Journals Journal of Diabetes and its Co...

Journal of Diabetes and its Complications
Sondre Meling, Erling Tjora, Heike Eichele, Rasmus Bach Nedergaard, Niels Ejskjaer, Christina Brock, Eirik Søfteland
No abstract text is available yet for this article.
September 9, 2023: Journal of Diabetes and its Complications
Ninna Hahn Tougaard, Tine Willum Hansen, Peter Rossing
AIMS: To investigate vitamin D deficiency as a risk marker for complications in individuals with type 1 and type 2 diabetes. METHODS: A cohort study including 1448 adults with type 1 and 770 with type 2 diabetes. Individuals in the decile with lowest vitamin D level were classified as vitamin D deficient. Outcomes based on medical records and registers included mortality, major adverse cardiovascular event (MACE), heart failure, a composite kidney endpoint, albuminuria progression and sight-threatening eye disease...
September 6, 2023: Journal of Diabetes and its Complications
Chun-Kwan O, Brian Wai-Hei Siu, Vanessa Wai-Shan Leung, Yuan-Yuan Lin, Chen-Zhao Ding, Eric Siu-Him Lau, Jamie Cheung, Andrea On-Yan Luk, Elaine Yee-Kwan Chow, Ronald Ching-Wan Ma, Juliana Chung-Ngor Chan, Rachel Ngan-Yin Chan, Yun Kwok Wing, Alice Pik-Shan Kong
AIMS: To examine the risk association of insomnia with incident chronic cognitive impairment in older adults with type 2 diabetes mellitus (T2D). METHODS: Between July 2010 and June 2015, patients with T2D aged ≥60 years enrolled in the Hong Kong Diabetes Register completed the Insomnia Severity Index (ISI) questionnaire. Patients were considered having insomnia if they had ISI score > 14. We prospectively followed up the cohort and censored outcome through reviewing diagnoses and clinical notes entered by attending physicians in electronic medical record to identify incident cases of mild cognitive impairment and dementia...
September 4, 2023: Journal of Diabetes and its Complications
Mengran Shi, Hao Zhang, Wei Wang, Xiao Zhang, Jiawei Liu, Qixian Wang, Yuan Wang, Chunlin Zhang, Xiaoqin Guo, Qiao Qiao, Chun Cui, Jing Xu, Jian Wang
AIMS: To evaluate the effect of dapagliflozin on liver fat content (LFC) and pancreatic fat content (PFC). MATERIALS AND METHODS: 84 patients with type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) were randomly assigned to receive either dapagliflozin (n = 42) or serve as controls (n = 42). The primary endpoint is changes in LFC and PFC using magnetic resonance imaging estimated proton density fat fraction. Secondary outcomes include liver fibrosis index, inflammatory cytokine levels, and liver enzyme levels...
September 1, 2023: Journal of Diabetes and its Complications
Atsuhiko Suenaga, Naoki Sawa, Yuki Oba, Daisuke Ikuma, Akinari Sekine, Eiko Hasegawa, Hiroki Mizuno, Tatsuya Suwabe, Sara Ikeda, Tetsuro Tsujimoto, Kei Kono, Yukako Shintani-Domoto, Keiichi Kinowaki, Kenichi Ohashi, Motoaki Miyazono, Yutaka Yamaguchi, Yoshifumi Ubara
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used to treat type 2 diabetes (T2D). Lowering blood glucose is expected also to reduce the progression of diabetic nephropathy. We experienced a patient with T2D who achieved good glycemic control with a DPP-4 inhibitor but experienced rapid deterioration of renal function. Therefore, we performed a retrospective study of similar patients treated at our hospital. METHODS: Out of 56 patients with biopsy-proven diabetic nephropathy who underwent native kidney biopsy at Toranomon Hospital from January 2018 through December 2022, we selected 22 patients who had been receiving DPP-4 inhibitors for at least 9 months at the time of kidney biopsy...
September 1, 2023: Journal of Diabetes and its Complications
Qing Zhou, Huan Tang, Shuting Li
AIMS: In this study, rat retinal Müller cells (RMCs) were cultured in vitro to investigate the protective mechanism of evolocumab on rat RMCs in diabetes mellitus (DM) and the expression of relevant inflammatory factors. METHODS: The expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the retinal tissues of diabetic rats was detected by immunohistochemistry. Sprague-Dawley (SD) rats at 5-7 d of life were selected as the source of RMCs and divided equally into three groups of 12 rats/24 eyes each...
August 30, 2023: Journal of Diabetes and its Complications
Viveca Ritsinger, Emil Hagström, Kristina Hambraeus, Stefan James, Tomas Jernberg, Bo Lagerqvist, Margrét Leosdottir, Pia Lundman, John Pernow, Ollie Östlund, Anna Norhammar
AIMS: To investigate if addition of metformin to standard care (life-style advice) reduces the occurrence of cardiovascular events and death after myocardial infarction (MI) in patients with newly detected prediabetes. METHODS: The Myocardial Infarction and new treatment with Metformin study (MIMET) is a large multicentre registry-based randomised clinical trial (R-RCT) within the SWEDEHEART registry platform expected to include 5160 patients with MI and newly detected prediabetes (identified with fasting blood glucose, HbA1c or 2-h glucose on oral glucose tolerance test) at ∼20 study sites in Sweden...
