Yuxi Sun, Jiaxin Li, Xinxin Zhang, Ning Wang, Ying Liu
INTRODUCTION: Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality but without available evidence-based therapies. It is essential to investigate changes in gene expression profiles in preclinical HFpEF animal models, with the aim of searching for novel therapeutic targets. METHODS: Wild-type male C57BL/6J mice were administrated with a combination of high-fat diet (HFD) and inhibition of constitutive nitric oxide synthase using N-nitro-<sc>l</sc>-arginine methyl ester (<sc>l</sc>-NAME) for 5 and 7 weeks...
June 14, 2024: Journal of Vascular Research
Héctor González-Pacheco, Luis Manuel Amezcua-Guerra, Martha Franco, Alexandra Arias-Mendoza, Jorge A Ortega-Hernández, Felipe Massó
BACKGROUND: Preservation of organ function and viability is a crucial factor for survival in cardiogenic shock (CS) patients. There is not information enough on cytoprotective substances that may delay organs damage in CS. We hypothesize that cytidine-5-diphosphocholine (CDP-choline) can act as a cytoprotective pharmacological measure that diminishes the target organ damage. So, we aimed to perform a review of works carried out in our institution to evaluate the effect of therapeutic cytoprotection of the CDP-choline...
May 22, 2024: Journal of Vascular Research
Sophie J Y Huang, Xuan Wang, Brayden D Halvorson, Yuki Bao, Stephanie J Frisbee, Jefferson C Frisbee, Daniel Goldman
INTRODUCTION: Acquisition of a deeper understanding of microvascular function across physiological and pathological conditions can be complicated by poor accessibility of the vascular networks and the necessary sophistication or intrusiveness of the equipment needed to acquire meaningful data. Laser Doppler fluximetry (LDF) provides a mechanism wherein investigators can readily acquire large amounts of data with minor inconvenience for the subject. However, beyond fairly basic analyses of erythrocyte perfusion (fluximetry) data within the cutaneous microcirculation (i...
May 15, 2024: Journal of Vascular Research
Arno F G Maas, Caroline Wyers, Arne Dielis, Dennis G Barten, Vivian E M van Kampen, Thomas E van der Krieken, Martijn de Kruif, Suat Simsek, Bart Spaetgens, Thijs van Haaps, Brent Appelman, Niels C Gritters, Stefan Doornbos, Hazra S Moeniralam, Peter G Noordzij, Auke Reidinga, Renée A Douma, Esther J Nossent, Martijn Beudel, Paul Elbers, Saskia Middeldorp, Nick van Es, Joop P W van den Bergh, Frits H M van Osch
INTRODUCTION: During the first COVID-19 outbreak in 2020 in the Netherlands, the incidence of pulmonary embolism (PE) appeared to be high in COVID-19 patients admitted to the intensive care unit (ICU). This study was performed to evaluate the incidence of PE during hospital stay in COVID-19 patients not admitted to the ICU. METHODS: Data were retrospectively collected from 8 hospitals in the Netherlands. Patients admitted between February 27, 2020, and July 31, 2020, were included...
April 17, 2024: Journal of Vascular Research
Steven K Malin, Uta Erdbrügger
BACKGROUND: Insulin resistance is a major etiological factor in obesity, type 2 diabetes, and cardiovascular disease (CVD). Endothelial dysfunction may precede impairments in insulin-stimulated glucose uptake, thereby making it a key feature in development of CVD. However, the mechanism by which vascular tissue becomes dysfunctional is not clear. SUMMARY: Extracellular vesicles (EVs) have emerged as potential mediators of insulin resistance and vascular dysfunction...
April 12, 2024: Journal of Vascular Research
Peiting Zhou, Yaolei Zhang, Kewei Xu, Yunchuan Liu, Jing Huang, Quanzhou Yao, Xin Chen, Longfu Zhou
INTRODUCTION: Following our recent finding that Ucp2 knockout promotes ferroptosis, we aimed to examine whether UCP2 alleviates myocardial ischemia/reperfusion injury (MI/RI) by inhibiting ferroptosis. METHODS: The left anterior descending coronary arteries of wild-type and Ucp2-/- C57BL/6 mice were ligated for 30 min and reperfused for 2 h to establish an MI/RI model. The effects of UCP2 on ferroptosis and MI/RI were determined by echocardiography, 2,3,5-triphenylttrazolium chloride staining, hematoxylin-eosin staining, Masson's trichrome staining, Sirius red staining, and analysis of myocardial injury markers and ferroptosis indicators...
