Journals Journal of Diabetes and its Co...

Journal of Diabetes and its Complications
Huda Kufaishi, Hatice Isik Mizrak, Birgitte Brock, Tine Willum Hansen, Peter Rossing, Christian Stevns Hansen
OBJECTIVE: We investigated associations between gastrointestinal symptoms - evaluated as a combined weighted symptom score (CWSS) - Diabetic autonomic neuropathy (DAN), and distal symmetrical polyneuropathy (DSPN) in type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS: Cross-sectional study in a tertiary outpatient clinic. CWSS was calculated based on questionnaires: gastroparesis composite symptom index (GCSI) and gastrointestinal symptom rating score (GSRS)...
April 13, 2024: Journal of Diabetes and its Complications
Dongming Zhao, Jingming Ma, Yuman Sun, Wei Huang, Jinyang Fan, Mingzhe Ye, Bo Hu, Xinyi Sun
INTRODUCTION: The prevalence of diabetes mellitus is increasing year by year globally, and diabetic cardiomyopathy (DCM), as the most common complication of type 2 diabetes mellitus, seriously affects the prognosis of patients. Trimetazidine (TMZ), as a drug affecting myocardial energy metabolism, mainly reduces the oxidation rate of β-oxidation by inhibiting 3-ketoacyl-CoA thiolase (3-KAT), a key enzyme in β-oxidation of free fatty acid (FFA), so that the energy metabolism substrate of cardiomyocytes preferentially selects glucose rather than fatty acids, increases the content of intracellular adenosine triphosphate (ATP), enhances the contractile function of cardiomyocytes, and improves the state of cellular ischemia and hypoxia...
April 5, 2024: Journal of Diabetes and its Complications
Abraham Edgar Gracia-Ramos, María Del Pilar Cruz-Dominguez, Eduardo Osiris Madrigal-Santillán, Raúl Rojas-Martínez, José Antonio Morales-González, Ángel Morales-González, Mónica Hernández-Espinoza, Joaquín Vargas-Peñafiel, María de Los Ángeles Tapia-González
AIMS: To compare the efficacy and safety of basal-plus (BP) insulin regimen with or without sitagliptin in non-critically ill patients with type 2 diabetes (T2D). METHODS: This open-label, randomized clinical trial included inpatients with a previous diagnosis of T2D and blood glucose (BG) between 180 and 400 mg/dL. Participants received basal and correctional insulin doses (BP regimen) either with or without sitagliptin. The primary outcome was the difference in the mean daily BG among the groups...
April 3, 2024: Journal of Diabetes and its Complications
Tiziana Filardi, Alessandra Feraco, Antoine Ouvrard-Pascaud, Manfredi Rizzo, Massimiliano Caprio
No abstract text is available yet for this article.
April 1, 2024: Journal of Diabetes and its Complications
Randa Farah, Abdulrahman Alhajahjeh, Oraib Al-Farahid, Hana Abuzaid, Dana Hyassat, Gaith Al-Khuraisat, Rana Al-Shimi, Faisal Athamnah, Ahmad Aldurgham, Husam Aljabiry, Kamel Ajlouni
AIMS: Chronic kidney disease (CKD) is prevalent in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate risk factors for CKD progression across the kidney disease-Improving Global Outcomes (KDIGO)categories in a Middle Eastern population beyond hyperglycemia as emphasized by KDIGO guidelines which classifying CKD by cause and severity. METHODS: This cross-sectional study targeted 1603 patients with T2DM. Risk factors for CKD progression were determined using odds ratios (ORs) and 95 % confidence intervals (CIs)...
March 27, 2024: Journal of Diabetes and its Complications
Luciana Mascarenhas Fonseca, Lauren Kanapka, Kellee Miller, Richard Pratley, Michael R Rickels, Shafaq Rizvi, Yogish C Kudva, Ruth S Weinstock, Naomi S Chaytor
BACKGROUND: Adults with type 1 diabetes (T1D) are considered at increased risk for cognitive impairment and accelerated brain aging. However, longitudinal data on cognitive impairment and dementia in this population are scarce. OBJECTIVE: To identify risk factors associated with cognitive performance and cognitive impairment in a longitudinal sample of older adults with T1D. METHODS: We analyzed data collected as part of the Wireless Innovation for Seniors with Diabetes Mellitus (WISDM) Study, in which 22 endocrinology practices participated...
March 26, 2024: Journal of Diabetes and its Complications
Robert Booker, Mandy Wong, Michael P Bancks, Mercedes R Carnethon, Lisa S Chow, Cora E Lewis, Pamela J Schreiner, Shaina J Alexandria
AIM: To assess the association of adipose-to-lean ratio (ALR) with incident type 2 diabetes mellitus (T2DM), hypertension, and dyslipidemia in middle adulthood. METHOD: Black and White Coronary Artery Risk Development in Young Adults participants without T2DM, hypertension, or dyslipidemia in 2005-06 (baseline) were included. Baseline adipose and lean mass were assessed via dual-energy X-ray absorptiometry. ALR was calculated as adipose divided by lean mass and then standardized within sex strata...
