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Journals Pharmacoepidemiology and Drug ...

Pharmacoepidemiology and Drug Safety

https://read.qxmd.com/read/38362651/letter-to-the-editor-re-davis-et-al-2023-belpreg-the-first-of-its-kind-real-world-data-source-on-medication-use-in-pregnancy-in-belgium
#21
LETTER
Michael Ceulemans, Laure Sillis, Karel Allegaert, Annick Bogaerts, Maarten De Vos, Titia Hompes, Anne Smits, Kristel Van Calsteren, Jan Y Verbakel, Veerle Foulon
No abstract text is available yet for this article.
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38362650/identification-of-misclassified-pregnancy-episodes-in-women-of-childbearing-potential-exposed-to-drugs-with-known-teratogenic-potential-in-the-cprd-gold-pregnancy-register
#22
LETTER
Christopher Lee, Silvia Rizzi, Ana Luiza Bierrenbach, Luis Antunes, Niina-Maria Nissinen, Olga Rocha, Jennifer Campbell, Caroline Minassian, Susan Hodgson, Anne Broe
No abstract text is available yet for this article.
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38362649/probabilistic-precision-calculations-for-the-planning-of-studies-assessing-negative-binomial-rates
#23
JOURNAL ARTICLE
Jonatan Hedberg, Stefan Franzén
PURPOSE: Outcome variables that are assumed to follow a negative binomial distribution are frequently used in both clinical and epidemiological studies. Epidemiological studies, particularly those performed by pharmaceutical companies often aim to describe a population rather than compare treatments. Such descriptive studies are often analysed using confidence intervals. While precision calculations and sample size calculations are not always performed in these settings, they have the important role of setting expectations of what results the study may generate...
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38362648/adherence-to-prescription-proton-pump-inhibitor-therapy-amongst-individuals-diagnosed-with-barrett-s-esophagus
#24
JOURNAL ARTICLE
Charles E Gaber, Abdullah I Abdelaziz, Jyotirmoy Sarker, Jennifer L Lund, Evan S Dellon, Cary C Cotton, Swathi Eluri, Nicholas J Shaheen
INTRODUCTION: In the United States, clinical guidelines recommend daily use of proton pump inhibitors (PPIs) amongst individuals diagnosed with Barrett's esophagus to decrease the risk of progression to dysplasia and neoplasia. Prior studies documenting adherence to PPIs in this population have not characterized heterogeneity in adherence patterns. Factors that may relate to adherence are incompletely described. METHODS: We used administrative claims data from the Merative MarketScan Commercial Claims and Encounters database to conduct a retrospective study of adherence to prescription PPIs...
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38357842/identifying-high-risk-medications-and-error-types-in-danish-patient-safety-database-using-disproportionality-analysis
#25
JOURNAL ARTICLE
Olga Tchijevitch, Søren F Birkeland, Søren B Bogh, Jesper Hallas
BACKGROUND: Medication error (ME) surveillance in Danish healthcare relies on the mandatory national incident reporting system, the Danish Patient Safety Database (DPSD). Individual case reviews and descriptive statistics with frequency counts are the most often used approaches when analyzing MEs in incident reporting systems, including the DPSD. However, incident reporting systems often generate a large number of reports and may suffer from underreporting; consequently, additional approaches are needed to overcome these challenges...
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38357834/where-are-the-data-to-assess-the-safety-of-paternal-drug-exposure-a-systematic-review-of-secondary-databases-a-contribution-from-imi-conception
#26
REVIEW
Sneha Gaitonde, Yola Moride, Elizabeth Suarez, Sandra Lopez-Leon
BACKGROUND: Most studies assessing the safety of parental drug exposures during pregnancy and around the time of conception describe the effects of maternal exposure. Recent publications have raised awareness of the need for additional research regarding the safety of paternal drug exposures on pregnancy outcomes. OBJECTIVES: To identify and describe studies that use secondary databases in paternal drug safety studies and to describe the secondary databases that were used...
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38357824/pain-related-hospitalization-and-emergency-room-visit-following-initial-analgesic-prescription-after-outpatient-surgery
#27
JOURNAL ARTICLE
Abhishek A Nair, Jennifer L Placencia, Harold J Farber, Rajender R Aparasu, Michael Johnson, Hua Chen
PURPOSE: Our study examined the association between outpatient postsurgical analgesic prescription and risk of insufficiently managed pain characterized by pain-associated hospital admission and emergency room (ER) visit. METHODS: Eligible individuals were children 1-17 years of age who filled an incident analgesic following an outpatient surgery during 2013-2018. Pain-associated hospital admission or ER visit were measured within 30 days following the outpatient surgical procedure...
