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Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine

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https://read.qxmd.com/read/31011852/safe-coordinated-trafficking-of-heme-and-iron-with-copper-maintain-cell-homeostasis-modules-from-the-hemopexin-system
#1
REVIEW
R Vanacore, J D Eskew, L Sung, T Davis, A Smith
Studies with patients, animal models of human disease and hemopexin null mice have shown that the heme-binding protein hemopexin is vital for the protection of a variety of cell types and tissues against heme toxicity. The presence of hemopexin in all biological fluids examined to date indicates wide roles in abrogating heme toxicity in human tissues; and, thus, is clinically relevant. Heme-hemopexin endocytosis leads to coordinated trafficking of heme, iron and copper as heme traffics from endosomes to heme oxygenases (HOs) in the smooth endoplasmic reticulum and to the nucleus...
April 22, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30941546/exposure-routes-and-health-effects-of-heavy-metals-on-children
#2
REVIEW
Muwaffak Al Osman, Fei Yang, Isaac Yaw Massey
Heavy metals are naturally existing elements that have relatively high atomic weight and a minimum density five times the density of water. Heavy metals have extensive applications in industries, homes, agriculture and medicine, leading to their wide distribution in the environment. Most heavy metals are reported to be highly toxic. They also have numerous exposure routes, including ingestion, inhalation, and dermal absorption, subsequently inducing some health effects resulting from human and heavy metals contact...
April 2, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30923992/the-indispensable-role-of-mammalian-iron-sulfur-proteins-in-function-and-regulation-of-multiple-diverse-metabolic-pathways
#3
REVIEW
Tracey A Rouault
In recent years, iron sulfur (Fe-S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently recognized roles in RNA and DNA metabolism. Fe-S cofactors have often been missed because of their intrinsic lability and oxygen sensitivity. More Fe-S proteins have now been identified owing to detection of their direct interactions with components of the Fe-S biogenesis machinery, and through use of informatics to detect a motif that binds the co-chaperone responsible for transferring nascent Fe-S clusters to domains of recipient proteins...
March 28, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30919118/synthetic-sideromycins-skepticism-and-optimism-selective-generation-of-either-broad-or-narrow-spectrum-gram-negative-antibiotics
#4
Yun-Ming Lin, Manuka Ghosh, Patricia A Miller, Ute Möllmann, Marvin J Miller
New or repurposed antibiotics are desperately needed since bacterial resistance has risen to essentially all of our current antibiotics, and few new antibiotics have been developed over the last several decades. A primary cause of drug resistance is the overuse of antibiotics that can result in alteration of microbial permeability, alteration of drug target binding sites, induction of enzymes that destroy antibiotics (i.e., β-lactamases) and even induction of efflux mechanisms. Research efforts are described that are designed to determine if the known critical dependence of iron assimilation by microbes for growth and virulence can be exploited for the development of new approaches to antibiotic therapy...
March 27, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30911924/staphylococcus-aureus-heme-and-siderophore-iron-acquisition-pathways
#5
Brigid S Conroy, Jason C Grigg, Maxim Kolesnikov, L Daniela Morales, Michael E P Murphy
Staphylococcus aureus is a versatile opportunistic human pathogen. Infection by this bacterium requires uptake of iron from the human host, but iron is highly restricted in this environment. Staphylococcus aureus iron sufficiency is achieved primarily through uptake of heme and high-affinity iron chelators, known as siderophores. Two siderophores (staphyloferrins) are produced and secreted by S. aureus into the extracellular environment to capture iron. Staphylococcus aureus expresses specific uptake systems for staphyloferrins and more general uptake systems for siderophores produced by other microorganisms...