March 20, 2024: Journal of Diabetes and its Complications
Enio A M Santos, Tatiana A Zaccara, Cristiane F Paganoti, Stela V Peres, Rossana P V Francisco, Rafaela A Costa
AIMS: To evaluate the association between extrapolated time in range (eTIR), measured by self-monitoring of blood glucose (SMBG), and large-for-gestational-age (LGA) infants in pregnancies with type 1 diabetes (T1D). METHODS: Retrospective cohort analysis including singleton pregnancies with T1D who started antenatal care before 20 gestational weeks and delivered live newborns at a Brazilian hospital between 2010 and 2019, with LGA fetuses as the main outcome. Glycemic records acquired using SMBG were categorized as eTIR, extrapolated time below range (eTBR), and extrapolated time above range (eTAR)...
March 19, 2024: Journal of Diabetes and its Complications
Pedro J Pinés-Corrales, María Carmen López-García, Alberto Sanz-Velasco, Antonio J Moya-Moya, César Gonzalvo Díaz, Lourdes García Blasco
In Spain, from October 10th, 2023, the FreeStyle Libre 2 system offers the possibility to automatically changed from isCGM to rtCGM with a system update. Our study aimed to evaluate the glucometric before and after that date. We didn't find significant changes in TIR, however time of use increased and TBR decreased.
March 16, 2024: Journal of Diabetes and its Complications
Ali Mahmoudi, Amin Jalili, Seyed Hamid Aghaee-Bakhtiari, Reza Kazemi Oskuee, Alexandra E Butler, Manfredi Rizzo, Amirhossein Sahebkar
BACKGROUNDS: Non-alcoholic fatty liver disease (NAFLD) is a common condition affecting >25 % of the population worldwide. This disorder ranges in severity from simple steatosis (fat accumulation) to severe steatohepatitis (inflammation), fibrosis and, at its end-stage, liver cancer. A number of studies have identified overexpression of several key genes that are critical in the initiation and progression of NAFLD. MiRNAs are potential therapeutic agents that can regulate several genes simultaneously...
March 12, 2024: Journal of Diabetes and its Complications
Andre Chateaubriand Campos, Eduardo Gomes Lima, Peter Karl Jacobsen, Louis Arnould, Simao Lottenberg, Renata Martins Maia, Livia Silva Conci, Tomas Minelli, Andrea Morato, Roberto Nery Dantas-Jr, Cesar Higa Nomura, Pedro Rissoli, Sergio Gianotti Pimentel, Carlos Vicente Serrano Junior
AIMS: To investigate the association between diabetic retinopathy (DR) and coronary artery disease (CAD) using coronary angiotomography (CCTA) and multimodal retinal imaging (MMRI) with ultra-widefield retinography and optical coherence tomography angiography and structural domain. METHODS: Single-center, cross-sectional, single-blind. Patients with diabetes who had undergone CCTA underwent MMRI. Uni and multivariate analysis were used to assess the association between CAD and DR and to identify variables independently associated with DR...
March 6, 2024: Journal of Diabetes and its Complications
Joel Willem Johan Lasschuit, Jacqueline Ruth Center, Jerry Richard Greenfield, Katherine Thuy Trang Tonks
AIMS: We aimed to investigate the effect of denosumab on pedal bone health and clinical resolution in active Charcot foot (CN). METHODS: This multicentre open-label phase 2 randomised controlled trial recruited adults with diabetes mellitus and active CN within 3 months of onset. Participants were randomised to standard care alone, or with denosumab 60 mg subcutaneously. Denosumab was administered at baseline and again at 6 months, unless foot temperature had normalised (i...
March 5, 2024: Journal of Diabetes and its Complications
Noa Tsur, Meir Frankel, Avivit Cahn, Anat Tsur
AIM: To investigate ethnic disparities in risk of gestational diabetes-mellitus (GDM) and future diabetes. METHODS: A population-based retrospective cohort study of women who underwent a 100-g oral glucose-tolerance-test (oGTT) during pregnancy between 2007 and 2017 in Clalit-Health-Services of the Jerusalem district. Univariate and multivariate logistic regression analyses were used to compare the risk of GDM in Arab versus Jewish women. Further, Cox-regression analysis was used to establish the risk of future diabetes...
