Tomotaka Tanabe, Hidemichi Mitome, Katsushiro Miyamoto, Kazuki Akira, Hiroshi Tsujibo, Koji Tomoo, Kenjiro Nagaoka, Tatsuya Funahashi
Siderophores are small-molecule iron chelators produced by many microorganisms that capture and uptake iron from the natural environment and host. Their biosynthesis in microorganisms is generally performed using non-ribosomal peptide synthetase (NRPS) or NRPS-independent siderophore (NIS) enzymes. Vibrio parahaemolyticus secretes its cognate siderophore vibrioferrin under iron-starvation conditions. Vibrioferrin is a dehydrated condensate composed of α-ketoglutarate, L-alanine, aminoethanol, and citrate, and pvsA (the gene encoding the ATP-grasp enzyme), pvsB (the gene encoding the NIS enzyme), pvsD (the gene encoding the NIS enzyme), and pvsE (the gene encoding decarboxylase) are engaged in its biosynthesis...
December 22, 2023: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine