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Journals Cardiovascular Pathology : the...

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology

https://read.qxmd.com/read/36460259/extracellular-vesicles-and-atherosclerotic-peripheral-arterial-disease
#21
REVIEW
Paul A Brown, Paul D Brown
Atherogenesis involves a complex multifactorial process including chronic inflammation that requires the participation of several cell types and molecules. In addition to their role in vascular homeostasis, extracellular vesicles also appear to play an important role in atherogenesis, including monocyte transmigration and foam cell formation, SMC proliferation and migration, leukocyte transmigration, and thrombosis. Peripheral arterial disease, a major form of peripheral vascular disease, is characterized by structural or functional impairment of peripheral arterial supply, often secondary to atherosclerosis...
November 29, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36442703/effect-of-sex-age-and-body-measurements-on-heart-weight-atrial-ventricular-valvular-and-subepicardial-fat-measurements-of-the-normal-heart
#22
JOURNAL ARTICLE
J D Westaby, E Zullo, L M Bicalho, R H Anderson, M N Sheppard
AIMS: Descriptive morphological studies of the normal heart are lacking. Previous autopsy studies have focussed mainly on heart weight. We characterise the normal heart by providing normal dimensions of the atria, ventricles, valves and subepicardial fat, comparing the findings in terms of sex, age and body measurements. METHODS: From 3602 referrals to our cardiovascular pathology unit, pathological criteria used for the classification of a morphologically normal heart were a weight of below 500 grams in males, and below 400 grams in females...
November 25, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36442702/increased-fibrosis-and-microvessel-disease-in-allograft-endomyocardial-biopsies-of-children-with-chronic-graft-failure-due-to-cardiac-allograft-vasculopathy
#23
JOURNAL ARTICLE
Kae Watanabe, Nazia Husain, Jennifer L Arzu, Joshua B Wechsler, Nicoleta C Arva
INTRODUCTION: Chronic graft failure (CGF) is the leading cause of mortality in pediatric heart transplant (PHT) patients and has multifactorial pathogenesis including cardiac allograft vasculopathy (CAV). CGF can present with microvessel disease (MVD) and myocardial fibrosis on endomyocardial biopsies (EMB). We investigated if CGF due to moderate- severe (M-S) CAV has histopathologic MVD and fibrosis prior to or at the time of CAV diagnosis. METHOD: This retrospective case-control study included PHT with CGF secondary to M-S CAV...
November 25, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36403918/can-transforming-growth-factor-beta-and-downstream-signalers-distinguish-bicuspid-aortic-valve-patients-susceptible-for-future-aortic-complications
#24
EDITORIAL
Nimrat Grewal, Robert Klautz, Robert E Poelmann
Patients with a bicuspid aortic valve have an extreme high risk to develop a thoracic aortic aneurysm and dissection (TAAD). TAADs form a leading cause of death worldwide, with the majority of deaths being preventable if individuals at risk are identified and properly managed. Risk stratification for TAADs in bicuspidy is so far solely based on the aortic diameter. Exclusive use of aortic wall dimension, as in the current guidelines, is however not sufficient in selecting patients vulnerable for future aortic wall complications...
November 17, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36375720/sudden-cardiac-death-in-the-young-a-consensus-statement-on-recommended-practices-for-cardiac-examination-by-the-pathologist-from-the-society-for-cardiovascular-pathology
#25
JOURNAL ARTICLE
Karen L Kelly, Peter T Lin, Cristina Basso, Melanie Bois, L Maximilian Buja, Stephen D Cohle, Giulia d'Amati, Emily Duncanson, John T Fallon, Dennis Firchau, Gregory Fishbein, Carla Giordano, Charles Leduc, Silvio H Litovsky, Shannon Mackey-Bojack, Joseph J Maleszewski, Katarzyna Michaud, Robert F Padera, Stavroula A Papadodima, Sarah Parsons, Stanley J Radio, Stefania Rizzo, Susan J Roe, Maria Romero, Mary N Sheppard, James R Stone, Carmela D Tan, Gaetano Thiene, Allard C van der Wal, John P Veinot
Sudden cardiac death is, by definition, an unexpected, untimely death caused by a cardiac condition in a person with known or unknown heart disease. This major international public health problem accounts for approximately 15-20% of all deaths. Typically more common in older adults with acquired heart disease, SCD also can occur in the young where the cause is more likely to be a genetically transmitted process. As these inherited disease processes can affect multiple family members, it is critical that these deaths are appropriately and thoroughly investigated...
November 11, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36336311/fatal-visceral-larva-migrans-from-toxocara-catis-infection-of-the-heart-and-liver-in-a-child
#26
Cassandra Maria Wygant, Stephen D Cohle
We discuss the pathophysiology and epidemiology of Toxocara catis infection complicated by visceral larval migrans (VLM). We describe a previously healthy 19-month-old white male child found dead in bed by his mother. He had what was thought to be an upper respiratory infection for several days.The child had eosinophilic hepatitis and myocarditis complicating VLM due to Toxocara catis infection from the family cat. We discuss the pathologic and clinical aspects of visceral larval migrans due to of Toxocara catis infection...
