journal
https://read.qxmd.com/read/38989976/increased-loss-of-function-filaggrin-gene-mutation-prevalence-in-atopic-dermatitis-patients-across-northern-latitudes-indicates-genetic-fitness-a-systematic-review-and-meta-analysis
#1
REVIEW
Casper Milde Khatib, Amalie Wandel Klein-Petersen, Amalie Thorsti Møller Rønnstad, Alexander Egeberg, Maria Oberländer Christensen, Jonathan Ian Silverberg, Simon Francis Thomsen, Alan David Irvine, Jacob Pontoppidan Thyssen
Loss-of-function (LoF) mutations in the filaggrin gene (FLG) constitute the strongest genetic risk for atopic dermatitis (AD). A latitude-dependent difference in the prevalence of LoF FLG mutations was systematically evaluated. A systematic review and meta-analysis were performed to estimate the prevalence of LoF FLG mutations in AD patients and the general population by geography and ethnicity. Risk of bias was assessed by Newcastle-Ottawa Scale and Jadad score. StatsDirect, version 3 software was used to calculate all outcomes...
July 2024: Experimental Dermatology
https://read.qxmd.com/read/38984465/eosinophils-in-hidradenitis-suppurativa-patients-exhibit-pro-inflammatory-traits-implicating-a-potential-pathogenic-role-in-the-disease
#2
JOURNAL ARTICLE
Yael Renert-Yuval, Juana Gonzalez, Sandra Garcet, Samuel C Williams, Ariana Moreno, James G Krueger
Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by painful nodules, abscesses and purulent secretions in intertriginous regions. Intense pruritus frequently accompanies HS lesions, adding further discomfort for patients. While Th17 pathway activation is implicated in HS pathogenesis, disease mechanisms are still not fully understood, and therapeutics are lacking. Previous reports raise a potential role for eosinophils in HS, showing a strong association of eosinophil levels with disease severity...
July 2024: Experimental Dermatology
https://read.qxmd.com/read/38973310/pulmonary-interstitial-lesions-in-pemphigus-mouse-model-verifying-pemphigus-may-not-be-only-limited-to-skin-and-mucosa
#3
LETTER
Chang Tang, Lanting Wang, Qingmei Liu, Zihua Chen, Jin Yang, Haiqing Gao, Chenggong Guan, Shan He, Luyao Zhang, Shenyuan Zheng, Fanping Yang, Shengan Chen, Li Ma, Zhen Zhang, Ying Zhao, Jiucun Wang, Xiaoqun Luo
Interstitial lung disease (ILD) has been identified as a prevalent complication and significant contributor to mortality in individuals with pemphigus. In this study, a murine model of pemphigus was developed through the subcutaneous administration of serum IgG obtained from pemphigus patients, allowing for an investigation into the association between pemphigus and ILD. Pulmonary interstitial lesions were identified in the lungs of a pemphigus mouse model through histopathology, RT-qPCR and Sircol assay analyses...
July 2024: Experimental Dermatology
https://read.qxmd.com/read/38973268/analysis-of-risk-factors-related-to-chronic-non-healing-wound-infection-and-the-construction-of-a-clinical-prediction-model
#4
JOURNAL ARTICLE
Jing Liu, Qiang He, Gaijuan Guo, Chunbao Zhai
This study is aimed to analyse the risk factors associated with chronic non-healing wound infections, establish a clinical prediction model, and validate its performance. Clinical data were retrospectively collected from 260 patients with chronic non-healing wounds treated in the plastic surgery ward of Shanxi Provincial People's Hospital between January 2022 and December 2023 who met the inclusion criteria. Risk factors were analysed, and a clinical prediction model was constructed using both single and multifactor logistic regression analyses to determine the factors associated with chronic non-healing wound infections...
July 2024: Experimental Dermatology
https://read.qxmd.com/read/38973262/metabolic-dynamics-in-psoriatic-epidermis-enhanced-glucose-and-lactate-uptake-glycolytic-pathway-and-tca-cycle-dynamics
#5
LETTER
Satoshi Nakamizo, Hiromi Doi, Kenji Kabashima
No abstract text is available yet for this article.
