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Journal of Diabetes and its Complications

Jing-Bo Zeng, Hai-Bin Liu, Fan Ping, Wei Li, Yu-Xiu Li
OBJECTIVE: Many studies demonstrated a close relationship between type 2 diabetes mellitus (T2DM) and leukocyte telomere length (LTL). However, how the LTL changes in T2DM and what are the potential causal factors in it, particularly in patients during a long period treatment, have not been studied. Here we performed a longitudinal observation of LTL in trained T2DM patients during a 6-year follow-up and evaluated the possible risk factors that were associated with LTL alteration. METHODS: Seventy-six patients with T2DM were enrolled in this 6-year longitudinal study...
February 12, 2019: Journal of Diabetes and its Complications
Dongni Wang, Haiyan Wang, Cun Liu, Xiaofeng Mu, Shaoyun Cheng
OBJECTIVE: MicroRNAs (miRNAs) have emerged as promising regulators of diabetes mellitus (DM)-induced angiogenic dysfunction in endothelial cells (ECs), but information vis-à-vis the functional roles of distinct miRNAs remain surprisingly scarce. The current study was designed to elucidate the expression and function of miR-140-3p in diabetic ECs. METHODS: miR-140-3p expression was evaluated in DM mouse model and in human ECs using RT-qPCR, Northern blot and RNA fluorescent in situ hybridization...
February 10, 2019: Journal of Diabetes and its Complications
Tatsumi Moriya, Takahiro Yamagishi, Madoka Matsubara, Motoshi Ouchi
AIMS: The aim of the present study was to explore the relationship between changes in renal structure in patients with type 2 diabetes at an early stage of diabetic nephropathy using serial renal biopsies, and change in renal function. METHODS: The study population comprised 10 patients with type 2 diabetes with normo- or microalbuminuria at baseline. Light and electron microscopy-based morphometric analyses were performed to quantitatively evaluate glomerular and interstitial structural changes...
February 10, 2019: Journal of Diabetes and its Complications
Kristine Bech Holte, Mona Svanteson, Kristian Folkvord Hanssen, Ylva Haig, Svein Solheim, Tore Julsrud Berg
AIMS: We studied the total prevalence of obstructive coronary artery disease (CAD), undiagnosed CAD and absent CAD in persons with ≥45-year duration of type 1 diabetes (T1D) versus controls, and associations with mean HbA1c , LDL-cholesterol and blood pressure over 2-3 decades. METHODS: We included 76% (n = 103) of all persons with T1D diagnosed ≤1970 attending a diabetes center and 63 controls without diabetes. We collected 20-30 years of HbA1c , LDL-cholesterol and blood pressure measurements...
January 31, 2019: Journal of Diabetes and its Complications
Tim D Robbins, S N Lim Choi Keung, S Sankar, H Randeva, T N Arvanitis
AIM: We have limited understanding of which risk factors contribute to increased readmission rates amongst people discharged from hospital with diabetes. We aim to complete the first review of its kind, to identify, in a systematic way, known risk factors for hospital readmission amongst people with diabetes, in order to better understand this costly complication. METHOD: The review was prospectively registered in the PROSPERO database. Risk factors were identified through systematic review of literature in PubMed, EMBASE & SCOPUS databases, performed independently by two authors prior to data extraction, with quality assessment and semi-quantitative synthesis according to PRISMA guidelines...
January 30, 2019: Journal of Diabetes and its Complications
L Darwish, M M Nguyen, M Saleem, K A Eakin, N Herrmann, K S Sugamori, P I Oh, P Yang, J Mitchell, K L Lanctôt, W Swardfager
BACKGROUND: Lower serum concentrations of the osteoblast-derived protein, osteocalcin, have been associated with poorer glycemic control, insulin resistance and atherosclerosis, and with the development of type 2 diabetes (T2DM). METHODS: This study compares concentrations of two physiological forms of osteocalcin, carboxylated (cOCN) and uncarboxylated (unOCN), between participants with T2DM (n = 20) and age-, gender- and body mass index (BMI)-matched participants without T2DM (n = 40) among patients with coronary artery disease (CAD), and it explores relationships between osteocalcin concentrations and cardiovascular risk factors...
