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Journal of Vascular Research

Filipa Cunha, Ann M Rajnicek, Colin D McCaig
Natural direct current electric fields (DC EFs) within tissues undergoing angiogenesis have the potential to influence vessel formation, but how they affect endothelial cells is not clear. We therefore quantified behaviours of human umbilical vein endothelial cells (HUVEC) and human microvasculature endothelial cells (HMEC) stimulated by EFsin vitro. Both cell types migrated faster and toward the cathode; HUVECs responded to fields as low as 50mV/mm, but the HMEC threshold was 100 mV/mm. Mitosis was stimulated at 50 mV/mm for HMEC and at 150 mV/mm for HUVECs, but the cleavage plane was oriented orthogonal to the field vector at 200 mV/mm for both cell types...
April 17, 2019: Journal of Vascular Research
Yajie Chen, Ahmed Bilal Waqar, Haizhao Yan, Yanli Wang, Jingyan Liang, Jianglin Fan
BACKGROUND: Hypertension is a major risk factor for atherosclerotic disease. However, it is still not clear whether mechanical stress caused by hypertension directly affects the atherosclerotic development in the aorta and coronary arteries. OBJECTIVES AND METHODS: We generated a hypertensive (HTN) rabbit model by surgical removal of the left kidney and partial ligation of the right renal artery. After a 16-week cholesterol diet, we compared aortic and coronary atherosclerosis of HTN rabbits with those of normotensive rabbits...
April 4, 2019: Journal of Vascular Research
Wei Xu, Xiao Hu, Xi Qi, Rui Zhu, Chen Li, Yanjing Zhu, Shuai Yin, Liming Cheng, Rongrong Zhu
Vitamin D has an important protective effect on chronic inflammatory disease. Angiotensin II (AngII) triggers vascular damage and plays a key role in vascular diseases via several mechanisms, including inflammation. Conversely, vitamin D has been shown to have an important protective effect on chronic inflammation. There is evidence showing that vitamin D can reverse the effects of AngII, but the molecular mechanisms by which this occurs are not known. Our results demonstrate that vitamin D improved the viability, migration ability, and tube formation of AngII-pretreated endothelial progenitor cells (EPCs) and inhibited the apoptosis of EPCs induced by AngII...
March 15, 2019: Journal of Vascular Research
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No abstract text is available yet for this article.
February 14, 2019: Journal of Vascular Research
Saereh Khanamiri, June-Wha Rhee, David T Paik, Ian Y Chen, Chun Liu, Nazish Sayed
Peripartum cardiomyopathy (PPCM) is a rare form of congestive heart failure characterized by left ventricular dysfunction that develops towards the end of pregnancy or during the early postpartum phase. Even though the majority of PPCM patients show partial or complete recovery of their heart functions, the mortality rate of PPCM remains high. Previous research has suggested that vascular dysfunction triggered by late-gestational hormones and potent anti-angiogenic factors play key roles in the pathogenesis of PPCM; however, the exact mechanisms remain elusive due to limited patient tissues for characterization...
February 14, 2019: Journal of Vascular Research
Ting Wu, Zhanhong Jia, Shifen Dong, Bing Han, Rong Zhang, Yaoyue Liang, Shuofeng Zhang, Jianning Sun
Panax notoginseng saponins (PNS) are known as clinical anti-stroke herbal medicines. The aim of this study is to describe the impact of PNS on ischemia-reperfusion-induced cerebral microvasculature barrier dysfunction which has not been investigated yet. Mice were subjected to transient middle cerebral artery occlusion and PNS were administrated to mice 3 days before and 2 days after surgery. Leukocyte adhesion, albumin leakage, tight junctions and other parameters in the cortex were measured. The PNS 45 mg/kg intervention alleviated leukocyte adhesion, inhibited endothelial barrier alterations evidenced by reduced albumin leakage and tight junction degradations, and ultimately ameliorated infarct volumes and neurological deficits subsequent to ischemia-reperfusion...
February 14, 2019: Journal of Vascular Research
Irene Hofer, Christine Schimp, Muna Taha, Jochen Seebach, Mohammed Aldirawi, Jiahui Cao, Quentin Leidl, Annelie Ahle, Hans Schnittler
Endothelial cells of the vascular system are dynamic cells whose molecular adaptability is decisive for the adjustment of homeostasis and organ perfusion. Advanced microscopic techniques, automation processing, and image analysis software was shown to improve the understanding of vascular biology. In this work, we describe advanced methods that allow investigating the dynamics of endothelial cell contacts. The development of viral vectors has contributed significantly to the genetic manipulation of endothelial cells...
