journal
https://read.qxmd.com/read/38836689/efficacy-of-ozonated-olive-oil-against-peri-implant-microbes-isolated-from-peri-implantitis
#1
JOURNAL ARTICLE
Ranj Nadhim Salaie, Shehab Ahmed Hamad, Zhala Dara Meran
This study aimed to investigate the antibacterial and antimicrobial activity of ozone gel against oral biofilms grown on titanium dental implant discs. The experiment used medical grade five titanium discs on which peri-implant isolated biofilms were grown. The experimental groups were control, Streptococcus mutans (S. mutans) and Granulicatella adiacens (G. adiacens), (n = 6). The oral microbes grown on titanium discs were exposed to ozone gel for 3 minutes and the antibacterial activity was assessed by turbidity test and adherence test for the antibiofilm activity test...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836688/genetic-analysis-of-sars-cov-2-spike-gene-using-next-generation-sequencing-from-covid-19-patients-in-erbil-iraq
#2
JOURNAL ARTICLE
Asma Ameen Ghareeb, Sazan Moffaq Abdulaziz
SARS-CoV-2 has been identified by the WHO as a new virus causing mild to severe respiratory illnesses that belong to the Coronavirus family. The virus underwent rapid and continuous changes in the genetic material, especially the S gene, during COVID-19 pandemic and generated a number of new variants announced by WHO in late 2020. Mutations in the S gene have greatly affected virus pathogenesis as the spike protein is responsible for many critical processes. Delta and Omicron variants were studied extensively due to increased mortality and morbidity rates associated with their pandemic waves...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836687/decoding-ly6g6d-in-colorectal-cancer-unraveling-biomarker-potential-and-therapeutic-insights
#3
JOURNAL ARTICLE
Mehwish Naqvi, Waqas Ahmad Abbasi, Muhammad Kaleem Samma, Asif Ali Gabol, Cynthia Innocent, Sana Iqbal, Samana Fatima, Kashif Ali
Colorectal cancer (CRC) poses a significant global health challenge with high morbidity and mortality rates. This study investigates the role of LY6G6D, a member of the LY6/uPAR superfamily, in CRC. Employing a bioinformatic approach, we analyzed LY6G6D expression across different cancer types, compared it with known oncogenes in CRC, explored the involved genomic alterations, and assessed associated clinicopathological characteristics. LY6G6D exhibited aberrant expression, particularly elevated in CRC adenocarcinoma and highly specific to tumor tissues when compared with other oncogenes, despite its comparatively low frequency of genomic alteration...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836686/experimental-study-of-slow-released-angiogenin-by-silicon-micro-needle-in-improving-blood-support-to-multiple-territory-perforator-flaps-in-rats
#4
JOURNAL ARTICLE
Xiaojun Liu, Xue Wang, Rui Zhao, Yunfeng Liu, Wei Chen, Jiandong Su, Guoliang Shen
This research aimed to investigate the effect of slow-released angiogenin by silicon micro-needle on angiogenesis in the Choke zone of dorsal multiple-territory perforator flap in rats, as well as its mechanism. Thirty-six adult Sprague-Dawley (SD) rats were randomly divided into control group, model group, and four experimental groups. In model group, slow-release saline through a silicon micro-needle was placed in choke II zone of the flap 7 days before the operation. For rats in four experimental groups, angiogenin was released via micro-needle in the choke I and choke II zones of the cross-zone flap 7 days before and 3 days before flap surgery, respectively...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836685/the-application-of-dpe-csea-and-ea-in-labor-analgesia-for-nulliparous-women-and-their-impact-on-maternal-and-infant-safety
#5
JOURNAL ARTICLE
Kai Kang, Yunbo Bai, Jie Gong, Yue Wang
This work compared the effects of dural puncture epidural (DPE), combined spinal epidural analgesia (CSEA) and epidural analgesia (EA) on labor analgesia for primiparae and their impacts on maternal and infant safety. A total of 204 primiparae in need of labor analgesia for vaginal delivery were allocated to DPE, CSEA and EA groups. At 10 min, 30 min and 1 h after analgesia, the DPE and CSEA groups showed lower VAS scores and quicker onset of action than EA group. There was no significant difference in the duration of analgesia and labor and fetal decelerations among the 3 groups...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836684/isolation-and-characterization-of-piceatannol-producing-bacteria-from-soil-in-erzurum-turkey
