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Journal of the European Academy of Dermatology and Venereology: JEADV

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https://read.qxmd.com/read/30770612/nested-case-control-study-investigating-the-diagnostic-role-of-tissue-eosinophilia-in-adverse-cutaneous-drug-reactions
#1
Liat Samuelov, Alexandra Nathan, Evgenia Slutsky, Dana Fruchter, Andrea Gat, Eli Sprecher, Ilan Goldberg
BACKGROUND: Although tissue-eosinophilia has traditionally been considered diagnostically supportive of adverse cutaneous drug reactions (ACDRs), studies have suggested it is neither a sensitive nor a specific finding in drug eruptions (DEs). OBJECTIVES: Determining whether skin-tissue eosinophilia is a reliable indicator of ACDR. METHODS: A nested case-control retrospective study conducted in a cohort of 170 patients at a single institution...
February 15, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30770592/clinicians-vs-epidemiologists-patch-testing-with-methyldibromo-glutaronitrile-as-a-controversial-issue
#2
A Schnuch, S Schubert, J Geier
The preservative methyldibromo glutaronitrile (MDBGN) (CAS 35691-65-7) is known since long as an important contact allergen mainly used in cosmetics (Review: [1]). MDBGN was banned EU-wide from being used in leave-on products in 2005, for rinse-off products in 2008, and further restricted for non-cosmetic (technical) applications in 2010. However, positive reactions in patch testing (PT) continued to occur. This article is protected by copyright. All rights reserved.
February 15, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30768820/ultrasonography-for-early-detection-of-non-infectious-necrotizing-fasciitis-secondary-to-cutaneous-loxoscelism
#3
Alvaro Martínez-Doménech, Marta García-Legaz-Martínez, Cristian Valenzuela-Oñate, Gemma Pérez-Pastor, Fernando Alfageme-Roldán, José Luis Sánchez-Carazo, Amparo Pérez-Ferriols
A 50-year-old woman consulted to the emergency department for painful erythematous swelling on her forearm hours after a spider bite. The patient had spent the evening cleaning the outside of her home, located in the periphery of an urban area, next to a ravine, on the western Mediterranean Basin, when she identified a spider on the dorsum of her forearm. She described it as a light-brown coloured spider, with darker long legs, between 1 and 1,5 cm in size. Though she felt no pain she brushed off the spider and it scared away...
February 15, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30768811/comparison-of-efficacy-of-cold-trypsinization-versus-warm-trypsinization-in-preparation-of-autologous-noncultured-epidermal-cell-suspension-for-treatment-of-stable-vitiligo
#4
Sankalp Awasti, Keshavamurthy Vinay, Vishal Thakur, Ravinder Kumar, Ananth Prasad Holla, Kanika Sahni, Davinder Parsad, Amrinder J Kanwar
Surgical modalities are the mainstay of treatment for medically resistant vitiligo. Among various techniques, non-cultured epidermal cell suspension (NCES) has proven to be an effective and most accepted technique because of its advantage of treating large areas. This article is protected by copyright. All rights reserved.
February 15, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767288/psoriasis-and-skin-pain-real-life-effectiveness-of-calcipotriol-plus-betamethasone-dipropionate-in-aerosol-foam-formulation
#5
L Gallo, M Megna, T Cirillo, P Caterino, G Lodi, R Mozzillo, V Dente, A Balato
BACKGROUND/OBJECTIVE: Although 40% of psoriasis patients reported skin pain, this symptom is often underestimated. A new formula of calcipotriol plus betamethasone dipropionate (Cal/BD) has been recently approved for psoriasis treatment. Therefore, we aimed to evaluate the efficacy of Cal/BD aerosol foam on skin pain of patients with plaque psoriasis. METHODS: A real-life 4 weeks prospective, open study on Cal/BD aerosol foam (not compared to vehicle or emollient cream) was performed in adult psoriasis patients attending three Dermatology units located in Campania region, Italy, between March and October 2018...
