Journals Journal of Assisted Reproducti...

Journal of Assisted Reproduction and Genetics
Persefoni Fragkiadaki, Elisavet Kouvidi, Anna Angelaki, Dimitra Nikolopoulou, Elena Vakonaki, Aristidis Tsatsakis
The current article is a literature review aiming to provide an overview of the existing knowledge on the association between telomere length and telomerase activity and in vitro fertilization. Recently, telomeres have been used as an effective biomarker to determine biological age, which may differ from chronological age due to genetic, lifestyle, and environmental factors. Cellular senescence, along with other exogenous and mainly environmental factors, can enhance telomere wear, further shortening their ends and may also affect reproductive aging...
May 2, 2024: Journal of Assisted Reproduction and Genetics
Xiyan Zhang, Ling Wang, Tongkun Yang, Li Kong, Luxiao Wei, Jing Du
PURPOSE: With advances in immunology, increasing evidence suggests that immunity is involved in premature ovarian insufficiency (POI) pathogenesis. This study investigated the roles of immune checkpoint genes and immune cell infiltration in POI pathogenesis and development. METHODS: The GSE39501 dataset and immune checkpoint genes were obtained from the Gene Expression Omnibus database and related literature. The two datasets were intersected to obtain immune checkpoint-related differentially expressed genes (ICRDEGs), which were analyzed using Gene Ontology and Kyoto Encyclopedia of Gene and Genomes enrichment analysis, weighted correlation network analysis, protein-protein interaction and related microRNAs, transcription factors, and RNA binding proteins...
May 2, 2024: Journal of Assisted Reproduction and Genetics
Alyssa Hochberg, Mohammed S Bazarah, Haitham A Baghlaf, Ahmad M Badeghiesh, Michael H Dahan
PURPOSE: To examine the effect of bariatric surgery (BS) on obstetric and neonatal outcomes in patients with polycystic ovary syndrome (PCOS). METHODS: A retrospective population-based cohort study utilizing the Healthcare Cost and Utilization Project Nationwide Inpatient Sample database, including women who delivered in the third trimester or had a maternal death in the USA (2004-2014). We compared obstetric and neonatal outcomes between groups in three analyses: (1) Primary analysis-women with an ICD-9 PCOS diagnosis who underwent BS compared to pregnant PCOS patients without BS...
April 30, 2024: Journal of Assisted Reproduction and Genetics
Xiao Liu, Qiling Wang, Huiqiang Sheng, Xiaowei Liang, Zhiqiang Wang, Tianqing Meng, Yushan Li, Hao Dong, Wenbing Zhu, Jigao Yang, Zhou Zhang, Xianglong Jiang, Aiping Zhang, Zuowen Liang, Xiaojin He, Chunying Song, Fuping Li, Xinzong Zhang
PURPOSE: Male cancer survivors experience confusion about fertility following cancer treatment. The aims of this study were to evaluate survivors' semen quality in different tumor type groups in China and to analyze the current situation and challenges of male cancer patients with sperm cryopreservation. METHODS: This was a multicenter retrospective study of male patients with cancer who underwent sperm cryopreservation in 16 regions of the national sperm banks over an 11-year period from 2010 to 2020...
April 27, 2024: Journal of Assisted Reproduction and Genetics
Jose Metello, Claudia Tomás, Pedro Ferreira, Isabel Natário, Samuel Santos-Ribeiro
PURPOSE: This study aims to evaluate whether the clinical outcomes of cycles with frozen embryo transfer (FET) in hormonal replacement treatment supplemented with dydrogesterone (DYD) following detection of low circulating levels of progesterone (P4) were comparable to the results of cycles with otherwise normal serum P4 values. METHODS: Extended analyses of a retrospective cohort that included FET cycles performed between July 2019 and March 2022 after a cycle of artificial endometrial preparation using valerate-estradiol and micronized vaginal P4 (400 mg twice daily)...
April 27, 2024: Journal of Assisted Reproduction and Genetics
Yang Xuan, Yue Duan
In a recent journal article, Chen et al. identified a germ cell-specific cofactor, STYXL1, associated with male fertility function. Deletion of STYXL1 prevents the LEGO player CCT complex from properly folding key microtubule proteins of the sperm flagellum, which affects sperm motility and male fertility function.
