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Breast: Official Journal of the European Society of Mastology

Maria-Eleni Spei, Evangelia Samoli, Francesca Bravi, Carlo La Vecchia, Christina Bamia, Vassiliki Benetou
AIM: To further quantify the association between physical activity (PA) after breast cancer diagnosis and all-cause mortality, breast cancer mortality and/or breast cancer recurrence. METHODS AND RESULTS: PubMed was searched until November 2017 for observational studies investigating any type of PA in association with total mortality, breast cancer mortality and/or breast cancer recurrence among women with breast cancer diagnosis. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using random-effects models for highest versus lowest categories of PA...
February 12, 2019: Breast: Official Journal of the European Society of Mastology
Robin Stuart-Harris, Jane E Dahlstrom, Ruta Gupta, Yanping Zhang, Paul Craft, Bruce Shadbolt
BACKGROUND: Evidence suggests recent improvements in outcome in early breast cancer (EBC). AIM: To analyse recurrence in women with EBC from our region from 1997 to 2015. METHODS: We analysed recurrence in 3,765 women with EBC. Median follow up was 83·0 months. 62·5% had a symptomatic presentation. 81·8% were hormone receptor positive and 38·5% were node positive. Lymphovascular invasion (LVI) was present in 24·3%. Of the 2,686 women entered from 2002 onwards tested for HER2 status, 72·7% had a luminal tumour, 15·2% had a HER2+ tumour and 12·1% had a triple negative (TN) tumour...
February 11, 2019: Breast: Official Journal of the European Society of Mastology
Carmen Criscitiello, Giulia Viale, Giuseppe Curigliano
The immune system plays a dual role of host-protecting and tumor-promoting, as elegantly expressed by the 'cancer immunoediting' hypothesis. Although breast cancer has not been traditionally considered to be immunogenic, recently there is accumulating and solid evidence on the association between immune system and breast cancer. To mount an effective anti-tumor response, host immunosurveillance must recognize tumor-specific epitopes, thus defining the antigenicity of a tumor. Neoantigens are mutant cancer peptides that arise as terminal products of the expression of somatic cancer mutations...
February 7, 2019: Breast: Official Journal of the European Society of Mastology
Sergio Daniel Simon, José Bines, Gustavo Werutsky, João Soares Nunes, Fernando Chalu Pacheco, José Getúlio Segalla, Andrea J S Gomes, Brigitte Marie H R Adam Van Eyll, Daniel Luiz Gimenes, Susanne Crocamo, Ruffo Freitas-Junior, Lissandra Dal Lago, Geraldo Silva Queiroz, Sérgio Jobim de Azevedo, Daniela Dornelles Rosa, Gilson Delgado, Giuliano Santos Borges, Yeni Verônica do Nascimento, Facundo Zaffaroni, Jeovany Martínez-Mesa, Carlos H E Barrios
OBJECTIVE: To describe stage I-III breast cancer (BC) molecular subtypes and outcomes among a cohort of patients from Brazil. METHODS: AMAZONA study is a retrospective cohort conducted from June 2008 to January 2009 including women of at least 18 years old, with histologically proven breast cancer, diagnosed in 2001 (n = 2198) and 2006 (n = 2714). In this analysis, we included patients who underwent surgery, had stage I-III disease and available pathological information (n = 2296)...
February 2, 2019: Breast: Official Journal of the European Society of Mastology
Caterina Calderon, Alberto Carmona-Bayonas, Raquel Hernández, Ismael Ghanem, Beatriz Castelo, Eva Martinez de Castro, Estrella Ferreira, Laura Ciria, María Muñiz, Paula Jimenez-Fonseca
INTRODUCTION: The aim was to analyze the effects of pessimism, depression, fatigue, and pain on functional health-related quality of life (HRQoL) in patients with resected, non-advanced breast cancer. METHODS: A prospective, multicenter study was conducted in 440 breast cancer patients. They completed the Brief Symptom Inventory (BSI), the European Organization for Research and Treatment of Cancer QoL-Questionnaire-Core-30 (EORTC-QLQ-C30), and the Revised Life Orientation Test (LOT-R)...
