Journals Journal of Assisted Reproducti...

Journal of Assisted Reproduction and Genetics
Myriam Safrai, Kyle E Orwig
PURPOSE: To evaluate the ability of ChatGPT-4 to generate a biomedical review article on fertility preservation. METHODS: ChatGPT-4 was prompted to create an outline for a review on fertility preservation in men and prepubertal boys. The outline provided by ChatGPT-4 was subsequently used to prompt ChatGPT-4 to write the different parts of the review and provide five references for each section. The different parts of the article and the references provided were combined to create a single scientific review that was evaluated by the authors, who are experts in fertility preservation...
April 15, 2024: Journal of Assisted Reproduction and Genetics
Jiang Wang, Shun Xiong, Xiangwei Hao, Yang Gao, Fei Xia, Haiyuan Liao, Jiayi Zou, Guoning Huang, Wei Han
PURPOSE: Zygotes with 2.1 pronuclei (2.1PN) present with two normal-sized pronuclei, and an additional smaller pronucleus, that is approximately smaller than two thirds the size of a normal pronucleus. It remains unclear whether the additional pronucleus causes embryonic chromosome abnormalities. In the majority of cases, in vitro fertilization (IVF) clinics discarded 2.1PN zygotes. Thus, the present study aimed to evaluate the developmental potential and value of 2.1PN zygotes. METHODS: 2...
April 13, 2024: Journal of Assisted Reproduction and Genetics
Hiromitsu Hattori, Noriyuki Okuyama, Kyota Ashikawa, Yoshiyuki Sakuraba, Hideki Igarashi, Koichi Kyono
PURPOSE: Are human embryos arising from two plus one small pronucleated zygotes, called 2.1 pronuclei (PN), clinically useful? METHODS: In a retrospective embryo cohort study and prospective experimental study, a total of 287 cycles in which at least one 2.1PN was identified in the fertilization check were included. Embryonic development and clinical outcome were compared for the 1395 2PN zygotes and 304 2.1PN zygotes that were siblings. All embryos were individually cultured in time-lapse systems...
April 13, 2024: Journal of Assisted Reproduction and Genetics
Alexandra M Herweck, Paris Chey, Heather S Hipp, Jennifer F Kawwass
PURPOSE: Oocyte cryopreservation (OC) is a medical intervention for reproductive-aged women, a demographic that uses social media heavily. This study characterizes the top TikTok videos and Instagram reels on OC. METHODS: Five hashtags pertaining to OC were selected: #oocytepreservation, #oocytecryopreservation, #eggfreezing, #oocytefreezing, and #fertilitypreservation. Top videos for each hashtag were evaluated for source, content, impact, and quality on both platforms...
April 13, 2024: Journal of Assisted Reproduction and Genetics
Ivy L Lersten, Laura Grau, Samad Jahandideh, Kate Devine, Laura Zalles, Shayne M Plosker, Anthony N Imudia, Luis R Hoyos, Meike L Uhler, Michael Homer, Cassandra Roeca, Mary D Sammel, Alex J Polotsky
PURPOSE: There is an unclear relationship between estradiol levels and fresh embryo transfer (ET) outcomes. We determined the relationship between estradiol on the day of trigger, in fresh ET cycles without premature progesterone elevation, and good birth outcomes (GBO). METHODS: We identified autologous fresh ET cycles from 2015 to 2021 at multiple clinics in the USA. Patients with recurrent pregnancy loss, uterine factor, and elevated progesterone on the day of trigger (progesterone > 2 ng/mL or 3-day area under the curve > 4...
April 11, 2024: Journal of Assisted Reproduction and Genetics
Elena V Soloveva, Maria M Skleimova, Larisa I Minaycheva, Anna F Garaeva, Daria I Zhigalina, Egor O Churkin, Yulia V Okkel, Oksana S Timofeeva, Ilya A Petrov, Gulnara N Seitova, Igor N Lebedev, Vadim A Stepanov
PURPOSE: To present the developed preimplantation genetic testing (PGT) for spinocerebellar ataxia type 1 (SCA1) and the outcomes of IVF with PGT. METHODS: PGT was performed for two unrelated couples from the Republic of Sakha (Yakutia) with the risk of SCA1 in one spouse. We have developed a system for PGT of a monogenic disease (PGT-M) for SCA1, which includes the analysis of a panel of 11 polymorphic STR markers linked to the ATXN1 gene and a pathogenic variant of the ATXN1 gene using nested PCR and fragment analysis...