February 15, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767327/extended-surgical-safety-margins-and-ulceration-are-associated-with-an-improved-prognosis-in-pleomorphic-dermal-sarcomas-pds
#6
O D Persa, C Loquai, M Wobser, M Baltaci, S Dengler, A Kreuter, A Volz, M Laimer, M Emberger, M Doerler, C Mauch, D Helbig
BACKGROUND: Pleomorphic dermal sarcomas (PDS) are frequent UV-induced sarcomas of the skin of intermediate grade malignant potential. Despite the fact that PDS have a noteworthy potential to recur (up to 28%) as well as to metastasize (up to 20%), there are no specific clinical guidelines with respect to follow-up these patients. Moreover, little is known about clinical, histological or molecular prognostic factors in PDS. OBJECTIVE: The aim of the present study was to identify risk factors to predict relapse in a large multicenter sample cohort of PDS which could aid to optimize personalized treatment recommendations regarding surgical safety margins and adjuvant radiotherapy...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767325/response-to-korean-gender-differences-in-hidradenitis-suppurativa-nature-or-nurture
#7
Ji Hae Lee, Jung Min Bae
We thank R. Happle for his invaluable comments1 on our recent article2 regarding the prevalence of hidradenitis suppurativa (HS) in Korea. We agree with the opinion that the low prevalence of HS in Korean women may be due to the low number of female smokers in Korea. Although the Korean National Health Insurance Claims Database used in our study did not record the smoking habit of each individual, another recent Korean study revealed interesting findings regarding this issue. This article is protected by copyright...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767295/general-health-status-in-psoriasis-patients-as-assessed-by-the-sf-12-questionnaire-is-poorly-associated-with-pasi
#8
F Sampogna, S Mastroeni, S Pallotta, E Gubinelli, P Teofili, R Fusari, C Uras, R M Quinto, M Napolitano, D Abeni
An important issue in medicine is how to measure the clinical severity of a disease. In psoriasis this is traditionally assessed using the Psoriasis Area and Severity Assessment (PASI). However, it is a concern that this measure does not really capture the burden that the disease has on patients. The aim of this observational study was to assess, in patients with psoriasis, the relationship between health status and clinical severity measures. This article is protected by copyright. All rights reserved.
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767294/food-protein-induced-enterocolitis-syndrome-in-south-tyrol-2012-2016-a-population-based-study
#9
M Giusti, M Gasser, P Valentini, L Pescollderungg, K Eisendle
Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE-mediated food allergy to protein mainly in cow milk (CM) that typically presents in early infancy. Projectile and repetitive vomiting are the main clinical symptoms after 1-4 hours of trigger food ingestion. Rapid recognition and installment of a specific diet are important to avoid serious complications in affected children (see figure 1).1 According to a multicenter Italian study2 atopy as co-morbidity is rarer than in other countries being 9% compared to a much higher frequency of 28% in Spain,3 57% in Australia4 and over 70% in the USA...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767284/validation-of-the-dermatology-specific-proxy-instrument-the-infants-and-toddlers-dermatology-quality-of-life
#10
P V Chernyshov, F Sampogna, N Pustišek, B Marinovic, L Manolache, A Suru, C M Salavastru, G S Tiplica, G Stoleriu, T Kakourou, A Alexopoulos, L Nasi, J C Szepietowski, M Trzeciak, R J Nowicki, O V Chubar, A V Chernyshov, T V Pochynok
BACKGROUND: The first dermatology-specific proxy health related quality of life (HRQoL) instrument for children 0-4 years old with skin diseases, the Infants and Toddlers Dermatology Quality of Life (InToDermQoL), was recently developed. In order to avoid the problem of cross-cultural inequivalence focus groups work and pilot tests were organized simultaneously in all national centres of the project. The InToDermQoL showed good comprehensibility, clarity and acceptance. OBJECTIVE: To validate the InToDermQoL questionnaire during international field tests...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767283/alopecia-neoplastica-as-a-sign-of-visceral-malignancies-a-systematic-review
#11
REVIEW
G Paolino, R Pampena, S Grassi, S R Mercuri, M Cardone, P Corsetti, E Moliterni, M Muscianese, A Rossi, P Frascione, C Longo
Alopecia neoplastica (AN) from visceral tumors is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumor. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767282/the-spectrum-of-benign-dermal-dendritic-melanocytic-proliferations
#12
REVIEW
C Baykal, Z Yılmaz, G P Sun, N Büyükbabani
Dermal melanocytoses (DMs) comprise a heterogeneous group of benign lesions, located on skin and mucous membranes, characterized by dendritic melanocytes in the dermis. Although they share common histopathological features, some variants may present only as bluish or gray patches, some only as papules/nodules/plaques and others may show combination of all of these lesions. Despite the fact that blue nevus is typically characterized with papulonodular lesions, its variants may show all of the aforementioned presentations...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30767281/korean-gender-differences-in-hidradenitis-suppuratva-nature-or-nurture
#13
R Happle
