journal
Journals Journal of Assisted Reproducti...

Journal of Assisted Reproduction and Genetics

https://read.qxmd.com/read/38470552/preimplantation-genetic-testing-for-monogenic-disorders-pgt-m-offers-an-alternative-strategy-to-prevent-children-from-being-born-with-hereditary-neurological-diseases-or-metabolic-diseases-dominated-by-nervous-system-phenotypes-a-retrospective-study
#21
JOURNAL ARTICLE
Weiwei Zou, Min Li, Xiaolei Wang, Hedong Lu, Yan Hao, Dawei Chen, Shasha Zhu, Dongmei Ji, Zhiguo Zhang, Ping Zhou, Yunxia Cao
BACKGROUND: Preimplantation genetic testing for monogenic disorders (PGT-M) is now widely used as an effective strategy to prevent various monogenic or chromosomal diseases. MATERIAL AND METHODS: In this retrospective study, couples with a family history of hereditary neurological diseases or metabolic diseases dominated by nervous system phenotypes and/or carrying the pathogenic genes underwent PGT-M to prevent children from inheriting disease-causing gene mutations from their parents and developing known genetic diseases...
March 12, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38470551/association-between-blood-lead-levels-and-unfavorable-ivf-outcomes-potential-involvement-of-endoplasmic-reticulum-stress-response-in-granulosa-cells
#22
JOURNAL ARTICLE
Dan Shan, Yanning Lv, Junzhao Zhao, Fan Zhang, Haitao Xi, Haifan Qiu, Jieqiang Lv, Haolin Chen
PURPOSE: To investigate the relationship between blood lead levels (BLLs) and IVF clinical outcomes in infertile females and to further explore the possible involvement of granulosa cell (GC) endoplasmic reticulum (ER) stress in the process. METHODS: One hundred twenty-three infertile women undergoing IVF cycles were included in the current study. All participants were divided into three (low, medium, and high) groups determined by BLL tertiles. Gonadotropin releasing hormone (GnRH) agonist regimen for ovarian stimulation was used for all patients, with follicular fluids being collected on the day of oocyte retrieval...
March 12, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38470550/patient-interest-in-and-clinician-reservations-on-polygenic-embryo-screening-a-qualitative-study-of-stakeholder-perspectives
#23
JOURNAL ARTICLE
D Barlevy, I Cenolli, T Campbell, R Furrer, M Mukherjee, K Kostick-Quenet, S Carmi, T Lencz, G Lázaro-Muñoz, S Pereira
PURPOSE: We explored and compared perspectives of reproductive endocrinology and infertility specialists (REIs) and in vitro fertilization (IVF) patients regarding polygenic embryo screening (PES), a new type of preimplantation screening that estimates the genetic chances of developing polygenic conditions and traits in the future. METHODS: Qualitative thematic analysis of semi-structured interviews with US-based REIs and IVF patients. RESULTS: Clinicians and patients often held favorable views of screening embryos for physical or psychiatric conditions, though clinicians tended to temper their positive attitudes with specific caveats...
March 12, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38460086/psychological-distress-vaccine-and-booster-acceptance-in-women-considering-or-undergoing-fertility-treatments-during-the-omicron-surge-of-the-covid-19-pandemic
#24
JOURNAL ARTICLE
Luce A Kassi, Angela K Lawson, Eve C Feinberg, Amelia Swanson, Shriya Shah, Mary Ellen Pavone
OBJECTIVE: Follow-up study to evaluate perceptions of COVID-19 vaccination and booster with psychological distress during the COVID-19 pandemic and Omicron surge in women considering or undergoing fertility treatment. MATERIALS AND METHODS: Cross-sectional anonymous survey (N = 2558) from a single academic fertility center. Five hundred forty patients completed the survey (response rate = 21.1%). Participants were randomized 1:1 to a one-page evidence-based graphic with information and benefits regarding COVID-19 vaccination...