March 25, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30911923/synthesis-structural-elucidation-and-antiradical-activity-of-a-copper-ii-naringenin-complex
#6
Gustavo Celiz, Sebastián A Suarez, Analía Arias, José Molina, Carlos D Brondino, Fabio Doctorovich
Coupling the extraction and derivatization of flavonoids to the Citrus processing industry is attractive from both the environmental and economic points of view. In the present work, the flavonoid naringin, obtained by "green" extraction with a water:ethanol mixture from waste grapefruit industry, was hydrolyzed to obtain naringenin. This flavonoid was used to synthesize the complex trans-di(aqua) bis(7-hydroxy-2-(4-hydroxyphenyl)-4-oxo-5-chromanolato) copper (II). This compound was characterized by spectroscopic techniques (UV/Vis, IR, Raman, NMR and EPR), and by thermal analysis (TG and DSC)...
March 25, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30895493/looking-for-a-partner-ceruloplasmin-in-protein-protein-interactions
#7
REVIEW
Vadim B Vasilyev
Ceruloplasmin (CP) is a mammalian blood plasma ferroxidase. More than 95% of the copper found in plasma is carried by this protein, which is a member of the multicopper oxidase family. Proteins from this group are able to oxidize substrates through the transfer of four electrons to oxygen. The essential role of CP in iron metabolism in humans is particularly evident in the case of loss-of-function mutations in the CP gene resulting in a neurodegenerative syndrome known as aceruloplasminaemia. However, the functions of CP are not limited to the oxidation of ferrous iron to ferric iron, which allows loading of the ferric iron into transferrin and prevents the deleterious reactions of Fenton chemistry...
March 20, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30895492/molecular-structure-of-thermostable-and-zinc-ion-binding-%C3%AE-class-carbonic-anhydrases
#8
Wenming Wang, Yao Zhang, Lele Wang, Qi Jing, Xiaolu Wang, Xiaoli Xi, Xuan Zhao, Hongfei Wang
The γ-class carbonic anhydrases (γ-CAs) mainly come from methanogens methane-producing bacteria that grow in hot springs and catalyze the interconversion of carbon dioxide and water to bicarbonate and protons. Here, the γ-CA from Thermus thermophilus HB8 (γ-TtCA) was expressed and purified, its crystal structure was determined at 2.3 Å resolution in space group P1. The asymmetric unit contains two trimers and six catalytic Zn2+ . In general, the fold of the protein is similar to those of homologous enzymes from Geobacillus Kaustophilus, Bacillus Cereus, Methanosarcina Thermophila and others...
March 20, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30874991/assessment-of-cell-free-levels-of-iron-and-copper-in-patients-with-friedreich-s-ataxia
#9
Deepti Pathak, Achal Kumar Srivastava, Sheffali Gulati, Moganty R Rajeswari
Friedreich's ataxia (FRDA), a progressive neurodegenerative disorder caused by trinucleotide (GAA) repeat expansion in frataxin (fxn) gene which results in decreased levels of frataxin protein. Insufficient frataxin levels leads to iron and copper deposits in the brain and cardiac cells. A total of hundred and twenty patients, suspected of FRDA were screened for the (GAA) repeats in the fxn gene and only confirmed patients (n = 25) were recruited in the study. The total Iron and total copper concentrations were measured in blood plasma using Nitro PAPS and Dibrom PAESA method, respectively both in patients and age, sex matched healthy controls...
March 14, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30847690/imaging-of-changes-in-copper-trafficking-and-redistribution-in-a-mouse-model-of-niemann-pick-c-disease-using-positron-emission-tomography
#10
Julia Baguña Torres, Zilin Yu, Jayanta Bordoloi, Kavitha Sunassee, David Smith, Claire Smith, Oscar Chen, Rupert Purchase, Karin Tuschl, John Spencer, Frances Platt, Philip J Blower
Niemann-Pick C disease (NPC) is an autosomal recessive lysosomal storage disorder resulting from mutations in the NPC1 (95% of cases) or NPC2 genes. Disturbance of copper homeostasis has been reported in NPC1 disease. In this study we have used whole-body positron emission tomography (PET) and brain electronic autoradiography with copper-64 (64 Cu), in the form of the copper(II) bis(thiosemicarbazonato) complex 64 Cu-GTSM, to image short-term changes in copper trafficking after intravenous injection in a transgenic mouse model of NPC1 disease...