July 2024: Experimental Dermatology
https://read.qxmd.com/read/38973249/spinal-histamine-h4-receptor-mediates-chronic-pruritus-via-p-erk-in-acetone-ether-water-aew-induced-dry-skin-mice
#6
JOURNAL ARTICLE
Ting-Ting Wang, Zi-Yang Li, Dan-Dan Hu, Xian-Yun Xu, Ning-Jing Song, Gang-Qiang Li, Ling Zhang
Dry skin is common to many pruritic diseases and is difficult to improve with oral traditional antihistamines. Recently, increasing evidence indicated that histamine H4 receptor (H4R) plays an important role in the occurrence and development of pruritus. Extracellular signal-regulated kinase (ERK) phosphorylation activation in the spinal cord mediates histamine-induced acute and choric itch. However, whether the histamine H4 receptor regulates ERK activation in the dry skin itch remains unclear. In the study, we explore the role of the histamine H4 receptor and p-ERK in the spinal cord in a dry skin mouse model induced by acetone-ether-water (AEW)...
July 2024: Experimental Dermatology
https://read.qxmd.com/read/38963087/decreased-serum-il-38-levels-in-pemphigus-vulgaris
#7
LETTER
Toyoki Yamamoto, Lixin Li, Yukiko Ito, Shinichi Sato, Sayaka Shibata
No abstract text is available yet for this article.
July 2024: Experimental Dermatology
https://read.qxmd.com/read/38946225/reactivity-against-the-bp180-ectodomain-in-patients-with-bullous-pemphigoid-mucous-membrane-pemphigoid-multiple-sclerosis-and-parkinson-disease
#8
JOURNAL ARTICLE
Jonathan Tegtmeyer, Maurizio Romagnuolo, Christoph M Hammers, Bianca Opelka, Christian Probst, Lars Komorowski, Angelo V Marzano, Enno Schmidt, Stephanie Goletz
The 16th non-collagenous domain (NC16A) of BP180 is the main antigenic target of autoantibodies in bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP). Commercially available assays detect serum autoantibodies against NC16A in the majority of BP (80%-90%) and in approximately 50% of MMP patients. However, a standardized test system for detecting antibodies against other regions of BP180 is still lacking. Moreover, anti-BP180 autoantibodies have been found in neurological conditions such as multiple sclerosis and Parkinson disease...
July 2024: Experimental Dermatology
https://read.qxmd.com/read/38922774/delta-opioid-receptor-expression-correlates-to-skin-ageing-and-melanin-expression-in-asian-women
#9
LETTER
Paul L Bigliardi, Sydney Lo, Elena Bigliardi, Yuri Dancik, Emmanuelle Leblanc-Noblesse, Mei Bigliardi-Qi
While the evidence for the implication of opioid receptors (OPr) in ageing is growing, there is, to our knowledge, no study focusing directly on changes in vivo cutaneous OPr expression with increasing age. We thus investigated OPr expression in 30 healthy female Asian volunteers in Southern China whose ages range from the early 20s to the early 60s. Excisional biopsies were taken from the sun-exposed extensor area of the lower arm and the photo-protected area of the upper inner arm. The thickness of the epidermal layers, melanin content, as well as expression of mu-opioid receptors (MOPr) and delta-opioid receptors (DOPr) were compared between different age ranges and photo-exposure status...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38888196/the-novel-prognostic-marker-spock2-regulates-tumour-progression-in-melanoma
#10
JOURNAL ARTICLE
Ji Young Kang, Hyeijin Cho, Minchan Gil, Haeryung Lee, Soochul Park, Kyung Eun Kim
Secreted protein acidic and cysteine rich/osteonectin, cwcv and kazal-like domain proteoglycan 2 (SPOCK2) is a protein that regulates cell differentiation and growth. Recent studies have reported that SPOCK2 plays important roles in the progression of various human cancers; however, the role of SPOCK2 in melanoma remains unknown. Therefore, this study investigated the roles of SPOCK2 and the related mechanisms in melanoma progression. To evaluate the clinical significance of SPOCK2 expression in patients with melanoma, we analysed the association between SPOCK2 expression and its prognostic value for patients with melanoma using systematic multiomic analysis...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38886965/integrated-bioinformatics-analysis-and-experimental-validation-identifies-cpe-as-a-potential-biomarker-and-therapeutic-target-for-skin-aging