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38357810/using-machine-learning-to-predict-the-bleeding-risk-for-patients-with-cardiac-valve-replacement-treated-with-warfarin-in-hospitalized
#28
JOURNAL ARTICLE
Yixing Hu, Xuemeng Zhang, Meng Wei, Tongtong Yang, Jinjin Chen, Xia Wu, Yifan Zhu, Xin Chen, Sheng Lou, Junrong Zhu
BACKGROUND: Distinguishing warfarin-related bleeding risk at the bedside remains challenging. Studies indicate that warfarin therapy should be suspended when international normalized ratio (INR) ≥ 4.5, or it may sharply increase the risk of bleeding. We aim to develop and validate a model to predict the high bleeding risk in valve replacement patients during hospitalization. METHOD: Cardiac valve replacement patients from January 2016 to December 2021 across Nanjing First Hospital were collected...
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38357800/self-harm-by-single-and-multi-agent-medication-poisoning-in-a-retrospective-analysis-of-a-poison-control-center-database-from-january-2018-to-december-2022
#29
JOURNAL ARTICLE
Michele Stanislaw Milella, Luisa Petraccia, Francesca Pirelli, Giuseppe Foti, Maria Sapio, Rosaria Berardi, Daniele Caprioli, Francesco Pugliese, Gabriella Vivino
PURPOSE: Medication poisoning is the most common method of self-harm. Longitudinal studies incorporating pre- and post-COVID-19 pandemic data are required to describe the phenomenon and to evaluate the long-term impact on mental health. METHODS: Calls to the Poison Control Center of Policlinico Umberto I Hospital - Sapienza University of Rome, Italy, were analyzed retrospectively for characteristics and clinical presentation of cases of interest from January 2018 to December 2022...
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38357780/patterns-of-filled-prescriptions-and-the-association-with-risk-of-drug-induced-death-a-population-based-nested-case-control-register-study
#30
JOURNAL ARTICLE
Ellen J Amundsen, Ingvild Odsbu, Svetlana O Skurtveit, Linn Gjersing
PURPOSE: Opioid analgesics (OA) and other pharmaceuticals have been associated with drug-induced deaths. However, there is a lack of knowledge regarding patterns of use of these pharmaceuticals in the population and regarding such associations. We identify and describe subgroups of people with different patterns of filled prescriptions of OA and other relevant pharmaceuticals and examine associations with drug-induced deaths. In addition, we estimate the proportion of drug-induced deaths with a filled OA prescription and OA as cause of death...
February 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38158381/descriptive-analysis-on-disproportionate-medication-errors-and-associated-patient-characteristics-in-the-food-and-drug-administration-s-adverse-event-reporting-system
#31
JOURNAL ARTICLE
Victor Pera, Frauke van Vaerenbergh, Jan A Kors, Erik M van Mulligen, Rowan Parry, Marcel de Wilde, Lies Lahousse, Johan van der Lei, Peter R Rijnbeek, Katia M C Verhamme
BACKGROUND: Medication errors (MEs) are a major public health concern which can cause harm and financial burden within the healthcare system. Characterizing MEs is crucial to develop strategies to mitigate MEs in the future. OBJECTIVES: To characterize ME-associated reports, and investigate signals of disproportionate reporting (SDRs) on MEs in the Food and Drug Administration's Adverse Event Reporting System (FAERS). METHODS: FAERS data from 2004 to 2020 was used...
January 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38112272/extracting-forced-vital-capacity-from-the-electronic-health-record-through-natural-language-processing-in-rheumatoid-arthritis-associated-interstitial-lung-disease
#32
JOURNAL ARTICLE
Bryant R England, Punyasha Roul, Yangyuna Yang, Daniel Hershberger, Harlan Sayles, Jorge Rojas, Grant W Cannon, Brian C Sauer, Jeffrey R Curtis, Joshua F Baker, Ted R Mikuls
PURPOSE: To develop a natural language processing (NLP) tool to extract forced vital capacity (FVC) values from electronic health record (EHR) notes in patients with rheumatoid arthritis-interstitial lung disease (RA-ILD). METHODS: We selected RA-ILD patients (n = 7485) in the Veterans Health Administration (VA) between 2000 and 2020 using validated ICD-9/10 codes. We identified numeric values in proximity to FVC string patterns from clinical notes in the EHR...
January 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38014926/adherence-to-riluzole-therapy-in-patients-with-amyotrophic-lateral-sclerosis-in-three-italian-regions-the-caesar-study
#33
JOURNAL ARTICLE
Sabrina Giometto, Marco Finocchietti, Olga Paoletti, Niccolò Lombardi, Maria Grazia Celani, Francesco Sciancalepore, Ersilia Lucenteforte, Ursula Kirchmayer
PURPOSE: Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease. Riluzole may increase survival and delay the need for mechanical ventilation. The CAESAR project ('Comparative evaluation of the efficacy and safety of drugs used in rare neuromuscular and neurodegenerative diseases', FV AIFA project 2012-2013-2014) involves evaluating prescribing patterns, and analysing effectiveness and comparative safety of drugs, in patients with neurodegenerative diseases. The aim of this study is to evaluate adherence to riluzole in patients with ALS during the first year of use, identifying adherence clusters...
