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Journals Cardiovascular Pathology : the...

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology

https://read.qxmd.com/read/38679299/clinical-and-pathological-spectrum-of-aortitis-in-a-chinese-cohort
#21
JOURNAL ARTICLE
Wei Qu, Youping Chen, Zhenlu Zhang
BACKGROUND: This study aimed to explore the clinical and pathological features of aortitis in China, which is a rare disease that is often overlooked preoperatively. METHODS: We reviewed the records of 2950 patients who underwent aortic surgery at Wuhan Asia General Hospital from 2016 to 2023. Clinical and pathological data were collected and compared across different groups. RESULTS: Out of 2950 patients, 15 had healed aortitis, 2 which were healed Takayasu Aortitis (TAK) and 13 that were not further classified...
April 26, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38677635/segmental-arterial-mediolysis-leading-to-spontaneous-rupture-of-splenic-artery-and-fatal-hemorrhage-in-pregnancy
#22
Silvia Farkašová Iannaccone, Ivana Kholová, Alžbeta Ginelliová, Lucia Fröhlichová, Daniel Farkaš
We report an unexpected death of a 22-year-old primigravida who was admitted to the hospital with sudden abdominal pain two days before a scheduled delivery. During an emergency caesarean section due to intrauterine asphyxia, intraabdominal bleeding was observed with no apparent source of bleeding. Newly formed blood clots in the subdiaphragmatic space and arterial bleeding near the splenic hilum required a surgery on the next day. Hemorrhagic shock led to multiple organ failure on the fourth day of admission...
April 25, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38677634/a-machine-learning-algorithm-improves-the-diagnostic-accuracy-of-the-histologic-component-of-antibody-mediated-rejection-amr-h-in-cardiac-transplant-endomyocardial-biopsies
#23
JOURNAL ARTICLE
Matthew Glass, Zhicheng Ji, Richard Davis, Elizabeth Pavlisko, Louis DiBernardo, John Carney, Gregory Fishbein, Daniel Luthringer, Dylan Miller, Richard Mitchell, Brandon Larsen, Yasmeen Butt, Melanie Bois, Joseph Maleszewski, Marc Halushka, Michael Seidman, Chieh-Yu Lin, Maximilian Buja, James Stone, David Dov, Lawrence Carin, Carolyn Glass
BACKGROUND: Pathologic antibody mediated rejection (pAMR) remains a major driver of graft failure in cardiac transplant patients. The endomyocardial biopsy remains the primary diagnostic tool but presents with challenges, particularly in distinguishing the histologic component (pAMR-H) defined by 1) intravascular macrophage accumulation in capillaries and 2) activated endothelial cells that expand the cytoplasm to narrow or occlude the vascular lumen. Frequently, pAMR-H is difficult to distinguish from acute cellular rejection (ACR) and healing injury...
April 25, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38649123/beh%C3%A3-et-s-syndrome-masquerading-as-infective-endocarditis-a-diagnostic-conundrum-and-therapeutic-challenge
#24
Wei Qu, Youping Chen, Zhenlu Zhang
This case report presents a 20-year-old male patient initially diagnosed with infective endocarditis, later correctly identified as Behçet's syndrome. The patient's complex clinical presentation, including chest pain, aortic dilation, severe aortic regurgitation, and aortic root abscess, posed significant diagnostic and therapeutic challenges. Despite initial misdiagnosis and treatment difficulties, the patient's condition significantly improved with appropriate immunosuppressive therapy, underscoring the potential for successful management of this complex condition...
April 20, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38649122/rapid-progression-of-a-coronary-artery-aneurysm-caused-by-igg4-related-disease
#25
JOURNAL ARTICLE
Yohei Miura, Kohei Koyama, Takashi Kohno, Kyoko Soejima, Sho Torii, Gaku Nakazawa
BACKGROUND: IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory disorder that can affect almost any organ. IgG4-RD has also been reported in coronary arteries as periarteritis. IgG4-related coronary periarteritis may cause coronary artery aneurysms, and IgG4-related coronary artery aneurysms (IGCAs) are life-threatening. We describe a case of a patient with IGCA that highlights the usefulness and limitations of various IGCA evaluation modalities and provides insight into disease pathophysiology...