November 3, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36334690/systematic-dissection-preservation-and-multiomics-in-whole-human-and-bovine-hearts
#27
JOURNAL ARTICLE
Jesse D Moreira, Adam C Gower, Liying Xue, Yuriy Alekseyev, Karan K Smith, Seung H Choi, Nir Ayalon, Melissa G Farb, Kenneth Tenan, Ashley LeClerc, Daniel Levy, Emelia J Benjamin, Marc E Lenburg, Richard N Mitchell, Robert F Padera, Jessica L Fetterman, Deepa M Gopal
OBJECTIVES: We sought to develop a rigorous, systematic protocol for the dissection and preservation of human hearts for biobanking that expands previous success in postmortem transcriptomics to multiomics from paired tissue. BACKGROUND: Existing cardiac biobanks consist largely of biopsy tissue or explanted hearts in select diseases and are insufficient for correlating whole organ phenotype with clinical data. METHODS: We demonstrate optimal conditions for multiomics interrogation (ribonucleic acid (RNA) sequencing, untargeted metabolomics) in hearts by evaluating the effect of technical variables (storage solution, temperature) and simulated postmortem interval (PMI) on RNA and metabolite stability...
November 2, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/35961503/peri-adventitial-smooth-muscle-inheritance-of-the-iliac-arterial-system
#28
JOURNAL ARTICLE
Rahul Kothari, Pradeep Vaideeswar, Swati Kolhe, Pranita Zare
The histo-morphology of the arterial walls is typically made of 3 distinct layers or tunics designated as intima, media and adventitia. Based on the composition of the media, the arteries are classified into elastic and muscular types. The common iliac artery is an elastic artery, whereas its branches, the external and internal iliac arteries are muscular arteries. In this study, the presence of smooth muscle bundles outside the adventitia was noted in 93 samples taken from the iliac arterial system and the reasons for their presence have been hypothesized...
November 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/35868495/histological-studies-shed-new-light-on-the-initiation-and-characteristics-of-calcification-of-coronary-artery-aneurysms-in-kawasaki-disease
#29
JOURNAL ARTICLE
Yuki Yokouchi, Toshiaki Oharaseki, Nanae Asakawa, Haruki Makino, Kei Takahashi
BACKGROUND: Calcification of coronary artery aneurysms (CAAs) is common in the remote phase of Kawasaki disease (KD), but the detailed features of its development remain unclear. This study aimed to elucidate the histological characteristics of calcification in KD CAAs. MATERIALS AND METHODS: The study materials consisted of 24 coronary artery branches with aneurysms that were obtained from 14 Japanese patients who died during the period from 40 days to 3 years after the onset of KD...
November 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36415008/diagnosing-myocarditis-in-endomyocardial-biopsies-survey-of-current-practice
#30
JOURNAL ARTICLE
Monica De Gaspari, Brandon T Larsen, Giulia d'Amati, Kasey Kreutz, Cristina Basso, Katarzyna Michaud, Marc K Halushka, Chieh-Yu Lin
BACKGROUND: Dallas criteria (DC) and European Society of Cardiology criteria (ESCC) have provided valuable frameworks for the histologic diagnosis and classification of myocarditis in endomyocardial biopsy (EMB) specimens. However, the adaptation and the usage of these criteria are variable and depend on local practice settings and regions/countries. Moreover, several ancillary tests that are not included in the current criteria, such as immunohistochemistry (IHC) or viral polymerase chain reaction (PCR), have proven useful for the diagnosis of myocarditis...
October 29, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36306969/response-to-manion-et-al
#31
LETTER
Dylan V Miller
No abstract text is available yet for this article.
October 25, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36206914/inflammation-and-fibrosis-characterize-different-stages-of-myocardial-remodeling-in-patients-after-stereotactic-body-radiotherapy-of-ventricular-myocardium-for-recurrent-ventricular-tachycardia
#32
JOURNAL ARTICLE
Tomáš Kučera, Kristína Jedličková, Marek Šramko, Petr Peichl, Jakub Cvek, Lukáš Knybel, Pavel Hurník, Radek Neuwirth, Otakar Jiravský, Luděk Voska, Josef Kautzner
We performed a histological and immunohistochemical analysis of myocardia from 3 patients who underwent radiosurgery and died for various reasons 3 months to 9 months after radiotherapy. In Case 1 (death 3 months after radiotherapy) we observed a sharp transition between relatively intact and irradiated regions. In the myolytic foci, only scattered cardiomyocytes were left and the area was infiltrated by immune cells. Using immunohistochemistry we detected numerous inflammatory cells including CD68+/CD11c+ macrophages, CD4+ and CD8+ T-lymphocytes and some scattered CD20+ B-lymphocytes...