#11
JOURNAL ARTICLE
Xiaozhen Peng, Yun Zhong, Rui Mao, Fanping He, Yufan Cheng, Mengting Chen, Lei Zhou, Hongfu Xie, Ji Li, Yiya Zhang
Ageing is an inevitable biological process characterized by progressive decline in physiological functions. It is a complex natural phenomenon that will cause structural and functional decline. Despite substantial progress in understanding the mechanism of ageing, both predictive biomarkers and preventive therapies remain limited. Using Weighted Gene Co-expression Network Analysis (WGCNA) and machine learning techniques, we identified Carboxypeptidase E (CPE) as a pivotal marker of skin ageing, based on ageing-related bulk transcriptome and single-cell transcriptome data...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38886904/interplay-between-diabetes-mellitus-and-atopic-dermatitis
#12
REVIEW
Dongyun Lei, Jiechen Zhang, Tingting Zhu, Litao Zhang, Mao-Qiang Man
Inflammatory dermatoses such as atopic dermatitis (AD) have long been linked to the pathogenesis of diabetes mellitus. Indeed, numerous studies show an increased risk of diabetes mellitus in individuals with AD although lower prevalence of diabetes mellitus is also observed in few studies. Though the underlying mechanisms accounting for the reciprocal influence between these two conditions are still unclear, the complex interplay between diabetes mellitus and AD is attributable, in part, to genetic and environmental factors, cytokines, epidermal dysfunction, as well as drugs used for the treatment of AD...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38884504/possible-role-of-%C3%AE-hydroxybutyrate-in-inducing-inflammation-in-alopecia-areata
#13
LETTER
Jung-Min Shin, Seungjin Son, Kyung Eun Jung, Chang Deok Kim, Young Lee
Alopecia areata (AA) is an autoimmune inflammatory disease characterized by non-scarring hair loss due to an immune response that targets hair follicles. The current treatment approach for AA involves the use of immunosuppressants and immunomodulators to reduce cytokine levels around affected hair follicles. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have emerged as potential anti-inflammatory agents with diverse beneficial effects in various medical conditions. This study investigates the role of beta-hydroxybutyrate (BHB), a ketone body produced during SGLT2 inhibition, in the pathogenesis of AA...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38884501/the-role-of-macrophage-migration-inhibitory-factor-family-and-cd74-in-the-pathogenesis-of-melanoma
#14
REVIEW
Keiji Tanese, Dai Ogata
Melanoma is an aggressive tumour with poor prognosis that arises from the malignant transformation of melanocytes. Over the past few decades, intense research into the pathogenesis of melanoma has led to the development of BRAF and immune checkpoint inhibitors, including antibodies against programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4), which have shown clinically significant efficacy. However, some tumours do not respond to these therapies initially or become treatment resistant...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38884423/subclinical-effects-of-botulinum-toxin-a-and-microwave-thermolysis-for-axillary-hyperhidrosis-a-descriptive-study-with-line-field-confocal-optical-coherence-tomography-and-histology
#15
RANDOMIZED CONTROLLED TRIAL
Gabriela Lladó Grove, Kevin Jacobsen, Nina Loeth Maartensson, Merete Haedersdal
