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Journals Cardiovascular Pathology : the...

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology

https://read.qxmd.com/read/39025343/descriptive-study-of-the-clinical-and-myocardial-status-of-a-population-with-anatomopathological-aortic-valve-amyloidosis
#1
JOURNAL ARTICLE
Jean-Baptiste Brette, Magali Colombat, Pauline Fournier, Maxime Moninhas, Bertrand Marcheix, Olivier Lairez, Eve Cariou
BACKGROUND: Aortic stenosis (AS) and transthyretin (ATTR) cardiac amyloidosis (CA) share the same clinical profiles and cardiac phenotype. Amyloid deposits have been frequently reported in aortic valves of patients with severe AS referred for surgical aortic valve replacement (SAVR). The aim of this study was to determine the clinical and myocardial status of patients with aortic valve amyloidosis after aortic valve surgery. METHODS AND RESULTS: We performed a retrospective descriptive study of 46 patients who underwent SAVR for severe AS with amyloid deposits upon histological analysis...
July 16, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38996851/current-concepts-in-the-epigenetic-regulation-of-cardiac-fibrosis
#2
REVIEW
Ali Fatehi Hassanabad, Anna N Zarzycki, Vaibhav B Patel, Paul W M Fedak
Cardiac fibrosis is a significant driver of congestive heart failure, a syndrome that continues to affect a growing patient population globally. Cardiac fibrosis results from a constellation of complex processes at the transcription, receptor, and signaling axes levels. Various mediators and signaling cascades, such as the transformation growth factor-beta pathway, have been implicated in the pathophysiology of cardiac tissue fibrosis. Our understanding of these markers and pathways has improved in recent years as more advanced technologies and assays have been developed, allowing for better delineation of the crosstalk between specific factors...
July 10, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38925242/recurrent-cardiac-tamponade-following-coronavirus-disease-2019-mrna-vaccination-correspondence
#3
LETTER
Hinpetch Daungsupawong, Viroj Wiwanitkit
No abstract text is available yet for this article.
June 24, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38906439/exploring-the-role-of-pericardial-mirnas-and-exosomes-in-modulating-cardiac-fibrosis
#4
REVIEW
Friederike I Schoettler, Ali Fatehi Hassanabad, Anshul S Jadli, Vaibhav B Patel, Paul W M Fedak
The potential of the pericardial space as a therapeutic delivery tool for cardiac fibrosis and heart failure (HF) treatment has yet to be elucidated. Recently, miRNAs and exosomes have been discovered to be present in human pericardial fluid (PF). Novel studies have shown characteristic human PF miRNA compositions associated with cardiac diseases and higher miRNA expressions in PF compared to peripheral blood. Five key studies found differentially expressed miRNAs in HF, angina pectoris, aortic stenosis, ventricular tachycardia, and congenital heart diseases with either atrial fibrillation or sinus rhythm...
June 19, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38880163/ultrastructural-cardiac-pathology-the-wide-yet-so-very-small-world-of-cardiac-electron-microscopy
#5
REVIEW
Gregory A Fishbein, Melanie C Bois, Giulia d'Amati, Carolyn Glass, Laura Masuelli, E Rene Rodriguez, Michael A Seidman
Electron microscopy (EM) was a popular diagnostic tool in the 1970s and early 80s. With the adoption of newer, less expensive techniques, such as immunohistochemistry, the role of EM in diagnostic surgical pathology has dwindled substantially. Nowadays, even in academic centers, EM interpretation is relegated to renal pathologists and the handful of (aging) pathologists with experience using the technique. As such, EM interpretation is truly arcane-understood by few and mysterious to many. Nevertheless, there remain situations in which EM is the best or only ancillary test to ascertain a specific diagnosis...