#6
JOURNAL ARTICLE
Taha Yasin Koc, Medine Gulluce, Bilal Yilmaz, Mehmet Karadayi
Piceatannol, resveratrol's derivative, and a valuable polyphenol has managed to become one of the most remarkable candidate molecules for drug development research, with its high bioactive properties and higher stability. On the other hand, the very low amount of piceatannol in plants which are its natural source increases the cost and limits the commercialization possibilities of the product. To overcome this bottleneck, a limited number of studies have recently shown that it is possible to produce piceatannol from the resveratrol precursor much cheaper by regioselective hydroxylation catalyzed by bacteria isolated from the soil, and the search for new bacteria of similar nature in new ecosystems has gained popularity...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836683/the-effect-of-external-fixator-on-bone-metabolism-in-patients-with-open-fracture-of-extremities
#7
RANDOMIZED CONTROLLED TRIAL
Yu Shi, Feng Niu, Zhong Liu, Yunsheng Teng, Jian Jiao, Pingan Xu, Ning Ma, Baoquan Gao, Beibei Liu, Fang Gao
This experiment aimed to explore the influence mechanism of external fixator on open fracture. A total of 128 patients with open tibiofibular fractures were included in this study. The patients were randomly divided into external fixator group (n=64) and control group (n=64) according to the order of admission. Double-blind controlled observation was used. The levels of osteocalcin (BGP), β-CTX, P1 NP, BALP, including haptoglobin (Hp), ceruloplasmin (CER), serum adrenocorticotropic hormone (ACTH), cortisol (COR), C-reactive protein (CRP), white blood cell (WBC) and interleukin-6 (IL-6) were recorded in different groups...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836682/linc01133-contributes-to-the-malignant-phenotypes-of-non-small-cell-lung-cancer-by-targeting-mir-30b-5p-foxa1-pathway
#8
JOURNAL ARTICLE
Xiangbing Xin, Yongshi Liu, Yan Li, Xiang Ji, Yuhui Yun, Guang Yang, Honggang Liu, Xiaohua Liang, Sanhu Yang
This study aimed to explore the mechanism of action of LINC01133 in non-small cell lung cancer. LINC01133 expression in NSCLC patient tissues and cells was detected by qRT-PCR. After transfecting siRNA-LINC01133 in NSCLC cells, the proliferation and invasive migration ability of the cells were assessed via CCK-8 and Transwell assay, respectively. The sublocalization of LINC01133 in NSCLC cells was analyzed by bioinformatics prediction and nucleoplasm separation assay and RNA-FISH assay. Analysis of the binding relationship between LINC01133, FOXA1 and miR-30b-5p was all through bioinformatics website analysis, dual-luciferase reporter and RNA Pulldown assay...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836681/linc00472-suppresses-non-small-cell-lung-cancer-progression-via-regulating-mir-23a-3p-ccl22-axis
#9
JOURNAL ARTICLE
Sanhu Yang, Yongshi Liu, Yan Li, Xiang Ji, Yuhui Yun, Guang Yang, Honggang Liu, Xiaohuang Liang, Haizhou Dang
Long non-coding RNA (lncRNA) LINC00472 has a close connection with the development of tumors. The aim was to explore the role of LINC00472 on NSCLC cell biological function in vivo and its potential mechanisms. The mRNA levels of LncRNA 00472 and microRNA-23a-3p, were determined by RT-qPCR. Cell Counting Kit-8, cell scratches and western blot assays were used to analyze the proliferation, migration and level of apoptosis-associated proteins. Luciferase reporter assay validates the binding between LINC00472/CCL22 and miR-23a-3p...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836680/mechanism-of-the-effect-of-trem2-on-cognitive-function-in-autistic-mice
#10
JOURNAL ARTICLE
Yi Tian, Rong Ai, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Xiaoping Zhu
This study aimed to investigate the mechanism of the effect of TREM2 on cognitive function in autistic mice. TREM2 overexpression and knockdown viruses were given to autism spectrum disorder (ASD) mice and BV2 microglia cell line. To assess cognitive performance, all groups of mice took part in the open field, new object recognition, Morris water maze, and three-box social experiments. Double immunofluorescence labeling demonstrated co-localization of LC3II and NeuN. Proteins from the PI3K/Akt/mTOR pathway were identified...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836679/glucocorticoids-promote-joint-microenvironment-alteration-of-gabbr1-expression-associated-with-mitigating-rheumatoid-arthritis
