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European Journal of Cancer Prevention

Uwe G Poehls, Carolin C Hack, Marius Wunderle, Stefan P Renner, Michael P Lux, Matthias W Beckmann, Peter A Fasching, Naiba Nabieva
Early breast cancer detection programs depend for effectiveness on the participation rate, which is affected by risk factor awareness. This study investigated changes in women's risk factor awareness between 2004 and 2016. Results from a 2004 survey of 2107 healthy women were compared with new data obtained using the same questionnaire in 2016, with 866 participants indicating their knowledge and perceptions regarding breast cancer incidence, risk factors, risk perceptions, and levels of concern. Logistic regression models assessed the influence of time point (2004 vs...
January 23, 2019: European Journal of Cancer Prevention
Maya N White, Martha J Shrubsole, Qiuyin Cai, Timothy Su, Jennings Hardee, John-Anthony Coppola, Sunny S Cai, Stephanie M Martin, Sandra Motley, Larry L Swift, Ginger L Milne, Wei Zheng, Qi Dai, Harvey J Murff
Fish oil supplementation may represent a potential chemopreventive agent for reducing colorectal cancer risk. The mechanism of action of fish oil is unknown but presumed to be related to eicosanoid modification. The purpose of this study was to evaluate the effects of fish oil supplementation on the levels of urinary and rectal eicosanoids. We conducted a randomized, double-blind, controlled trial of 2.5 g of fish oil per day compared with olive oil supplementation over a 6-month period. Study participants had a history of colorectal adenomas...
January 10, 2019: European Journal of Cancer Prevention
Walid Saliba, Hedy S Rennert, Naomi Gronich, Stephen B Gruber, Gad Rennert
To examine the association between red meat subtypes intake and risk of colorectal cancer (CRC) among Jewish and Arabs populations in a unique Mediterranean environment. The Molecular Epidemiology of Colorectal Cancer study (n=10 026) is a prospective population-based case-control study in northern Israel. Participants were interviewed in-person about their dietary intake and lifestyle using a questionnaire that included a food-frequency questionnaire. Red meat consumption in Israel was found to be especially low in the Jewish population (1...
January 10, 2019: European Journal of Cancer Prevention
Mohammad Hadi Karbalaie Niya, Mina Mobini Kesheh, Glavizh Keshtmand, Ali Basi, Hamidreza Rezvani, Farid Imanzade, Mahshid Panahi, Nasser Rakhshani
The human papilloma virus (HPV) as a major causative agent of different cancers is under investigation globally. In this study, we aim to investigate HPV infection in different cytological and pathological stages by different molecular methods, and then the viral genome integration of HPV-16 and -18 is determined by a specific real-time PCR method. The study included women who underwent liquid-based cytology. HPV PCR was conducted by MY09/11 universal primers, HPV genotyping was performed by INNO-LiPA HPV genotyping assay, and the viral genome status was defined by two real-time PCR assays...
December 5, 2018: European Journal of Cancer Prevention
Roy Kessous, Tamar Wainstock, Asnat Walfisch, Eyal Sheiner
The hyperglycemic intrauterine environment has been shown to have long-term effects on offspring. We aimed to evaluate its effect on the long-term risk of childhood malignancies. This was a population-based cohort analysis comparing the risk for long-term childhood malignancies (≤18 years) in children born to mothers with and without gestational diabetes mellitus (GDM). Childhood malignancies were diagnosed by physicians and recorded in hospital medical files according to predefined codes based on ICD-9. Deliveries occurred between the years 1991 and 2014 in a tertiary medical center...
November 26, 2018: European Journal of Cancer Prevention
Na-Hui Kim, Ju Eun Seol, Jeongseon Kim, Bong-Hwa Lee, Dae-Yong Hwang, Jinyoung Jeong, Hun-Jae Lee, Yoon-Ok Ahn, Dong-Hyun Kim, Jung Eun Lee
The association between red meat intake and colorectal cancer (CRC) may be modulated by genetic polymorphisms of cytochrome P450 2E1 (CYP2E1), a key enzyme in the metabolism of nitrosamines, and peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor involved in adipogenesis and lipid and glucose metabolism. We conducted a case-control study of 971 patients with CRC and 658 controls who were admitted to two university hospitals between 1995 and 2004 in Seoul, Korea. Participants were asked about red meat intake by using a validated food frequency questionnaire...
