Journals Journal of Diabetes and its Co...

Journal of Diabetes and its Complications
Sarah K Adie, Scott W Ketcham, Vincent D Marshall, Nicholas Farina, Devraj Sukul
BACKGROUND: Current guidelines recommend maintaining serum blood glucose (BG) levels between 150 and 180 mg/dL for patients admitted to the intensive care unit (ICU); however, these recommendations are based on randomized controlled trials among general ICU patients and observational studies among specific subgroups. Little is known about the impact of glucose control among patients cared for in the cardiac intensive care unit (CICU). METHODS: This was a retrospective cohort analysis of patients >18 years of age admitted to the University of Michigan CICU from December 2016 through December 2020 with at least one BG measurement during CICU admission...
March 10, 2023: Journal of Diabetes and its Complications
Aris Bechlioulis, Georgios Markozannes, Ifigeneia Chionidi, Evangelos Liberopoulos, Katerina K Naka, Evangelia E Ntzani, Stavros Liatis, Manfredi Rizzo, Evangelos C Rizos
BACKGROUND: Pulse wave velocity (PWV) and augmentation index (AIx) are indices used to assess arterial stiffness. We aim to compare the effect of empagliflozin, liraglutide and their sequential combination on arterial stiffness indices in patients with type 2 diabetes (T2D). METHODS: This was a randomized single blind study evaluating the effect of empagliflozin vs liraglutide in adult patients with T2D. Patients were randomized to liraglutide titrated gradually to 1...
February 23, 2023: Journal of Diabetes and its Complications
Jiahe Guo, Guoyong Jiang, Jing Chen, Maojie Zhang, Kaituo Xiang, Cheng Wang, Tao Jiang, Yu Kang, Yue Sun, Xiang Xu, Xiaofan Yang, Zhenbing Chen
The diabetic wound nowadays remains a major public health challenge, which is characterized by overproduced reactive oxygen species (ROS). However, the current therapy for diabetic wounds is limited for reliable data in the general application. The growth of tumors has been revealed to share parallels with wound healing. Extracellular vesicles (EVs) derived from breast cancer have been reported to promote cell proliferation, migration and angiogenesis. The tumor tissue-derived EVs (tTi-EVs) of breast cancer performance a feature inheritance from original tissue and might accelerate the diabetic wound healing...
February 20, 2023: Journal of Diabetes and its Complications
Viktor Rotbain Curovic, Nete Tofte, Morten Lindhardt, Katarina Adamova, Stephan J L Bakker, Joachim Beige, Joline W J Beulens, Andreas L Birkenfeld, Gemma Currie, Christian Delles, Ingo Dimos, Lidmila Francová, Marie Frimodt-Møller, Peter Girman, Rüdiger Göke, Tine W Hansen, Tereza Havrdova, Adriaan Kooy, Gozewijnw D Laverman, Harald Mischak, Gerjan Navis, Giel Nijpels, Marina Noutsou, Alberto Ortiz, Aneliya Parvanova, Frederik Persson, John R Petrie, Piero L Ruggenenti, Femke Rutters, Ivan Rychlík, Justyna Siwy, Goce Spasovski, Marijn Speeckaert, Matias Trillini, Petra Zürbig, Heiko von der Leyen, Peter Rossing
AIMS: Baseline diabetic retinopathy (DR) and risk of development of microalbuminuria, kidney function decline, and cardiovascular events (CVEs) in type 2 diabetes. METHODS: Post-hoc analysis of the PRIORITY study including 1758 persons with type 2 diabetes and normoalbuminuria followed for a median of 2.5 (IQR: 2.0-3.0) years. DR diagnosis included non-proliferative and proliferative abnormalities, macular oedema, or prior laser treatment. Cox models were fitted to investigate baseline DR presence with development of persistent microalbuminuria (urinary albumin-creatinine ratio > 30 mg/g); chronic kidney disease (CKD) G3 (eGFR <60 ml/min/1...
February 18, 2023: Journal of Diabetes and its Complications
Kevin M Pantalone, Xinge Ji, Sheldon X Kong, Jay C Elliott, Alex Milinovich, Anita D Misra-Hebert, Ryan Farej, Rakesh Singh, Janine M Bauman, Robert S Zimmerman, Tushar J Vachharajani, Jamie Partridge, Jennifer Cameron, Todd Williamson, Michael W Kattan
This brief report utilizes EHR data from a large US health system to summarize unmet needs in patients with type 2 diabetes and chronic kidney disease and identifies areas of opportunity to optimize management within this patient population from treatment, screening and monitoring, and health care resource use perspectives.
