journal
https://read.qxmd.com/read/38131062/abdominal-aortic-occlusion-and-the-inflammatory-effects-in-heart-and-brain
#21
JOURNAL ARTICLE
Jun Xu, Sijie Li, Alexandra Wehbe, Xunming Ji, Yong Yang, Yu Yang, Linhui Qin, Feng-Yong Liu, Yuchuan Ding, Changhong Ren
BACKGROUND: Abdominal aortic occlusion (AAO) occurs frequently and causes ischemia/reperfusion (I/R) injury to distant organs. In this study, we aimed to investigate whether AAO induced I/R injury and subsequent damage in cardiac and neurologic tissue. We also aimed to investigate the how length of ischemic time in AAO influences reactive oxygen species (ROS) production and inflammatory marker levels in the heart, brain, and serum. METHODS: Sixty male C57BL/6 mice were used in this study...
2023: Mediators of Inflammation
https://read.qxmd.com/read/38077228/comparison-of-inflammatory-cytokine-levels-in-hepatic-and-jugular-veins-of-patients-with-cirrhosis
#22
JOURNAL ARTICLE
Leonard Kaps, Carolina Medina-Montano, Matthias Bros, Stephan Grabbe, Simon Johannes Gairing, Eva M Schleicher, Stephan Gehring, Jörn M Schattenberg, Peter R Galle, Marcus-Alexander Wörns, Michael Nagel, Christian Labenz
BACKGROUND: Systemic inflammation with elevated inflammatory cytokines is a hallmark in patients with cirrhosis and the main driver of decompensation. There is insufficient data on whether inflammatory cytokine levels differ between hepatic and jugular veins, which may have implications for further immunological studies. METHODS: Blood from the hepatic and jugular veins of 40 patients with cirrhosis was collected during hepatic venous pressure gradient (HVPG) measurements...
2023: Mediators of Inflammation
https://read.qxmd.com/read/38077227/pan-cancer-analysis-of-the-cuproptosis-related-gene-dld
#23
JOURNAL ARTICLE
Jiahui Lin, Guowei Wang, Sha Cheng, Yanan Hu, Huan Li, Wanjiang Feng, Xiaoming Liu, Canxia Xu
BACKGROUND: Cancer affects millions of people each year and imposes a huge economic and social burden worldwide. Cuproptosis is a recently discovered novel mode of cell death. The exact function of the cuproptosis-related gene dihydrolipoamide dehydrogenase (DLD) and its role in pan-cancer is unknown. METHODS: Data were retrieved from the GTEx, TCGA, and multiple online websites. These data were used to assess the expression, prognosis, and diagnostic value of DLD in various tumors...
2023: Mediators of Inflammation
https://read.qxmd.com/read/38022688/association-between-the-systemic-immune-inflammation-index-and-thyroid-function-in-u-s-adults
#24
JOURNAL ARTICLE
Xin-Yu Hu, Ying-Chao Liang, Huan-Huan Zhang, Hui-Lin Li, De-Liang Liu
BACKGROUND: The systemic immune-inflammation index (SII) is used as an indicator of prognosis for a wide range of diseases. Thyroid function has been found to be strongly associated with inflammation. The purpose of this investigation was to analyze the correlation between SII and various thyroid functions. METHODS: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. The association between SII and thyroid function was analyzed using weighted univariate and multivariate linear regression analyses...
2023: Mediators of Inflammation
https://read.qxmd.com/read/38022687/contribution-of-m5c-rna-modification-related-genes-to-prognosis-and-immunotherapy-prediction-in-patients-with-ovarian-cancer
#25
JOURNAL ARTICLE
Yibin Liu, Shouze Liu, Lu Yan, Qianqian Zhang, Wenhua Liu, Xianghua Huang, Shikai Liu
BACKGROUND: 5-Methylcytosine (m5C) RNA modification is closely implicated in the occurrence of a variety of cancers. Here, we established a novel prognostic signature for ovarian cancer (OC) patients based on m5C RNA modification-related genes and explored the correlation between these genes with the tumor immune microenvironment. METHODS: Methylated-RNA immunoprecipitation sequencing helped us to identify candidate genes related to m5C RNA modification at first...