August 30, 2023: Journal of Diabetes and its Complications
Stephanie Griggs, Grant Pignatiello, Issam Motairek, Jorden Rieke, Quiana Howard, Sybil L Crawford, Sanjay Rajagopalan, Sadeer Al-Kindi, Ronald L Hickman
AIMS: To examine the associations between environmental determinants of health and blood pressure and whether age, sex, or race moderated the associations among 18,754 adolescents and adults from the type 1 diabetes (T1D) Exchange Clinic Registry. METHODS: We used multivariable linear regression. Environmental determinants included exposure to ambient fine particulate matter (PM2.5 , obtained from an integrated model), nitrogen dioxide (NO2 ), noise and light pollution, and the normalized difference vegetation index (NDVI, a marker of green space) at the ZIP code level of residence...
August 25, 2023: Journal of Diabetes and its Complications
Li Huang, Andrzej S Januszewski, Yusuke Takahashi, David N O'Neal, Jian-Xing Ma, Alicia J Jenkins
microRNAs (miRs), including miR-142, modulate gene expression and processes implicated in vascular damage and may serve as therapeutic targets and agents, including in Type 1 diabetes (T1D). The project aimed to assess whether miR-142 levels differ between people with and without T1D, and to analyse miR-142 associations with cardiovascular (CVD) risk factors. Intracellular miRs were isolated from whole blood cell pellets using TRIzol-based methodology. In a cross-sectional study in 102 adults cellular miR-142 levels were significantly higher (on unadjusted and adjusted analyses) in 69 adults with T1D relative to 33 non-diabetic subjects: mean ± SD, 3...
August 25, 2023: Journal of Diabetes and its Complications
Frederik N Pedersen, Lonny Stokholm, Nis Andersen, Jens Andresen, Toke Bek, Javad N Hajari, Steffen Heegaard, Kurt Højlund, Ryo Kawasaki, Sören Möller, Caroline S Laugesen, Katja C Schielke, Anne S Thykjær, Tunde Peto, Frans Pouwer, Jakob Grauslund
OBJECTIVE: Diabetic retinopathy (DR) is a feared complication and a leading course of visual impairment, but the connection between DR and depression including the direction has never been studied in a nationwide cohort. We aimed to assess, whether the associations between DR and diagnosed depression are bidirectional. METHODS: We performed a national register-based cohort study of individuals with type 2 diabetes, who attended diabetic eye screening between January 2013 and June 2022...
August 24, 2023: Journal of Diabetes and its Complications
Yu Kataoka, Satoshi Kitahara, Sayaka Funabashi, Hisashi Makino, Masaki Matsubara, Miki Matsuo, Yoko Omura-Ohata, Ryo Koezuka, Mayu Tochiya, Tamiko Tamanaha, Tsutomu Tomita, Kyoko Honda-Kohmo, Michio Noguchi, Maki Maruki, Emi Kanai, Kota Murai, Takamasa Iwai, Kenichiro Sawada, Hideo Matama, Satoshi Honda, Masashi Fujino, Syuichi Yoneda, Kensuke Takagi, Fumiyuki Otsuka, Yasuhide Asaumi, Kiminori Hosoda, Stephen J Nicholls, Satoshi Yasuda, Teruo Noguchi
BACKGROUND: Continuous glucose monitoring (CGM) improves glycemic fluctuation and reduces hypoglycemic risk. Whether CGM-guided glycemic control favorably modulates coronary atherosclerosis in patients with type 2 diabetes (T2DM) remains unknown. METHODS: The OPTIMAL trial was a prospective, randomized, single-center trial in which 94 T2DM patients with CAD were randomized to CGM- or HbA1c-guided glycemic control for 48 weeks (jRCT1052180152). The primary endpoint was the nominal change in total atheroma volume (TAV) measured by serial IVUS...
August 23, 2023: Journal of Diabetes and its Complications
Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, Marie-Amélie Barbet-Massin, Claire Ducos, Lila Rami-Arab, Frédéric Domenge, Kamel Mohammedi, Eric Ducasse, Caroline Caradu, Vincent Rigalleau
OBJECTIVES: The long-term glycemic memory contributes to vascular complications in type 2 diabetes, including those patients with Diabetic Foot Ulcers (DFU). We investigated whether the skin autofluorescence (SAF) of Advanced Glycation End-products related to later DFUs. RESEARCH DESIGN & METHODS: SAF was measured with an AGE-Reader in a retrospective cohort of patients hospitalized from 2009 to 2017 for Type 2 Diabetes. New DFUs were registered until the year 2020 and survival analyses were performed...