December 13, 2018: Journal of Vascular Research
Zeqin Xu, Yongquan Gu, Jianxin Li, Zengguo Feng, Lianrui Guo, Zhu Tong, Lin Ye, Chunmei Wang, Rong Wang, Xue Geng, Cong Wang, Jian Zhang
In the field of vascular graft research, poly-ε-caprolactone (PCL) is used owing to its good mechanical strength and biocompatibility. In this study, PCL scaffold was prepared by electrospinning and surface modification with heparin via hexamethylenediamine. Then the scaffolds were implanted into the infrarenal abdominal aorta of Wistar rats and contrast-enhanced micro-ultrasound was used to monitor the patency of grafts after implantation. These grafts were extracted from the rats at 1, 3, and 6 months for histological analysis, immunofluorescence staining, and scanning electron microscopy observation...
November 28, 2018: Journal of Vascular Research
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Yuichi Hori
PURPOSE: To determine: (1) whether variables of a pulse wave form analysis of ocular microcirculation shown by laser speckle flowgraphy (LSFG) correlate with left ventricular (LV) systolic dysfunction and (2) whether these variables correlate with LV diastolic dysfunction in subjects without LV systolic dysfunction as assessed by echocardiography. METHODS: We studied 200 consecutive subjects. LV systolic dysfunction has been determined to be present when the LV ejection fraction was < 50%...
November 8, 2018: Journal of Vascular Research
Jia-Wang Ding, Cai-Yun Luo, Xin-An Wang, Tian Zhou, Xia-Xia Zheng, Zai-Qiang Zhang, Bin Yu, Jing Zhang, Xiao-Hong Tong
BACKGROUND: High-mobility group box protein 1 (HMGB1) is known to have proinflammatory properties; however, the mechanisms by which HMGB1 influences immune responses during atherosclerosis (AS) development are not well understood. Thus, this study investigated the relationship between HMGB1 and vascular inflammation in Apoe-/- mice and whether glycyrrhizin (GLY), a small inhibitor of HMGB1, could have atheroprotective effects in AS. METHODS: Apoe-/- mice on a high-fat diet were treated with GLY (50 mg/kg) or vehicle by gavage once daily for 12 weeks, respectively...
2018: Journal of Vascular Research
Aaron Gelinne, Lucia Brown, Nga Ling Ko, George Osol, Stephen Brown
BACKGROUND/AIMS: Ten-eleven translocation 2 (Tet2), a DNA demethylase enzyme, has been identified as a master epigenetic regulator of vascular smooth muscle cell plasticity. We hypothesized that pregnancy will induce significant adaptive changes in aortic biomechanics that correlate with the Tet family gene expression. METHODS: Abdominal aortas from pregnant and nonpregnant mice were dissected and cannulated. Intraluminal pressure was adjusted using a pressure-servo system while using a video dimension analyzer to measure the lumen diameter...
2018: Journal of Vascular Research
Chia-Ching Hsu, Wu-Chien Chien, Jen-Chun Wang, Chi-Hsiang Chung, Wen-I Liao, Wei-Shiang Lin, Chin-Sheng Lin, Shih-Hung Tsai
OBJECTIVE: Atrial fibrillation (AF) is the most common form of sustained arrhythmia. Several molecular pathways associated with the pathogenesis of AF also participate in the initiation and progression of aortic aneurysm (AA). In this study, we aimed to evaluate potential associations between AA and AF. PATIENTS AND METHODS: The data for this nationwide population-based retrospective cohort study were obtained from Taiwan's National Health Insurance Research Database (NHIRD)...
2018: Journal of Vascular Research
Hua Liu, Wenbo Zhang, Brenda Lilly
Loss of vascular pericytes has long been associated with the onset of diabetic retinopathy; however, mechanisms contributing to pericyte dropout are not understood. Notch3 has been implicated in pericyte stability and survival, and linked to vascular integrity. Notch3 mutant mice exhibit progressive loss of retinal pericytes. Given that diabetic retinopathy is associated with pericyte loss, we sought to determine whether perturbation of Notch3 signaling contributes to diabetes-induced pericyte dropout and capillary degeneration...
2018: Journal of Vascular Research
Gábor Fazekas, László Benkő, Gábor Kasza, Endre Arató, László Sínay, Szaniszló Jávor, Tibor Nagy, Péter Hardi, Lajos Kollár, Gábor Jancsó, Gábor Menyhei
AIMS: Prosthetic graft infection frequently requires graft replacement. Among other options, a biological graft could serve as an alternative choice. Decellularization reduces tissue immunogenicity. Our aim was to determine an efficient decellularization method and to evaluate the decellularized porcine biografts' adaptability. METHODS: Four different protocols were implemented to decellularize porcine aortic segments (n = 4). Cell removal effectiveness and matrix structure preservation were histologically examined...
