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Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology

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https://read.qxmd.com/read/30772639/description-of-the-aortic-root-anatomy-in-relation-to-transcatheter-aortic-valve-implantation
#1
Arpandeep Randhawa, Tulika Gupta, Parmod Singh, Anjali Aggarwal, Daisy Sahni
INTRODUCTION: Transcatheter aortic valve implantation (TAVI) has emerged as a less invasive treatment than surgical aortic valve replacement in patients with aortic stenosis. Understanding the anatomy of aortic valve complex may help in optimal positioning of prosthetic valve and circumvent complications that can arise during its implantation. MATERIAL AND METHODS: The anatomy of aortic root was studied in 30 formalin-fixed cadavers. Aortic root and left ventricular cavity was opened to measure the diameter at the base of aortic root and sinotubular junction (STJ); distance of coronary ostia from base of aortic root and STJ; height and width of aortic valve leaflets; length and thickness of membranous septum (MS)...
January 21, 2019: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30769235/iatrogenic-embolization-following-cardiac-intervention-postmortem-analysis-of-110-cases
#2
Tyler Bm Hickey, Asaf Honig, Avrum J Ostry, Jason B Chew, James Caldwell, Michael A Seidman, Hamid Masoudi, John A Maguire
INTRODUCTION: Iatrogenic embolization following cardiac investigative procedures may result from hydrophilic polymer emboli (HPE) from catheter valve and vessel wall calcifications, and air embolism from open heart surgery. This retrospective clinical pathologic analysis was undertaken to ascertain the frequency and extent of these potentially fatal complications. METHODS: This retrospective clinical pathologic autopsy analysis with premortem diagnostic imaging correlation identified 110 individuals who had undergone endovascular procedures between 2010 and 2016 within 90 days of death and followed by hospital autopsy...
January 19, 2019: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30739066/arthur-stanley-kent-and-accessory-muscular-atrioventricular-connections
#3
LETTER
Robert H Anderson
No abstract text is available yet for this article.
January 16, 2019: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30731330/intraesophageal-aortopulmonary-collateral-artery-occlusion-in-an-infant-with-tetralogy-of-fallot-and-flow-dependent-major-aortopulmonary-collateral-arteries
#4
Katy L Lawson, Vanessa Wong, J Paul Finn, Gregory A Fishbein
Patients with flow-dependent aortopulmonary collateral arteries often exhibit tenuous clinical statuses. Here we present an infant with Tetralogy of Fallot with pulmonary atresia (TOF-PA) and major aortopulmonary collateral arteries (MAPCAs) who experienced clinically significant oxygen desaturations during feedings. These frequent episodes were attributed to gastroesophageal reflux. In preparation for possible surgical correction of her complex congenital heart condition, she was intubated for a cardiac catheterization to better characterize her anatomy, but terminally decompensated shortly after extubation and restarting feeding...
January 9, 2019: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30763826/cardiac-iron-overload-following-liver-transplantation-in-patients-without-hereditary-hemochromatosis-or-severe-hepatic-iron-deposition
#5
Stavroula Papadodima, Ricard Masia, James R Stone
BACKGROUND: Cardiac iron overload following liver transplantation in patients without hemochromatosis but with severe hepatic iron deposition has been reported to result in heart failure and/or death in case reports and small case series. However, the frequency and causes of cardiac iron overload following liver transplantation and its relationship to cardiac dysfunction in patients without severe hepatic iron deposition are unclear. METHODS: The primary inclusion criteria for this study were liver transplantation followed by autopsy or cardiac transplantation within 1 year...
January 3, 2019: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30684748/eosinophilic-granulomatosis-with-polyangiitis-in-a-continuous-flow-left-ventricular-assist-device-patient-a-case-report-and-review-of-literature
#6
Lydia R Engwenyu, Amanda Tchakarov, Bihong Zhao
Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome (CSS), is a rare autoimmune disease with an estimated incidence of approximately 0.11 to 2.66 new cases per 1 million people per year and an overall prevalence of 10.7 to 14 per 1 million adults [1]. No gender predominance or ethnic predisposition has clearly been demonstrated in CSS [1]. Most of the patients are misdiagnosed over a period of time prior to being correctly classified with the disease. Here, we report the complex case of a 64-year-old African American man with advanced heart failure who received a left ventricular assist device (LVAD) and was subsequently diagnosed with EGPA...
December 28, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30682585/ampanozi-g-krinke-e-laberke-p-schweitzer-w-thali-m-ebert-l-comparing-fist-size-to-heart-size-is-not-a-viable-technique-to-assess-cardiomegaly-cardiovascular-pathology-2018-36-1-5
#7
LETTER
Adegbenro Omotuyi John Fakoya, Deborah Williams, David Adeiza Otohinoyi
No abstract text is available yet for this article.
