Zhanji Zhao, Jiabing Zhu, Lijian Zhou, Nan Sun, Kaile Chang, Xiaoyue Hu, Yuting Hu, Mingzhi Ren, Yan Cheng, Derong Xu, Hongbo Xin, Chunbo Zhang
Chronic hepatitis B virus (HBV) poses a significant global health challenge as it can lead to acute or chronic liver disease and hepatocellular carcinoma (HCC). To establish a safety experimental model, a homolog of HBV-duck HBV (DHBV) is often used for HBV research. Hydrodynamic-based gene delivery (HGD) is an efficient method to introduce exogenous genes into the liver, making it suitable for basic research. In this study, a duck HGD system was first constructed by injecting the reporter plasmid pLIVE-SEAP via the ankle vein...
March 9, 2024: Transgenic Research