January 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38011912/risk-of-ischemic-stroke-associated-with-direct-oral-anticoagulants-discontinuation-on-patients-with-non-valvular-atrial-fibrillation
#34
JOURNAL ARTICLE
T Álvaro Thomsen, J Mesa Guadalupe, C Huerta, A de Burgos, L Cea Soriano
INTRODUCTION: Although direct oral anticoagulants' (DOACs) prescriptions have experienced immense growth in the last decade, the proportion of discontinuers is still common yielding an increased risk of ischemic stroke (IS) onset. AIMS: We aimed to estimate the association between DOACs discontinuation and risk of IS among patients with non-valvular atrial fibrillation (NVAF). METHODS: We used data from a cohort of new DOACs users, followed patients from the first DOAC prescription date up to IS (index date) and conducted a nested case-control analysis using conditional logistic regression...
January 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/37974394/drug-induced-orthostatic-hypotension-cluster-analysis-of-co-prescription-patterns-in-older-people-in-uk-primary-care
#35
JOURNAL ARTICLE
Cini Bhanu, Irene Petersen, Mine Orlu, Daniel Davis, Reecha Sofat, Juan Carlos Bazo-Alvarez, Kate Walters
PURPOSE: Over 250 medications are reported to cause orthostatic hypotension, associated with serious adverse outcomes in older adults. Studies suggest a harmful cumulative risk of orthostatic hypotension with multiple medication use. However, there is limited evidence on the potential for harm in practice, particularly which drugs is co-prescribed and may increase risk of orthostatic hypotension. METHODS: Retrospective cohort study and cluster analysis using general practice data from IQVIA Medical Research Data (IMRD) in patients aged ≥50 contributing data between 1 January 2018 and 31 December 2018...
January 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/37800356/trajectories-of-opioid-consumption-as-predictors-of-patient-reported-outcomes-among-individuals-attending-multidisciplinary-pain-treatment-clinics
#36
JOURNAL ARTICLE
Adriana Angarita-Fonseca, Anaïs Lacasse, Manon Choinière, Jean-Luc Kaboré, Marie-Pierre Sylvestre, Gillis Delmas Tchouangue Dinkou, Julie Bruneau, Marc O Martel, Richard Hovey, Aude Motulsky, Elham Rahme, M Gabrielle Pagé
PURPOSE: This study aimed to identify opioid consumption trajectories among persons living with chronic pain (CP) and put them in relation to patient-reported outcomes 6 months after initiating multidisciplinary pain treatment. METHODS: This study used data from the Quebec Pain Registry (2008-2014) linked to longitudinal Quebec health insurance databases. We included adults diagnosed with CP and covered by the Quebec public prescription drug insurance plan. The daily cumulative opioid doses in the first 6 months after initiating multidisciplinary pain treatment were transformed into morphine milligram equivalents...
January 2024: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38158387/the-marked-oscillatory-pattern-in-prescription-opioid-utilization-in-canada-since-2000-selected-observations-and-questions-for-outcomes-and-policy
#37
JOURNAL ARTICLE
Benedikt Fischer, Tessa Robinson
No abstract text is available yet for this article.
December 29, 2023: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38156547/use-of-pembrolizumab-among-older-adults-with-cancer-in-the-united-states-before-and-after-fda-approval-of-its-tumor-agnostic-indication
#38
JOURNAL ARTICLE
Yoon Duk Hong, Lindsey Enewold, Michael T Halpern, Chris Zeruto, Angela B Mariotto
INTRODUCTION: Pembrolizumab, an anticancer immunotherapy agent, has received multiple approvals since its first approval by the U.S. Food and Drug Administration (FDA) in 2014. Limited data exist on its real-world use and shifts post tumor-agnostic approval in 2017 for the treatment of patients with any microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) solid tumors. This study analyzes pembrolizumab's pre and post-tumor-agnostic approval use among older U.S. adults, revealing its evolving role in oncology practice...
December 29, 2023: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38151485/assessing-cumulative-effects-of-medication-use-new-insights-and-new-challenges
#39
JOURNAL ARTICLE
Michal Abrahamowicz
No abstract text is available yet for this article.
December 27, 2023: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/38126218/new-antipsychotic-prescription-and-recurrent-infections-among-adult-sepsis-survivors-a-population-based-cohort-study
#40
JOURNAL ARTICLE
Augusto Ferraris, Alejandro G Szmulewicz, Lisa Burry, Amanda Phipps, Hannah Wunsch, Damon C Scales, Federico Angriman
PURPOSE: Antipsychotic agents, which may increase the risk of infection through dopaminergic dysregulation, are prescribed to a fraction of patients following critical illness. We compared the rate of recurrent sepsis among patients who filled a prescription for antipsychotics with high- or low-D2 affinity. METHODS: Population-based cohort with active comparator design. We included sepsis survivors older than 65 years with intensive care unit admission and new prescription of antipsychotics in Ontario 2008-2019...
December 21, 2023: Pharmacoepidemiology and Drug Safety
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