February 2, 2019: Breast: Official Journal of the European Society of Mastology
Lucy Bai, Brita Arver, Hemming Johansson, Kerstin Sandelin, Marie Wickman, Yvonne Brandberg
PURPOSE: To prospectively follow-up and investigate women's perceptions of the cosmetic outcome of their implant-based breast reconstruction, body image, sexuality, anxiety/depressive symptoms, and health-related quality of life (HRQoL) 6-20 years after bilateral risk-reducing mastectomy (RRM), or complementary RRM after breast cancer diagnosis, due to increased risk of hereditary breast cancer. PATIENTS AND METHODS: Women with and without previous breast cancer diagnosis that underwent RRM between March 1997 and September 2010 were invited (n = 200)...
February 1, 2019: Breast: Official Journal of the European Society of Mastology
Liliana Coutiño-Escamilla, Maricela Piña-Pozas, Aurelio Tobías Garces, Brenda Gamboa-Loira, Lizbeth López-Carrillo
OBJECTIVE: Depressive symptoms are common comorbidities among breast cancer (BC) patients. Non-pharmacological therapies (NPTs) such as exercise and psychotherapy may reduce depressive symptoms; however, the evidence is inconclusive. The objective of this study is to evaluate if NPTs reduce depressive symptoms among BC patients. METHODS: A systematic review and meta-analysis of randomized clinical trials (RCTs) of NPTs for BC patients were performed. A literature search was conducted from eight databases in English, Portuguese and Spanish from 2006 to 2017...
January 31, 2019: Breast: Official Journal of the European Society of Mastology
M J Cardoso, L Wyld, I T Rubio, M Leidenius, G Curigliano, B Cutuli, L Marotti, L Biganzoli
During the last two decades the number of breast implants used in aesthetic, oncologic and risk reducing surgery has increased substantially mainly due to the improvement and confirmed safety of these devices. Since identification of the first case of anaplastic large cell lymphoma associated with a breast implant (BIA-ALCL) 20 years ago, there has been an increase in the number of reports of this very rare disease, demonstrating a clear association with breast implants. Whilst the majority of cases are localised and cured by implant removal and full capsulectomy, a small percentage require chemotherapy and the mortality rate is very low...
January 26, 2019: Breast: Official Journal of the European Society of Mastology
A L Corter, B Speller, F C Wright, M L Quan, N N Baxter
AIM: International guidelines highlight the importance of implementation supports and quality monitoring of multidisciplinary care for breast cancer. In Canada, Ontario has standards for formal multidisciplinary cancer conferences (MCCs), but other provinces/territories do not. This study aimed to stocktake MCCs for breast cancer in Canadian sites participating in the RUBY cohort study (Reducing the Burden of Breast Cancer in Young Women) to better understand variations in multidisciplinary care across Canada and to add to the international literature...
January 25, 2019: Breast: Official Journal of the European Society of Mastology
Anna Olsson-Brown, Pavlos Piskilidis, Julie O'Hagan, Nicky Thorp, Peter Robson, Helen Innes, Helen Wong, Silvia Cicconi, Richard Jackson, Tamara Kiernan, Christopher Holcombe, Susan O'Reilly, Carlo Palmieri
PURPOSE: The 21-gene recurrence score (Oncotype DX) (RS) informs systemic therapy decision making in ER-positive HER2-negative early breast cancer (BC). To date no study has described the more nuanced discussions that take place regarding systemic therapy or the impact of the RS on concordance in such decision making. Here we utilized a novel decision making tool to assess the impact of the RS on decision making as well as concordance of treatment recommendations. PATIENTS AND METHODS: The clinicopathological information (CPI) of 50 BCs without and with the RS were presented to a panel of breast oncologists in a simulated MDT...