June 14, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38871199/a-challenging-case-of-eosinophilic-myocarditis-leading-to-heart-failure-and-transplantation
#6
JOURNAL ARTICLE
Wissam Harmouch, Jared R Zhang, Joshua M Peterson, Diana Palacio Uran, Louis Maximilian Buja, Bihong Zhao, Paul J Boor, Jose Iturrizaga Murrieta, Khaled Chatila, Heather L Stevenson
The large spectrum of etiologies, severities, and histologic appearances of eosinophilic myocarditis (EoM) poses challenges to its diagnosis and management. Endomyocardial biopsy is the current gold standard for diagnosis. However, cardiovascular magnetic resonance imaging is becoming more frequently used to diagnose acute myocarditis because of enhanced sensitivity when compared to histopathologic examination, and its less invasive nature. We report a complicated case of EoM in a male in his mid-thirties that led to fulminant cardiogenic shock that required immunosuppressive therapy on day 5 of admission and implantation of a left ventricular assist device (LVAD) on day 30...
June 11, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38866089/a-pathological-study-on-the-efficacy-of-syk-inhibitors-in-a-candida-albicans-induced-aortic-root-vasculitis-murine-model
#7
JOURNAL ARTICLE
Nanae Asakawa, Toshiaki Oharaseki, Yuki Yokouchi, Noriko Miura, Naohito Ohno, Kei Takahashi
BACKGROUND: The activation of innate immunity may be involved in the development of Candida albicans-induced murine vasculitis, which resembles Kawasaki disease (KD) vasculitis. This study aimed to histologically clarify the time course of the development of vasculitis in this model in detail and to estimate the potential role of spleen tyrosine kinase (Syk) inhibitors in KD vasculitis. METHODS AND RESULTS: DBA/2 male mice were intraperitoneally injected with a vasculitis-inducing substance and treated with a Syk inhibitor (R788 or GS-9973)...
June 11, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38866090/vascular-calcification-high-incidence-sites-distribution-and-detection
#8
REVIEW
Zebin Gui, Chen Shao, Yuanzi Zhan, Zhongqun Wang, Lihua Li
Vascular calcification is an important pathological change in a variety of disease states such as atherosclerosis (AS), diabetes, chronic kidney disease (CKD), hypertension, and is a strong predictor of cardiovascular events. The distribution and location of calcification in different vessels may have different clinical effects and prognosis. Therefore, the study of high-risk sites of vascular calcification will help us to better understand the prevention, diagnosis and treatment of related diseases, as well as to evaluate the efficacy and prognosis...
June 10, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38866088/recurrent-cardiac-tamponade-following-coronavirus-disease-2019-mrna-vaccination-a-case-report
#9
JOURNAL ARTICLE
Ryo Kaimori, Haruto Nishida, Takaaki Yahiro, Takashi Miura, Takahiro Iwami, Tsutomu Daa
A 64-year-old woman with a history of subarachnoid hemorrhage, breast cancer, cervical spine tumor, and syringomyelia developed recurrent pericardial effusion and cardiac tamponade after receiving the third dose of coronavirus disease 2019 mRNA vaccine, mRNA-1273 (Spikevax, Moderna). The cardiac tamponade of unknown etiology was intractable with nonsteroidal anti-inflammatory drugs, colchicine, and prednisolone. She underwent thoracoscopic pericardiectomy, and microthrombi were detected in the pericardial tissue...
June 10, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38825060/clinicopathological-features-of-immunoglobulin-g4-related-constrictive-pericarditis
#10
JOURNAL ARTICLE
Satomi Kasashima, Yasushi Matsumoto, Atsuhiro Kawashima, Nozomu Kurose, Satoru Ozaki, Hinako Yamamoto, Fuminori Kasashima, Hirofumi Takemura, Hiroko Ikeda
AIM: Constrictive pericarditis (CP) is characterised by scarring fibrosis and a loss of pericardial elasticity, which causes heart failure. IgG4 (immunoglobulin G4)-related disease (IgG4-RD) is a systemic fibro-inflammatory disease characterised by the infiltration of IgG4-immunopositive plasmacytes and high serum IgG4 levels that frequently shape tumorous lesions. Although pericardial involvement of IgG4-RD is rare, with indications of CP, pericardial effusion and irregular masses, the clinical and pathological features remain unclear...