January 17, 2019: Journal of Diabetes and its Complications
Maciej Haberka, Michael Skilton, Małgorzata Biedroń, Karolina Szóstak-Janiak, Małgorzata Partyka, Monika Matla, Zbigniew Gąsior
Carotid artery atherosclerosis is a complex and multifactorial chronic disease. Our aim was to assess the associations between obesity, fat depots and carotid artery stenosis (CAS) in patients with high cardiovascular (CV) risk. METHODS: The study group included 391 patients (F/M: 136/255 pts.; age: 61.8 ± 8 years) scheduled for elective coronary angiography. A comprehensive clinical assessment included a carotid artery and abdominal ultrasound involving the following fat depots: (1) carotid extra-media thickness (EMT) indexed to the body mass index (perivascular adipose tissue [PVAT]), and (2) abdominal visceral and subcutaneous fat...
January 17, 2019: Journal of Diabetes and its Complications
William H Polonsky, Lawrence Fisher, Danielle Hessler, Heather Stuckey, Frank J Snoek, Tricia Tang, Norbert Hermanns, Xavier Mundet, Maria Silva, Jackie Sturt, Kentaro Okazaki, Irene Hadjiyianni, Dachuang Cao, Jasmina Ivanova, Urvi Desai, Magaly Perez-Nieves
AIMS: To identify actions of healthcare professionals (HCPs) that facilitate the transition to insulin therapy (IT) in type 2 diabetes (T2D) adults. METHODS: Included were T2Ds in seven countries (n = 594) who reported initial IT reluctance but eventually began IT. An online survey included 38 possible HCP actions: T2Ds indicated which may have occurred and their helpfulness. Also reported were delays in IT start after initial recommendation and any period of IT discontinuation...
January 17, 2019: Journal of Diabetes and its Complications
Ivana Dedinská, Karol Graňák, Matej Vnučák, Petra Skálová, Lea Kováčiková, Ľudovít Laca, Juraj Miklušica, Dana Prídavková, Peter Galajda, Marián Mokáň
INTRODUCTION: Sex differences are defined as biology-linked differences between women and men that occur through the sex chromosomes and their effects on organ systems. MATERIAL AND METHODS: The objective of this prospective study was to determine risk factors for post-transplant diabetes mellitus (PTDM) in men and women. RESULTS: A total of 417 patients (271 men and 146 women) were included in the monitored group. Age at the time of kidney transplantation (KT) >60 years and hypovitaminosis D at the time of KT (<20 μg/l) were identified as independent risk factors for PTDM in both men and women...
January 4, 2019: Journal of Diabetes and its Complications
Tine Maria Hansen, Birgitte Brock, Anne Juhl, Asbjørn Mohr Drewes, Henrik Vorum, Carl Uggerhøj Andersen, Poul Erik Jakobsen, Jesper Karmisholt, Jens Brøndum Frøkjær, Christina Brock
AIMS: Emerging evidence shows, that distal symmetric peripheral neuropathy (DSPN) also involves alterations in the central nervous system. Hence, the aims were to investigate brain metabolites in white matter of adults with diabetes and DSPN, and to compare any cerebral disparities with peripheral nerve characteristics. METHODS: In type 1 diabetes, brain metabolites of 47 adults with confirmed DSPN were compared with 28 matched healthy controls using proton magnetic resonance spectroscopy (H-MRS) in the parietal region including the sensorimotor fiber tracts...
January 4, 2019: Journal of Diabetes and its Complications
N Wah Cheung, K Y Carmen Wong, Pramesh Kovoor, Mark McLean
AIM: We aimed to explore the relationship between stress, hyperglycemia and diabetes in myocardial infarction (MI), using serum cortisol as a surrogate marker for the severity of stress. METHODS: Subjects with acute MI were prospectively recruited upon hospital admission. Serum glucose and cortisol were measured in addition to standard testing. Subjects were defined as having stress hyperglycemia (SH) if they had an admission glucose ≥7.8 mmol/L without a history of glucose intolerance...
January 4, 2019: Journal of Diabetes and its Complications
Dylan Zylla, Grace Gilmore, Justin Eklund, Sara Richter, Anders Carlson
BACKGROUND: Glucocorticoids are commonly used in chemotherapy regimens and may lead to hyperglycemia and increased infection rates. METHODS: We performed a retrospective analysis on 1781 patients who received intravenous chemotherapy with glucocorticoids between 2010 and 2015. Data was obtained using electronic medical record, billing modules, and tumor registry. We compared new infections and survival between patients with and without diabetes, after adjusting for demographic and cancer-related variables...
