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Romanian Journal of Internal Medicine | Page 2

Simella Provatopoulou, Dimitra Kalavrizioti, Maria Stangou, Maria-Nikoleta Kouri, Pantellitsa Kalliakmani, Marios Papasotiriou, Evangelos Papachristou, Dimitrios S Goumenos, Aikaterini Papagianni
INTRODUCTION: Circulating autoantibodies against phospholipase A2 receptor (anti-PLA2R) are recognized as key elements in the pathogenesis of idiopathic membranous nephropathy. In current clinical practice, they are increasingly gaining attention as novel tools for diagnosis and disease monitoring. We investigated the diagnostic and prognostic utility of anti-PLA2R antibody measurements in Greek patients with biopsy-proven membranous nephropathy. METHODS: Anti-PLA2R levels were measured in serum samples from 33 patients at diagnosis using ELISA and were associated with treatment outcome...
December 1, 2018: Romanian Journal of Internal Medicine
Sara Machado, Rui Marques, Edite Nascimento, Ana Matos, Carla Henriques
INTRODUCTION: Diabetes Control and Complications Trial has established the importance of glycemic control in reducing the progression of retinopathy, nephropathy, and neuropathy in type 1 diabetics. There is little literature linking the frequency of glycemic monitoring with glycated hemoglobin A (HbA1c) in type 2 diabetics. The objectives were to assess the influence of glycemic self-monitoring on HbA1c in three groups of patients with type 2 diabetes (with insulin, with oral antidiabetics and with combination therapy)...
December 1, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Hüseyin Avni Findikli, Ayşe Şahin Tutak, Hakan Aydin
INTRODUCTION: Changes in thyroid hormone level can affect the cardiovascular system. The aim of this study was to show how the Tpeak -Tend (Tpe) interval, which is a new marker of ventricular arrythmia, is affected in patients who have become euthyroid following Levothyroxine treatment for hypothyroidism, as this has not been examined previously in literature. MATERIALS AND METHODS: This, cross-sectional study included a total of 119 females aged 18-45 years, separated into 3 groups as hypothyroid, euthyroid and control groups...
December 1, 2018: Romanian Journal of Internal Medicine
Larisa Pinte, Cristian Baicuș
BACKGROUND: In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. Our aim is to investigate the potential causes of EA development, as well as clinical, laboratory, endoscopic and radiologic features, management and outcome in these patients. METHODS: The following research was performed on PubMed (MEDLINE) database using the medical subject headings [Mesh] terms "Ascites" AND "Eosinophils"...
December 1, 2018: Romanian Journal of Internal Medicine
Alireza Sepehri Shamloo, Nikolaos Dagres, Arash Arya, Gerhard Hindricks
Atrial fibrillation (AF), as the most common cardiac arrhythmia worldwide, is associated with increased mortality and morbidity. Successful therapeutic strategies have been introduced so far, but they are associated with significant costs. Therefore, identification of modifiable risk factors of AF and the development of appropriate preventive strategies may play a substantial role in promoting community health and reducing health care system costs. Modifiable cardiovascular risk factors including obesity, hypertension, diabetes mellitus, obstructive sleep apnea, alcohol consumption, smoking, and sedentary lifestyles have been proposed as possible contributors to the development and progression of AF...
December 1, 2018: Romanian Journal of Internal Medicine
Andrada-Loredana Popescu, Florentina Ioniţa-Radu, Mariana Jinga, Andrei-Ionuţ Gavrilă, Florin-Alexandru Săvulescu, Carmen Fierbinţeanu-Braticevici
The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Different treatment modalities have been proposed to treat obese patients, but bariatric surgery due to its complex interactions via anatomic, physiologic and neurohormonal changes achieved the best long-term results, with sustained weight loss and decrease of complications and mortality caused by obesity...