April 27, 2024: Journal of Assisted Reproduction and Genetics
Yu Qin, Koksear Touch, Menghan Sha, Yanan Sun, Shunran Zhang, Jianli Wu, Yuanyuan Wu, Ling Feng, Suhua Chen, Juan Xiao
PURPOSE: This study aimed to investigate the correlation between chromosomal abnormalities in spontaneous abortion with clinical features and seek copy number variations (CNVs) and genes that might be connected to spontaneous abortion. METHODS: Over 7 years, we used CNV-seq and STR analysis to study POCs, comparing chromosomal abnormalities with clinical features and identifying critical CNVs and genes associated with spontaneous abortion. RESULTS: Total chromosomal variants in the POCs were identified in 66...
April 26, 2024: Journal of Assisted Reproduction and Genetics
Li Yu, Chen Wang, Miao Liu, Lingjin Xia, Te Liu, Qi Che, Wei Cai, Xi Dong, Baishen Pan, Beili Wang, Suying Liu, Wei Guo
OBJECTIVE: Women who are of reproductive age can suffer from polycystic ovary syndrome (PCOS), an endocrine disorder. Anovulatory infertility is mostly caused by aberrant follicular development, which is seen in PCOS patients. Due to the dysfunction of reproductive and endocrine function in PCOS patients, assisted reproduction treatment is one of the main means to obtain clinical pregnancy for PCOS patients. Long non-coding RNA (lncRNA) as a group of functional RNA molecules have been found to participate in the regulation of oocyte function, hormone metabolism, and proliferation and apoptosis of granulosa cells...
April 24, 2024: Journal of Assisted Reproduction and Genetics
Goli Ardestani, Marion Martins, Olcay Ocali, Tim H Sanchez, Colwyn Gulliford, C Brent Barrett, Denny Sakkas
PURPOSE: This study is aiming to test whether variation in post warming culture time impacts blastocyst metabolism or pregnancy outcome. METHODS: In this single center retrospective cohort study, outcomes of 11,520 single frozen embryo transfer (FET) cycles were analyzed from January 2015 to December 2020. Patient treatments included both natural and programmed cycles. Time categories were determined using the time between blastocyst warming and embryo transfer: 0 (0- <1h), 1 (1-<2h), 2 (2-<3h), 3(3-<4h), 4 (4-<5), 5 (5-<6), 6 (6-<7) and 7 (7-8h)...
April 20, 2024: Journal of Assisted Reproduction and Genetics
Pavan Gill, Nicolas Garrido Puchalt, Thomas Molinaro, Marie Werner, Emre Seli, James Hotaling, Philip Cheng
PURPOSE: To investigate whether leukocytospermia (defined as the presence of ≥ 1 × 106 white blood cells/mL) affects clinical and embryologic outcomes in in vitro fertilization (IVF) cycles with intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A). METHODS: This was a retrospective cohort study including 5425 cycles between January 2012 to December 2021 at a single large university-affiliated fertility clinic...
April 20, 2024: Journal of Assisted Reproduction and Genetics
Silvia Madritsch, Vivienne Arnold, Martha Haider, Julia Bosenge, Mateja Pfeifer, Beatrix Weil, Manuela Zechmeister, Markus Hengstschläger, Jürgen Neesen, Franco Laccone
PURPOSE: Various screening techniques have been developed for preimplantation genetic testing for aneuploidy (PGT-A) to reduce implantation failure and miscarriages in women undergoing in vitro fertilisation (IVF) treatment. Among these methods, the Oxford nanopore technology (ONT) has already been tested in several tissues. However, no studies have applied ONT to polar bodies, a cellular material that is less restrictively regulated for PGT-A in some countries. METHODS: We performed rapid short nanopore sequencing on pooled first and second polar bodies of 102 oocytes from women undergoing IVF treatment to screen for aneuploidy...
April 20, 2024: Journal of Assisted Reproduction and Genetics
Ludovico Muzii, Giulia Galati, Ilenia La Barbiera, Antonella Linari, Oriana Capri, Daniela Pietrangeli, Edgardo Somigliana
PURPOSE: Failure to collect oocytes at the time of oocyte pick-up is an unfavorable outcome of in vitro fertilization (IVF) cycles. In these cases, prompt intrauterine insemination (IUI) could be an option (rescue IUI), but this possibility has been poorly studied. METHODS: Rescue IUI is routinely offered in our unit in women failing to retrieve oocytes, provided that they have at least one patent tube, normal male semen analysis, and the total number of developed follicles is ≤ 3...
April 18, 2024: Journal of Assisted Reproduction and Genetics
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No abstract text is available yet for this article.
