar. Efficacy outcomes focused on the risk of stroke and mortality, whereas safety outcomes assessed the risk of bleeding. Review Manager generated forest plots for data synthesis. Statistical significance was set at P < 0...
July 11, 2024: Cardiology in Review
https://read.qxmd.com/read/38980079/the-modern-clinician-as-an-argonaut-guiding-through-the-symplegades-of-evidence-for-pfo-closure-in-patients-with-migraine
#2
JOURNAL ARTICLE
Eirini Beneki, Kyriakos Dimitriadis, Laurence Campens, Ioannis Skalidis, Nikolaos Pyrpyris, Panagiotis Kostakis, Constantina Aggeli, Ole de Backer, Konstantinos Tsioufis
Patent foramen ovale (PFO) has been associated with migraine, especially migraine with aura, and 30-50% of individuals with migraine with aura have a PFO, suggesting it could be more than just an "innocent bystander''. Observational data showed a reduction of the frequency and severity of migraine attacks, particularly those with aura, following transcatheter PFO closure for established indications. Three small randomized controlled trials have demonstrated significant benefits of PFO closure in most of their secondary endpoints, such as reductions in the mean number of monthly migraine attacks and migraine days...
July 9, 2024: Cardiology in Review
https://read.qxmd.com/read/38980077/the-bittersweet-reality-the-cardiovascular-risk-of-artificial-sweeteners
#3
JOURNAL ARTICLE
Mesrob Yeterian, Manish A Parikh, William H Frishman, Stephen J Peterson
Artificial sweeteners are increasingly popular as alternatives to sugar. Approximately 41% of the American adult population reports regular consumption of low-calorie sweeteners. People are not even aware they are ingesting artificial sweeteners as they are now in chewing gum, toothpaste, various food products, baked goods, and even pharmaceutical products. Some of these sweeteners are sweeter than sugar, some less sweet than sugar, and some are natural sweeteners. With the goal of increasing palatability, many products have multiple additives to create the perfect taste...
July 9, 2024: Cardiology in Review
https://read.qxmd.com/read/38980048/cardiac-manifestations-in-inherited-metabolic-diseases
#4
JOURNAL ARTICLE
Mubeena Javed, Danish Kumar Goswami, Hem Raj, Kiran Lohana, Barkha Goswami, Ali Karim, Allah Warayo, Palwasha Farooqi, Haroon Alamy, Zainab Obaid Ullah, Aamer Mohammad, Syed Ahmad Farooqi, Hafsah Ali, Darab Shuja, Jahanzeb Malik, Zulfiqar Qutrio Baloch
Inherited metabolic diseases (IMDs) stem from genetic defects affecting enzyme function within specific metabolic pathways, collectively constituting rare conditions with an incidence of less than 1/100,000 births. While IMDs typically manifest with multisystemic symptoms, cardiac manifestations are common, notably hypertrophic cardiomyopathy. Additionally, they can lead to dilated or restrictive cardiomyopathy, as well as noncompacted left ventricular cardiomyopathy. Rhythm disturbances such as atrioventricular conduction abnormalities, Wolff-Parkinson-White syndrome, and ventricular arrhythmias, along with valvular pathologies and ischemic coronary issues, are also prevalent...
July 9, 2024: Cardiology in Review
https://read.qxmd.com/read/38980010/atherosclerosis-and-hiv-exploring-cardiovascular-risks-and-management
#5
JOURNAL ARTICLE
Matthew Seplowe, Anjali Goyal, Tolison Fowler, Liana Michaud, Rebecca Glassman, William H Frishman, Wilbert S Aronow
The advent of antiretroviral therapy has markedly improved the life expectancy of individuals with HIV, leading to a shift in clinical focus from managing opportunistic infections to addressing chronic conditions, such as atherosclerotic cardiovascular disease (ASCVD). Emerging evidence highlights an elevated risk of ASCVD among people living with HIV, characterized by a higher incidence of acute myocardial infarction, ischemic stroke, and heart failure compared with the general population. This review examines the epidemiology, pathophysiology, and management of ASCVD in the context of HIV...
