journal
https://read.qxmd.com/read/37264684/analysis-of-optical-absorption-of-photoaged-human-skin-using-a-high-frequency-illumination-microscopy-analysis-system
#1
JOURNAL ARTICLE
Yuki Ogura, Mihoko Shimano, Ryoma Bise, Toyonobu Yamashita, Chika Katagiri, Imari Sato
Skin is composed of different layers, including the stratum corneum, epidermal living layer and papillary and reticular dermis. Each has specific optical properties due to differences in their biological components. Alterations in the skin's cutaneous biological components resulting from photoaging caused by chronic exposure to UV light affect the deterioration of appearance associated with the skin's optical properties. Various methods for analysing cutaneous optical properties have been previously proposed, including mathematical models and computer simulations...
June 2, 2023: Experimental Dermatology
https://read.qxmd.com/read/37264715/generalized-pustular-psoriasis-caused-by-bupropion-with-rapid-recurrence-after-self-rechallenge
#2
LETTER
Yu-Chen Jeng, Yu-Chen Lin, Chao-Kai Hsu, Julia Yu-Yun Lee, Chaw-Ning Lee
No abstract text is available yet for this article.
June 1, 2023: Experimental Dermatology
https://read.qxmd.com/read/37264692/the-crosstalk-between-pten-induced-kinase-1-mediated-mitophagy-and-the-inflammasome-in-the-pathogenesis-of-alopecia-areata
#3
JOURNAL ARTICLE
Jung-Min Shin, Kyung Min Kim, Mi Soo Choi, Sanghyun Park, Dongkyun Hong, Kyung-Eun Jung, Young-Joon Seo, Chang Deok Kim, Hanseul Yang, Young Lee
Alopecia areata (AA) is a T-cell-mediated autoimmune disease that causes chronic, relapsing hair loss; however, its precise pathogenesis remains to be elucidated. Recent studies have provided compelling evidence of crosstalk between inflammasomes and mitophagy-a process that contributes to the removal of damaged mitochondria. Our previous studies showed that the NLR family pyrin domain containing 3 (NLRP3) inflammasome is important for eliciting and progressing inflammation in AA. In this study, we detected mitochondrial DNA damage in AA-affected scalp tissues and IFNγ and poly(I:C) treated outer root sheath (ORS) cells...
June 1, 2023: Experimental Dermatology
https://read.qxmd.com/read/37261383/mild-generalised-pustular-psoriasis-patient-with-a-heterozygous-hypomorphic-mpo-variant-successfully-treated-with-granulocyte-and-monocyte-adsorption-apheresis
#4
JOURNAL ARTICLE
Takuya Takeichi, Takenori Yoshikawa, Muhammad Nasir Iqbal, Muhammad Farooq, Tomoki Taki, Yoshinao Muro, Yutaka Shimomura, Mariko Seishima, Masashi Akiyama
Pathogenic variants in MPO, which encodes the myeloperoxidase, were reported as causative genetic defects in several cases of generalised pustular psoriasis (GPP) in addition to patients with myeloperoxidase deficiency in 2020. However, which clinical subtypes of GPP patients have pathogenic variants in MPO remains largely undetermined, and elucidating this is clinically important. The present report outlines a mild case of GPP with a rare missense heterozygous variant, c.1810C>T p.(Arg604Cys), in MPO. Our structural analysis and functional assays to measure myeloperoxidase activity suggest that the present MPO substitution is a hypomorphic variant in MPO...
June 1, 2023: Experimental Dermatology
https://read.qxmd.com/read/37260420/divergent-in-situ-expression-of-il-31-and-il-31ra-between-bullous-pemphigoid-and-pemphigus-vulgaris
#5
JOURNAL ARTICLE
Ecem Zeliha Ergun, Rui Aoki, Orsolya N Horváth, Daniela Hartmann, Takashi K Satoh, Laura Calabrese, Ayşe Esra Koku Aksu, Mehmet Salih Gürel, Vildan Manav, Michael J Flaig, Miklós Sárdy, Thomas Ruzicka, Lars E French, Işın Sinem Bağcı
Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are two major autoimmune blistering skin diseases. Unlike PV, BP is accompanied by intense pruritus, suggesting possible involvement of the pruritogenic cytokine IL-31. However, the underlying mechanisms of the clinical difference between BP and PV in terms of pruritus are not fully understood. To compare the expression levels of IL-31 and its receptor IL-31RA in the lesional skin, including peripheral nerves in BP and PV patients, immunohistochemical staining for IL-31 and IL-31RA was performed in skin samples of BP and PV patients and healthy controls (HC)...