January 3, 2019: Journal of Diabetes and its Complications
Min Ding, Qian-Hua Fang, Yuan-Tao Cui, Qi-Ling Shen, Qian Liu, Peng-Hua Wang, De-Min Yu, Chun-Jun Li
AIMS: High glucose (HG)-induced pancreatic β-cell apoptosis may be a major contributor to the progression of diabetes mellitus (DM). NADPH oxidase (NOX2) has been considered a crucial regulator in β-cell apoptosis. This study was designed to evaluate the impact of GLP-1 receptor agonist (GLP-1Ra) liraglutide on pancreatic β-cell apoptosis in diabetes and the underlying mechanisms involved. METHODS: The diabetic rat models induced by streptozotocin (STZ) and a high fat diet (HFD) received 12 weeks of liraglutide treatment...
January 2, 2019: Journal of Diabetes and its Complications
Candice A Myers
No abstract text is available yet for this article.
December 22, 2018: Journal of Diabetes and its Complications
Elizabeth B Norton
No abstract text is available yet for this article.
December 21, 2018: Journal of Diabetes and its Complications
Chutatip Limkunakul, Ian H de Boer, Bryan R Kestenbaum, Jonathan Himmelfarb, T Alp Ikizler, Cassianne Robinson-Cohen
CONTEXT: Diabetic kidney disease (DKD) is the leading cause of end stage kidney disease (ESKD) and is associated with a considerably shortened lifespan. While glucose-lowering therapy targeting glycated hemoglobin (HbA1c) <7% is proven to reduce the risk of developing DKD, its effects on complications of DKD are unclear. OBJECTIVE: We examined the associations of HbA1c with risks of progression to ESKD and death within a clinic-based study of CKD. We hypothesized that higher HbA1c concentrations would be associated with increased risks of ESKD and death...
April 2019: Journal of Diabetes and its Complications
Yongming Pan, Yili Rong, Junjie Huang, Keyan Zhu, Jiaojiao Chen, Chen Yu, Minli Chen
AIMS: A long-term high-fat/cholesterol (HFC) diet leads to hepatic insulin resistance (IR), which is associated with autonomic dysfunction and cardiovascular diseases risk increasing. However, whether this occurs in Tibetan minipigs remains unknown. We tested that a long-term HFC diet caused hepatic IR and promote cardiovascular disorders in Tibetan minipigs, and are associated with the reduction of cardiovagal tone and baroreflex sensitivity (BRS). METHODS: Male Tibetan minipigs were fed either a standard diet or a HFC diet, and were euthanized at 12 weeks...
April 2019: Journal of Diabetes and its Complications
Tina K Thethi, Veichi Batuman
Microalbuminuria, urine albumin-to-creatinine ratio >30 and less than <300 mg/g has widely been accepted as biomarker of early diabetic kidney disease (DKD). Based on absence of beta-2 microglobulinuria in earlier studies on microalbuminuria, its possible tubular origin has been dismissed. Microalbuminuria has been assumed as a marker of endothelial injury. Low-molecular-weight (LMW) proteins are smaller than albumin and less restricted by the glomerular filtration barrier. Normal individuals excrete no >10 to 20 mg/day low-molecular-weight proteins in urine, as they are absorbed in the proximal tubules...
March 2019: Journal of Diabetes and its Complications
LáShauntá M Glover, Alain G Bertoni, Sherita H Golden, Peter Baltrus, Yuan-I Min, Mercedes R Carnethon, Herman Taylor, Mario Sims
AIM: To examine the association of psychosocial resources with prevalent type 2 diabetes (T2D) in 5104 African American men and women. METHODS: Using data from the Jackson Heart Study (JHS), we evaluated the cross-sectional associations of four psychosocial resources (social support, optimism, religiosity, and social networks) with T2D [fasting glucose ≥126 mg/dL, or HbA1c ≥ 6.5%, or use of diabetic medication]. Multivariable Poisson regression estimated prevalence ratios (PR, 95% confidence interval-CI) of T2D by each psychosocial measure, adjusting for demographics, SES, waist circumference, health behaviors, and depressive symptoms...
February 2019: Journal of Diabetes and its Complications
Clement Lo, Edward Zimbudzi, Helena J Teede, Peter G Kerr, Sanjeeva Ranasinha, Alan Cass, Gregory Fulcher, Martin Gallagher, Kevan R Polkinghorne, Grant Russell, Tim Usherwood, Rowan Walker, Sophia Zoungas
AIMS: In patients with comorbid diabetes and chronic kidney disease, the extent to which patient-reported barriers to health-care and patient reported outcomes influence the quality of health care is not well established. This study explored the association between patient-reported barriers to health-care, patient activation, quality of life and diabetes self-care, with attainment of glycaemic and blood pressure (BP) targets. METHODS: This cross-sectional study recruited adults with diabetes and CKD (eGFR 20 to <60 ml/min/1...
January 2019: Journal of Diabetes and its Complications
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