July 9, 2024: Cardiology in Review
https://read.qxmd.com/read/38970481/outpatient-continuous-intravenous-inotropy-in-the-modern-era
#6
JOURNAL ARTICLE
Tzvi Fishkin, Yaakov Spira, Antonella D'Ascanio, Sameer Bahl, William H Frishman, Chhaya Aggarwal Gupta, Wilbert S Aronow, Avi Levine, Alan Gass, Stephen Pan, Gregg M Lanier
The use of continuous inotropy in patients with advanced heart failure (HF) has been historically controversial due to the prevailing notion that it will increase mortality. In practice, clinicians have continued to revisit this idea as there remains a lack of treatment options for patients in stage D HF. Clinical trials in the past have generally not shown favorable effects of long-term chronic infusions of positive IV inotropic agents on symptoms and exercise tolerance. However, these older studies which indicated poor outcomes with palliative inotropes may not apply to current practice...
July 6, 2024: Cardiology in Review
https://read.qxmd.com/read/38970477/managing-the-intricacies-of-coronary-revascularization-a-close-look-at-the-complete-versus-culprit-only-approach-and-its-implications-in-elderly-patients
#7
JOURNAL ARTICLE
Mahmoud El Hajj, Bana Hadid, Akiva Rosenzveig, Somar Hadid, William H Frishman, Wilbert S Aronow
Coronary heart disease is the leading cause of mortality in the United States, and data indicates that 805,000 Americans will face a new or recurrent myocardial infarction (MI) attack every year. Frailty, a conceptual syndrome categorized by a functional decline that occurs with aging, has been linked to adverse health outcomes in cardiovascular disease and all cardiac-related procedures in general. It is therefore reasonable to deliberate that more conservative medical therapy or medical management should be considered in the frail population when managing acute coronary syndrome...
July 6, 2024: Cardiology in Review
https://read.qxmd.com/read/38970476/transcatheter-edge-to-edge-repair-in-valvular-heart-disease-a-comprehensive-exploration-of-equipment-efficacy-gender-racial-and-socioeconomic-disparities-and-future-prospects
#8
JOURNAL ARTICLE
Aman Goyal, Samia Aziz Sulaiman, Darsh Safi, Kahan Mehta, Hritvik Jain, Jyoti Jain, Surabhi Maheshwari, Gauranga Mahalwar
The 2 primary components of valvular heart disease are mitral regurgitation (MR) and tricuspid regurgitation (TR). Transcatheter edge-to-edge repair (TEER) is an advanced, minimally invasive procedure that has recently displayed encouraging outcomes in the treatment of these pathologies. TEER offers a nonsurgical alternative for individuals diagnosed with conditions deemed to be high-risk surgical candidates. Currently, the TEER procedure employs devices such as MitraCLIP and TriCLIP, as well as innovative PASCAL (transcatheter valve repair system used for mitral and tricuspid valve repair) and FORMA (repair system used for tricuspid valve repair) repair systems...
July 6, 2024: Cardiology in Review
https://read.qxmd.com/read/38970472/role-of-the-electrocardiogram-for-identifying-the-development-of-atrial-fibrillation
#9
JOURNAL ARTICLE
Sahar Memar Montazerin, Zareh Ekmekjian, Chrystina Kiwan, Joaquim J Correia, William H Frishman, Wilbert S Aronow
Atrial fibrillation (AF), a prevalent cardiac arrhythmia, is associated with increased morbidity and mortality worldwide. Stroke, the leading cause of serious disability in the United States, is among the important complications of this arrhythmia. Recent studies have demonstrated that certain clinical variables can be useful in the prediction of AF development in the future. The electrocardiogram (ECG) is a simple and cost-effective technology that is widely available in various healthcare settings. An emerging body of evidence has suggested that ECG tracings preceding the development of AF can be useful in predicting this arrhythmia in the future...
July 6, 2024: Cardiology in Review
https://read.qxmd.com/read/38934619/transcatheter-intervention-for-management-of-tricuspid-regurgitation-using-triclip
#10
JOURNAL ARTICLE
Anmol Sharedalal, Alexandra Zois, Parija Sharedalal, William H Frishman, Wilbert S Aronow
Severe tricuspid regurgitation (TR) is an underrated, common pathology that affects over 70 million individuals worldwide. Traditionally, TR has been managed with diuretic therapies without any significant mortality benefit. The underlying cause of TR can be primary, coming from structural issues with tricuspid valve and more commonly secondary, arising from conditions affecting the right ventricle or the pulmonary circulation. Management of TR has seen few improvements until recently. Traditionally, valve replacement and surgical repair were the therapeutic options available...