May 31, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38823525/primary-diffuse-large-b-cell-lymphoma-of-the-heart-a-rare-case-of-heart-failure
#11
Mariana Martinho, Liliana Brochado, Bárbara Marques Ferreira, Susana Guimarães, Ana Rita Almeida, Hélder Pereira
A 65-year-old man with previous history of smoking, controlled HIV infection, treated hepatitis B infection, and type III cryoglobulinemia, was admitted due to right heart failure symptoms and significant weight loss. Despite being haemodynamically stable, he had periods of 1:1 conduction atrial flutter and presented with respiratory alkalosis and metabolic acidosis, as well as acute kidney and hepatic dysfunction, elevated D-dimer and cardiac markers. He underwent imaging with chest computed tomography and echocardiogram that confirmed pulmonary embolism and most notably revealed a significant sized cardiac mass causing almost complete obstruction of the right chambers, with no cleavage plane with the myocardial walls and tricuspid valve...
May 30, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38821230/hamartoma-of-mature-cardiac-myocytes-presenting-as-a-polypoid-epicardial-tumor-in-the-interatrial-groove-and-with-gene-fusions-by-copy-number-anomalies-of-chromosome-7
#12
Silvia Planas, Noelia Salvador, Cinzia Lavarino, Flavio Zuccarino, Daniel Pereda, Juan Pablo Muñoz, Esther Aurensanz Clemente
Hamartoma of Mature Cardiac Myocytes (HMCM) is an extremely rare cardiac tumor characterized by benign growth of differentiated mature striated cardiac myocytes, and usually involves the ventricular myocardium. We describe the case of a 15-year-old female who presented with a short history of atrial fibrillation and a polypoid epicardial tumor that was attached to the interatrial groove by a short pedicle. The resected specimen showed features consistent with HMCM. Although these tumors are not associated with any known molecular or cytogenetic abnormalities, we identified fusions transcripts along with complex copy number anomalies of chromosome 7...
May 29, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38815841/glandular-cardiac-myxoma-with-intraepithelial-ductal-neoplasia-features-report-of-the-first-case
#13
E Nardi, V Arena
Cardiac myxoma are the most common primary tumor of the heart in adults. In approximately 2-5%, glandular differentiation occurs within these tumors. In the presence of glandular features attention must be taken to exclude and prevent a misdiagnosis of cardiac metastases of adenocarcinoma. Nevertheless, the localization in the left atrium, the solitary disposition of the cardiac mass, the histological features and the immunohistochemistry performed, argued against the possibility of a metastatic nature of the tumor...
May 28, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38815840/unusual-cardiac-aneurysms-a-surgical-pathology-experience
#14
JOURNAL ARTICLE
Pradeep Vaideeswar, Pranita Zare, Pranav Bhatia
Among the cardiac outpouchings, left ventricular aneurysms or pseudo-aneurysms that develop secondary to myocardial infarctions are the most common. On the other hand, atrial appendageal and valvular aneurysms are uncommon occurrences. The appendageal aneurysms develop possibly due to congenital dysplasia of atrial pectinate muscles, while valvular aneurysms result from infective endocarditis, mechanical injury or degenerative changes. Despite their unusual locations, they are prone to life-threatening complications...
May 28, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38801983/early-rapidly-progressive-vasculopathy-in-a-transplanted-heart-a-possible-complication-of-covid-19
#15
Bryan G Pearson, David H Walker, Alfred S Lea, Wissam Khalife, Karen K Kislingbury, Scott D Lick, Paul J Boor
The epidemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has had a significant global impact, especially on immunosuppressed populations such as heart transplant recipients. While SARS-CoV-2 initially infects the respiratory system, cardiovascular complications induced by coronavirus disease 2019 (COVID-19) include cardiac arrest, myocardial infarction, heart failure, myocarditis, arrhythmia, acute myocyte injury, thrombotic events, and cardiogenic shock. Here, we present a case of a 45-year-old African American male who tested positive for COVID-19 infection six months after receiving a heart transplant...
May 25, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38777138/calcification-and-atheroma-plaques-is-there-any-impact-on-the-anatomical-features-of-the-aortic-root-and-its-elements
#16
JOURNAL ARTICLE
Kader Yılar, Buse Naz Çandır, Ceyhun Küçük, Baha Berk Arpak, Kemal Özdemir, Aysin Kale, Osman Coskun, Özcan Gayretli
OBJECTIVES: Morphometric information of the structures within the borders of the aortic root is a guide for surgical interventions. It is essential to determine the effects of aortic calcification and atheroma plaque findings on the structures of this region. This study aims to establish the normal values of aortic root structures and to investigate the impact of pathologic findings in order to guide diagnosis and treatment in the clinic. METHODS: The aortic root structures were morphometrically analyzed in fresh hearts of 110 patients (89 males, 21 females) brought to the forensic medicine institution...