Botulinum toxin A (BTX) and microwave thermolysis (MWT) are standard axillary hyperhidrosis treatments, but comparison of their subclinical effects is lacking. Line-field confocal optical coherence tomography (LC-OCT) is a promising non-invasive imaging tool for visualizing tissue-interactions. This study aimed to describe subclinical effects of BTX and MWT for axillary hyperhidrosis with LC-OCT-imaging compared to histology. This study derived from an intra-individual, randomized, controlled trial, treating axillary hyperhidrosis with BTX versus MWT...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38881438/unravelling-the-metabolic-landscape-of-cutaneous-melanoma-insights-from-single-cell-sequencing-analysis-and-machine-learning-for-prognostic-assessment-of-lactate-metabolism
#16
JOURNAL ARTICLE
Jiaheng Xie, Pengpeng Zhang, Chenfeng Ma, Qikai Tang, Xinxin Zhou, Xiaolong Xu, Min Zhang, Songyun Zhao, Liping Zhou, Min Qi
This manuscript presents a comprehensive investigation into the role of lactate metabolism-related genes as potential prognostic markers in skin cutaneous melanoma (SKCM). Bulk-transcriptome data from The Cancer Genome Atlas (TCGA) and GSE19234, GSE22153, and GSE65904 cohorts from GEO database were processed and harmonized to mitigate batch effects. Lactate metabolism scores were assigned to individual cells using the 'AUCell' package. Weighted Co-expression Network Analysis (WGCNA) was employed to identify gene modules correlated with lactate metabolism...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38874433/mir-4521-a-novel-biomarker-for-human-lentigos
#17
LETTER
Hiroshi Maeno, Yoko Suzuki-Horiuchi, Ayaka Funakoshi, Onuma Chumsakul, Yasunari Sato, Tsuyoshi Ishii, John T Seykora
No abstract text is available yet for this article.
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38855894/effect-of-a-low-mineralized-thermal-spring-water-on-skin-barrier-mechanical-properties-using-atomic-force-microscopy
#18
JOURNAL ARTICLE
C Mias, A Stennevin, G Doat, A Catté, J Chlasta, S Bessou-Touya, H Duplan
The mineral content of thermal spring water (TSW) applied to the skin surface can directly influence the skin barrier. Indeed, our previous study showed that Avène TSW (ATSW), a low mineral content thermal spring water, protects the stratum corneum from dehydration compared to a mineral-rich TSW (MR-TSW) and maintains skin surface ultrastructure. While many TSWs have been recognized to have beneficial effects on skin, little is known about their localized and specific effects on skin barrier biomechanics at the nanometric scale...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38855893/il-4-and-il-13-are-not-involved-in-il-31-induced-itch-associated-scratching-behaviour-in-mice
#19
LETTER
Rana Kawai, Nao Ichimasu, Kazumoto Katagiri
Itchy skin or pruritus is a common cutaneous symptom that causes an urge to scratch, and the role of interleukins (IL) in itchy skin has been widely studied. IL-4 and IL-13 are known to induce chronic itch. Similarly, the direct role of IL-31 in inducing itch has been demonstrated in clinical situations such as atopic dermatitis and prurigo nodularis. Moreover, IL-4 receptor α antibodies (dupilumab) and IL-31 receptor A antibodies (nemolizumab) inhibit pruritus. However, the interplay between these ILs in pruritus remains unclear...
June 2024: Experimental Dermatology
https://read.qxmd.com/read/38855891/malassezia-specific-ige-in-head-and-neck-dermatitis-of-eczema-a-systematic-review-meta-analysis
#20
JOURNAL ARTICLE
Hui Xin See Tow, Yik Weng Yew
Head and neck atopic dermatitis (HNAD) is a subtype of atopic dermatitis (AD), a common inflammatory skin condition with a distinctive clinical appearance. Malassezia spp., a predominant skin yeast, is considered to exacerbate HNAD. In this study, we investigate the prevalence of Malassezia-specific IgE among HNAD patients. A comprehensive search was performed for observational studies analysing the association between Malassezia-specific IgE and HNAD. This study was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 checklist and quality was assessed via the Newcastle-Ottawa Quality Assessment Scale (NOS)...
June 2024: Experimental Dermatology
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