February 13, 2023: Journal of Diabetes and its Complications
Solomon Tesfaye, Silviu Brill, Mariëlle Eerdekens, Mercedes Maderuelo Labrador, Gudula Petersen, Angela de Rooij Peek, Ainhoa Reta, Deirdre Ryan, Nicolaas Schaper, Thomas Tölle, Andrea Truini, Dan Ziegler
AIMS: The aim of this study was to assess patient perspectives and experiences of the impact of neuropathic pain, painful diabetic neuropathy (pDPN) diagnosis and treatment, and the patient-healthcare professional (HCP) relationship. METHODS: We conducted a quantitative online survey in Germany, the Netherlands, Spain, and the UK among adults with diabetes who responded "yes" to at least four of ten questions of in the Douleur Neuropathique en 4 Questions (DN4) questionnaire...
February 10, 2023: Journal of Diabetes and its Complications
Niki Katsiki, Manfredi Rizzo, Dimitri P Mikhailidis
No abstract text is available yet for this article.
February 10, 2023: Journal of Diabetes and its Complications
Xiaoli Xiang, Xiaoli Huang, Zhicheng Zhang, Jie Gu, Zhengru Huang, Tingwang Jiang
AIMS: We aimed to determine an association between follicular helper T (Tfh) cells and Bcl-6 and CXCL13 levels and determine the role of Tfh cells, Bcl-6, and CXCL13 serum levels in the pathogenesis of diabetic retinopathy (DR) since Tfh cells have an important role in type 1 diabetes; however, their role in type 2 diabetes-related DR requires exploration. METHODS: Blood samples were collected from 24 patients with non-proliferative diabetic retinopathy (NPDR), 20 with proliferative diabetic retinopathy (PDR), and 18 age- and sex-matched healthy volunteers...
February 9, 2023: Journal of Diabetes and its Complications
Ceylan Onursal, Buket Reel, Caglar Bintepe, Mehmet Guzeloglu, Nevin Ersoy, Alper Bagriyanik
AIMS: The aim of this study was to investigate the effects of pioglitazone on reactive oxygen species (ROS), expressions/activities of MMPs and TIMP-2, and VSMC proliferation and vascular reactivity in high glucose (HG)-induced human saphenous vein (HSV) grafts. METHODS: HSV grafts (n = 10) obtained from patients undergoing CABG were incubated with 30 mM glucose and/or 10 μM pioglitazone or 0.1 % DMSO for 24 h after endothelium removal...
February 8, 2023: Journal of Diabetes and its Complications
Jelena Vekic, Anca Pantea Stoian, Manfredi Rizzo
No abstract text is available yet for this article.
February 6, 2023: Journal of Diabetes and its Complications
Yuanpin Zhang, Qi Zhang, Yuetian Bai, Hangping Zheng, Lijin Ji, Xiaoming Zhu, Wanwan Sun, Xiaoxia Liu, Shuo Zhang, Yiming Li, Bin Lu
AIMS: Explore whether Glycogen synthesis kinase-3β (GSK3β) involved in the analgesic effect of liraglutide on diabetic neuropathic pain (DNP). METHODS: DNP was induced by streptozocin (STZ) in WT and GSK3β(S9A) mice, which carried a constitutively active form of GSK3β. DNP mice were intracerebroventricularly injected with liraglutide 5 weeks after STZ injection. The behavior of neuropathic pain was evaluated 2 h after drugs administration...
February 4, 2023: Journal of Diabetes and its Complications
Mohamed Abo El-Asrar, Eman Abdel Rahman Ismail, Alaa Mohamed Elnhrawy, Rasha Adel Thabet
BACKGROUND: Diabetic nephropathy is a major cause of morbidity and mortality in type 1 diabetes mellitus (T1DM). Fatty acid binding proteins (FABP1 and FABP2) play a role in the development and progression of chronic kidney disease including type 2 diabetes mellitus. AIM: We assessed serum FABP1 and FABP2 levels in children and adolescents with T1DM as potential markers for diabetic nephropathy and their relation to carotid intima media thickness (CIMT). METHODS: Sixty patients with T1DM were divided into 2 groups according to the presence of nephropathy and compared with 30 healthy controls...
February 3, 2023: Journal of Diabetes and its Complications
Nihar R Desai, Sankar D Navaneethan, Susanne B Nicholas, Kevin M Pantalone, Christoph Wanner, Stefanie Hamacher, Alain Gay, David C Wheeler
AIMS: Contemporary patterns of care of patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D) and the adoption of finerenone are not known. The FINE-REAL study (NCT05348733) is a prospective observational study in patients with CKD and T2D to provide insights into the use of the nonsteroidal mineralocorticoid receptor antagonist (MRA) finerenone in clinical practice. METHODS: FINE-REAL is an international, prospective, multicenter, single-arm study enrolling approximately 5500 adults with CKD and T2D in an estimated 200 sites across 22 countries...