October 4, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36202192/response-to-commentary-on-development-of-the-molecular-microscope-mmdx-assay-for-heart-transplant-rejection-surveillance-scvp-journal-club
#33
LETTER
Heather Manion, Chris McCloskey, Pradeep Ramesh, Christopher Lawrence
No abstract text is available yet for this article.
October 3, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36183854/an-unexpected-intracardiac-location-of-yolk-sac-tumor
#34
Kutay Sel, Dursun Alehan, Bilgehan Yalçin, Sevgen Çelik Önder, Hayrettin Hakan Aykan, Canan Akyüz, Rıza Doğan
No abstract text is available yet for this article.
September 29, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36162786/origin-of-the-right-coronary-artery-from-the-left-sinus-of-valsalva-in-a-donor-heart-with-unsuccessful-repair
#35
JOURNAL ARTICLE
William C Roberts, Dan M Meyer
Described herein is a 62-year-old man who had orthotopic heart transplantation (OHT) because of severe heart failure secondary to idiopathic dilated cardiomyopathy. Because of continued symptoms of heart failure, a coronary angiogram was performed 3 years after the OHT and it showed anomalous origin of the right coronary artery (RCA) from the left sinus of Valsalva. As a consequence, an operation was performed to transfer the origin of the RCA to the right sinus of Valsalva. Unfortunately, the lumen of the RCA clotted off shortly after the operative procedure...
September 23, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36155836/apolipoprotein-e-genotypes-were-not-associated-with-intracranial-atherosclerosis-a-population-based-autopsy-study
#36
JOURNAL ARTICLE
Regina Silva Paradela, Daniela Souza Farias-Itao, Renata E P Leite, Carlos A Pasqualucci, Lea T Grinberg, Michel Satya Naslavsky, Mayana Zatz, Ricardo Nitrini, Wilson Jacob-Filho, Claudia Kimie Suemoto
BACKGROUND: Apolipoprotein E gene (APOE) ε4 allele is associated with a higher risk of carotid atherosclerosis, but less is known about the association of APOE with intracranial atherosclerotic disease (IAD). We aimed to investigate the association of APOE alleles with IAD in a cross-sectional autopsy study. METHODS: We measured the stenosis in the 12 arteries of the Circle of Willis using postmortem morphometric measurements. The APOE polymorphism was determined by real-time polymerase chain reaction...
September 22, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36155835/structural-abnormalities-in-the-non-dilated-ascending-aortic-wall-of-bicuspid-aortic-valve-patients
#37
JOURNAL ARTICLE
Nimrat Grewal, Evaldas Girdauskas, Mohammed Idhrees, Bashi Velayudhan, Robert Klautz, Antoine Driessen, Robert E Poelmann
BACKGROUND: A bicuspid aortic valve (BAV) is the most common congenital cardiac malformation. The development of the aortic valve is closely related to the development of the ascending aorta, associated with structural differences in the bicuspid aorta. Here we describe the non-dilated ascending aortic wall in bicuspid aortic valve patients. METHODS: BAV (n=41) and tricuspid aortic valve (TAV) (n=18) non-dilated ascending aortic wall samples were studied. We investigated the following features of the aortic wall: vessel wall thickness, endothelial cell morphology, atherosclerosis, and elastic lamellae organization...
September 22, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36152734/intracardiac-echocardiography-guided-endomyocardial-biopsy-for-the-early-detection-of-giant-cell-myocarditis-causing-recurrent-ventricular-tachycardia
#38
JOURNAL ARTICLE
Pawel Lewandowski, Jerzy Nozynski, Piotr Kulakowski, Jakub Baran
No abstract text is available yet for this article.
September 22, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36122893/myocarditis-in-the-forensic-setting
#39
JOURNAL ARTICLE
Adele Oyarzun, Sarah Parsons, Richard Bassed
Diagnosis of myocarditis as the cause of death in the forensic setting at post-mortem is currently determined by a forensic pathologist. There is no systematic method for diagnosis and thus the determination is subject to inter-observer variability and is often non-reproducible. The primary aim of this study was to investigate the differences in the amount of inflammation between cases where myocarditis was deemed the cause of death, compared to cases where myocardial inflammation was incidentally present at autopsy, but not determined to be the cause of death...
September 16, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/36116635/myocarditis-in-the-forensic-setting-a-review-of-the-literature
#40
REVIEW
Adele Oyarzun, Sarah Parsons, Richard Bassed
Diagnosis of myocarditis as the cause of death at post-mortem is currently determined by a forensic pathologist. There is no systematic method for diagnosis and thus the determination is subject to inter-observer variability and is non-reproducible. Postmortem studies often rely on the clinical method of diagnosis, which is inaccurate. Furthermore, there is no current standardised method of distinguishing between myocarditis as cause of death, and myocardial inflammation as an incidental finding post-mortem...
September 15, 2022: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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