April 5, 2024: Journal of Assisted Reproduction and Genetics
Krystian Zieliński, Anna Kloska, Piotr Wygocki, Marcin Zieleń, Michał Kunicki
PURPOSE: Ovarian stimulation with gonadotropins is crucial for obtaining mature oocytes for in vitro fertilization (IVF). Determining the optimal gonadotropin dosage is essential for maximizing its effectiveness. Our study aimed to develop a machine learning (ML) model to predict oocyte counts in IVF patients and retrospectively analyze whether higher gonadotropin doses improve ovarian stimulation outcomes. METHODS: We analyzed the data from 9598 ovarian stimulations...
April 4, 2024: Journal of Assisted Reproduction and Genetics
Mina Shojaedini, Masoud Hemadi, Ghasem Saki, Fereshtehsadat Fakhredini, Mohammad Javad Khodayar, Layasadat Khorsandi
PURPOSE: In this study, the effect of thymoquinone (TQ) on CP-induced spermatogenesis defects in mice has been investigated. METHODS: Sperm parameters, serum testosterone concentration, histology, Bax/Bcl-2 ratio, and expression of autophagy-related biomarkers have been assessed. Total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in testicular tissue were examined for the evaluation of oxidative stress levels. RESULTS: CP has induced histological changes and significantly increased the Bax/Bcl-2 ratio, decreased testosterone concentration, testicular weight, and sperm quality...
April 3, 2024: Journal of Assisted Reproduction and Genetics
Sarah Hunt, Jing Liu, Pulin Luo, Ying Zhong, Ben W Mol, Ling Chi, Rui Wang
PURPOSE: To examine the interaction between serum progesterone concentration on the trigger day and choice of freeze-all and fresh transfer strategies on live birth in an unselected population as well as in patients over 35 years old. METHODS: We performed a retrospective cohort study of 26,661 patients commencing their first IVF cycle in a large fertility centre between 2015 and 2019, including 4687 patients over 35 years old. We performed a multivariable fractional polynomial interaction analysis within a logistic regression model to investigate the interaction between serum progesterone concentration and the choice of freeze-all or fresh transfer strategy following the first transfer...
April 3, 2024: Journal of Assisted Reproduction and Genetics
Wenqing Lu, Yong Li, Lanlan Meng, Chen Tan, Hongchuan Nie, Qianjun Zhang, Yuying Song, Huan Zhang, Yue-Qiu Tan, Chaofeng Tu, Haichun Guo, Longxiang Wu, Juan Du
PURPOSE: This study aimed to identify the genetic causes of male infertility and primary ciliary dyskinesia (PCD)/PCD-like phenotypes in three unrelated Han Chinese families. METHODS: We conducted whole-exome sequencing of three patients with male infertility and PCD/PCD-like phenotypes from three unrelated Chinese families. Ultrastructural and immunostaining analyses of patient spermatozoa and respiratory cilia and in vitro analyses were performed to analyze the effects of SPEF2 variants...
April 3, 2024: Journal of Assisted Reproduction and Genetics
David F Albertini
No abstract text is available yet for this article.
April 2, 2024: Journal of Assisted Reproduction and Genetics
B Bekaert, A Boel, A Rybouchkin, G Cosemans, S Declercq, S M Chuva de Sousa Lopes, J Parrington, D Stoop, P Coucke, B Menten, B Heindryckx
PURPOSE: Unpredictable genetic modifications and chromosomal aberrations following CRISPR/Cas9 administration hamper the efficacy of germline editing. Repair events triggered by double-strand DNA breaks (DSBs) besides non-homologous end joining and repair template-driven homology-directed repair have been insufficiently investigated in mouse. In this work, we are the first to investigate the precise repair mechanisms triggered by parental-specific DSB induction in mouse for paternal mutational correction in the context of an infertility-related mutation...
April 1, 2024: Journal of Assisted Reproduction and Genetics
Cristina Guarneri, Marco Reschini, Monica Pinna, Lucia Perego, Elena Sanzani, Edgardo Somigliana, Ugo Sorrentino, Matteo Cassina, Daniela Zuccarello, Marta Ciaffaglione
PURPOSE: To evaluate whether a second biopsy, following a first diagnostic failure on blastocysts tested for preimplantation genetic testing for monogenic diseases (PGT-M), allows to obtain genetic diagnosis and to what extent this procedure can influence clinical pregnancy and live birth rates compared to the PGT-M process with a successful genetic diagnosis from the first biopsy. METHODS: Embryos from women who underwent PGT-M in an infertility centre and who had been transferred after two biopsies for genetic analysis (n = 27) were matched in a 1:1 ratio accordingly to women's age (± 1 year) and fertility status (fertile vs infertile), as well as with the study period, with embryos who were transferred after receiving a conclusive PGT result straight after the first biopsy (n = 27)...