March 9, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38456992/mining-phase-separation-related-diagnostic-biomarkers-for-endometriosis-through-wgcna-and-multiple-machine-learning-techniques-a-retrospective-and-nomogram-study
#25
JOURNAL ARTICLE
Qiuyi Liang, Shengmei Yang, Meiyi Mai, Xiurong Chen, Xiao Zhu
OBJECTIVE: The objective of this study was to investigate the role of phase separation-related genes in the development of endometriosis (EMs) and to identify potential characteristic genes associated with the condition. METHODS: We used GEO database data, including 74 non-endometriosis and 74 varying-degree EMs patients. Our approach involved identifying significant gene modules, exploring gene intersections, identifying core genes, and screening for potential EMs biomarkers using weighted gene co-expression network analysis (WGCNA) and various machine learning approaches...
March 8, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38456991/meta-analysis-of-endometrial-transcriptome-data-reveals-novel-molecular-targets-for-recurrent-implantation-failure
#26
JOURNAL ARTICLE
Venkatlaxmi Chettiar, Alpesh Patel, Shiva Shankaran Chettiar, Devendrasinh D Jhala
PURPOSE: Gene expression analysis of the endometrium has been shown to be a useful approach for identifying the molecular signatures and pathways involved in recurrent implantation failure (RIF). Nevertheless, individual studies have limitations in terms of study design, methodology and analysis to detect minor changes in expression levels or identify novel gene signatures associated with RIF. METHOD: To overcome this, we conducted an in silico meta-analysis of nine studies, the systematic collection and integration of gene expression data, utilizing rigorous selection criteria and statistical techniques to ensure the robustness of our findings...
March 8, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38448786/correction-to-optimizing-non%C3%A2-invasive-preimplantation-genetic-testing-investigating-culture-conditions-sample-collection-and-ivf-treatment-for-improved-non%C3%A2-invasive-pgt%C3%A2-a-results
#27
Judy F C Chow, Kevin K W Lam, Heidi H Y Cheng, Shui Fan Lai, William S B Yeung, Ernest H Y Ng
No abstract text is available yet for this article.
March 7, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38446290/high-resolution-dynamic-ultrasound-atlas-of-embryonic-and-fetal-development-of-the-common-marmoset
#28
JOURNAL ARTICLE
Rohan R Soman, Margaret M Fabiszak, Michael McPhee, Peter Schade, Winrich Freiwald, Ali H Brivanlou
PURPOSE: The common marmoset (Callithrix jacchus) provides an ideal model to study early development of primates, and an in vivo platform to validate conclusions from in vitro studies of human embryos and embryo models. Currently, however, no established staging atlas of marmoset embryonic development exists. Using high-resolution, longitudinal ultrasound scans on live pregnant marmosets, we present the first dynamic in vivo imaging of entire primate gestation beginning with attachment until the last day before birth...
March 6, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38438770/seminal-cell-free-dna-as-a-potential-marker-for-in-vitro-fertility-of-nellore-bulls
#29
JOURNAL ARTICLE
Margot A N Dode, Natalia Capobianco, Luna Nascimento Vargas, Bruna Mion, Nayara Ribeiro Kussano, José Felipe Spricigo, Mauricio Machaim Franco
PURPOSE: This study aimed to identify a marker for freezability and in vitro fertility of sperm samples before freezing. METHODS: Semen was collected from nine Nelore bulls; half of the ejaculate was used for seminal plasma cell-free DNA (cfDNA) quantification, and the other half was cryopreserved. Evaluation of sperm movement using computer-assisted semen analysis and plasma membrane integrity and stability, acrosomal integrity, apoptosis, and mitochondrial potential using flow cytometry were performed on fresh and frozen/thawed semen at 0, 3, 6, and 12 h after thawing...
March 5, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38438769/histological-analysis-of-antral-follicle-density-in-ovarian-cortex-tissue-attached-to-stripped-endometriomas
#30
JOURNAL ARTICLE
Rozemarijn de Koning, Mathijs D Blikkendaal, Susana M Chuva de Sousa Lopes, Lotte E van der Meeren, Hui Cheng, Frank Willem Jansen, Eileen E L O Lashley
PURPOSE: When resecting endometriomas with the stripping technique, in the majority of cases, a thin line of adjacent ovarian cortex is attached to the endometrioma. In this study, we performed histological analysis to determine (antral) follicle density in the ovarian cortex tissue attached to stripped endometriomas and assessed patient- and surgical characteristics that could affect this. METHODS: Histological slides of previously removed endometriomas were assessed...
