Elif Öcal, Marianna Alunni-Fabbroni, Ignazio Piseddu, Matthias Thaler, Mathias J Zacherl, Lukas Salvermoser, Matthias M R Stechele, Lu Fornés Burnell, Heidrun Hirner-Eppeneder, Melanie A Kimm, Martina Rudelius, Max Seidensticker, Moritz Wildgruber, S Nahum Goldberg, Jens Ricke
PURPOSE: To assess immunogenic effects in unembolized contralateral tumor after single lobar Y90-radioembolization (SIRT) of colorectal liver metastases(CRLM). MATERIAL AND METHODS: The analysis comprised 10 patients with microsatellite stable (MSS) CRLM scheduled for staged treatment in the prospective BLINDED trial. Eligibility criteria included bilobar metastatic disease with >5 lesions without any treatment within 3 weeks. Baseline biopsy was followed by initial SIRT treatment of one liver lobe, followed by a second biopsy of yet untreated tumors in the other liver lobe at a median of 13 (4-49) days immediately prior to second treatment...
July 22, 2024: Journal of Vascular and Interventional Radiology: JVIR