April 20, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38604505/pulmonary-vascular-disease-in-veterans-with-post-deployment-respiratory-syndrome
#26
JOURNAL ARTICLE
Sergey S Gutor, Bradley W Richmond, Vineet Agrawal, Evan L Brittain, Ciara M Shaver, Pingsheng Wu, Taryn K Boyle, Ravinder R Mallugari, Katrina Douglas, Robert N Piana, Joyce E Johnson, Robert F Miller, John H Newman, Timothy S Blackwell, Vasiliy V Polosukhin
Exertional dyspnea has been documented in U.S. military personnel after deployment to Iraq and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associated with pulmonary vascular disease (PVD). We performed detailed histomorphometry of pulmonary vasculature in 52 Veterans with biopsy-proven post-deployment respiratory syndrome (PDRS) and then recruited five of these same Veterans with continued exertional dyspnea to undergo a follow-up clinical evaluation, including symptom questionnaire, pulmonary function testing, surface echocardiography, and right heart catheterization (RHC)...
April 9, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38570104/rare-cardiac-inflammatory-pseudotumor-in-a-toddler-complementary-roles-of-cardiac-magnetic-resonance-and-positron-emission-tomography
#27
Melissa Mejia-Bautista, Jennifer Romanowicz, Monica Hollowell, Tal Geva, Chrystalle Katte Carreon, Rebecca S Beroukhim
We present a rare pediatric case of cardiac inflammatory pseudotumor (IPT) with a unique presentation of fever of unknown origin with markedly elevated inflammatory markers. A right atrial mass was discovered incidentally by echocardiography. The cardiac magnetic resonance (CMR) signal characteristics and mass location were not consistent with any of the common benign cardiac tumors of childhood. The presence of high signal intensity on T2 imaging and late gadolinium enhancement, in conjunction with intense metabolic activity at the mass site on positron emission tomography (PET), raised the possibility of an inflammatory or malignant mass...
April 1, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38555005/erdheim-chester-disease-requires-extensive-prospective-and-thorough-work-up-for-multisystem-involvement
#28
LETTER
Josef Finsterer
No abstract text is available yet for this article.
March 28, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38552930/the-distribution-of-the-depth-of-aortic-dissection-and-the-correlation-of-the-dissection-depth-index-with-other-parameters
#29
JOURNAL ARTICLE
Youping Chen, Wei Qu, Zhenlu Zhang, Mengya Li, Yang Wu
BACKGROUND: In patients with aortic dissection, the aortic wall is separated into two layers along a dissection plane. In this study, a survey was performed to investigate the distribution of the depth of dissection plane and its correlation with other clinical and pathological parameters to help understand and expand the current knowledge of aortic dissection. METHODS: Pathology information system were searched for patients with aortic dissection who had undergone aortic replacement between 2019 and 2022 in Wuhan Asia General Hospital...
March 27, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38521140/incidence-of-quadricuspid-pulmonary-valves-at-post-mortem-examination
#30
JOURNAL ARTICLE
Michael Duffy, Sarah Parsons, Joseph Westaby, Mary Sheppard
Quadricuspid pulmonic valve (QPV) is a rare congenital abnormality and because of its difficult non-invasive assessment, it is usually discovered incidentally at autopsies (reported prevalence in post-mortem specimens ranges from 1 in 400 to 1 in 2000) [1,12]. Unlike a bicuspid pulmonary valve, it rarely presents with clinical complications, such as valvular insufficiency or stenosis [3]. Abnormal function is rarely reported in cases that are not associated with other congenital heart disease. With increased sophistication of imaging coincidental quadricuspid valves autopsy studies are important to understand the anatomical consequences of this finding...