March 5, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38436798/influx-of-zwitterionic-buffer-after-intracytoplasmic-sperm-injection-icsi-membrane-piercing-alters-the-transcriptome-of-human-oocytes
#31
JOURNAL ARTICLE
Robert J Mendola, Leelabati Biswas, Karen Schindler, Renee H Walmsley, Helena Russell, Marlane Angle, G John Garrisi
PURPOSE/STUDY QUESTION: Does piercing oocyte membranes during ICSI allow the influx of surrounding zwitterionic buffer into human oocytes and result in altered developmental competence? METHODS: Human oocytes directed to IRB-approved research were used to determine the unrestricted influx of surrounding buffer into the oocyte after piercing of membranes via confocal fluorescence microscopy (n = 80 human MII oocytes) and the influence of the select buffer influx of HEPES, MOPS, and bicarbonate buffer on the oocyte transcriptome using ultra-low input RNA sequencing (n = 40 human MII oocytes)...
March 4, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38430325/achieving-an-optimal-pregnancy-outcome-through-the-combined-utilization-of-micro-tese-and-icsi-in-cryptorchidism-associated-with-a-non-canonical-splicing-variant-in-rxfp2
#32
JOURNAL ARTICLE
Lewen Ruan, Meng Gu, Hao Geng, Zongliu Duan, Hui Yu, Zhongmei Shao, Kuokuo Li, Mingrong Lv, Dongdong Tang
PURPOSE: To identify the genetic cause of a cryptorchidism patient carrying a non-canonical splicing variant highlighted by SPCards platform in RXFP2 and to provide a comprehensive overview of RXFP2 variants with cryptorchidism correlation. METHODS: We identified a homozygous non-canonical splicing variant by whole-exome sequencing and Sanger sequencing in a case with cryptorchidism and non-obstructive azoospermia (NOA). As the pathogenicity of this non-canonical splicing variant remained unclear, we initially utilized the SPCards platform to predict its pathogenicity...
March 2, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38430324/ethical-legal-social-and-policy-issues-of-ovarian-tissue-cryopreservation-in-prepubertal-girls-a-critical-interpretive-review
#33
REVIEW
Aliya O Affdal, Mahmoud Salama, Vardit Ravitsky
PURPOSE: Despite the increasing number of childhood cancer survivors, significant advances in ovarian tissue cryopreservation (OTC) technique and medical societies' recommendations, fertility preservation (FP) and FP discussions are not always offered as a standard of care in the pediatric context. The aim of this literature review is to understand what ethical, legal, social, and policy issues may influence the provision of FP by OTC in prepubertal girls with cancer. METHODS: A critical interpretive review of peer-reviewed papers published between 2000 and January 2023 was conducted, guided by the McDougall's version of the critical interpretive synthesis (Dixon-Woods), to capture recurring concepts, principles, and arguments regarding FP by OTC for prepubertal girls...
March 2, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38411745/in-memoriam-dr-robert-n-taylor-md-phd
#34
JOURNAL ARTICLE
Kirk P Conrad
No abstract text is available yet for this article.
February 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38403804/genetic-profiling-of-azoospermic-men-to-identify-the-etiology-and-predict-reproductive-potential
#35
JOURNAL ARTICLE
Stephanie Cheung, Lily Ng, Philip Xie, Olena Kocur, Rony Elias, Peter Schlegel, Zev Rosenwaks, Gianpiero D Palermo
PURPOSE: To identify germline mutations related to azoospermia etiology and reproductive potential of surgically retrieved spermatozoa, and to investigate the feasibility of predicting seminiferous tubule function of nonobstructive azoospermic men by transcriptomic profiling of ejaculates. MATERIALS AND METHODS: Sperm specimens were obtained from 30 men (38.4 ± 6 years) undergoing epididymal sperm aspiration for obstructive azoospermia (OA, n = 19) acquired by vasectomy, or testicular biopsy for nonobstructive azoospermia (NOA, n = 11)...