February 2, 2023: Journal of Diabetes and its Complications
Bin Feng, Fan Yang, Jie Liu, Qichao Sun, Ran Meng, Dalong Zhu
Diabetic kidney disease (DKD) is a major cause of chronic and end-stage renal disease in diabetic patients. Here, we investigated protective effects and possible mechanisms of dapagliflozin on renal injury in diabetic mice. DKD mice were established by high fat diet (HFD) feeding. Half of DKD mice were randomly assigned to receive dapagliflozin treatment (200 μg/day) for 8 weeks. Renal lipid droplets, fibrosis, oxidative and endoplasmic reticulum stress were evaluated. Glomerular injury was assessed by immunohistochemistry and transmission electron microscopy...
January 28, 2023: Journal of Diabetes and its Complications
Antonio Ceriello, Nebjosa Lalic, Eduard Montanya, Paul Valensi, Kamlesh Khunti, Michael Hummel, Oliver Schnell
AIMS: We used N-terminal pro-B-type natriuretic peptide (NT-proBNP) point-of-care testing (POCT) for heart failure risk stratification of individuals with type 2 diabetes for >10 years and hypertension. METHODS: Overall 259 participants aged 50 years or older with type 2 diabetes (duration of >10 years), hypertension, and no overt cardiovascular disease (CVD) were recruited at two study centers. Patients' data were acquired and NT-proBNP levels were measured using the CARDIAC proBNP+ test (Roche) and the cobas h232 instrument (Roche)...
January 27, 2023: Journal of Diabetes and its Complications
Joonas Wirkkala, Anna-Maria Kubin, Pasi Ohtonen, Aura Falck, Nina Hautala
AIMS: To evaluate clinical outcomes, functional vision and quality of life (QoL) after 35-year duration of type 1 diabetes (T1D) and proliferative diabetic retinopathy (PDR). METHODS: A population-based cohort study of T1D. Data from laboratory tests, ophthalmic examinations, multifunctional vision-test, and 15D-QoL measurements were analysed. RESULTS: 35 % of the original cohort (n = 216) had PDR, and 48 % of them were re-evaluated...
January 25, 2023: Journal of Diabetes and its Complications
Yanyan Chen, Yi Wang, Ying Zhang, Mengying Li, Weiqing Zhang, Yingni Zhou, Xiangyang Liu, Jianfang Fu, Zuowei Lu, Qian Xu, Tao Liu, Zeping Li, Xiaomiao Li, Jie Zhou
OBJECTIVES: The impacts of diabetic peripheral neuropathy (DPN) on clinical manifestations of left ventricular (LV) function in patients suffering from type 2 diabetes mellitus (T2DM) and the preserved LV ejection fraction (LVEF) lack a full evaluation. This study was carried out to investigate the correlation of peripheral neuropathy with subclinical LV systolic dysfunction, accompanied by the exploration of the relevant clinical features of peripheral neuropathy in these patients. METHODS: A retrospective analysis was conducted depending on the data of 101 consecutive inpatients with T2DM and preserved LVEF (all ≥ 50 %), without coronary artery disease and other histories of heart disease...
January 14, 2023: Journal of Diabetes and its Complications
Anna A Poradzka, Leszek Czupryniak
No abstract text is available yet for this article.
January 2, 2023: Journal of Diabetes and its Complications
Camila Pinto, Joao Roberto Sá, Janaina Lana, Patricia Dualib, Monica Gabbay, Sergio Dib
AIM: This study aimed to determine whether the insulin resistance (IR) and lipid profiles in Type 1 Diabetes (T1D) offspring are associated with IR and other cardiovascular risk factors in their parents. METHODS: This study included 99 T1D patients (19.6 ± 4.0 yrs.), 85 mothers and 60 fathers. Parents' IR was assessed by HOMA-IR, and the insulin sensitivity in T1D patients was assessed by the estimated Glucose Disposal Rate (eGDR). RESULTS: The eGDR in the T1D offspring was negatively related to age (p = 0...
January 2, 2023: Journal of Diabetes and its Complications
Alexandros Leonidas Liarakos, Anastasios Tentolouris, Alexandros Kokkinos, Ioanna Eleftheriadou, Nikolaos Tentolouris
Peripheral arterial disease (PAD) is a common macrovascular complication of diabetes mellitus (DM). Glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RAs) are among the latest class of antidiabetic medications that stimulate insulin synthesis and secretion and have been used for the management of type 2 DM. Apart from the effect on glycaemic control, GLP-1RAs also have a robust impact on weight reduction and have shown favorable effects on cardiovascular morbidity and mortality in cardiovascular outcome trials (CVOTs)...
December 30, 2022: Journal of Diabetes and its Complications
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