May 20, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38777137/cardiac-genetic-test-yields-and-genotype-phenotype-correlations-from-large-cohort-investigated-by-medical-examiner-s-office
#17
JOURNAL ARTICLE
Sarah Saxton, Amy R Kontorovich, Dawei Wang, Bo Zhou, Sung Yon Um, Ying Lin, Lisa Rojas, Erin Tyll, Gregory Dickinson, Michelle Stram, Cynthia K Harris, Bruce D Gelb, Barbara A Sampson, Jason Graham, Yingying Tang
BACKGROUND: Few reports describe the yield of postmortem genetic testing from medical examiners' offices or correlate genetic test results with autopsy-confirmed phenotypes from a large cohort. OBJECTIVES: To report results from cardiomyopathy- and cardiac arrhythmia-associated genetic testing in conjunction with autopsy findings of cases investigated at the United States' largest medical examiner office. METHODS: Postmortem cases tested from 2015 to 2022 with a cardiomyopathy- and cardiac arrhythmia-associated gene panel were reviewed...
May 20, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38750778/the-natural-history-of-cvb3-myocarditis-in-c57bl-6j-mice-an-extended-in-depth-characterization
#18
JOURNAL ARTICLE
Kasper Favere, Manon Van Hecke, Sander Eens, Matthias Bosman, Kim Stobbelaar, An Hotterbeekx, Samir Kumar-Singh, Peter L Delputte, Erik Fransen, Johan De Sutter, Pieter-Jan Guns, Tania Roskams, Hein Heidbuchel
BACKGROUND AND AIMS: Viral infections are the leading cause of myocarditis. Besides acute cardiac complications, late-stage sequelae such as myocardial fibrosis may develop, importantly impacting the prognosis. Coxsackievirus B3 (CVB)-induced myocarditis in mice is the most commonly used translational model to study viral myocarditis and has provided the majority of our current understanding of the disease pathophysiology. Nevertheless, the late stages of disease, encompassing fibrogenesis and arrhythmogenesis, have been underappreciated in viral myocarditis research to date...
May 13, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38740356/the-mitochondrial-uncoupler-2-4-dinitrophenol-modulates-inflammatory-and-oxidative-responses-in-trypanosoma-cruzi-induced-acute-myocarditis-in-mice
#19
JOURNAL ARTICLE
José Edson Caetano-da-Silva, Elda Gonçalves-Santos, Elisa L B C Domingues, Ivo S Caldas, Graziela D A Lima, Lívia F Diniz, Reggiani V Gonçalves, Rômulo D Novaes
By uncoupling oxidative phosphorylation, 2,4-dinitrophenol (DNP) attenuates reactive oxygen species (ROS) biosynthesis, which are known to aggravate infectious myocarditis in Chagas disease. Thus, the impact of DNP-based chemotherapy on Trypanosoma cruzi-induced acute myocarditis was investigated. C56BL/6 mice uninfected and infected untreated and treated daily with 100 mg/kg benznidazole (Bz, reference drug), 5 and 10 mg/kg DNP by gavage for 11 days after confirmation of T. cruzi infection were investigated...
May 11, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38703970/the-cardiovascular-pathologist-in-the-aortic-team
#20
REVIEW
Angela Pucci, Martina Rossetti, Chiara Lenzi, L Maximilian Buja
Aortic diseases require a multidisciplinary management for diagnosis, treatment and follow-up with better outcomes in referral centers using a team-based approach. The setting up of a multi-disciplinary aortic team for the discussion of complex cases has been already proposed; it is also supported by the ACC/AHA. Surgeons and radiologists, more or less other physicians such as cardiologists, geneticists, rheumatologists/internal medicine specialists and pathologists are involved into such a team. The role of the cardiovascular pathologist is to examine the aortic specimens, to diagnose and classify the aortic lesions...
May 2, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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