December 28, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30763825/distinct-molecular-signature-of-phospholamban-p-arg14del-arrhythmogenic-cardiomyopathy
#8
Wouter P Te Rijdt, Angeliki Asimaki, Jan D H Jongbloed, Edgar T Hoorntje, Elisabetta Lazzarini, Paul A van der Zwaag, Rudolf A de Boer, J Peter van Tintelen, Jeffrey E Saffitz, Maarten P van den Berg, Albert J H Suurmeijer
Phospholamban (PLN) p.Arg14del cardiomyopathy is characterized by a distinct arrhythmogenic biventricular phenotype that can be predominantly left ventricular, right ventricular, or both. Our aim was to further elucidate distinct features of this cardiomyopathy with respect to the distribution of desmosomal proteins observed by immunofluorescence (IF) in comparison to desmosomal arrhythmogenic cardiomyopathy and co-existent genetic variants. We studied eight explanted heart specimens from PLN p.Arg14del mutation carriers...
December 21, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30682586/response-to-the-letter-to-the-editor-by-fakoya-et-al
#9
LETTER
Garyfalia Ampanozi, Lars C Ebert, Wolf Schweitzer
No abstract text is available yet for this article.
December 21, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30665185/two-autopsy-cases-of-rupture-of-the-aorta-by-fistula-formation-after-thoracic-endovascular-aortic-repair-and-open-stent-grafting-on-aortic-arch-aneurysm
#10
Shinjiro Mori, Satoko Kimura, Ayako Ro, Akira Hayakawa, Izumi Funakoshi, Tatsushige Fukunaga, Hajime Mizukami
The mortality rate of aortic aneurysm/dissection is low in Japan. Two surgical procedures, the thoracic endovascular aortic repair (TEVAR) and the open stent-grafting have contributed much in survival of such aneurysmal patients. We encountered with two autopsy cases of death by aortic rupture with fistula formation after these procedures. Case 1 is an 85-year-old male who had the history of TEVAR for thoracic aorta aneurysm one and a half year before his death. His endovascular stent-graft was composed of a steel endoskeleton consisting of six Z-shape elements while at autopsy, one of the elements locating at the distal part was found inserted deep into the wall of descending aorta, causing aorto-esophageal fistula...
December 21, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30660869/evaluation-of-cellular-ingrowth-within-porcine-extracellular-matrix-scaffolding-in-congenital-heart-disease-surgery
#11
Jesse L Cox, James M Hammel, Stanley J Radio
The search for an ideal material for cardiac tissue repair has led to utilization of porcine small intestinal submucosa extracellular matrix (CorMatrix). Here, we examine the histologic features of CorMatrix and the associated cellular growth at a variety of time intervals. Tissues with CorMatrix from ten patients (4 male, 6 female) with ages ranging from 2 weeks to 2 years, and implant duration ranging from 1 week to 2 years were included in this study. Samples for analysis were collected at autopsy. Surgical repair sites included great vessel repair (n=9), atrial septum defect (n=1), coronary vessels (n=1), as well as aortic (n=1) and mitral valve (n=2) leaflets...
December 21, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30660022/metakaryotic-cells-linked-to-pediatric-pulmonary-vein-stenosis
#12
Edward C Kirkpatrick, Michael E Mitchell, William G Thilly, Pip Hidestrand, Aoy Tomita-Mitchell, Mats Hidestrand, Elena V Gostjeva
No abstract text is available yet for this article.
December 21, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30616084/increased-mesenchymal-podoplanin-expression-is-associated-with-calcification-in-aortic-valves
#13
Juha Näpänkangas, Pasi Ohtonen, Pauli Ohukainen, Jonna Weisell, Timo Väisänen, Tuomas Peltonen, Panu Taskinen, Jaana Rysä
BACKGROUND AND AIM OF THE STUDY: Calcific aortic valve disease (CAVD) is a progressive disease starting from mild valvular sclerosis and progressing to severe aortic stenosis (AS) with calcified valves. The origin of the calcification is proposed to be mesenchymal cells which have differentiated towards an osteoblastic phenotype. Podoplanin is a glycoprotein expressed in the endothelium of lymphatic vessels and in osteoblasts and osteocytes, mesenchymal cells, as well as in many carcinomas and aortic atherosclerotic lesions...