February 26, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38403803/impact-of-mildly-evaluated-thyroid-stimulating-hormone-levels-on-in-vitro-fertilization-or-intracytoplasmic-sperm-injection-outcomes-in-women-with-the-first-fresh-embryo-transfer-a-large-study-from-china
#36
JOURNAL ARTICLE
Mingmei Lin, Di Mao, Kai-Lun Hu, Ping Zhou, Fen-Ting Liu, Jingwen Yin, Hua Zhang, Rong Li
PURPOSE: This study aimed to investigate the association between mild elevation of thyroid-stimulating hormone (TSH) levels and pregnancy outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments in women with the first fresh embryo transfer. METHODS: Large single-center retrospective cohort study of 15,728 patients from January 2018 to December 2022 were enrolled in the analyses. Clinical pregnancy rates, live birth rates, miscarriage rates, and ectopic pregnancy rates were compared between the TSH levels < 2...
February 26, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38386120/impact-of-vaginal-microecological-differences-on-pregnancy-outcomes-and-endometrial-microbiota-in-frozen-embryo-transfer-cycles
#37
JOURNAL ARTICLE
Quan Wei, Huijia Chen, Heng Zou, Hong Zhang, Shuaibin Liu, Jie Zheng, Shen Zhang, Lina Hu
PURPOSE: This prospective study investigates the correlation between vaginal microecology and pregnancy outcomes and explores their impact on endometrial microbiota composition during frozen embryo transfer (FET) cycles. Additionally, the impact of transvaginal Lactobacillus supplementation on reproductive outcomes in patients with previous failed cycles was assessed. METHODS: A total of 379 patients undergoing FET at a reproductive medicine center were categorized into clinical pregnancy (CP), miscarriage (MISC), and non-pregnant (NP) groups...
February 22, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38386119/preimplantation-genetic-testing-for-aneuploidy-predictive-embryonic-factors
#38
JOURNAL ARTICLE
Mireia Florensa, Anna Cladellas, Agustín Ballesteros, Marga Esbert
PURPOSE: In a preimplantation genetic testing for aneuploidy (PGT-A) cycle, does the blastocyst quality before biopsy, or the day of biopsy, or the embryo hatching status have an impact on either euploidy or the rate of embryo survival after freezing? METHODS: This was a retrospective study including 6130 biopsied blastocysts coming from 1849 PGT-A cycles performed in our center (2016-2022). Embryos were categorized according to the inner cell mass and trophectoderm quality, using Gardner's scoring (excellent: AA; good: AB, BA, BB; poor: AC, CA, BC, CB, CC); the day of biopsy (5 or 6); and their hatching status (fully hatched blastocysts [FHB] or non-fully hatched blastocysts [nFHB])...
February 22, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38386118/mechanism-of-chromosomal-mosaicism-in-preimplantation-embryos-and-its-effect-on-embryo-development
#39
REVIEW
Xue Zhang, Peng-Sheng Zheng
Aneuploidy is one of the main causes of miscarriage and in vitro fertilization failure. Mitotic abnormalities in preimplantation embryos are the main cause of mosaicism, which may be influenced by several endogenous factors such as relaxation of cell cycle control mechanisms, defects in chromosome cohesion, centrosome aberrations and abnormal spindle assembly, and DNA replication stress. In addition, incomplete trisomy rescue is a rare cause of mosaicism. However, there may be a self-correcting mechanism in mosaic embryos, which allows some mosaicisms to potentially develop into normal embryos...
February 22, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38386117/indications-affect-neonatal-outcomes-following-early-rescue-icsi-a-retrospective-study
#40
JOURNAL ARTICLE
Jie Geng, Jiali Cai, Ling Ouyang, Lanlan Liu, Zhenfang Liu, Caihui Ma, Xiaoming Jiang, Jianzhi Ren
PURPOSE: To investigate the impact of heterogeneity in patient indications or insemination protocols on neonatal outcomes of singletons following early rescue ICSI (rICSI) treatments. METHODS: A retrospective study was conducted. Propensity score matching and multivariable logistic regression were used to adjust for confounders and biases. RESULTS: A total of 9095 IVF patients, 2063 ICSI patients, and 642 early rICSI patients were included in the study...
February 22, 2024: Journal of Assisted Reproduction and Genetics
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