March 4, 2024: Journal of Diabetes and its Complications
Miska Vuorlaakso, Verna Karèn, Juha Kiiski, Jorma Lahtela, Ilkka Kaartinen
AIMS: Diabetic foot syndrome is a global challenge best managed through multidisciplinary collaboration. This study aimed to investigate the effect of a systematic multidisciplinary team (MDT) on the overall survival and major amputation-free survival of hospitalized patients with diabetic foot infection (DFI). METHODS: This retrospective cohort study was conducted at Tampere University Hospital. Cohorts of hospitalized patients with DFI before and after the initiation of multidisciplinary wound ward were compared after an 8-year follow-up...
March 3, 2024: Journal of Diabetes and its Complications
Shun Matsuura, Soichiro Nagata, Koji Shibazaki, Reiko Uchida, Yukiko Imai, Shoko Shibata, Hiroshi Morita
AIM: This study aimed to investigate the association between changes in body composition, glycated hemoglobin, and lipid ratio during the treatment of patients with type 2 diabetes mellitus (T2DM). METHODS: This retrospective analysis used data from outpatients with T2DM who had confirmed body composition and measured laboratories at administration and after treatment. The baseline characteristics and prescribed treatment were collected. The total cholesterol/high-density lipoprotein cholesterol (HDL) ratio, low-density lipoprotein cholesterol (LDL)/HDL ratio, and triglyceride-glucose (TyG) index were also calculated...
February 27, 2024: Journal of Diabetes and its Complications
Anojian Koneshamoorthy, Dilan Seneviratne Epa, David N O'Neal, Melissa H Lee, John D Santamaria, Richard J MacIsaac
AIMS: To relate adverse events with glucose correction rates in diabetic ketoacidosis (DKA) using variable rate intravenous insulin-infusions (VRIII). METHODS: Retrospective, observational study in adults with DKA who received insulin infusions between 2012 and 2017 at St Vincent's Hospital, Melbourne. Early correction of hyperglycaemia (<10 mmol/L) was evaluated for association with hypoglycaemia (<4.0 mmol/L), hypokalaemia (potassium <3.3 mmol/L) and clinical outcomes via regression analysis...
February 15, 2024: Journal of Diabetes and its Complications
Luc Rakotoarisoa, Laurence Weiss, François Lefebvre, Michele Porzio, Benjamin Renaud-Picard, Bruno Ravoninjatovo, Michel Abely, Isabelle Danner-Boucher, Séverine Dubois, Françoise Troussier, Anne Prevotat, Gilles Rault, Romain Kessler, Laurence Kessler
BACKGROUND: Cystic fibrosis related diabetes (CFRD) is commonly associated with declining lung function and nutritional status. We aimed to evaluate the pulmonary impact of early glucose abnormalities by using 2-h standard oral glucose tolerance testing (OGTT) and continuous glucose monitoring (CGM) in people with cystic fibrosis (PwCF). METHODS: PwCF aged ≥10 years old without known CFRD were included in a five-year prospective multicentre study. Annual evaluation of nutritional status, lung function, OGTT and CGM was set up...
February 14, 2024: Journal of Diabetes and its Complications
Daniel S Hsia, Naji Younes, Heidi Krause-Steinrauf, Laure Sayyed Kassem
Based on self-report in the GRADE diabetes study, cumulative incidence of retinopathy was low over 5 years (3.7 %; 184 of 4098 participants) and did not differ among the 4 treatment groups (glargine 4.0 %, glimepiride 3.2 %, liraglutide 3.7 %, sitagliptin 3.8 %). There were no differences in retinopathy with specific therapies in GRADE. identifier: NCT01794143.
February 5, 2024: Journal of Diabetes and its Complications
Daniel de Luis, David Primo, Olatz Izaola, Juan José Lopez Gomez
BACKGROUND: Adiponectin is one of the most important adipokines in human beings. Obesity and sarcopenia are associated with a low-level chronic inflammatory status, and adiponectin plays an anti-inflammatory role. AIMS: The objective of the current work was to study the association between muscle mass, determined via bioelectrical impedance (BIA), and circulating adiponectin levels among obese patients with metabolic syndrome who are older than 60 years of age...
April 2024: Journal of Diabetes and its Complications
Gui-Lin Ran, Yan-Ping Li, Li-Chin Lu, Shao-Huan Lan
BACKGROUND: Alpha-lipoic acid, epalrestat, and mecobalamin are widely used as monotherapies for diabetic peripheral neuropathy. However, whether a triple-combination therapy with these three drugs is superior to monotherapy or dual therapy remains debatable. METHODS: Nine randomized controlled trials were identified through a search on electronic databases such as PubMed, Web of Science, and Cochrane Library. The trial participants (N = 1153) were divided into the experimental group who received the triple-combination therapy and the control group who received conventional or dual therapy with the aforementioned drugs...
February 2024: Journal of Diabetes and its Complications
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