April 12, 2024: Journal of Vascular Research
Krzysztof Bartkowiak, Mateusz Bartkowiak, Ewa Jankowska-Steifer, Anna Ratajska, Marek Kujawa, Olga Aniołek, Justyna Niderla-Bielińska
BACKGROUND: Elevated mortality rates in patients with metabolic syndrome (MetS) are partly due to adverse remodeling of multiple organs, which may lead to cardiovascular disease, nonalcoholic fatty liver disease, kidney failure, or other conditions. MetS symptoms, such as obesity, hypertension, hyperglycemia, dyslipidemia, associated with insulin and leptin resistance, are recognized as major cardiovascular risk factors that adversely affect the heart. SUMMARY: Pathological cardiac remodeling is accompanied by endothelial cell dysfunction which may result in diminished coronary flow, dysregulated oxygen demand/supply balance, as well as vessel rarefaction...
April 12, 2024: Journal of Vascular Research
Hideki Ishimaru, Yohei Ikebe, Tsuyoshi Izumo, Hiroshi Imai, Minoru Morikawa, Reiko Ideguchi, Ayano Ishiyama, Hirofumi Koike, Masataka Uetani, Ryo Toya
INTRODUCTION: We aimed to compare conventional vessel wall MR imaging techniques and quantitative susceptibility mapping (QSM) to determine the optimal sequence for detecting carotid artery calcification. METHODS: Twenty-two patients who underwent carotid vessel wall MR imaging and neck CT were enrolled. Four slices of 6-mm sections from the bilateral internal carotid bifurcation were subdivided into 4 segments according to clock position (0-3, 3-6, 6-9, and 9-12) and assessed for calcification...
March 28, 2024: Journal of Vascular Research
Lina Lin, Wei Gao, Linya Feng, Chundong Wang, Ruiqi Yang, Weijian Wang, Qiaolin Wu
INTRODUCTION: Previous studies have confirmed that low shear stress (LSS) induces glycocalyx disruption, leading to endothelial dysfunction. However, the role of autophagy in LSS-induced glycocalyx disruption and relevant mechanism are not clear. In this study, we hypothesized that LSS may promote autophagy, disrupting the endothelium glycocalyx. METHODS: Human umbilical vein endothelial cells were subjected to physiological shear stress and LSS treatments, followed by the application of autophagy inducers and inhibitors...
March 19, 2024: Journal of Vascular Research
Rehan T Junejo, Dhiraj Gupta, Richard L Snowdon, Gregory Y H Lip, James P Fisher
INTRODUCTION: Atrial fibrillation (AF) is associated with endothelial damage/dysfunction. Herein, we tested the hypothesis that brachial artery flow-mediated dilation (FMD) is superior in AF patients taking apixaban compared to warfarin. METHODS: AF patients on apixaban (n = 46; 67 [7] years; mean [standard deviation]; 15 women) and warfarin (n = 27; 73 [9] years (p &lt; 0.01); 11 women) were recruited. Duplex Doppler ultrasound imaging was undertaken during baseline (2 min), cuff inflation (5 min), and following cuff deflation (3 min)...
March 6, 2024: Journal of Vascular Research
Cong Zhang, Shunbo Wei, Liwei Zhang, Chunyang Lou, Jianbang Fang, Yuanfeng Liu, Hao He, Zhuo Li, Jing'an Li, Hualong Bai
INTRODUCTION: Vascular prosthetic grafts are widely used in vascular surgery; however, graft infection remains a major concern. Silver-coated vascular grafts have demonstrated anti-infection properties in clinical settings; however, whether the silver irons influence foreign body reaction or neointimal hyperplasia remains unclear. METHODS: Sodium alginate and hyaluronic acid (SA/HA) hydrogel patches loaded with rhodamine, with or without silver, were fabricated...
February 16, 2024: Journal of Vascular Research
Manon Doué, Guillaume Marques, Anaïs Okwieka, Laëtitia Gorisse, Christine Piétrement, Philippe Gillery, Stéphane Jaisson
INTRODUCTION: Carbamylation is a nonenzymatic post-translational modification of proteins characterized by the binding of isocyanic acid to amino groups of proteins, which leads to the alteration of their properties. An increase in serum carbamylation-derived products, including homocitrulline (HCit), has been shown to be associated with the development of cardiovascular diseases. METHODS: HCit was quantified by LC-MS/MS within extracts of aneurysmal and control human aortas...