June 27, 2024: Cardiology in Review
https://read.qxmd.com/read/38934590/the-best-second-arterial-conduit-for-coronary-artery-bypass-grafting-a-meta-analysis-of-reconstructed-individual-patient-data
#11
JOURNAL ARTICLE
Mohammed Al-Tawil, Basel F Alqeeq, Mona Jaffar-Karballai, Basma B Khalefa, Mohammed Ayyad, Maram AlBandak, Mohammed AboAbdo, Haytham Sabry, Amer Harky, Assad Haneya
Multiple arterial conduit revascularization in coronary bypass surgery is being advocated over the use of venous conduits. However, there is a critical gap regarding the optimal sequence of arterial conduit selection following the left internal thoracic artery. This study is the first individual patient data meta-analysis, which aimed to compare the right internal thoracic artery (RITA) versus the radial artery (RA) as a second-best arterial conduit. A comprehensive literature search was conducted in MEDLINE, Embase, Scopus, and CENTRAL...
June 27, 2024: Cardiology in Review
https://read.qxmd.com/read/38920361/zalunfiban-a-review-of-current-knowledge-and-future-applications-of-an-innovative-antiplatelet-agent
#12
JOURNAL ARTICLE
Kassidy Veasaw, Pritika Sharma, William H Frishman, Wilbert S Aronow
Zalunfiban is a novel glycoprotein IIb/IIIa inhibitor currently being tested for its use in the prehospital setting for antiplatelet effect in patients with ST-elevation myocardial infarction. It has shown to be safe and effective in both phase 1 and phase 2 trials and is under investigation in phase 3 trials. In this review, we discuss zalunfiban in detail, including its mechanism of action, adverse effects, current recommendations for use, and ongoing trials.
June 26, 2024: Cardiology in Review
https://read.qxmd.com/read/38869272/new-perspectives-in-the-management-of-paroxysmal-atrial-fibrillation-dual-antiarrhythmic-medications
#13
JOURNAL ARTICLE
Safa Al-Jammali, Rana Al-Zakhari, Arun Umesh Mahtani, Nidal Isber
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice projected to affect 12.1 million individuals by the year 2030. Patients who are diagnosed with AF have an increased risk of morbidity and mortality. Although catheter ablation is a class I treatment recommendation in patients with symptomatic paroxysmal AF, antiarrhythmic medications (AAM) continue to be the mainstay of treatment in limited resource settings not offering ablation procedures. Currently, the most used AAMs are those which block either the sodium or potassium channels...
June 13, 2024: Cardiology in Review
https://read.qxmd.com/read/38836621/emergence-of-artificial-intelligence-and-machine-learning-models-in-sudden-cardiac-arrest-a-comprehensive-review-of-predictive-performance-and-clinical-decision-support
#14
JOURNAL ARTICLE
Hritvik Jain, Mohammed Dheyaa Marsool Marsool, Ramez M Odat, Hamid Noori, Jyoti Jain, Zaid Shakhatreh, Nandan Patel, Aman Goyal, Shrey Gole, Siddhant Passey
Sudden cardiac death/sudden cardiac arrest (SCD/SCA) is an increasingly prevalent cause of mortality globally, particularly in individuals with preexisting cardiac conditions. The ambiguous premortem warnings and the restricted interventional window related to SCD account for the complexity of the condition. Current reports suggest SCD to be accountable for 20% of all deaths hence accurately predicting SCD risk is an imminent concern. Traditional approaches for predicting SCA, particularly "track-and-trigger" warning systems have demonstrated considerable inadequacies, including low sensitivity, false alarms, decreased diagnostic liability, reliance on clinician involvement, and human errors...
June 5, 2024: Cardiology in Review
https://read.qxmd.com/read/38833498/robert-gross-md-and-the-birth-of-pediatric-heart-surgery
#15
JOURNAL ARTICLE
Matthew Krell, George L Hines
Robert Gross performed the first repair of a patent ductus arteriosus in 1938. His life and career were dedicated to the advancement of vascular, cardiac, pediatric surgery, and the unrelenting care of his patients.