March 21, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38508436/cellular-and-molecular-mechanisms-driving-cardiac-tissue-fibrosis-on-the-precipice-of-personalized-and-precision-medicine
#31
REVIEW
Ali Fatehi Hassanabad, Anna N Zarzycki, Paul W M Fedak
Cardiac fibrosis is a significant contributor to heart failure, a condition that continues to affect a growing number of patients worldwide. Various cardiovascular comorbidities can exacerbate cardiac fibrosis. While fibroblasts are believed to be the primary cell type underlying fibrosis, recent and emerging data suggest that other cell types can also potentiate or expedite fibrotic processes. Over the past few decades, clinicians have developed therapeutics that can blunt the development and progression of cardiac fibrosis...
March 18, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38508435/subclinical-maternal-autoimmune-disease-leading-to-congenital-high-degree-atrioventricular-block-case-report-and-review-of-the-literature
#32
Shelby E Walcott, Dr Christian H Tan, Dr Jason Wicker, Dr Silvio Litovsky
Maternal autoimmune disease is the most common cause of congenital heart block (CHB), a rare illness characterized by fibrosis and calcification of the fetal atrioventricular (AV) node due to maternal autoantibodies anti-SSA/Ro and anti-SSB/La. We report the full autopsy and clinical information on a female neonate with high degree AV block and calcification in the AV node, atrial approaches to the AV node, and both right and left bundle branches, born to a 27-year-old female with subclinical autoimmune disease...
March 18, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38492686/frequent-protein-kinase-a-regulatory-subunit-a1-mutations-but-no-gnas-mutations-as-potential-driver-in-sporadic-cardiac-myxomas
#33
JOURNAL ARTICLE
Annette Zimpfer, Liza M Abel, Anthony Alozie, Christian D Etz, Björn Schneider
PURPOSE: Cardiac myxomas (CMs) are the second most common benign primary cardiac tumors, mainly originating within the left atrium. Approximately 5% of CM cases are associated with Carney Complex (CNC), an autosomal dominant multiple neoplasia syndrome often caused by germline mutations in the Protein Kinase A regulatory subunit 1A (PRKAR1A). Data concerning PRKAR1A alterations in sporadic myxomas are variable and sparse, with PRKAR1A mutations reported to range from 0% to 87%. Therefore, we investigated the frequency of PRKAR1A mutations in sporadic CM using next-generation sequencing (NGS)...
March 14, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38490313/sudden-death-with-cardiac-involvement-in-a-neonate-with-carnitine-acylcarnitine-translocase-deficiency
#34
Dongfang Qiao, Jiayu Jing, Cui Zhang, Sihao Du, Xiaohui Tan, Xia Yue
A female neonate born with normal Apgar scores at 38+2 weeks of gestational age unexpectedly passed away within less than 30 hours after birth. The situation mirrors her brother's earlier demise within 24 hours post-delivery, suggesting a possible genetic disorder. A gross examination revealed widespread cyanosis and distinct yellowish changes on the cardiac ventricles. Histopathological analysis disclosed lipid accumulation in the liver, heart, and kidney. Tandem mass spectrometry detected elevated levels of 10 amino acids and 14 carnitines in cardiac blood...
March 13, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38485103/sudden-unexpected-intrapartum-death-and-left-ventricular-noncompaction-involving-the-right-ventricle
#35
Giulia Ottaviani, Tobia Tomasello, Francesca Boggio, Letterio Runza, Alessandro Del Gobbo, L Maximilian Buja
Left ventricular noncompaction (LVNC), involving mainly the right ventricle, is a rare form of congenital heart disorder characterized by a developmental arrest in myocardial compaction, resulting in a spongy appearance of the myocardium, mainly of the right ventricle, rarely detected in fetuses. We report the case of a female fetus with a gestational age of 41+4 weeks who came to our attention for intrapartum sudden unexpected death, resulting in stillbirth. The ventricular walls, particularly the right ventricular wall, appeared thick, hypertrabeculated and spongy, leading to the diagnosis of LVNC involving mainly the right ventricle...