January 19, 2024: Journal of Vascular Research
Meghan W Sedovy, Xinyan Leng, Farwah Iqbal, Mark C Renton, Melissa Leaf, Kailynn Roberts, Arya Malek, W Scott Arnold, David A Wyatt, Cynthia W Choate, Joseph F Rowe, Joseph W Baker, Scott R Johnstone, Mark Joseph
INTRODUCTION: While multiple factors influence coronary artery bypass graft (CABG) success rates, preserving saphenous vein endothelium during surgery may improve patency. Standard preparations include saphenous vein preparation in heparinized saline (saline) which can result in endothelial loss and damage. Here, we investigated the impact of preparing saphenous graft vessels in heparinized patient blood (blood) versus saline. METHODS: Saphenous vein tissues from a total of 23 patients undergoing CABG were split into 2 groups (1) saline and (2) heparinized patient blood...
January 12, 2024: Journal of Vascular Research
Qi Li, Zhongsha Li, Jingyu Li, Xiaoling Qin, Fengjiao Wu, Chang Chen
INTRODUCTION: This study aimed to determine whether bone morphogenetic protein-4 (BMP-4), which increases in response to intimal hyperplasia, promotes phenotype transition in vascular smooth muscle cells (VSMCs). METHODS: Balloon injury was used to induce intimal hyperplasia in rats. Hematoxylin-eosin staining was used to detect the alteration of vascular structure. Serum levels of BMP-4 and lactate were detected by ELISA. Human aortic smooth muscle cells (HA-SMCs) were cultured...
December 27, 2023: Journal of Vascular Research
Caitlin Wilson, Janice M Thompson, Leah Terrian, Adam D Lauver, Emma D Flood, Gregory D Fink, Lisa Sather, Sudin Bhattacharya, G Andres Contreras, Stephanie W Watts
INTRODUCTION: Tunica media extracellular matrix (ECM) remodeling is well understood to occur in response to elevated blood pressure, unlike the remodeling of other tunicas. We hypothesize that perivascular adipose tissue (PVAT) is responsive to hypertension and remodels as a protective measure. METHODS: The adventitia and PVAT of the thoracic aorta were used in measuring ECM genes from 5 pairs of Dahl SS male rats on 8 or 24 weeks of feeding from weaning on a control (10% Kcal fat) or high-fat (HF; 60%) diet...
December 19, 2023: Journal of Vascular Research
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December 15, 2023: Journal of Vascular Research
Brayden D Halvorson, Moeiz Ahmed, Sophie J Huang, Jefferson C Frisbee
BACKGROUND: Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Arteriolar tone regulation plays a critical role in maintaining appropriate organ blood flow and perfusion distribution, which is vital for both vascular and overall health. SUMMARY: This scoping review aimed to explore the interplay between five major regulators of arteriolar tone: metabolism (adenosine), adrenergic control (norepinephrine), myogenic activation (intravascular pressure), perivascular oxygen tension, and intraluminal flow rates...
December 14, 2023: Journal of Vascular Research
Robert G Hahn
INTRODUCTION: Oscillations are frequently observed on plasma dilution curves during intravenous fluid therapy. This study aimed to examine how common these oscillations are and what they represent. METHODS: Fourier transforms were used to analyze the residuals obtained during fitting of a volume kinetic model to 269 plasma dilution curves. Oscillating patterns were identified in two-thirds of the fluid infusion experiments. RESULTS: The wave frequency usually had a dominating frequency of 1 h or multiples thereof...
December 14, 2023: Journal of Vascular Research
Mengmeng Liu, Di Song, Shaofu Hong, Yinghui Dong, Wenjing Gao, Yigang Du, Lei Zhu, Jinfeng Xu, Fajin Dong
INTRODUCTION: The aim of the study was to evaluate characteristics and provide the normal values of wall shear stress (WSS) and flow turbulence (Tur), and the relationship between them in the carotid bifurcation based on an ultrasound vector flow imaging (V Flow) in healthy adults. METHODS: Max and mean WSS and Tur values at three segments (initial segments of internal and external carotid arteries [IICA and IECA]; distal segment of common carotid artery [DCCA]), both in anterior and posterior walls, were successfully obtained in 56 healthy adults, using ultrasound V Flow function...
December 7, 2023: Journal of Vascular Research
Daniel Henrion, Philippe Bonnin, Emilie Vessieres, Anne-Laure Guihlot, Marc Iglarz, Bernard I Lévy
INTRODUCTION: Cerebral blood flow (CBF) is reduced in patients with Alzheimer's disease (AD). Flow-mediated dilation (FMD), which plays a key role in the regulation of blood flow, is attenuated by endothelin-1. We hypothesized that endothelin receptor blockade may improve CBF in AD. METHODS: We investigated cerebrovascular reactivity in a mouse model of AD (APP-PS1; 5-6-month-old male subjects). We assessed the in vivo response to normoxic hypercapnia and in vitro FMD in isolated cerebral and mesenteric resistance arteries before and after endothelin receptor blockade (bosentan)...
November 17, 2023: Journal of Vascular Research
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