June 4, 2024: Cardiology in Review
https://read.qxmd.com/read/38833432/safety-and-outcomes-with-direct-oral-anticoagulants-versus-vitamin-k-antagonists-in-chronic-thromboembolic-pulmonary-hypertension-a-systematic-review-meta-analysis-and-meta-regression
#16
JOURNAL ARTICLE
Hritvik Jain, Ramez M Odat, Mushood Ahmed, Jyoti Jain, Aman Goyal, Muhammad Idrees, Siddhant Passey, Jagriti Jha, Janhvi Shah, Shrey Gole
Chronic thromboembolic pulmonary hypertension (CTEPH) is a subtype of pulmonary hypertension characterized by organized thrombi inside the pulmonary vasculature, leading to an increase in pulmonary artery pressure. CTEPH is seen in about 3-4% of patients with acute pulmonary embolism and is associated with poor outcomes. Apart from surgical intervention, lifelong anticoagulation is the mainstay of CTEPH management. Traditionally, CTEPH is managed with vitamin-K antagonists (VKA); however, direct oral anticoagulants (DOACs) are recently gaining popularity...
June 4, 2024: Cardiology in Review
https://read.qxmd.com/read/38832784/a-review-of-terlipressin-in-hepatorenal-syndrome-targeting-endothelial-dysfunction-and-subsequent-cardiovascular-adverse-events
#17
JOURNAL ARTICLE
Adrienne M Bielawski, William H Frishman
Hepatorenal syndrome (HRS) is a serious complication of decompensated liver cirrhosis that results in acute kidney injury (AKI). The mortality rate is high. Endothelial dysfunction secondary to liver cirrhosis is a key driver of the development of portal hypertension, which is eventually complicated by ascites and HRS. Ultimately, splanchnic vasodilation and excess gut lymph production result in ascites, low effective arterial blood volume, and maladaptive compensatory mechanisms that contribute to renal hypoperfusion and injury...
June 4, 2024: Cardiology in Review
https://read.qxmd.com/read/38814100/cardiac-manifestations-of-lymphoma-a-review-of-primary-and-secondary-cardiac-lymphoma
#18
JOURNAL ARTICLE
Aatif Khurshid, Chisom Okezue, William H Frishman, Wilbert S Aronow
Primary cardiac lymphoma (PCL) is a very unique and uncommon disease presentation, with reports in the literature limited to case reports. Most often it is B-cell in origin, predominantly diffuse large B-cell lymphoma. Symptomatic presentation of PCL depends on the location of anatomic involvement, but most often involves the right heart, with presentation consistent with heart failure, pericardial effusions, and atrioventricular nodal blockade. Endomyocardial biopsy is necessary for diagnosis, but cardiac magnetic resonance imaging has been the most useful for staging of the disease...
May 30, 2024: Cardiology in Review
https://read.qxmd.com/read/38814094/sudden-cardiac-death-risk-stratification-in-heart-failure-with-preserved-ejection-fraction
#19
JOURNAL ARTICLE
Xu Huang, Yangjie Li, Honglu Zheng, Ying Xu
Heart failure with preserved ejection fraction (HFpEF) poses a significant clinical challenge, with sudden cardiac death (SCD) emerging as one of the leading causes of mortality. Despite advancements in cardiovascular medicine, predicting and preventing SCD in HFpEF remains complex due to multifactorial pathophysiological mechanisms and patient heterogeneity. Unlike heart failure with reduced ejection fraction, where impaired contractility and ventricular remodeling predominate, HFpEF pathophysiology involves heavy burden of comorbidities such as hypertension, obesity, and diabetes...
May 30, 2024: Cardiology in Review
https://read.qxmd.com/read/38814089/the-risk-of-ventricular-septal-defects-associated-with-prenatal-marijuana-exposure-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Ariel Stonberg, Samuel A Beber, Elizabeth Drugge, William H Frishman
With the recent legalization of marijuana across the United States, its usage in pregnant women has increased. The aim of this meta-analysis was to determine if prenatal marijuana use increases the likelihood of ventricular septal defects. The analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The search strategy identified 4 case-control studies that were ultimately included in the analysis with a combined 381,621 infant records...
May 30, 2024: Cardiology in Review
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