November 26, 2018: European Journal of Cancer Prevention
Irene Lorenzo, Nerea Fernández-de-Larrea, Angelika Michel, Beatriz Romero, Virginia Lope, Xavier Bessa, Victor Moreno, Vicente Martín, Pilar Amiano, Jesús Castilla, Adonina Tardón, Trinidad Dierssen-Sotos, Rosana Peiró, Marian Díaz-Santos, Carmen Navarro, José J Jiménez-Moleón, Julia Butt, Aurelio Barricarte, Irune Ruiz, Antonio J Molina-de-la-Torre, Delphine Casabonne, Beatriz Pérez-Gómez, Manolis Kogevinas, Rosa Del Campo, Silvia de Sanjosé, Marina Pollán, Tim Waterboer, Nuria Aragonés
Helicobacter pylori (H. pylori) chronic infection causes severe digestive diseases, including gastric cancer, and certain strains entail a higher risk. Risk factors for this infection are still not fully understood. The aim of this study was to describe the association of adult and childhood sociodemographic factors with the seroprevalence of H. pylori, and with CagA and VacA antigen-specific seropositivity among H. pylori-seropositive individuals in the Spanish adult population. Serum antibody reactivity to H...
November 26, 2018: European Journal of Cancer Prevention
Giorgio Bogani, Elena Tagliabue, Stefano Ferla, Fabio Martinelli, Antonino Ditto, Valentina Chiappa, Umberto Leone Roberti Maggiore, Francesca Taverna, Claudia Lombardo, Domenica Lorusso, Francesco Raspagliesi
The widespread introduction of screening methods allow to identify cervical dysplasia before having invasive cancer. The risk of developing cervical dysplasia persistence/recurrence following conization represent a major health issue. Although several studies tried to identify predictors for cervical dysplasia persistence/recurrence, no previous study has been conducted to develop a risk calculator. The current study aimed to identify predictors of cervical dysplasia persistence/recurrence among women undergoing primary conization...
November 26, 2018: European Journal of Cancer Prevention
Viroj Wiwanitkit
No abstract text is available yet for this article.
March 2019: European Journal of Cancer Prevention
Maurizio Bifulco, Mario Abate
No abstract text is available yet for this article.
March 2019: European Journal of Cancer Prevention
Long Shu, Cai-Juan Si, Pei-Fen Zheng
No abstract text is available yet for this article.
March 2019: European Journal of Cancer Prevention
Taweesak Tongtawee
No abstract text is available yet for this article.
January 2019: European Journal of Cancer Prevention
Ransome Eke, Tooba Tariq, Tong Li, Furqan B Irfan
Colorectal cancer (CRC) is preventable with regular screening. This study aims to determine estimates and predictors of inpatient CRC screening during hospitalization in the USA. This nationwide population-based study utilized data from the National Inpatient Sample database from 2005 to 2014 to examine rates of CRC screening among hospitalized patients. There were 6470 inpatient CRC screening nationwide from 129 645 394 inpatient hospitalizations. Multivariable analysis showed that higher rates of inpatient CRC screening were associated with: females compared to males [odds ratio (OR): 0...
November 15, 2018: European Journal of Cancer Prevention
Mary Pegington, D Gareth Evans, Anthony Howell, Louise S Donnelly, Julia Wiseman, Jack M Cuzick, Michelle N Harvie
Women at increased breast cancer (BC) risk are eligible for chemoprevention. Healthy lifestyles are potentially important for these women to improve efficacy and minimise side effects of chemoprevention and reduce the risk of BC and other lifestyle-related conditions. We investigated whether women taking chemoprevention adhere to healthy lifestyle recommendations, how their lifestyle risk factors and health measures compare to women in the general population, and whether these change whilst taking chemoprevention...
November 15, 2018: European Journal of Cancer Prevention
Dania Bucchi, Manuela Chiavarini, Fortunato Bianconi, Maria E Galeotti, Alessio Gili, Fabrizio Stracci
Cervical cancer (CC) control is based on the implementation of effective screening programs. In the coming years, human papilloma virus vaccination coverage will contribute considerably toward cancer prevention. In Italy, where an organized screening program has been implemented, immigration from low/middle-income countries with a high prevalence of human papilloma virus infections has increased steadily over the last decades. To assess the impact of screening efforts in counteracting background changes, we analyzed the incidence trends of cervical intraepithelial neoplasia grade 3 carcinomas in situ (CIS) and invasive CC from 1994 to 2013 through an Age-Period-Cohort model using data of a regional population-based registry...
November 13, 2018: European Journal of Cancer Prevention
Alexandra Vulcan, Ulrika Ericson, Jonas Manjer, Bodil Ohlsson
The World Cancer Research Fund International has concluded strong evidence for that high intake of dairy products and foods containing dietary fiber and low intake of processed meat are associated with decreased risk of colorectal cancer (CRC). As food items are consumed together, it is important to study dietary patterns. The aim of the present study was to examine the association between an a priori constructed dietary index and incident CRC and between intake of processed meat, fiber, and dairy products and CRC...
November 12, 2018: European Journal of Cancer Prevention
Yusuke Kobayashi, Kouji Banno, Haruko Kunitomi, Shimpei Nagai, Takayuki Takahashi, Mayuka Anko, Moito Iijima, Takashi Takeda, Yusuke Matoba, Kanako Nakamura, Kosuke Tsuji, Eiichiro Tominaga, Daisuke Aoki
Novel pharmacological therapies are in development for cancer, ranging from conventional chemotherapeutic drugs to molecular targeted drugs, antibody-based drugs, and immune checkpoint inhibitors, which are developed using new technologies. However, the increasing cost of new drug development is increasing the costs of national healthcare and putting pressure on government finances worldwide. Under these circumstances, drug repositioning (i.e. discovering novel effects of existing drugs, thereby allowing their use to treat other diseases) has become a major focus because of reliability and cost reduction...
November 8, 2018: European Journal of Cancer Prevention
Sharada H Sharma, Vinothkumar Rajamanickam, Sangeetha Nagarajan
Suppression of colorectal cancer by means of chemoprevention is gaining great attention owing to promising outcomes with less adverse effects in preclinical and clinical trials. The present study aims to explore the mechanism of chemoprevention by p-coumaric acid (p-CA) in a short-term preclinical model of colon cancer. 1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2, and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation...
November 6, 2018: European Journal of Cancer Prevention
Inês A Gomes, Ana Miranda, Carla Nunes
Breast cancer (BC) is the most frequent malignancy in Portuguese women, and more than half of the registered cases live in the south of the country. The main of this study was to characterize patients with locoregional and metastatic incident BC living in the Southern Portuguese and Madeira regions in 2005-2012 according to demographic, clinical and contextual characteristics. Additionally it aimns to find the associations and relative influences of these factors with locoregional or metastatic disease at diagnosis...
November 6, 2018: European Journal of Cancer Prevention
Mai V Nguyen, Mo T Tran, Chi TDu Tran, Quang H Tran, Thuy Tv Tuong, Lam N Phung, Huyen X Vu, Linh C Le, Paolo Boffetta, Hung N Luu
The incidence of childhood brain tumors (CBT) has increased worldwide, likely resulting from the improvements of early diagnostics. We conducted a systematic review and meta-analysis to clarify the association between birth order and CBT. We followed established guidelines to systematically search Ovid Medline, PubMed, and the Cochrane Library for English language studies, published before March 2018. Quality assessment was performed using the Newcastle-Ottawa Scale. Meta-analysis provided pooled risk estimates and their 95% confidence intervals (CIs) for birth order and CBT...
November 5, 2018: European Journal of Cancer Prevention
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