June 1, 2023: Experimental Dermatology
https://read.qxmd.com/read/37237288/male-pattern-hair-loss-can-developmental-origins-explain-the-pattern
#6
JOURNAL ARTICLE
Leah C Redmond, Summik Limbu, Bessam Farjo, Andrew G Messenger, Claire A Higgins
Male pattern hair loss (MPHL), also referred to as male androgenetic alopecia (AGA) is the most common type of non-scarring progressive hair loss, with 80% of men suffering from this condition in their lifetime. In MPHL, the hair line recedes to a specific part of the scalp which cannot be accurately predicted. Hair is lost from the front, vertex, and the crown, yet temporal and occipital follicles remain. The visual effect of hair loss is due to hair follicle miniaturisation, where terminal hair follicles become dimensionally smaller...
May 26, 2023: Experimental Dermatology
https://read.qxmd.com/read/37218931/phosphorylation-of-glucocorticoid-receptor-induced-by-16-kauren-2-beta-18-19-triol-decreases-expression-of-melanophilin-through-jnk-signalling
#7
JOURNAL ARTICLE
Cheol-Hwan Myung, Chan-Song Jo, Jae-Sung Hwang
16-kauren-2-beta-18, 19-triol (16-kauren) is a natural diterpenoid substance derived from Asteraceae psiadia punctulata, a small tropical shrub in Africa and Asia, and it can reduce Mlph expression without affecting the expression of Rab27a and MyoVa in melanocytes. Melanophilin (Mlph) is an important linker protein in the melanosome transport process. However, the signal transduction pathway for the regulation of Mlph expression has not been fully established. We examined the mechanism of 16-kauren on Mlph expression...
May 23, 2023: Experimental Dermatology
https://read.qxmd.com/read/37218430/overexpression-and-potential-roles-of-midkine-via-regulation-of-vascular-endothelial-growth-factor-a-in-psoriasis
#8
JOURNAL ARTICLE
Lin Li, Huidi Shucheng, Lixin Fu, Baoqiang Pei, Wen Xu, Xian Jiang
Midkine plays a critical role in angiogenesis by regulating the vascular endothelial growth factor (VEGF) signalling pathway, which is known to be associated with psoriasis pathogenesis. However, research on midkine-psoriasis relationship remains limited. The objective of this study was to detect midkine expression in psoriasis and investigate its potential role in the disease. Midkine expression was measured using immunohistochemistry and ELISA. Effects of midkine on HaCaT cell proliferation, VEGF-A production and signalling pathways were assessed using CCK8, RT-PCR and WB...
May 23, 2023: Experimental Dermatology
https://read.qxmd.com/read/37194367/transcriptomic-responses-of-peripheral-blood-mononuclear-cells-to-cyclosporin-and-etanercept-in-a-female-infant-with-juvenile-generalized-pustular-psoriasis
#9
JOURNAL ARTICLE
Yu-Chen Lin, Yu-Chen Jeng, Wilson Jr F Aala, Yi-Kai Hong, Pin-Hsuan Chen, Ya-Ru Chuang, Chao-Chun Yang, Chao-Kai Hsu
Generalized pustular psoriasis (GPP) is a rare but severe form of psoriasis. An early onset of the diseases is correlated with mutations among IL36RN, CARD14, AP1S3, MPO and SERPINA3 genes. Systemic biological agents including anti-TNF-α, anti-IL-17, anti-IL-12/IL-23, anti-IL1R, anti-IL1β and anti-IL-36R act as novel treatment methods for GPP. Herein we report a female infant clinically diagnosed with GPP since she was 10-month-old. Results of whole-exome sequencing (WES) and Sanger sequencing revealed a reported heterozygous IL36RN (c...
May 17, 2023: Experimental Dermatology
https://read.qxmd.com/read/37190906/the-shh-gli1-pathway-is-required-in-skin-expansion-and-angiogenesis
#10
JOURNAL ARTICLE
Xinling Zhang, Yujie Chen, Pengbing Ding, Zhiyu Lin, Zhixuan Sun, Mengying Jin, Chong Li, Zhenmin Zhao, Hongsen Bi
To investigate the role of GLI1 on skin proliferation and neovascularization during skin expansion in mice. We constructed GLI1-cre/R26-Tdtomato and GLI1-cre/R26-mtmg gene-tagged skin expansion mouse models. Using a two-photon in vivo imaging instrument to observe the changes in the number and distribution of GLI1(+) cells during the expansion process and to clarify the spatial relationship between GLI1(+) cells and blood vessels during the expansion process. In vitro proliferation assays were performed to further validate the effects of SHH (sonic hedgehog) and its downstream component GLI1 on cell proliferation viability...