2023: Mediators of Inflammation
https://read.qxmd.com/read/38022686/rhoa-promotes-synovial-proliferation-and-bone-erosion-in-rheumatoid-arthritis-through-wnt-pcp-pathway
#26
JOURNAL ARTICLE
Ning Chen, Chao-Yue Diao, Xin Huang, Wei-Xing Tan, Ya-Bing Chen, Xin-Yu Qian, Jie Gao, Dong-Bao Zhao
Ras homolog gene family member A (RhoA) plays a major role in the Wnt/planar cell polarity (PCP) pathway, which is significantly activated in patients with rheumatoid arthritis (RA). The function of RhoA in RA synovitis and bone erosion is still elusive. Here, we not only explored the impact of RhoA on the proliferation and invasion of RA fibroblast-like synoviocytes (FLSs) but also elucidated its effect on mouse osteoclast and a mouse model of collagen-induced arthritis (CIA). Results showed that RhoA was overexpressed in RA and CIA synovial tissues...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37954637/jia-wei-kai-xin-san-treatment-alleviated-mild-cognitive-impairment-through-anti-inflammatory-and-antiapoptotic-mechanisms-in-samp8-mice
#27
JOURNAL ARTICLE
Xiaolu Zhang, Yingxin Sun, Qun Yu, Wenyun Zeng, Yue Zhang, Miao Zeng, Kexin Pang, Yifei Yu, Jiali Gan, Huhu Li, Lin Yang, Xijuan Jiang
BACKGROUND: Alleviating mild cognitive impairment (MCI) is crucial to delay the progression of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism of JWKXS in the treatment of MCI is unclear. Thus, this study aimed to investigate the effect and mechanism of JWKXS in SAMP8 mice models of MCI. METHODS: MCI models were established to examine learning and memory ability and explore the pathomechanisms in brain of SAMP8 mice at 4, 6, and 8 months...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37899988/prognostic-value-of-endothelial-progenitor-cells-in-acute-myocardial-infarction-patients
#28
JOURNAL ARTICLE
Gongjie Ye, Xiaodan Chen, Yinchao Zhou, Jianqing Zhou, Yongfei Song, Xiaoyong Yang, Lei Yang
OBJECTIVE: To determine prognostic role of endothelial progenitor cells (EPCs) in intensive care patients with acute myocardial infarction (AMI). MATERIALS AND METHODS: From December 2018 to July 2021, a total of 91 eligible patients with AMI were consecutively examined in a single intensive care unit (ICU) in China. Patients with a history of acute coronary artery disease were excluded from the study. Samples were collected within 24 hr of onset of symptoms...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37885469/ige-immune-complexes-mitigate-eosinophilic-immune-responses-through-nlrc4-inflammasome
#29
JOURNAL ARTICLE
Ece Oylumlu, Goksu Uzel, Lubeyne Durmus, Ceren Ciraci
Immune complexes (ICs) skew immune responses toward either a pro- or anti-inflammatory direction based on the type of stimulation. Immunoglobulin E (IgE) is associated with Th2 immune responses and known to activate innate immune cells. However, roles of antigen (Ag)-specific-IgE ICs in regulating human eosinophil responses remain elusive; therefore, this study builts upon the mechanism of which ovalbumin (Ova)-IgE ICs affects eosinophilic responses utilizing human EoL-1 cell line as a model. Eosinophils are granulocytes functioning through pattern recognition receptors (PRRs) and destructive granule contents in allergic inflammation and parasitic infections...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37868614/amphiregulin-induces-inos-and-cox-2-expression-through-nf-%C3%AE%C2%BA-b-and-mapk-signaling-in-hepatic-inflammation
#30
JOURNAL ARTICLE
Yu Jung Heo, Nami Lee, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim
BACKGROUND: Inflammation is a major cause of hepatic tissue damage and accelerates the progression of nonalcoholic fatty liver disease (NAFLD). Amphiregulin (AREG), an epidermal growth factor receptor ligand, is associated with human liver cirrhosis and hepatocellular carcinoma. We aimed to investigate the effects of AREG on hepatic inflammation during NAFLD progression, in vivo and in vitro . METHODS: AREG gene expression was measured in the liver of mice fed a methionine choline-deficient (MCD) diet for 2 weeks...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37840694/dimethyl-fumarate-protects-against-lipopolysaccharide-lps-induced-sepsis-through-inhibition-of-nf-%C3%AE%C2%BA-b-pathway-in-mice