March 7, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30810877/highly-conserved-nucleotide-motifs-present-in-the-5-utr-of-the-heme-receptor-gene-shmr-are-required-for-hmup-dependent-expression-of-shmr-in-ensifer-meliloti
#11
Vanesa Amarelle, Uriel Koziol, Elena Fabiano
Heme may represent a major iron-source for bacteria. In the symbiotic nitrogen-fixing bacterium Ensifer meliloti 1021, iron acquisition from heme depends on the outer-membrane heme-receptor ShmR. Expression of shmR gene is repressed by iron in a RirA dependent manner while under iron-limitation its expression requires the small protein HmuP. In this work, we identified highly conserved nucleotide motifs present upstream the shmR gene. These motifs are widely distributed among Alpha and Beta Proteobacteria, and correlate with the presence of HmuP coding sequences in bacterial genomes...
February 27, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30810876/the-anti-bacterial-iron-restriction-defence-mechanisms-of-egg-white-the-potential-role-of-three-lipocalin-like-proteins-in-resistance-against-salmonella
#12
Louis Alex Julien, Florence Baron, Sylvie Bonnassie, Françoise Nau, Catherine Guérin, Sophie Jan, Simon Colin Andrews
Salmonella enterica serovar Enteritidis (SE) is the most frequently-detected Salmonella in foodborne outbreaks in the European Union. Among such outbreaks, egg and egg products were identified as the most common vehicles of infection. Possibly, the major antibacterial property of egg white is iron restriction, which results from the presence of the iron-binding protein, ovotransferrin. To circumvent iron restriction, SE synthesise catecholate siderophores (i.e. enterobactin and salmochelin) that can chelate iron from host iron-binding proteins...
February 27, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30806852/iron-uptake-by-zip8-and-zip14-in-human-proximal-tubular-epithelial-cells
#13
S E G van Raaij, S K S Srai, D W Swinkels, R P L van Swelm
In patients with iron overload disorders, increasing number of reports of renal dysfunction and renal iron deposition support an association between increased iron exposure and renal injury. In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury. However, the mechanisms of tubular iron handling remain elusive. To unravel molecular renal proximal tubular NTBI and TBI handling, human conditionally immortalized proximal tubular epithelial cells (ciPTECs) were incubated with 55 Fe as NTBI and fluorescently labeled holo-transferrin as TBI...
February 26, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30798502/dietary-iron-absorption-during-early-postnatal-life
#14
Sheridan L Helman, Gregory J Anderson, David M Frazer
Inadequate iron levels during early life can have adverse consequences for the developing infant. Iron deficiency during this critical period of growth can affect brain development and cognitive function, problems that can be lifelong despite subsequent correction of the iron deficit. Therefore, it is critical that the suckling infant has sufficient iron for their developmental needs. Much of the iron used in the immediate post-natal period is stored iron that was acquired from the mother in the final trimester of pregnancy, however, despite having low iron levels, breast milk can also make a significant contribution to infant iron needs...
February 23, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30788645/transition-metals-and-host-microbe-interactions-in-the-inflamed-intestine
#15
Wenhan Zhu, Luisella Spiga, Sebastian Winter
Host-associated microbial communities provide critical functions for their hosts. Transition metals are essential for both the mammalian host and the majority of commensal bacteria. As such, access to transition metals is an important component of host-microbe interactions in the gastrointestinal tract. In mammals, transition metal ions are often sequestered by metal binding proteins to limit microbial access under homeostatic conditions. In response to invading pathogens, the mammalian host further decreases availability of these micronutrients by regulating their trafficking or releasing high-affinity metal chelating proteins, a process termed nutritional immunity...