#11
JOURNAL ARTICLE
Shilong Song, Yuhang Wang, Yun Fang, Fengmeng Teng, Tao Yue, Lu Chen, Xing Wan, Ruoyang Hong, Mingxin Xue
GABBR1 receptors have been implicated in the progression of rheumatoid arthritis (RA), and p38 MAP kinase (MAPK) was shown to be downregulated by GABA and result in unchecked production of pro-inflammatory cytokine. GABBR1 is a member of GABA receptors, and it is known to be upregulated and plays a vital role in RA. Glucocorticoids are efficient therapeutics in rheumatoid arthritis (RA) and are known to regulate GABA actions; therefore, we intended to investigate the potential of glucocorticoids in RA concerning the potential pathway GABBR1/MAPK...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836678/m2-macrophages-regulate-kdm6b-pfkfb2-metabolic-reprogramming-of-cervical-squamous-cell-carcinoma-through-cxcl1
#12
JOURNAL ARTICLE
Jing Yu, Longzhang Huang, Lihua Cao
Macrophages in the tumor microenvironment can polarize into M1 or M2 forms, with M2 macrophages (M2φ) promoting tumor growth and metastasis in cervical squamous cell carcinoma (CESC). This study explored the effects of M2φ on CESC metabolic reprogramming both in vitro and in vivo. Results showed that M2φ secreted CXCL1, which significantly increased CESC migration and metabolic regulation. Further experiments revealed that CXCL1 upregulated KDM6B to enhance PFKFB2 transcriptional activity, thus regulating CESC glucose metabolism...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836677/maternal-and-filial-consumption-of-probiotics-protects-from-acute-stress-induced-anxiety-and-loss-of-benevolent-gut-microbes
#13
JOURNAL ARTICLE
Abdulazeez Kadhim Wali, Hamid Reza Mohajerani, Kumarss Amini
The study aimed to determine the effects of probiotic consumption during pregnancy and lactation and post-weaning on acute stress-induced anxiety and gut beneficial microbiota of the female offspring mice.The female offspring mice were divided into several groups: intact, control (only stressed), PBS/dam (dams gavaged with PBS), PRO/dam (dams gavaged with probiotics), PRO/dam+off (both dams and offspring gavaged with probiotics), and PBS/dam+off (both dams and offspring gavaged with PBS)The probiotics chosen are mainly L...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836676/the-combination-of-tetramethylpyrazine-and-vitamin-a-acid-in-the-treatment-of-skin-photoaging-by-activating-the-hif-1%C3%AE-pathway
#14
JOURNAL ARTICLE
Weijun Chen, Jianyong Fan, Xuelian Zou, Yuansheng Wu
Skin photoaging is a skin degenerative disease that causes patients to develop malignant tumors. The existing clinical treatment of photoaging has limitations. This greatly reduces the recovery rate of photoaging patients. Studies have confirmed that Ligusticum wallichii Franch (LWF) monomer tetramethylpyrazine (TMP) alleviates various skin diseases. The combination of traditional Chinese medicine and Western medicine helps with this process. Our research aimed to explore the specific treatment mode and molecular mechanism of TMP in treating skin photoaging...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836675/the-impact-of-laparoscopic-radical-gastrectomy-on-the-inflammatory-response-and-immune-function-of-patients-with-gastric-cancer
#15
JOURNAL ARTICLE
Jie Ling, Xiangjun Wang, Junfeng Ying
The currest study aimed to measure the effects of laparoscopic radical gastrectomy on inflammatory response along with immune function in gastric cancer (GC) patients. Seventy patients with GC in our hospital were retrospectively chosen to be the study objects and separated into control group (CG, 35 cases) and observation group (OG, 35 cases). Patients in the OG received radical laparotomy. Patients in the OG received laparoscopic radical gastrectomy. The surgical indicators, postoperative recovery indicators, inflammatory factors, immune function, incidence of adverse reactions along with quality of life of patients in both groups were compared...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836674/in-silico-and-in-vitro-studies-revealed-alpha-amyrin-as-a-potent-pnhibitor-of-tlr2-for-the-therapeutics-of-bacterial-infection-and-sepsis