#31
JOURNAL ARTICLE
He Fang, Xingtong Wang, Mahendra Damarla, Rongju Sun, Qingli He, Ruojing Li, Pengfei Luo, Jun O Liu, Zhaofan Xia
Sepsis is one of the most severe complications and causes of mortality in the clinic. It remains a great challenge with no effective treatment for clinicians worldwide. Inhibiting the release of proinflammatory cytokines during sepsis is considered as an important strategy for treating sepsis and improving survival. In the present study, we have observed the effect of dimethyl fumarate (DMF) on lipopolysaccharide- (LPS-) induced sepsis and investigated the possible mechanism. By screening a subset of the Johns Hopkins Drug Library, we identified DMF as a novel inhibitor of nitric oxide synthesis in LPS-stimulated RAW264...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37830076/retracted-cortical-plasticity-mechanism-and-efficacy-prediction-of-repeated-transcranial-magnetic-stimulation-in-the-treatment-of-depression-with-continuous-short-bursts-of-rapid-pulse-stimulation-ctbs
#32
https://read.qxmd.com/read/37830075/empagliflozin-reverses-oxidized-ldl-induced-reck-suppression-cardiotrophin-1-expression-mmp-activation-and-human-aortic-smooth-muscle-cell-proliferation-and-migration
#33
JOURNAL ARTICLE
Bysani Chandrasekar, Srinivas Mummidi, Vincent G DeMarco, Yusuke Higashi
Persistent oxidative stress and inflammation contribute causally to smooth muscle cell (SMC) proliferation and migration, the characteristic features of vascular proliferative diseases. Oxidatively modified low-density lipoproteins (OxLDL) elevate oxidative stress levels, inflammatory responses, and matrix metallopeptidase (MMP) activation, resulting ultimately in SMC migration, proliferation, and phenotype change. Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a membrane-anchored MMP inhibitor...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37795408/effects-of-omalizumab-on-serum-levels-of-substance-p-calcitonin-gene-related-peptide-neuropeptide-y-and-interleukin-31-in-patients-with-chronic-spontaneous-urticaria
#34
JOURNAL ARTICLE
Cagdas Boyvadoglu, Hasan Ulusal, Seyithan Taysı, Goknur Ozaydin-Yavuz, Ibrahim Halil Yavuz, Pınar Korkmaz, Huseyin Serhat Inaloz
The mechanism of action of omalizumab in urticaria is still not literally known. This study examines the serum values of substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), and interleukin-31 (IL-31) in patients using omalizumab. In this study, 30 patients with chronic spontaneous urticaria (CSU) who were going to be treated with omalizumab and 20 healthy volunteers took part. Demographic data, clinical data, and disease activity scores were noted. For serum SP, CGRP, NPY, and IL-31 values, 10 mL of blood were taken from the patients before starting the treatment, 3 months after the treatment, at the end of the 6th month, and from healthy volunteers all at once...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37789884/betulinic-acid-attenuates-osteoarthritis-via-limiting-nlrp3-inflammasome-activation-to-decrease-interleukin-1-%C3%AE-maturation-and-secretion
#35
JOURNAL ARTICLE
Bo Liu, Yanglin Wu, Ting Liang, Yunlong Zhou, Guangdong Chen, Jiaheng He, Chenchen Ji, Peixin Liu, Chenhui Zhang, Jun Lin, Kece Shi, Zongping Luo, Naicheng Liu, Xinlin Su
INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disorder. Prior studies revealed that activation of NLRP3 inflammasome could promote the activation and secretion of interleukin-1 β (IL-1 β ), which has an adverse effect on the progression of OA. Betulinic acid (BA) is a compound extract of birch, whether it can protect against OA and the mechanisms involved are still unknown. MATERIALS AND METHODS: In vivo experiments, using gait analysis, ELISA, micro-CT, and scanning electron microscopy (SEM), histological staining, immunohistological (IHC) and immunofluorescence (IF) staining, and atomic force microscopy (AFM) to assess OA progression after intraperitoneal injection of 5 and 15 mg/kg BA in an OA mouse model...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37780399/trans-anethole-alleviates-dss-induced-ulcerative-colitis-by-remodeling-the-intestinal-flora-to-regulate-immunity-and-bile-acid-metabolism
#36
JOURNAL ARTICLE
Xu-Hui Li, Li Liu, Wen-Zhong Wu
Ulcerative colitis (UC) is the most common inflammatory bowel disease (IBD); it is incurable, and the treatment is expensive. Trans-anethole (TA), the main component of fennel, exhibits various biological activities. An increasing number of studies have demonstrated the efficacy of herbal active ingredients in the treatment of UC. This study aimed to investigate the effect and mechanism of TA in UC. In this study, we have experimented on mice with dextran sulfate sodium salt (DSS)-induced UC. The TA group was gavaged with 62...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37746550/retracted-efficacy-of-human-recombinant-epidermal-growth-factor-combined-with-povidone-iodine-for-pressure-ulcers-and-its-influence-on-inflammatory-cytokines
#37
Mediators Of Inflammation
[This retracts the article DOI: 10.1155/2022/3878320.].
2023: Mediators of Inflammation
https://read.qxmd.com/read/37736616/bcl-3-promotes-intracerebral-hemorrhage-progression-by-increasing-blood-brain-barrier-permeability-inflammation-and-cell-apoptosis-via-endoplasmic-reticulum-stress
#38
JOURNAL ARTICLE
Hao Yin, Zhongying Ran, Tao Luo, Zexin Jin, Jun Ma
BACKGROUND: Intracerebral hemorrhage (ICH) is among the common types of stroke with high mortality and morbidity. Molecular biomarker selection is crucial for ICH diagnosis and treatment. However, the identification of ICH-related biomarkers remains inadequate. MATERIALS AND METHODS: In vivo and in vitro ICH models were generated and transfected with silenced B-cell lymphoma-3 (BCL-3 and siRNA BCL-3), overexpressed BCL-3, and endoplasmic reticulum stress (ERS) agonist (2-CLHA)...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37731844/increased-expression-of-long-noncoding-rna-loc100506314-in-t-cells-from-patients-with-nonsegmental-vitiligo-and-its-contribution-to-vitiligo-pathogenesis
#39
JOURNAL ARTICLE
Ning-Sheng Lai, Hui-Chun Yu, Hsien-Bin Huang, Hsien-Yu Huang Tseng, Ming-Chi Lu
This study aimed to identify the abnormal expression of long noncoding RNAs (lncRNAs) in T cells from patients with vitiligo and to investigate their functional roles in the immune system. Using microarray analysis, the expression levels of RNA transcripts in T cells from patients with vitiligo and controls were compared. We identified several genes and validated their expression levels in T cells from 41 vitiligo patients and 41 controls. The biological functions of the lncRNAs were studied in a transfection study using an RNA pull-down assay, followed by proteomic analysis and western blotting...
2023: Mediators of Inflammation
https://read.qxmd.com/read/37731843/influence-of-inflammatory-cytokines-il-1-%C3%AE-and-ifn-%C3%AE-on-sarcoplasmic-aggregation-of-p62-and-tdp-43-in-myotubes
#40
JOURNAL ARTICLE
Bryony McCord, Richard M Day
Skeletal muscle of patients with sporadic inclusion body myositis (sIBM) presents with inflammation, including upregulation of inflammatory cytokines such as interferon γ (IFN γ ). Non-inflammatory features are also observed, like the sarcoplasmic accumulation of proteins including TDP-43 and p62. This study aimed to investigate the effect of IFN γ and interleukin 1- β (IL-1 β ) on TDP-43 and p62 aggregation in vitro. Primary human myotubes were treated with IL-1 β (20 ng/mL) and IFN γ (750 ng/mL) separately or combined for 48 hr...
2023: Mediators of Inflammation
journal
journal
31058
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.