May 15, 2023: Experimental Dermatology
https://read.qxmd.com/read/37183311/a-pilot-study-profiling-the-gut-microbiome-in-acne-patients-of-different-racial-backgrounds-experimental-considerations-and-pitfalls
#11
JOURNAL ARTICLE
Omkar Mayur, Rebeca Martinez, Julie Z Yi, Hye Jin Chung, Jean S McGee
No abstract text is available yet for this article.
May 14, 2023: Experimental Dermatology
https://read.qxmd.com/read/37183301/dynamic-evaluation-of-pathological-changes-in-a-mouse-acne-model-by-optical-imaging-technology
#12
JOURNAL ARTICLE
Dongying Li, Yanan Sun, Xing Ren, Na Zhou, Lu Li, Gaiying He, Shuhua Ma, Yi Wang
Acne vulgaris is a disorder of the pilosebaceous unit that is primarily caused by hyperseborrhoea, colonization with Propionibacterium acnes, hyperkeratosis and an inflammatory response. Existing pharmacodynamic assessment methods primarily focus on a single causative factor at a certain time point, making it difficult to assess multiple factors simultaneously in real time. Therefore, it is crucial to establish a dynamic and nondestructive method for the assessment of acne in vivo. This study utilized four-dimensional optical imaging techniques to assess the pathogenic factors and pathological progression of acne...
May 14, 2023: Experimental Dermatology
https://read.qxmd.com/read/37160722/extremely-hair-follicle-density-is-associated-with-a-significantly-different-cecal-microbiota-in-rex-rabbits
#13
JOURNAL ARTICLE
Feng Yang, Yang Ruixin, Ma Xiaochun, Zhang Fan, Liu Junbin, Dong Pengmei, Jiang Guoyan
It has become increasingly clear that gut microbiota and skin are interconnected since the discovery of the 'gut-brain-skin' axis. Hair follicles (HFs) are skin microorganisms, but few studies have investigated their relationship to gut microbiota. Hence, we hypothesize that HFs have a close relationship with the gut, similarly to what was reported for the skin. Using rex rabbits as an animal model, one hundred healthy half-sibling rex rabbits were selected for the experiment, and 16 s rRNA gene sequencing was performed on the cecal microbiota of nine rabbits with the extremely high (HS) and low (LS) hair density (n = 9 per group) to determine differences between the composition and function of these communities...
May 9, 2023: Experimental Dermatology
https://read.qxmd.com/read/37157235/clinical-efficacy-and-safety-of-two-different-hematoporphyrin-monomethyl-ether-mediated-photodynamic-therapy-regimen-in-chinese-children-with-port-wine-stain
#14
JOURNAL ARTICLE
Sheng Zhang, Xiuwei Wang, Hongguang Chen, Huina Cao, Hongli Zhang, Ming Yang, Yun Zhu, Qin Qin, Xiaoyan Liu, Jianhua Wang, Gaolei Zhang
Hematoporphyrin monomethyl ether-photodynamic therapy (HMME-PDT) has achieved encouraging clinical outcomes in adult port-wine stain (PWS). Optimal treatment option for children with PWS was minimal. To compare whether the clinical effectiveness of HMME-PDT with the 5-min (fast) administration treatment regimen (FATR) was better than the 20-min (slow) administration treatment regimen (SATR) for PWS of children in vivo and in vitro. Thirty-four children with PWS were divided into two groups including FATR and SATR...
May 8, 2023: Experimental Dermatology
https://read.qxmd.com/read/37150588/prevalence-and-predictors-of-hypothyroidism-in-patients-with-chronic-spontaneous-urticaria
#15
LETTER
Nadja Højgaard Pedersen, Ditte Georgina Zhang, Jennifer Astrup Sørensen, Christian Vestergaard, Katrine Baumann, Misbah Noshela Ghazanfar, Simon Francis Thomsen
No abstract text is available yet for this article.