In a recent population-based study on hidradenitis suppurativa (HS) in Korea, Lee et al. found that the female to male ratio was 1:1.6. They describe "a remarkable predisposition for HS among males" and note that this finding was contrary to what is usually reported in European studies.2,3 Drs. Lee and coworkers argue that the inverse female-to-male ratio suggests "a major racial difference". On the other hand, the female to male ratio of 1:1.6 was consistent with the results obtained in a Japanese study...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30762909/jak-inhibitors-for-alopecia-areata-a-systematic-review-and-meta-analysis
#14
REVIEW
Kevin Phan, Deshan F Sebaratnam
BACKGROUND: There have been a number of case reports and small clinical trials reporting promising outcomes of JAK inhibitors tofacitinib, ruxolitinib, and baracitinib for alopecia areata (AA). The majority of the literature to date is based on small volume data, with a lack of definitive evidence or guidelines. OBJECTIVE: To determine the expected response of AA to JAK inhibitor therapy, and factors which influence response and recurrence rates. METHODS: A systematic review and meta-analysis was performed according to PRISMA guidelines...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30762901/algorithms-for-ascertaining-keratinocyte-carcinomas-using-health-insurance-claims-and-prescription-records
#15
T Zhang, T K Lee, H Lui, B Kunimoto, C Han, Y Zhou, S Kalia
Skin cancer is the most common human malignancy with an ongoing continual increase in global incidence.1-3 Despite their high prevalence, keratinocyte carcinomas (KCs), namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are often excluded from population-based cancer registries. As there are over 3000 defined skin disease varieties that can be diagnosed,4 robust ascertainment methods are needed to capture KC cases for epidemiologic purposes. In the United States (US), Eide et al. This article is protected by copyright...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30742721/the-course-of-chronic-itch-in-hemodialysis-patients-results-of-a-4-year-follow-up-study-of-gehis-german-epidemiological-hemodialysis-itch-study
#16
Natalie Plewig, Robert Ofenloch, Thomas Mettang, Elke Weisshaar
BACKGROUND: Chronic itch (CI) is a frequent symptom in hemodialysis (HD) patients. Previous studies demonstrated great impairments of general well-being and health-related quality of life (HRQOL) as well as a higher mortality in those suffering from CI. OBJECTIVE: The German Epidemiological Hemodialysis Itch Study (GEHIS) is a representative cohort of HD patients in Germany. All patients were followed-up 4 years later. The current analyses present data on the course of CI in HD patients, its associated factors including comorbidities, laboratory values and HRQOL...
February 11, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30742719/galli-galli-disease-successfully-treated-with-alitretinoin
#17
N J Deenen, J Damman, T E C Nijsten
A 62-year-old man presented with a 10-year history of itchy erosions starting in the axillary region and inguinal area with progression to the trunk. He was previously diagnosed with Hailey-Hailey disease after clinicopathological correlation. Treatment with different combinations of topical and systemic antibiotics and corticosteroids showed no response. This article is protected by copyright. All rights reserved.
February 11, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30742717/iceberg-sign-as-a-dermoscopic-clue-of-actinic-keratosis-neglecta
#18
J F Mir-Bonafé, E Rozas-Muñoz, J Dalmau, M Mir-Bonafé, H Iznardo, C García-Melendo, L Puig
Diagnosis of actinic keratosis (AK) is mainly clinical, but dermoscopy has proven useful in improving diagnostic accuracy. The patterns, structures and colors of AK can vary widely.1 Lesions may appear as white scales on a pseudo-network pattern, as keratotic plugs on a scaly white to yellow background, or as a strawberry pattern with white to yellow areas and keratotic follicular openings on an erythematous background. This article is protected by copyright. All rights reserved.
February 11, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30739344/epidermal-aquaporin-3-downexpression-in-symmetrical-acrokeratoderma
#19
Ming-Lei Rong, Zi-Wei Zhang, Yun Luo, Ge Shi, Yi-Ming Fan
We read with interest the article by Chen et al that proposes a new term "pigmented carpotarsal hyperkeratosis" for "symmetrical acral keratoderma" or "symmetrical acrokeratoderma (SAK)". Aquaporin-3 (AQP3) is the most abundant aquaglyceroporin in human epidermis, and regulates skin hydration, keratinocyte migration and proliferation, wound healing, and tumorigenesis. Although skin hydration was decreased with incremental transepidermal water loss (TEWL) in SAK, AQP3 expression is unreported in SAK...
February 9, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30735612/efficacy-and-safety-of-systemic-treatments-in-psoriatic-arthritis-a-systematic-review-meta-analysis-and-grade-evaluation
#20
REVIEW
C Dressler, L Eisert, P A Pham Thi, A Nast
Twenty percent of patients with plaque psoriasis also have psoriatic arthritis - a disease affecting joints and entheses. Different treatment options exist but currently no succinct systematic overview exists. A systematic review of approved systemic treatments for psoriatic arthritis was conducted. We systematically searched in 3 databases (last update 09/2017). Data was extracted for ACR 20/50, HAQ-DI, SF-36 and adverse/serious adverse events after 16-24 weeks. We assessed the quality of evidence using GRADE...
February 8, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
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