2018: Journal of Vascular Research
Sera Gonelevue, Abhirup Bandyopadhyay, Saumya Bhagat, Md Iqbal Alam, Gausal A Khan
High mobility group box 1 protein (HMGB1), a sterile inflammatory molecule and damage-associated molecular pattern (DAMP) released from various cells during stress has been implicated in inflammation. Several reports show that there is a direct relationship between inflammation and cardiovascular diseases (CVDs) such as thrombosis, hypertension, insulin resistance, preeclampsia, etc. Here, we intend to summarize the concept of the emerging link between HMGB1 and CVDs. Furthermore, we will discuss the possible therapeutic strategies that target HMGB1 for the treatment of different CVDs...
2018: Journal of Vascular Research
Anastasia Logothetidou, Ward De Spiegelaere, Tim Vandecasteele, Waltraud Tschulenk, Ingrid Walter, Wim Van den Broeck, Pieter Cornillie
BACKGROUND/AIMS: Intussusceptive angiogenesis (IA) is a dynamic process which contributes to vascular expansion and remodeling. Intraluminal pillars have long been the distinctive structural indicator of IA. However, the mechanism of their formation has not been fully elucidated. METHODS: Using light and electron microscopy, we studied intussusceptive vascular growth in the developing porcine metanephric kidney. RESULTS: We observed intraluminal pillars formed by endothelial cells in the vasculature of developing glomeruli...
2018: Journal of Vascular Research
Souleiman Ghanem, Bence Tanczos, Adam Deak, Laszlo Bidiga, Norbert Nemeth
BACKGROUND: Arteriovenous fistulae impair the distal circulation, but their effects at the microcirculatory level are not well understood. This study presents the carotid-jugular fistula (CJF) as a model to evaluate fistula-related microcirculatory and systemic changes. MATERIALS AND METHODS: Female Wistar rats were anesthetized and divided into a fistula group (FG, n = 10) and a sham group (SG, n = 6). End-to-end anastomosis was performed between the right carotid artery and the jugular vein in the FG...
2018: Journal of Vascular Research
David A Prim, Vinal Menon, Shahd Hasanian, Laurel Carter, Tarek Shazly, Jay D Potts, John F Eberth
Adaptive remodeling processes are essential to the maintenance and viability of coronary artery bypass grafts where clinical outcomes depend strongly on the tissue source. In this investigation, we utilized an ex vivo perfusion bioreactor to culture porcine analogs of common human bypass grafts: the internal thoracic artery (ITA), the radial artery (RA), and the great saphenous vein (GSV), and then evaluated samples acutely (6 h) and chronically (7 days) under in situ or coronary-like perfusion conditions. Although morphologically similar, primary cells harvested from the ITA illustrated lower intimal and medial, but not adventitial, cell proliferation rates than those from the RA or GSV...
2018: Journal of Vascular Research
Chang-Chih Shih, Jen-Chun Wang, Shih-Hung Tsai, Chi-Hsiang Chung, Sy-Jou Chen, Wen-I Liao, Chang-Huei Tsao, Yung-Fu Wu, Wu-Chien Chien
OBJECTIVE: To determine whether patients with obstructive sleep apnoea (OSA) have an increased risk of aortic aneurysm (AA). METHODS: The data for the nationwide population-based retrospective cohort study described here were obtained from the Taiwan National Health Insurance Research Database (NHIRD). We selected adult patients who had been newly diagnosed as having OSA and were followed up between 2000 and 2010. We excluded patients who had been diagnosed as having AA before the date of the new OSA diagnosis...
2018: Journal of Vascular Research
Samia Neggazi, Laurence Canaple, Nadjiba Hamlat, Karine Gauthier, Jacques Samarut, Giampiero Bricca, Souhila Aouichat-Bouguerra, Michel Beylot
Thyroid hormone (TH) regulates gene transcription by binding to TH receptors (TRs). TRs regulate the genes of lipid metabolism and the renin-angiotensin system (RAS). We examined the effect of TRα deletion in ApoE-/- mice (DKO mice) on the following: (i) the expression of genes controlling cholesterol metabolism and tissue (t)RAS in the liver and aorta and (ii) the expression of these genes and the regulation of cholesterol content in cultured vascular smooth muscle cells (VSMCs). TRα deletion in ApoE-/- mice led to the repression of genes involved in the synthesis and influx of cholesterol in the liver...
2018: Journal of Vascular Research
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