January 18, 2019: Breast: Official Journal of the European Society of Mastology
Margaret F Bedillion, Emily B Ansell, Gwendolyn A Thomas
OBJECTIVES: Breast cancer survivors report significant cognitive impairments post treatment, particularly following chemotherapy. Depression may also occur post treatment and may partially mediate the effects of cancer treatment on cognition. Additionally, physical activity has been shown to mitigate treatment effects on cognition and depression. This study examined the role of depression in mediating the effects of cancer treatment on cognitive function (perceived cognitive impairment, PCI; perceived cognitive ability, PCA) in breast cancer survivors and explored the role of physical activity in moderating these effects...
January 16, 2019: Breast: Official Journal of the European Society of Mastology
Kari Britt Hagen, Turid Aas, Jan Terje Kvaløy, Håvard Søiland, Ragna Lind
PURPOSE: Adjuvant endocrine therapy (ET) in breast cancer reduces recurrence risk and increases overall survival. The aim of the study was to quantify non-adherence and discontinuation to ET in postmenopausal women with breast cancer, and identify possible clinical or social risk factors. METHODS: Women with hormone-receptor positive breast cancer (N = 138), mean age 58 (SD 9.3) years, filled in 4 questionnaires within 1-12, 24, 36 and 48-60 months after surgery; Subjective Health Complaints Inventory (SHC), Functional Assessment of Cancer Therapy-Social Support Subscale (FACT-ES), and Quality of Patient Information Questionnaire (QPI)...
January 8, 2019: Breast: Official Journal of the European Society of Mastology
Annika Diekmann, Christian Heuser, Nicole Ernstmann, Franziska Geiser, Sophie Elisabeth Groß, Evamarie Midding, Holger Pfaff, Lena Ansmann
OBJECTIVES: Aim of this study was to investigate the experiences of breast cancer patients who participated in multidisciplinary tumor conferences (MTCs). STUDY DESIGN: Data from two consecutive years of an annual postal survey of patients with primary breast cancer were combined. Data was collected between February and July 2015 (response rate 72%) and 2016 (response rate 73%) from N = 8893 patients (ICD-10 C50) after hospital discharge from 86 breast cancer center hospitals in North Rhine-Westphalia, Germany...
January 4, 2019: Breast: Official Journal of the European Society of Mastology
Fei-Hsiu Hsiao, Wen-Hung Kuo, Guey-Mei Jow, Ming-Yang Wang, King-Jen Chang, Yu-Ming Lai, Yu-Ting Chen, Chiun-Sheng Huang
OBJECTIVES: This 14-month study aimed to examine the changes of quality of life following breast cancer surgery and associations of such changes with depression and anxiety levels, and protective factors (attachment styles in close relationship, and meaning in life) based on positive psychology theory. MATERIALS AND METHODS: Women with breast cancer were recruited within one week of completion of breast cancer surgery. They were asked to complete several questionnaires to measure the generic and breast cancer specific quality of life, depression and anxiety levels, attachment styles in close relationship, and meaning in life...
January 4, 2019: Breast: Official Journal of the European Society of Mastology
L M Knapen, S M E Geurts, K I E Ibragimova, S Croes, B E P J Vriens, F W P J van den Berkmortel, M W Dercksen, A J van de Wouw, M J A E Pepels, A O J de Fallois, D J A Lobbezoo, M de Boer, V C G Tjan-Heijnen
PURPOSE: We aimed to assess the implementation and effectiveness of exemestane plus everolimus treatment per hospital type in real-life, shortly after approval of everolimus. METHODS: Advanced breast cancer patients treated with exemestane plus everolimus in 2012-2014 were included from the SONABRE registry. Progression-free survival (PFS) and a 12-week conditional PFS (post-hoc) were estimated by Kaplan-Meier method. The multivariable Cox proportional hazards model was performed by type of hospital and adjusted for patient, tumour and treatment characteristics...