#16
JOURNAL ARTICLE
Thoraya A- Elgadir, Basiouny El-Gamal, Mohamed Abd Ellatif, Khalid Ali Nasif, Safaa Omer, Muniera Mohieldeen, Ayyub A Patel, Mohammed Amanullah, Arshi Malik, Ahmed A Mahfouz, Ayman H Shaamash, Awad S Alsamghan
This study employed a multifaceted approach to investigate the inhibitory potential of alpha-amyrin against TLR2, a key player in bacterial infection and sepsis. A high-resolution TLR2 model was constructed using Swiss-MODEL, exhibiting excellent quality with 100% sequence identity and coverage. Cavity detection revealed five significant cavities on TLR2. Molecular docking identifies alpha-amyrin as a potent inhibitor, displaying a strong binding affinity of -8.6 kcal/mol. Comprehensive analyses, including ADMET predictions, PASS analysis, and SwissTargetPrediction, affirm alpha-amyrin's drug-like properties and diverse biological activities...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836673/oridonin-represses-lung-cancer-cell-proliferation-and-migration-by-modulating-afap1-as1-igf2bp1
#17
JOURNAL ARTICLE
Min Chen, Yahui Shen
Oridonin belongs to a small molecule from the Chinese herb Rabdosia rubescens with potent anticancer activity. In spite of the lncRNA AFAP1-AS1 has been proven to exert promoting function in lung cancer, its relationship with oridonin in lung cancer is obscure. Therefore, our study planned to explore the potential of oridonin in lung cancer as well as unveil the regulatory mechanism of oridonin on AFAP1-AS1 in lung cancer cells. In the present study, oridonin inhibited lung cancer cell proliferation, migration, as well as invasion, as evidenced by MTT, wound healing, as well as transwell assays...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836672/micror-1199-5p-targeting-srd5a2-promotes-the-biological-behavior-and-emt-of-hypospadias-cells
#18
JOURNAL ARTICLE
Yifu Chen, Jianjun Hu, Liucheng Peng, Yaowang Zhao
Hypospadias, an oft-occurring penis anomaly, ranks among neonatal's foremost birth defects. The SRD5A2 can affect male reproductive system development and is abnormally expressed in its epithelial cells. This study exploration aimed at understanding the role of SRD5A2 in the development of hypospadias from a molecular perspective. SRD5A2 levels in hypospadias primary cells were analyzed by Western blot, while targeted interaction with miR-1199-5p was ascertained by dual-luciferase gene reporter assay. In vitro biological experiments were used to confirm the biological function of SRD5A2 in hypospadias...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836671/exploration-of-mitochondrial-autophagy-related-genes-in-the-diagnosis-model-construction-and-molecular-marker-mining-of-alzheimer-s-disease-based-on-multi-omics-integration
#19
JOURNAL ARTICLE
Shan Wang, Jiejie Zhang, Haitao Zhang, Yihan Yang, Ya Wen
Key features of Alzheimer's disease include neuronal loss, accumulation of beta-amyloid plaques, and formation of neurofibrillary tangles. These changes are due in part to abnormal protein metabolism, particularly the accumulation of amyloid beta. Mitochondria are the energy production centers within cells and are also the main source of oxidative stress. In AD, mitochondrial function is impaired, leading to increased oxidative stress and the production of more reactive oxidative substances, further damaging cells...
June 5, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38836670/immunohistochemical-co-expression-of-pax2-and-caix-predicts-better-prognosis-in-clear-cell-renal-cell-carcinoma-after-nephrectomy-a-retrospective-observational-study
#20
JOURNAL ARTICLE
Honggang Shao, Yougang Liao, Min Xiang, Deng Hu, Sha Liu
Clear cell renal cell carcinoma (ccRCC) is a lethal malignancy with high metastatic probability. Paired box 2 gene product (PAX2) carbonic anhydrase IX were biomolecules closely linked with ccRCC development and outcomes of multiple malignancies. We aim to explore the role of immunohistochemical staining of PAX2 and CAIX to predict ccRCC prognosis after nephrectomy. Surgical specimens of patients who were pathologically diagnosed as ccRCC were reviewed. Expression levels of PAX2 and CAIX were assessed via immunohistochemical staining...
June 5, 2024: Cellular and Molecular Biology
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