April 1, 2024: Journal of Assisted Reproduction and Genetics
Nathalie Hoffmann-Dishon, Zohar Barnett-Izhaki, Daniel Zalko, Rina Hemi, Nahid Farzam, Russ Hauser, Catherine Racowsky, Andrea A Baccarelli, Ronit Machtinger
PURPOSE: To determine correlations between chemicals in follicular fluid (FF) and follicular reproductive hormone levels. METHODS: The analysis was part of a larger cohort study to determine associations between exposure to EDCs and in vitro fertilization (IVF) outcomes. FF was aspirated from a single leading follicle per participant. Demographics and data on exposure to EDCs were self-reported by the participants using a questionnaire. The concentrations of estradiol (E2), progesterone (PG), anti-Mullerian hormone (AMH), and inhibin B, as well as that of 12 phthalate metabolites and 12 phenolic chemicals were measured in each FF sample...
April 1, 2024: Journal of Assisted Reproduction and Genetics
Yuchen Li, Yanling Yu, Dejun Li, Lei Li
PURPOSE: Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been reported to play pivotal roles in the development of PE. However, the mechanism underlying the role of maternal exosomes in trophoblast dysfunction regarding the development of PE is poorly understood. METHODS: Plasma exosomes from maternal peripheral blood were collected from pregnant women with PE and from those with normal pregnancy...
March 27, 2024: Journal of Assisted Reproduction and Genetics
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In the first of two companion papers, we comprehensively reviewed the recent evidence in the primary literature, which addressed the increased prevalence of hypertensive disorders of pregnancy, late-onset or term preeclampsia, fetal overgrowth, postterm birth, and placenta accreta in women conceiving by in vitro fertilization. The preponderance of evidence implicated frozen embryo transfer cycles and, specifically, those employing programmed endometrial preparations, in the higher risk for these adverse maternal and neonatal pregnancy outcomes...
March 27, 2024: Journal of Assisted Reproduction and Genetics
Zhiqi Ye, Da Li, Xiangli Niu, Aimin Yang, Zhiqi Pan, Ran Yu, Hao Gu, Rong Shi, Ling Wu, Yanfang Xiang, Guimin Hao, Yanping Kuang, Biaobang Chen, Lei Wang, Qing Sang, Lin Li, Juanzi Shi, Qiaoli Li
AIM: Abnormalities in oocyte maturation, fertilization, and early embryonic development are major causes of primary infertility in women who are undergoing IVF/ICSI attempts. Although many genetic factors responsible for these abnormal phenotypes have been identified, there are more additional pathogenic genes and variants yet to be discovered. Previous studies confirmed that bi-allelic PATL2 deficiency is an important factor for female infertility. In this study, 935 infertile patients with IVF/ICSI failure were selected for whole-exome sequencing, and 18 probands carrying PATL2 variants with a recessive inheritance pattern were identified...
March 27, 2024: Journal of Assisted Reproduction and Genetics
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In this first of two companion papers, we critically review the evidence recently published in the primary literature, which addresses adverse maternal and neonatal pregnancy outcomes associated with programmed embryo transfer cycles. We next consider whether these pathological pregnancy outcomes might be attributable to traditional risk factors, unknown parental factors, embryo culture, culture duration, or cryopreservation. Finally, in the second companion article, we explore potential etiologies and suggest strategies for prevention...
March 27, 2024: Journal of Assisted Reproduction and Genetics
Li Wang, Jinfeng Chen, Huihui Li, Qianqian Zhou, Chunxia Zhang
AIMS: Hypertensive disorders of pregnancy (HDP) is a unique disease during gestational period, which is detrimental to pregnancy outcome. This study examined the clinical significance of long non-coding RNA GAS5 in gestational hypertension (GH) and preeclampsia (PE), aiming to explore potential biomarkers for the disease detection. METHODS: 180 pregnant women with HPD including 90 cases with GH and 90 cases with PE, and another 100 healthy pregnant women were enrolled...
March 26, 2024: Journal of Assisted Reproduction and Genetics
Liping Chen, Fangfang Dai, Yanjie Huang, Jing Chen, Zhidian Li, Hua Liu, Yanxiang Cheng
PURPOSE: The purpose of our study is to investigate the function of YAP1 in the trophoblast ferroptosis and maternal-fetal interface communication of RPL. METHODS: We collected 25 villous tissues and detected the expression of YAP1. Cell counting kit-8 assay, scratch wound-healing assay, and Matrigel invasion assay were performed to observe the proliferation, migration, and invasion of HTR-8/SVneo and JAR cells. Subsequently, measured the levels of reactive oxygen species (ROS), malondialdehyde (MDA), reduced glutathione (GSH), SLC7A11, SOD2, and GPX4...
March 25, 2024: Journal of Assisted Reproduction and Genetics
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