January 4, 2019: Breast: Official Journal of the European Society of Mastology
Elsa Curtit, Jean-Michel Vannetzel, Jean-Claude Darmon, Sophie Roche, Hugues Bourgeois, Sylvain Dewas, Stéphanie Catala, Emile Mereb, Charlotte Furtos Fanget, Dominique Genet, Anne-Marie Forest, Céline Bernier, Xavier Pivot
Adjuvant chemotherapy shows clear benefits in HER2-positive and triple-negative breast cancer (BC). Its benefits are less universal in BCs expressing hormone receptors. The 21-gene Oncotype DX® Breast Recurrence Score test was designed for HR+, HER2- early-stage BC before decision on adjuvant chemotherapy. Its validity and utility was demonstrated prospectively across multiple studies. The observational study PONDx characterized the use of Oncotype DX® Breast in routine practice in France and evaluated its decision impact...
January 3, 2019: Breast: Official Journal of the European Society of Mastology
Vincenzo Graziano, Antonino Grassadonia, Laura Iezzi, Patrizia Vici, Laura Pizzuti, Maddalena Barba, Alberto Quinzii, Annarita Camplese, Pietro Di Marino, Marta Peri, Serena Veschi, Saverio Alberti, Teresa Gamucci, Mario Di Gioacchino, Michele De Tursi, Clara Natoli, Nicola Tinari
The immune system seems to play a fundamental role in breast cancer responsiveness to chemotherapy. We investigated two peripheral indicators of immunity/inflammation, i.e. neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), in order to reveal a possible relationship with pathological complete response (pCR) in patients with early or locally advanced breast cancer treated with neoadjuvant chemotherapy (NACT). We retrospectively analyzed 373 consecutive patients affected by breast cancer and candidates to NACT...
January 2, 2019: Breast: Official Journal of the European Society of Mastology
Albert Grinshpun, Yakir Rottenberg
OBJECTIVES: The population of breast cancer survivors is growing. In Western societies, many of these women are working age, and therefore, potentially desire to return to the work force. We aimed to evaluate the unemployment risk for up to 8 years following a breast cancer diagnosis and identify contributing socio-economic factors. METHODS: This historical prospective study included baseline measurements from the Israeli Central Bureau of Statistics 1995 National Census, with follow-up to 2011...
December 27, 2018: Breast: Official Journal of the European Society of Mastology
Miriam Deniz, Amelie DeGregorio, Nikolaus DeGregorio, Inga Bekes, Peter Widschwendter, Fabienne Schochter, Kristina Ernst, Christoph Scholz, Emanuel Ca Bauer, Viktoria Aivazova-Fuchs, Tobias Weissenbacher, Bernd Kost, Julia Jueckstock, Ullrich Andergassen, Julia Steidl, Elisabeth Trapp, Peter A Fasching, Lothar Häberle, Matthias W Beckmann, Andreas Schneeweiss, Iris Schrader, Wolfgang Janni, Brigitte Rack, Thomas Wp Friedl
OBJECTIVES: In breast cancer, large tumor size, positive nodal stage and a triple-negative tumor subtype are associated with reduced survival, but the interactions between these prognostic factors are not well understood. MATERIAL AND METHODS: Here we re-evaluated the impact of tumor size, nodal stage and tumor subtype on disease-free survival (DFS), overall survival (OS), distant disease-free survival (DDFS) and breast cancer specific survival (BCSS) in a retrospective analysis using data from the adjuvant SUCCESS A trial...
December 20, 2018: Breast: Official Journal of the European Society of Mastology
Nancy Tray, Jessica Taff, Baljit Singh, James Suh, Nhu Ngo, Maryann Kwa, Andrea B Troxel, Young Kwang Chae, Razelle Kurzrock, Sandip Pravin Patel, Elad Sharon, Carsten Denkert, Jeffrey S Ross, Sylvia Adams
Metaplastic breast cancer (MPBC) is a rare subtype that accounts for <1% of all breast cancers. Although these are typically "triple negative," they are relatively chemotherapy-refractory compared to conventional triple negative invasive breast cancers with more aggressive features and an overall poor prognosis. MPBC is a heterogeneous group of tumors that are enriched for TP53 and PIK3CA mutations, and have been found to have high PD-L1 expression though the mechanisms underlying its immunogenicity remain unclear...
December 20, 2018: Breast: Official Journal of the European Society of Mastology
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