February 20, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30758762/complex-formation-between-the-escherichia-coli-nife-hydrogenase-nickel-maturation-factors
#16
Mozhgan Khorasani-Motlagh, Meissam Noroozifar, Kagan Kerman, Deborah B Zamble
The biosynthesis of the dinuclear metal cluster at the active sites of the [NiFe]-hydrogenase enzymes is a multi-step process executed by a suite of accessory proteins. Nickel insertion during maturation of Escherichia coli [NiFe]-hydrogenase 3 is achieved by the metallochaperones HypA, SlyD and the GTPase HypB, but how these proteins cooperate to ensure nickel delivery is not known. In this study, the complexes formed between the individual purified proteins were examined by using several methods. Size exclusion chromatography (SEC) indicated that SlyD and HypB interact primarily in a 1:1 complex...
February 13, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30756218/an-engineered-gfp-fluorescent-bacterial-biosensor-for-detecting-and-quantifying-silver-and-copper-ions
#17
Adam Radek Martinez, John R Heil, Trevor C Charles
Presented here are two engineered bacterial biosensors for detecting and quantifying silver and copper ions. The biosensors contain a silver/copper resistance operon and a Green Fluorescent Protein gene that is strictly regulated through silver activated promoter regions normally found on a silver resistance gene (sil operon). The two biosensors efficiently detected silver and copper concentrations of 40 µM-300 µM and 20 µM-600 µM respectively. A strong correlation (R2  = 0.90 or above) between silver/copper and GFP signal makes it possible to quantify the ions using a linear regression...
February 13, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30756217/an-h-ferritin-from-the-hydrothermal-vent-shrimp-rimicaris-exoculata-and-its-potential-role-in-iron-metabolism
#18
Xiao-Li Liu, Sen Ye, Hua-Wei Li, Bo Lu, Yan-Qin Yu, Yu-Peng Fan, Wei-Jun Yang, Jin-Shu Yang
Rimicaris exoculata (Decapoda: Bresiliidae) is one of the dominant species among hydrothermal vent communities along the Mid-Atlantic Ridge. This shrimp can tolerate high concentrations of heavy metals such as iron, but the mechanisms used for detoxification and utilization of excess metals remain largely unknown. Ferritin is a major iron storage protein in most living organisms. The central heavy subunit of ferritin (H-ferritin) possesses ferroxidase activity and converts iron from Fe2+ to Fe3+ , the non-toxic form used for storage...
February 12, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30739301/profiling-of-nuclear-copper-binding-proteins-under-hypoxic-condition
#19
Haiying Fu, Xueqin Ding, Wenjing Zhang, Y James Kang
Under hypoxic condition, copper (Cu) accumulates in cell nuclei, and regulates the activity of hypoxia-inducible factor-1 (HIF-1) through Cu-binding proteins (CuBPs). To understand the CuBPs in the nucleus, proteomic approach was undertaken to explore the dynamic changes of the CuBPs in response to hypoxia. Human umbilical vein endothelial cells (HUVECs) were treated with dimethyloxalylglycine in a final concentration of 100 μM for 4 h to induce hypoxia, resulting in the accumulation of HIF-1α and Cu in the nucleus...
February 9, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30706282/purification-and-characterization-of-campylobacter-jejuni-ferric-uptake-regulator
#20
Sabina Sarvan, Allison Yeung, François Charih, Alain Stintzi, Jean-François Couture
The ferric uptake regulator (Fur) is a superfamily of transcription factors found in bacteria which control the expression of a myriad of genes. In this study, we report a simple protocol for the purification of recombinant untagged Campylobacter jejuni Fur (CjFur). CjFur was isolated using a combination of three ion exchange chromatography steps followed by size exclusion chromatography on a Superdex 75. ESI-MS analysis shows that our method yields pure CjFur and that this tag-free version incorporates metal more efficiently than recombinant CjFur harboring a tag or tag remnants...
January 31, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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