May 7, 2023: Experimental Dermatology
https://read.qxmd.com/read/37150587/spatial-transcriptomics-in-human-skin-research
#16
REVIEW
Stavroula Tekkela, Georgios Theocharidis, John A McGrath, Alexandros Onoufriadis
Spatial transcriptomics is a revolutionary technique that enables researchers to characterise tissue architecture and localisation of gene expression. A plethora of technologies that map gene expression are currently being developed, aiming to facilitate spatially resolved, high-dimensional assessment of gene transcription in the context of human skin research. Knowing which gene is expressed by which cell and in which location within skin, facilitates understanding of skin function and dysfunction in both health and disease...
May 7, 2023: Experimental Dermatology
https://read.qxmd.com/read/37150538/a-systematic-review-on-efficacy-safety-and-treatment-durability-of-intravenous-immunoglobulin-in-autoimmune-bullous-dermatoses-special-focus-on-indication-and-combination-therapy
#17
REVIEW
Nika Kianfar, Shayan Dasdar, Maryam Daneshpazhooh, Zeinab Aryanian, Azadeh Goodarzi
Autoimmune bullous diseases (AIBDs) are a group of rare blistering dermatoses of the mucous membrane and/or skin. The efficacy, safety and treatment durability of intravenous immunoglobulin (IVIg) as an alternative treatment should be explored to systematically review the available literature regarding treatment outcomes with IVIg in AIBD patients. The predefined search strategy was incorporated into the following database, MEDLINE/PubMed, Embase, Scopus and Web of Science on 18 July 2022. Sixty studies were enrolled using Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines...
May 7, 2023: Experimental Dermatology
https://read.qxmd.com/read/37148203/evidence-of-inter-and-intra-keloid-heterogeneity-through-analysis-of-dermal-fibroblasts-a-new-insight-in-deciphering-keloid-physiopathology
#18
JOURNAL ARTICLE
Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel
Keloid scars are hypertrophic and proliferating pathological scars extending beyond the initial lesion and without tendency to regression. Usually, keloids are considered and treated as a single entity but clinical observations suggest heterogeneity in keloid morphologies with distinction of superficial/extensive and nodular entities. Within a keloid, heterogeneity could also be detected between superficial and deep dermis or centre and periphery. Focusing on fibroblasts as main actors of keloid formation, we aimed at evaluating intra- and inter-keloid fibroblast heterogeneity by analysing their gene expression and functional capacities (proliferation, migration, traction forces), in order to improve our understanding of keloid pathogenesis...
May 6, 2023: Experimental Dermatology
https://read.qxmd.com/read/37140216/confocal-microscopy-and-optical-coherence-tomography-of-inflammatory-skin-diseases-in-hairs-and-pilosebaceous-units-a-systematic-review
#19
REVIEW
Rami Nabil Al-Chaer, Dorra Bouazzi, Gregor Jemec, Mette Mogensen
Common skin disorders such as acne vulgaris, rosacea and folliculitis are bothersome prevalent inflammatory diseases of hair follicles that can easily be investigated bedside using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) with micrometre resolution, opening a novel era for high-resolution hair follicle diagnostics and quantitative treatment evaluation. EMBASE, PubMed and Web of Science were searched until 5 January 2023 to identify all studies imaging hair follicle characteristics by RCM and OCT for diagnosis and monitoring of treatment in hair follicle-based skin disorders...
May 4, 2023: Experimental Dermatology
https://read.qxmd.com/read/37140190/efficacy-of-spesolimab-for-the-treatment-of-generalized-pustular-psoriasis-flares-across-pre-specified-patient-subgroups-in-the-effisayil-1-study
#20
JOURNAL ARTICLE
A D Burden, Y Okubo, M Zheng, D Thaçi, P van de Kerkhof, N Hu, M Quaresma, C Thoma, S E Choon
Effisayil 1 was a multicentre, randomized, double-blind, placebo-controlled study of the anti-interleukin (IL)-36 receptor monoclonal antibody, spesolimab, in patients presenting with a generalized pustular psoriasis (GPP) flare. Previously published data from this study revealed that within 1 week, rapid pustular and skin clearance were observed in patients receiving spesolimab versus placebo. In this pre-specified subgroup analysis, the efficacy of spesolimab was evaluated according to patient demographic and clinical characteristics at baseline in patients receiving spesolimab (n = 35) or placebo (n = 18) on Day 1...
May 4, 2023: Experimental Dermatology
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