December 1, 2018: Romanian Journal of Internal Medicine
Serghei Covantev
Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. There is evidence that PD can be associated with pancreatic tumors (up to 12.5% of cases). The golden standard for diagnosing PD is endoscopic retrograde cholangiopancreatography, but since it is an invasive procedure magnetic resonance cholangiopancreatography with secretin is a good alternative...
December 1, 2018: Romanian Journal of Internal Medicine
Tatiana Ashcheulova, Nina Gerasimchuk, Olga Kovalyova, Oleksii Honchar
INTRODUCTION: Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. This process is proven to have contributed by immune inflammation activation which is mediated by pro-inflammatory cytokines and oxidative stress...
December 1, 2018: Romanian Journal of Internal Medicine
Maria Mirabela Manea, Ana Maria Dobri, Dorin Dragoş, Gabriela Borsaru, Sorin Tuţă
Acute promyelocytic leukemia often manifests with hemorrhagic diathesis, thrombotic events being much rarer. This is the case of a 59-year-old patient with thrombotic cerebro-vascular complications as the onset manifestation of acute promyelocytic leukemia.
December 1, 2018: Romanian Journal of Internal Medicine
Mujgan Tek, Mehmet Serkan Çetin, Erdem Diker, Savaş Çelebi, Basri Amasyali, Berkten Berkalp
BACKGROUND: Platelet to lymphocyte ratio (PLR) has been demonstrated as an risk and prognostic marker in many of cardiovascular diseases. Relationship between PLR and severity of carotid stenosis has been shown. The aim of our study was to investigate the relationship between PLR and all cause mortality in patients with carotid arterial disease. METODS: This retrospective study included 146 patients who had been performed selective carotid angiography. Carotid stenosis were graded by the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria...
December 1, 2018: Romanian Journal of Internal Medicine
Khadija Sellami, Madiha Mseddi, Mouna Snoussi, Hela Gharbi, Faten Frikha, Rayda Ben Salah, Moez Jallouli, Sameh Marzouk, Abderrahmen Masmoudi, Zouhir Bahloul, Hamida Turki
INTRODUCTION: The prognosis of dermatomyositis (DM)/ polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia. METHODS: A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015...
December 1, 2018: Romanian Journal of Internal Medicine
Stamatis S Papadatos, Stamatis J Karakatsanis, George Deligiannis, Eleni Gatsa
Thrombotic Thrombocytopenic Purpura (TTP) is a thrombotic microangiopathy syndrome resulting from decrease or absence of "a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13" (ADAMTS13). TTP has been characterized by the classical pentad of thrombocytopenia, hemolysis, fever, renal injury and neurological deficits, yet the patient may present with any atypical symptom related to microthrombi formation in the microcirculation. Here we present a rare case of a young patient with retrosternal chest pain and myocardial injury as the first manifestation of TTP...
November 15, 2018: Romanian Journal of Internal Medicine
Nicoleta Dumitru, Mara Carşote, Andra Cocoloş, Eugenia Petrova, Maria Olaru, Andra Caragheorgheopol, Constantin Dumitrache, Adina Ghemigian
INTRODUCTION: Current studies support the implication of metabolic changes associated with type 2 diabetes in altering bone metabolism, structure and resistance. OBJECTIVE: We conducted a cross-sectional study on postmenopausal women aimed to analyze the differences in metabolic and bone profile in patients with and without type 2 diabetes Methods: We analyzed the metabolic and bone profile in postmenopausal women with and without type 2 diabetes(T2DM). Clinical, metabolic, hormonal parameters, along with lumbar, hip and femoral bone mineral density (BMD) and trabecular bone score (TBS) were evaluated...
November 15, 2018: Romanian Journal of Internal Medicine
Hilal Yücel, Abitter Yücel, Hamdi Arbağ, Erkan Cure, Mehmet Akif Eryilmaz, Ahmet Bedri Özer
INTRODUCTION: It is known that hyperlipidemia reduces hearing functions. In this study, we aimed to study the effect of antihyperlipidemic drugs on hearing functions and tinnitus. METHODS: Eighty-four patients aged 18 to 84, who were diagnosed with hyperlipidemia and started treatment with the statin group (atorvastatin 20 mg and 40 mg, rosuvastatin 10 mg and 20 mg, and simvastatin 20 mg) of antihyperlipidemic drugs, were included in this study. All patients underwent pure-tone audiometry before starting treatment with antihyperlipidemic drugs...
