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Journals Dermatology : International Jo...

Dermatology : International Journal for Clinical and Investigative Dermatology

https://read.qxmd.com/read/38493762/epidemiology-characteristics-of-disease-and-unmet-needs-of-patients-with-generalized-pustular-psoriasis-a-large-italian-delphi-consensus
#21
JOURNAL ARTICLE
Francesca Prignano, Laura Atzori, Francesco Bellinato, Giovanni Damiani, Carlotta Galeone, Paolo Mariani, Concetta Potenza, Annalisa Scopinaro, Stefano Piaserico, Gabriella Fabbrocini
INTRODUCTION: Generalized pustular psoriasis (GPP) is a rare and chronic, debilitating skin condition characterised, in its acute flare phase, by clinically severe and potentially life-threatening systemic manifestations. Data on GPP are still scanty, particularly in Europe and at a national level. To provide expert indications on several disease-related and patient-related aspects of GPP, with specific focus to the Italian context. METHODS: We conducted an iterative eDelphi study following the recommended criteria for reporting methods and results...
March 17, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38442697/associations-of-digital-ulcers-in-patients-with-systemic-sclerosis-an-8-year-retrospective-study
#22
JOURNAL ARTICLE
Miaomiao Chi, Qi An, Xiuyuan Feng, Lan He, Ying Pan
INTRODUCTION: This study aimed to investigate the associations of digital ulcers (DUs) in patients with systemic sclerosis (SSc). METHODS: This retrospective study investigated the demographic characteristics, specific autoantibodies, organ involvement, and laboratory tests in patients with SSc from our hospital. RESULTS: This study enrolled 144 patients with SSc. The DU+ group consisted of 15 (10.4%) patients. Patients with SSc having DUs have longer disease duration, higher fibrinogen, higher fibrin degradation product, and lower cholesterol...
March 5, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38422999/early-organ-metastasis-in-granulomatous-mycosis-fungoides-a-systematic-review
#23
Melika Motamedi, Maggie Zx Xiao, Jean Deschenes, Jori Hardin, Russell Sterrett, Lesley Street, Minakshi Taparia, Etienne Mahe, Giovanni Ferrara, James R Barrie, Robert Gniadecki
BACKGROUND: Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate. OBJECTIVE: The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there are both favorable and unfavorable outcomes documented. METHODS: We performed a systematic review of 116 GMF cases previously described in the literature. RESULTS: In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course...
February 29, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38417409/bridging-molecular-mechanism-and-clinical-practice-in-vitiligo-treatment-an-updated-review
#24
REVIEW
Hyun Jeong Ju, Jung Min Bae
BACKGROUND: In recent years, a great advance has been made in the area of pathogenesis of vitiligo and the understanding of vitiligo treatment is also expanding. SUMMARY: Treatment of vitiligo seeks to achieve three goals: cessation of disease progression, regeneration of pigmentation, and prevention of recurrence. To achieve these goals, a number of non-surgical interventions are available that suppress the autoimmune response and regenerate the remaining melanocytes from the reservoir, and optimal treatment outcome can be achieved when each modality is used properly...
February 28, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38402858/tattoo-pigment-biokinetics-in-vivo-in-a-28-day-porcine-model-elements-undergo-fast-distribution-to-lymph-nodes-and-reach-steady-state-after-7-days
#25
JOURNAL ARTICLE
Janos Cambiaso-Daniel, Hanna Luze, Silvia Meschnark, Julia Fink, Ines Schreiver, Thomas Rappl, Walter Goessler, Petra Kotzbeck, Lars-Peter Kamolz
INTRODUCTION: Pigments of tattoo inks may over time migrate to other parts of the body. Inks kinetics are still poorly understood and little studied. The aim of this first study was to investigate the kinetics of tattoo inks pigment in tattooed porcine skin, which is closer to human skin than mouse skin studied in the past. METHODS: Three animals were tattooed on the inner thigh and one animal served as untreated control. Skin biopsies were taken on days 7, 14, and 28 after tattooing...