August 23, 2023: Journal of Diabetes and its Complications
Lea Kirstine Lewerenz Skriver, Malene Winther Nielsen, Simone Walther, Jannie Damsgaard Nørlev, Stine Hangaard
BACKGROUND AND AIM: One of the greatest barriers to the treatment of T2DM is nonadherence which particularly applies to insulin therapy. There is a need for a comprehensive overview of all factors associated with nonadherence to insulin therapy. The aim of this study was to identify factors associated with adherence or nonadherence to insulin therapy among adults with T2DM. METHODS: A scoping review was conducted in accordance with the PRISMA 2020 statement. A systematic search was performed in PubMed, Cinahl, and Web of Science (January 2013 to March 2023)...
August 22, 2023: Journal of Diabetes and its Complications
Yanping Yuan, Xianghai Zhou, Linong Ji
BACKGROUND: Studies on whether remnant cholesterol (RC) affects the progression of chronic kidney disease (CKD) remain insufficient. This study aimed to determine whether RC level was associated with the severity of CKD in patients with type 2 diabetes mellitus (T2DM). METHODS: In total, 3383 individuals diagnosed with T2DM were enrolled in this cross-sectional study from China. The severity of CKD was defined as no, moderate, severe, and very severe CKD based on the urinary albumin-to-creatinine ratio and estimated glomerular filtration rate...
August 17, 2023: Journal of Diabetes and its Complications
Zsolt Hermányi, Vanda Csiki, Adrienn Menyhárt, Karola Osgyán, Anna Körei, Ildikó Istenes, Zsuzsanna Putz, Abdallah Benhamida, Attila Berey, Judit Hetthéssy, Szabolcs Varbiro, Miklós Kozlovszky, Péter Kempler
AIMS: The aim of the article is to describe the method for creating a close to ideal diabetes database. The MÉRY Diabetes Database (MDD) consists of a large quantity of reliable, well-maintained, precise and up-to-date data suited for clinical research with the intention to improve diabetes care in terms of maintaining targeted blood glucose levels, avoiding hypoglycemic episodes and complications and improving patient compliance and quality of life. METHODS: Based on the analysis of the databases found in the literature and the experience of our research team, nine important characteristics were identified as critical to an ideal diabetes database...
August 15, 2023: Journal of Diabetes and its Complications
Athina Stamati, Georgia Sotiriou, Meropi Dimitriadou, Athanasios Christoforidis
AIMS: To assess the efficacy and safety of faster aspart (FIAsp) in paediatric population with type 1 diabetes mellitus (T1DM) and insulin pumps in real-world settings. METHODS: Of 44 patients, 20 used FIAsp, 16 of which switched from aspart to FIAsp and 24 used aspart/lispro. We performed within-groups and between-groups analyses in three time points for anthropometric data, % of 24-h time in range of 70-180 mg/dl (TIR), time < 70 mg/dl and <54 mg/dl and time > 180 mg/dl and >250 mg/dl, bolus and basal insulins doses (units/kg/day and %), total daily dose (TDD, units/kg/day), glycaemic variability, frequency of set changes, sensor wear per week and meals per day...
August 15, 2023: Journal of Diabetes and its Complications
Pablo Repetto, Daria Ayago
AIMS: To evaluate the benefit and safety of a switch in the basal insulin protocol to glargine 300 U/ml (Gla-300) on inpatients' overall dysglycemic events. Efficacy and safety data on insulin Gla-300 in the inpatient setting are limited. METHODS: Retrospective observational study conducted on 7455 patients admitted to acute care (n = 5414) or geriatric and social healthcare (n = 2041) units of the Regional Hospital of Amposta (Spain) between January 2017 and December 2020 who received basal insulin during hospitalization...
August 9, 2023: Journal of Diabetes and its Complications
Giuseppe Mainas, Luigi Nibali, Manfredi Rizzo
Periodontal disease leads to a systemic hyper-inflammatory state that might impair other co-morbidities including cardiovascular disease. Evidence-based findings showed that periodontitis may be linked with subclinical signs of cardiovascular diseases such as arterial stiffness. Nevertheless, some contrasting results have been reported over the years. A cross-sectional study regarding the relationship between periodontal disease and subclinical cardiovascular diseases, in non-diabetic and diabetic individuals, has been recently published...
August 5, 2023: Journal of Diabetes and its Complications
Mary R Rooney, Natalie R Daya, Aaron Leong, Michael J McPhaul, Dov Shiffman, James B Meigs, Elizabeth Selvin
We found that individuals in the top tertile of HOMA-IR and with HbA1c-defined prediabetes have elevated risk of cardiometabolic outcomes.
August 2, 2023: Journal of Diabetes and its Complications
Rasmus Rørth, Margit Kriegbaum, Mia Klinten Grand, Peter Karl Jacobsen, Bent Struer Lind, Christen Lykkegaard Andersen, Frederik Persson
OBJECTIVE: Diabetes is a risk factor for atrial fibrillation (AF), and increases the risk of thromboembolic events in persons with AF. However, the link between the two conditions is not fully elucidated. Few studies have investigated the association of dysglycemia and incident AF. We investigated the risk of incident AF and prognosis according to diabetes status. RESEARCH DESIGN AND METHODS: The Copenhagen Primary Care Laboratory Database was merged with data on medical prescriptions, in- and outpatient contacts and vital status...
July 29, 2023: Journal of Diabetes and its Complications
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