November 15, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Romeo-Gabriel Mihăilă
INTRODUCTION: The severity of liver fibrosis can be assessed noninvasively today by liver stiffness measurements. Vibration-controlled transient elastography, shear wave elastography or magnetic resonance elastography are techniques increasingly used for this purpose. METHODS: This article presents the recent advances in the use of new techniques for liver fibrosis assessment in chronic hepatitis C: the correlation between liver stiffness values and liver fibrosis estimated by liver biopsies, the prognosis role of liver stiffness values, their usefulness in monitoring the treatment response, in assessing the severity of portal hypertension and in estimating the presence of esophageal varices...
November 15, 2018: Romanian Journal of Internal Medicine
Stamatis Karakonstantis, Niki Gryllou, George Papazoglou, Charalampos Lydakis
INTRODUCTION: Eosinopenia has been previously investigated as a marker to differentiate infectious from non-infectious diagnoses and as a prognostic marker. Most previous studies were conducted in intensive care unit patients. Our study focuses on the value of eosinopenia in patients admitted to the Internal Medicine department. METHODS: We retrospectively analyzed 271 consecutive patients with infection and 31 patients presenting with fever or inflammatory syndrome and a non-infectious diagnosis...
November 1, 2018: Romanian Journal of Internal Medicine
Theodor Voiosu, Andrei Voiosu, Andreea Benguş, Bogdan Mateescu
BACKGROUND: Endoscopic retrograde cholangiopancreatography has evolved significantly in recent years. The increase in complexity and range of applications has not been adequately reflected in an improvement of training methods for ERCP, with many endoscopists failing to meet required performance standards during their training period and limited available data on their performance immediately after completing training. We aimed to analyze the performance of an independent operator from a developing country after the completion of formal training with regard to procedure and patient-related outcomes...
November 1, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Mihaela Dobranici, Anamaria Tocitu, Caterina Delcea, Gheorghe-Andrei Dan
Left ventricular noncompaction is a rare structural cardiomyopathy that can occur isolated or in relationship with other conditions, mainly with musculoskeletal diseases or congenital heart defects. The association of left ventricular noncompaction and connective tissue disorders, including systemic lupus erythematosus, was scarcely described in the literature. Reported cases are, more likely, cardiomyopathies mimicking left ventricular noncompaction or transient left ventricular noncompaction with ventricular function improving after appropriate treatment...
October 27, 2018: Romanian Journal of Internal Medicine
Pooneh Pashapour, Samad Ghaffarii, Ahmad Separham
INTRODUCTION: One of the inflammatory factors affecting the prognosis of myocardial infarction is the high level of neutrophil count in blood. In this study, we investigated the relationship of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in peripheral blood with ST-segment resolution and clinical outcomes of patients with ST-elevation myocardial infarction (STEMI) receiving thrombolytic therapy. METHODS: This cross-sectional study was conducted on the patients referring to the emergency department in Tabriz, Iran who were diagnosed with STEMI and began receiving treatment with reteplase...
October 27, 2018: Romanian Journal of Internal Medicine
Tarek Samy Abdelaziz, Khaled Marzouk Sadek
INTRODUCTION: Medication Regimen complexity is an important issue of patients care that needs to be addressed. The aim of this study is the safe reduction of regimens complexities. The effect of this intervention on glycemic control was assessed in this study. METHODS: Seventy eight patients were recruited to the study. The entry criteria were non optimal glycemic, non-adherence (as demonstrated by indirect tools), and polypharmacy. The only intervention was the safe reduction of medication regimen complexity...
October 4, 2018: Romanian Journal of Internal Medicine
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