February 23, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38377977/identification-of-tnf-%C3%AE-as-major-susceptible-risk-locus-for-vitiligo-a-systematic-review-and-meta-analysis-study-in-asian-population
#26
JOURNAL ARTICLE
Tithi Dutta, Sambuddha Sengupta, Suchismita Adhya, Arpan Saha, Debmalya Sengupta, Ritisri Mondal, Samsiddhi Bhattacharjee, Mainak Sengupta
INTRODUCTION: Vitiligo is a common depigmentation disorder characterized by defined white patches on the skin and affecting around 0.5 % to 2% of the general population. Genetic association studies have identified several pre-disposing genes and single nucleotide polymorphisms (SNPs) for vitiligo pathogenesis; nonetheless, the reports are often conflicting, and rarely conclusive. This comprehensive meta-analysis study was designed to evaluate the effect of the risk variants on vitiligo aetiology and covariate stratified vitiligo risk in the Asian population considering all the studies published so far...
February 20, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38354719/comprehensive-ophthalmological-evaluation-in-atopic-dermatitis
#27
JOURNAL ARTICLE
Anais Valeille, Coralie Ouilhon, Fabien Subtil, Florence Hacard, Coline Jaulent, Fréderic Bérard, Jean-François Nicolas, Jean-Luc Fauquert, Audrey Nosbaum
BACKGROUND: Atopic dermatitis (AD), a chronic Type 2 inflammatory skin disease, is frequently associated with ocular surface diseases (OSD) which may appear or worsen under anti-Type 2-targeted treatments. However, the exact prevalence of OSD and the ophthalmology referral criteria remain ill-defined in AD patients before initiating such biotherapies. OBJECTIVE: We aimed to characterize the prevalence, the nature and the factors related to OSD development in AD that may justify an ophthalmological management...
February 14, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38354718/the-global-hidradenitis-suppurativa-atlas-ghisa-methodology-combining-global-proportions-in-a-pooled-analysis
#28
JOURNAL ARTICLE
Dorra Bouazzi, Rune Kjærsgaard Andersen, Gabrielle R Vinding, Cecilia E Medianfar, Sabrina Mai Nielsen, Ditte M L Saunte, Nisha S Chandran, Hessel H van der Zee, Christos C Zouboulis, Farida Benhadou, Bente Villumsen, Afsaneh Alavi, Perpetua U Ibekwe, Iltefat H Hamzavi, John R Ingram, Haley B Naik, Amit Garg, Jurr Boer, Robin Christensen, Gregor B E Jemec
INTRODUCTION: Data concerning the global burden of Hidradenitis Suppurativa (HS) are limited. Reported prevalence estimates vary between 0.0003% and 4.1%, and data from various geographical regions are still to be collected. Previously reported prevalence rates have been limited by the methodological approach and source of data. This has resulted in great heterogeneity as prevalence data from physician-diagnosed cases poorly match those of self-reported apparent HS disease. METHODS: The Global Hidradenitis Suppurativa Atlas (GHiSA) introduces an innovative approach to determine the global prevalence of HS...
February 14, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38330926/bacterial-skin-dysbiosis-in-darier-disease
#29
JOURNAL ARTICLE
Ofer Reiter, Avner Leshem, Rivka Alexander-Shani, Michael Brandwein, Yotam Cohen, Algit Yeshurun, Michael Ziv, Eran Elinav, Emmilia Hodak, Roni P Dodiuk-Gad
INTRODUCTION: Darier disease is a rare inherited disease with dominant skin manifestations including keratotic papules and plaques on sebaceous and flexural areas. Secondary infection of skin lesions is common and Staphylococcus aureus commonly colonizes these lesions. The aim of the study was to characterize the bacterial microbiome of cutaneous Darier lesions compared to normal-looking skin and to disease severity. METHODS: All patients with a history of Darier followed-up at Emek Medical Center were invited to participate in the study...