March 12, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38467167/aortic-valve-fibroelastoma-presenting-with-myocardial-infarction-with-non-obstructive-coronary-arteries-minoca-a-case-report-and-review-of-the-literature
#36
Martino Pepe, Rocco Tritto, Maria Ludovica Naccarati, Simona Quarta, Andrea Marzullo, Marco Matteo Ciccone
Cardiac papillary fibroelastomas (CPFs) are rare benign cardiac tumors more often involving the left-sided valves and related with threatening embolic complications. We report the case of a 35-year-old woman presenting with relapsing-remitting chest pain and elevated cardiac troponins. After a negative coronary angiography, an integrated imaging assessment based on echocardiography and cardiac magnetic resonance showed a pedunculated mass on the aortic valve causing an intermittent obstructive engagement of the right coronary ostium...
March 9, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38461960/the-potential-involvement-of-glycocalyx-disruption-in-abdominal-aortic-aneurysm-pathogenesis
#37
REVIEW
Bibi Rabia, Shivshankar Thanigaimani, Jonathan Golledge
BACKGROUND: Abdominal aortic aneurysm (AAA) is a weakening and expansion of the abdominal aorta. Currently, there is no drug treatment to limit AAA growth. The glycocalyx (GC) is the outermost layer of the cell surface, mainly composed of glycosaminoglycans (GAGs) and proteoglycans. OBJECTIVE: The aim of this review was to identify a potential relationship between GC disruption and AAA pathogenesis. METHODS: A narrative review of relevant published research was conducted...
March 8, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38458505/3d-models-of-the-cardiac-conduction-system-in-healthy-neonatal-human-hearts
#38
JOURNAL ARTICLE
Brian Cottle, Karl Schriewer, Sarthak Tiwari, Dylan Miller, Aditya Kaza, Robert Hitchcock, Frank B Sachse
Iatrogenic damage to the cardiac conduction system (CCS) remains a significant risk during congenital heart surgery. Current surgical best practice involves using superficial anatomical landmarks to locate and avoid damaging the CCS. Prior work indicates inherent variability in the anatomy of the CCS and supporting tissues. This study introduces high-resolution, 3D models of the CCS in normal pediatric human hearts to evaluate variability in the nodes and surrounding structures. Human pediatric hearts were obtained with an average donor age of 2...
March 6, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38417471/multisystem-erdheim-chester-disease-presenting-with-pericardial-effusion-confirmed-by-the-effusion-cytology-specimen
#39
Shishuo Dai, Xueying Su, Wei-Ping Liu, Yu Wu
Erdheim-Chester disease (ECD) is a rare histiocytosis characterized by the foamy CD68+CD1a- histiocytes infiltrating multiple organs and tissues. ECD might be asymptomatic or present with variable manifestations. The diagnosis of ECD requires characteristic radiological findings and pathological features. Herein, we described a 52-year-old female patient who was admitted to our hospital for recurrent pericardial effusion for two months. She has a medical history of papillary thyroid carcinoma (PTC) and underwent a total thyroidectomy two years before admission...
February 26, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38412903/transthyretin-derived-amyloid-attr-and-sarcoidosis-does-attr-deposition-cause-a-granulomatous-inflammatory-response-in-older-adults-with-sarcoidosis
#40
JOURNAL ARTICLE
Shojiro Ichimata, Yukiko Hata, Kazuhiro Nomoto, Naoki Nishida
This study aimed to assess the frequency and association between transthyretin-derived (ATTR) amyloidosis and sarcoidosis in a large autopsy cohort including many cases of sudden cardiac death (SCD). We identified 73 sporadic ATTR amyloidosis cases and 11 sarcoidosis cases, among which we found two cases with concomitant ATTR amyloidosis and sarcoidosis (2.4% of all cases; 2.7% within the sporadic ATTR group). The first case involved a 92-year-old man who experienced SCD. In this patient's heart, we observed ATTR deposition and noncaseating epithelioid granulomas consistent with sarcoidosis...
February 25, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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