April 18, 2024: Journal of Assisted Reproduction and Genetics
Jillian Pecoriello, Anna- Grace Lilly, Dona Jalili, Clarisa Mendoza, Gwendolyn P Quinn, Christina A Penfield
PURPOSE: The purpose of this narrative review was to assess the limited literature on fetal anomalies diagnosed in the second trimester of pregnancy and parental decision-making and identify sources of information deemed as facilitators and barriers to medical decisions. METHODS: This was a literature review of source material and information about fetal anomalies diagnosed in the second trimester of pregnancy, decision-making, decision tools or aids, and sources of information for anomalies...
April 17, 2024: Journal of Assisted Reproduction and Genetics
Myriam Safrai, Kyle E Orwig
PURPOSE: To evaluate the ability of ChatGPT-4 to generate a biomedical review article on fertility preservation. METHODS: ChatGPT-4 was prompted to create an outline for a review on fertility preservation in men and prepubertal boys. The outline provided by ChatGPT-4 was subsequently used to prompt ChatGPT-4 to write the different parts of the review and provide five references for each section. The different parts of the article and the references provided were combined to create a single scientific review that was evaluated by the authors, who are experts in fertility preservation...
April 15, 2024: Journal of Assisted Reproduction and Genetics
Jiang Wang, Shun Xiong, Xiangwei Hao, Yang Gao, Fei Xia, Haiyuan Liao, Jiayi Zou, Guoning Huang, Wei Han
PURPOSE: Zygotes with 2.1 pronuclei (2.1PN) present with two normal-sized pronuclei, and an additional smaller pronucleus, that is approximately smaller than two thirds the size of a normal pronucleus. It remains unclear whether the additional pronucleus causes embryonic chromosome abnormalities. In the majority of cases, in vitro fertilization (IVF) clinics discarded 2.1PN zygotes. Thus, the present study aimed to evaluate the developmental potential and value of 2.1PN zygotes. METHODS: 2...
April 13, 2024: Journal of Assisted Reproduction and Genetics
Hiromitsu Hattori, Noriyuki Okuyama, Kyota Ashikawa, Yoshiyuki Sakuraba, Hideki Igarashi, Koichi Kyono
PURPOSE: Are human embryos arising from two plus one small pronucleated zygotes, called 2.1 pronuclei (PN), clinically useful? METHODS: In a retrospective embryo cohort study and prospective experimental study, a total of 287 cycles in which at least one 2.1PN was identified in the fertilization check were included. Embryonic development and clinical outcome were compared for the 1395 2PN zygotes and 304 2.1PN zygotes that were siblings. All embryos were individually cultured in time-lapse systems...
April 13, 2024: Journal of Assisted Reproduction and Genetics
Alexandra M Herweck, Paris Chey, Heather S Hipp, Jennifer F Kawwass
PURPOSE: Oocyte cryopreservation (OC) is a medical intervention for reproductive-aged women, a demographic that uses social media heavily. This study characterizes the top TikTok videos and Instagram reels on OC. METHODS: Five hashtags pertaining to OC were selected: #oocytepreservation, #oocytecryopreservation, #eggfreezing, #oocytefreezing, and #fertilitypreservation. Top videos for each hashtag were evaluated for source, content, impact, and quality on both platforms...
April 13, 2024: Journal of Assisted Reproduction and Genetics
Elena V Soloveva, Maria M Skleimova, Larisa I Minaycheva, Anna F Garaeva, Daria I Zhigalina, Egor O Churkin, Yulia V Okkel, Oksana S Timofeeva, Ilya A Petrov, Gulnara N Seitova, Igor N Lebedev, Vadim A Stepanov
PURPOSE: To present the developed preimplantation genetic testing (PGT) for spinocerebellar ataxia type 1 (SCA1) and the outcomes of IVF with PGT. METHODS: PGT was performed for two unrelated couples from the Republic of Sakha (Yakutia) with the risk of SCA1 in one spouse. We have developed a system for PGT of a monogenic disease (PGT-M) for SCA1, which includes the analysis of a panel of 11 polymorphic STR markers linked to the ATXN1 gene and a pathogenic variant of the ATXN1 gene using nested PCR and fragment analysis...
April 5, 2024: Journal of Assisted Reproduction and Genetics
Krystian Zieliński, Anna Kloska, Piotr Wygocki, Marcin Zieleń, Michał Kunicki
PURPOSE: Ovarian stimulation with gonadotropins is crucial for obtaining mature oocytes for in vitro fertilization (IVF). Determining the optimal gonadotropin dosage is essential for maximizing its effectiveness. Our study aimed to develop a machine learning (ML) model to predict oocyte counts in IVF patients and retrospectively analyze whether higher gonadotropin doses improve ovarian stimulation outcomes. METHODS: We analyzed the data from 9598 ovarian stimulations...
April 4, 2024: Journal of Assisted Reproduction and Genetics
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