February 8, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38290487/response-to-letter-to-the-editor-on-comparison-of-social-media-content-on-hidradenitis-suppurativa-a-cross-sectional-study
#30
LETTER
Anna Wolinska, Gregg Murray, Madonna Andrawis, Paula Beatty, Marta Costa Blasco, Claire Doyle, Orla Mc Feely, Lisa Murphy, Anne-Marie Tobin
N/a.
January 30, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38290473/a-retrospective-study-of-diameter-and-breslow-thickness-in-invasive-melanomas
#31
REVIEW
Clio Dessinioti, Mihaella Plaka, Angelliki Befon, Dorothea Polidorou, Irene Stefanaki, Katerina Kypreou, Varvara Theology, Alexander J Stratigos
INTRODUCTION: A diameter larger than 6 millimeters is included in the criteria used in public health messages to detect a cutaneous melanoma. We aim to investigate the independent association of Breslow thickness with the melanoma diameter. METHODS: A retrospective study was performed in patients with invasive melanomas of the nodular melanoma or superficial spreading melanoma subtype. The quartiles of the diameter (lower, median, upper) were studied in non-parametric quantile regression model...
January 30, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38228126/atopic-dermatitis-severity-and-risk-for-psoriasis-a-nationwide-population-based-study
#32
JOURNAL ARTICLE
Hyun Ji Lee, Yong Jun Hong, Kyung Do Han, Ji Hyun Lee
BACKGROUND: As research on the role of the Th17/IL-23 pathway gains importance, the relationship between atopic dermatitis (AD) and psoriasis is becoming elucidated. OBJECTIVE: To evaluate whether AD and its severity affects the risk for psoriasis. METHODS: This retrospective population-based study used the database from the 2009 National Health Insurance Services-Health Screening Cohort in Korea. A total of 3,957,922 adult subjects were included and observed until 2018...
January 16, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38228125/mental-health-of-school-aged-children-treated-with-propranolol-or-atenolol-for-infantile-hemangioma-and-their-parents
#33
JOURNAL ARTICLE
Mireille M Hermans, Renske Schappin, Peter C J de Laat, Elodie J Mendels, Johannes M P J Breur, Hester R Langeveld, Martine F Raphael, Marlies de Graaf, Corstiaan C Breugem, Saskia N de Wildt, Jolanda M E Okkerse, Suzanne G M A Pasmans, André B Rietman
BACKGROUND: Infants with infantile hemangioma (IH) have been effectively treated with propranolol or atenolol. Concerns were raised about the mental health of these children at school-age, due to central nervous system effects of propranolol and visible nature of IH. OBJECTIVE: This study aimed to compare the mental health at school-age of children treated with propranolol to children treated with atenolol for IHs, and their parents. METHODS: This two-center cross-sectional study included children aged ≥6 years and treated with either propranolol or atenolol for IH during infancy...
January 16, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38228120/preliminary-evaluation-of-in-vivo-reflectance-confocal-microscopy-features-of-neonatal-lupus-erythematosus
#34
JOURNAL ARTICLE
Ying Wang, LiXin Chen, Bei Qin, Xibo Gao, Qinfeng Li
BACKGROUND: Neonatal lupus erythematosus (NLE) is a rare autoimmune disease,which need to distinguish from eczema, congenital syphilis, and tinea corporis in newborns. Reflectance confocal microscopy (RCM) could be a helpful noninvasive diagnostic tool,which has been used to evaluate several inflammatory skin conditions. The aim of this study was to describe the RCM characteristics of NLE. METHODS: 9 NLE patients were included in the study,all patients were evaluated clinically with RCM...
January 16, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38228102/letter-to-the-editor-on-comparison-of-social-media-content-on-hidradenitis-suppurativa-a-cross-sectional-study
#35
LETTER
Sophia Fruechte, Ronda Farah, Noah Goldfarb
No abstract text is available yet for this article.