December 7, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30597423/a-novel-alignment-procedure-to-assess-calcified-coronary-plaques-in-histopathology-post-mortem-computed-tomography-angiography-and-optical-coherence-tomography
#14
REVIEW
Helle Precht, Alexander Broersen, Pieter H Kitslaar, Jouke Dijkstra, Oke Gerke, Jesper Thygesen, Kenneth Egstrup, Peter Mygind Leth, Michael Hardt-Madsen, Bjarne Nielsen, Erling Falk, Jess Lambrechtsen
PURPOSE: Improve mapping and registration of longitudinal view on histopathology vessels in a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses. This new procedure is applied and results shown using calcified coronary plaque analyses within post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and the gold standard of histopathology. RESULTS: In total, 338 annotated histopathology images were included, 166 PMCTA transversal images and 285 OCT images were aligned in the comparison...
December 7, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30623879/congenital-abnormalities-of-the-aortic-arch-revisiting-the-1964-stewart-classification
#15
REVIEW
Shengli Li, Huaxuan Wen, Meiling Liang, Dandan Luo, Yue Qin, Yimei Liao, Shuyuan Ouyang, Jingru Bi, Xiaoxian Tian, Errol R Norwitz, Guoyang Luo
The traditional classification of congenital aortic arch abnormalities was described by James Stewart and colleagues in 1964. Since that time, advances in diagnostic imaging technology have led to better delineation of the vasculature anatomy and the identification of previously unrecognized and unclassified anomalies. In this manuscript, we review the existing literature and propose a series of modifications to the original Stewart classification of congenital aortic arch abnormalities to incorporate this new knowledge...
December 6, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30594732/lysosomal-storage-disorders-affecting-the-heart-a-review
#16
REVIEW
Vidhya Nair, Eric C Belanger, John P Veinot
Lysosomal storage disorders (LSD) comprise a group of diseases caused by a deficiency of lysosomal enzymes, membrane transporters or other proteins involved in lysosomal biology. Lysosomal storage disorders result from an accumulation of specific substrates, due to the inability to break them down. The diseases are classified according to the type of material that is accumulated; for example, lipid storage disorders, mucopolysaccharidoses and glycoproteinoses. Cardiac disease is particularly important in lysosomal glycogen storage diseases (Pompe and Danon disease), mucopolysaccharidoses and in glycosphingolipidoses (Anderson-Fabry disease)...
December 1, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30579128/primary-angiosarcoma-of-the-femoral-artery-in-patient-with-kidney-and-liver-polycystosis-and-multiple-arterial-aneurysms-report-of-the-case-and-review-of-the-literature
#17
Ondrej Fabian, Dana Mokra, Jan Masopust, Jiri Skorepa, Daniela Novakova Kodetova, Josef Zamecnik
The association between kidney and liver polycystosis and arterial aneurysms is well documented. However, it remains unclear whether these patients are at increased risk of malignant transformation. In this article, we describe a case of a primary angiosarcoma of the femoral artery with metastatic spread into the lungs and hilar lymph node arising in a 74-year-old man with kidney and liver polycystosis and multiple arterial aneurysms.
November 30, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30466068/co-2-related-vasoconstriction-superimposed-on-ischemic-medullary-brain-autonomic-nuclei-may-contribute-to-sudden-death
#18
REVIEW
J Howard Jaster, Josef Zamecnik, Aldo Bruno Giannì, Giulia Ottaviani
INTRODUCTION: In 2015, a multinational randomized controlled phase IV clinical trial of adaptive servoventilation for the management of heart failure with central sleep apnea was halted in progress because more patients in the study group were dying than in the control group. One year later, another large clinical trial reported results on the effectiveness of continuous positive airway pressure (CPAP) in preventing sudden death and other cardiovascular events such as heart attack and stroke in patients with preexisting vascular disease as well as obstructive sleep apnea...
January 2019: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30447516/vascular-malformation-in-a-bicuspid-aortic-valve
#19
Paul Cotier, Patrick Bruneval, Kisaki Amemiya
We report here a case of capillary vascular malformation developed in a bicuspid aortic valve incidentally detected during valve replacement in a 67-year-old male patient. The International Society for the Study of Vascular Anomalies (ISSVA) classification was used to classify this vascular lesion instead of using the term hemangioma. The differential diagnosis and the literature are reviewed.
January 2019: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/30428421/morphology-and-mechanisms-of-a-novel-absorbable-polymeric-conduit-in-the-pulmonary-circulation-of-sheep
#20
Marieke Brugmans, Aurélie Serrero, Martijn Cox, Oleg Svanidze, Frederick J Schoen
BACKGROUND: Right ventricular outflow tract (RVOT) conduits used in children with congenital heart disease often degenerate rapidly or develop other complications, and they do not grow with the patient. This leads to multiple surgeries until adult-sized conduits can be implanted. We report experimental in vivo experience with an entirely synthetic absorbable graft, designed to be replaced by tissue in-vivo by host cells, in a process termed Endogenous Tissue Restoration (ETR), and to grow commensurate with somatic growth...
January 2019: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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