January 16, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38228098/dermatofibrosarcoma-protuberans-a-study-of-148-patients
#36
Joaquim Marcoval, Carlos Moreno-Vílchez, Clara Torrecilla-Vall-Llossera, Clara Muntaner-Virgili, Diana Pérez Sidelnikova, Xavier Sanjuán, Rosa Maria Penin
INTRODUCTION: Dermatofibrosarcoma protuberans (DFSP) is the most common sarcoma of the skin. Although distant metastases are infrequent, DFSP is highly aggressive locally with frequent local recurrences. It has been reported that the presence within the tumour of areas histopathologically mimicking fibrosarcoma may increase the risk of recurrence. OBJECTIVE: To review the clinical features of our patients with DFSP and the factors associated with recurrence of the tumour, focusing on the presence of fibrosarcomatous areas...
January 16, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38198756/the-agreement-between-consumer-driven-self-assessment-of-psoriasis-severity-and-physician-assessed-severity-based-on-patient-taken-photographs-is-weak-cross-sectional-study
#37
JOURNAL ARTICLE
Zarqa Ali, Ali Al-Mousawi, Benóný Björnsson, Alexander Egeberg, Christian Riemer, Simon Francis Thomsen
INTRODUCTION: Digital advancements have given access to huge amounts of real-world data (RWD) widely used for dermatological research. OBJECTIVES: To investigate the agreement between consumer-driven self-assessed psoriasis severity and physician-assessed severity based on photographs. METHODS: Customer IDs in the Nøie database (Danish skincare company) from 2009 to 2022 with a smartphone photograph of psoriasis vulgaris on the body and a corresponding completed questionnaire were included...
January 10, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38190809/hidradenitis-suppurativa-is-associated-with-severe-sexual-impairment
#38
JOURNAL ARTICLE
Piotr K Krajewski, Alexandra Strobel, Michael Schultheis, Petra Staubach, Stephan Grabbe, Katharina Hennig, Lukasz Matusiak, Esther von Stebut, Simone Garcovich, Hans Bayer, Marcus Heise, Uwe Kirschner, Georgios Nikolakis, Jacek C Szepietowski
INTRODUCTION: Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the pilosebaceous unit, often affecting and deforming intimate regions. HS is associated with severe pain, pruritus, and constant, purulent, malodorous discharge expected to impair sexual health of patients. METHODS: We performed a cross-sectional, multicentric study involving 199 German patients from the health services research project "Epidemiology and Care in Acne inversa (EpiCAi)"...
January 8, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38185115/mortality-and-autopsy-findings-in-patients-with-pyoderma-gangrenosum-a-multi-institutional-series
#39
Hadir Shakshouk, Mallory deCampos-Stairiker, Shannon Kody, Peter Stenzel, Eric Xia, Arash Mostaghimi, Bicong Wu, Michi M Shinohara, Angelo V Marzano, Samantha Polly, Anthony P Fernandez, Alex G Ortega-Loayza
INTRODUCTION: Pyoderma gangrenosum (PG) is a rare ulcerative skin condition with an increased risk of mortality compared to the general population. The causes of this increased risk are not well understood. Misdiagnosis is common in pyoderma gangrenosum, and many studies are limited by the inclusion of misdiagnosed cases. The goal of this study is to review autopsy findings, identify causes of death, and identify factors that may worsen outcomes among deceased patients confirmed to have PG...
January 6, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38185114/atypical-and-typical-presentation-of-erythema-nodosum-clinical-differences-in-treatment-and-outcome
#40
JOURNAL ARTICLE
Nina Meienberger, Julia-Tatjana Maul, Fabienne Fröhlich, Lara Valeska Maul, Thomas Kündig, Thierry Nordmann, Florian Anzengruber
Introduction Erythema nodosum (EN) is the most common form of panniculitis that predominantly affects the shins. While EN in atypical sites has been described by many authors, there are currently only case studies published on this topic. This study aimed to evaluate clinical differences between patients suffering from EN on the shins, compared to patients with EN in atypical locations. Methods We analyzed 105 patients in a retrospective, single-center study at a University Hospital in Switzerland. Typical EN was defined as lesions, found only on the lower legs, while atypical EN as lesions on the upper legs, trunk, arms, or face, only or in addition to lesions on the lower legs...
January 5, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
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