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Dermatology: International Journal for Clinical and Investigative Dermatology

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https://read.qxmd.com/read/30759429/use-of-complementary-and-alternative-therapies-in-outpatients-with-atopic-dermatitis-from-a-dermatological-university-department
#1
Jesper Grønlund Holm, Maja-Lisa Clausen, Tove Agner, Simon Francis Thomsen
BACKGROUND: Treatment of atopic dermatitis (AD) may be challenging, therefore some patients seek complementary and alternative medications (CAM). We determined prevalence and predictors for CAM use in a hospital cohort of AD patients. MATERIAL AND METHODS: Between January 1, 2012, and December 31, 2017, AD patients referred to the dermatological outpatient clinic at Bispebjerg Hospital were included in the study. Information on CAM use, demographics and disease characteristics were obtained by questionnaire, and associations were determined by χ2 and t test separately for children (< 16 years) and adults (≥16 years)...
February 13, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30726838/a-retrospective-review-of-dupilumab-for-hand-dermatitis
#2
LETTER
Nicole Lee, Naina Chipalkatti, Pedro Zancanaro, Courtney Kachuk, Nicole Dumont, David Rosmarin
No abstract text is available yet for this article.
February 6, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30721908/pembrolizumab-for-unresectable-or-metastatic-melanoma-in-patients-older-than-85-years-of-age
#3
Johan Chanal, Nora Kramkimel, Carole Ratour, Selim Aractingi, Sarah Guégan, Marie-Françoise Avril
BACKGROUND: Programmed cell death protein-1 (PD-1) inhibitors (pembrolizumab and nivolumab) have been approved for the treatment of advanced melanoma. Over the past decades, patients older than 85 years represent an expanding group of patients in developed countries. In France, 25% of melanomas are diagnosed in patients older than 75 years. OBJECTIVE: To perform a monocentric retrospective study of patients older than 85 years and treated with pembrolizu-mab for unresectable or metastatic melanoma in order to evaluate tolerance and potential benefits of this immunotherapy...
February 5, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30716732/idiopathic-generalized-exfoliative-dermatitis-and-association-with-antihypertensive-drugs-and-statins-a-retrospective-case-control-study
#4
Kah Wai Cheong, Yik Weng Yew, Hong Liang Tey
BACKGROUND/AIMS: We aim to examine the hypothesis that antihypertensive drugs and statins may be responsible for the development of idiopathic generalized exfoliative dermatitis (GED) with a case-control study. METHODS: All inpatients who were hospitalized under the dermatology service at the Tan Tock Seng Hospital, Singapore, between 1 May 2013 and 31 May 2015, were analysed. Idiopathic GED cases had consistent clinical and histological features but no apparent cause despite comprehensive evaluation...
February 4, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30654384/spanish-validation-of-the-gepard-questionnaire-for-the-detection-of-psoriatic-arthritis-in-argentinian-patients-with-psoriasis
#5
María Victoria Martire, María Paula Girard Bosch, Santiago Scarafia, Vanesa Cosentino, Maria Janina Tapia Moreira, Natalia Estrella, Josefina Marín, Fernando Sommerfleck, Hernán Maldonado Ficco, Erika Roxana Catay, Mariana Benegas, Eduardo Kerzberg, Enrique R Soriano
BACKGROUND/OBJECTIVE: Psoriatic arthritis (PsA) is preceded by psoriasis in approximately 80% of cases. Dermatologists are pivotal for early detection. It is important to have simple tools that allow the detection of PsA in patients with skin psoriasis. The aim of our study was to evaluate the performance of an adapted version of the GEPARD Questionnaire in Spanish in Argentinian patients with psoriasis. METHODS: This is a cross-sectional study. A new Spanish (Argentinian) (GEPARDa) translated version of the original questionnaire (German) was developed and then tested as a diagnostic tool in patients with psoriasis, PsA, osteoarthritis associated to psoriasis, and osteoarthritis, all evaluated by rheumatologists who used the CASPAR criteria...
January 17, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30650424/long-wave-medical-infrared-thermography-a-clinical-biomarker-of-inflammation-in-hidradenitis-suppurativa-acne-inversa
#6
Christos C Zouboulis, André Nogueira da Costa, Gregor B E Jemec, Dietrich Trebing
BACKGROUND: A more reliable classification of skin inflammation and severity of active disease results from ultrasound sonography and the new hidradenitis suppurativa/acne inversa (HS) classification system IHS4. However, an objective assessment of skin inflammation in a continuous mode is still the ultimate goal. Long-wave medical infrared thermography (MIT) may offer a blood flow and temperature differential assessment in inflammatory conditions. OBJECTIVE: To evaluate the application of MIT in HS...
January 16, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30650420/influence-of-the-topographic-vascular-distribution-of-the-face-on-dermal-filler-accidents
#7
María Angustias Palomar-Gallego, Francisco Gómez-Esquer, Stella Maris Gómez-Sánchez, Gema Díaz-Gil, Rafael Linares García-Valdecasas
OBJECTIVE: Dermal fillers are an important tool in the field of aesthetic dermatology. Fillers are relatively noninvasive and easy to use but are not free of secondary complications. The main complications are vascular and are due to either the compression of an artery or the direct introduction of the product into the arterial lumen. The aim of this study is to provide an overview of the vascular territories of the face to avoid many possible complications when using facial fillings...
January 16, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30605905/the-effectiveness-of-topical-cerium-nitrate-silver-sulfadiazine-application-on-overall-outcome-in-patients-with-calciphylaxis
#8
Amandine Darres, Ronan Delaval, Alain Fournier, Emilie Tournier, Olivier Cointault, Francoise Moussion, Dominique Chauveau, Bruno Seigneuric, Catherine Lumbroso, Nassim Kamar, David Ribes, Sylvie Leou, Antoine Huart, Pascale Testevuide, Stanislas Faguer
BACKGROUND: Calciphylaxis (CPX) is a rare and life-threatening disease characterized by vascular calcification and development of painful and necrotizing skin lesions with a challenging management. Mechanisms of CPX are complex and include an imbalance between vascular calcification promoters and inhibitors, and frequently vitamin K deficiency. OBJECTIVES: To describe the various presentations and identify predictive factors of death in patients with CPX. METHODS: In this multicenter retrospective study, we included 71 CPX patients followed in South-West France (n = 26) and in French Polynesia (n = 45), and who all received sodium thiosulfate (25 g thrice weekly for a median of 61 days)...
January 3, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30566941/janus-kinase-inhibitors-for-the-treatment-of-severe-alopecia-areata-an-open-label-comparative-study
#9
Nawaf Almutairi, Tarek M Nour, Nasser Haji Hussain
BACKGROUND: Alopecia areata (AA) is a common autoimmune disorder characterized by patchy hair loss. There are many treatments available for AA. However, treatments of severe forms of AA are not satisfactory. Recently, oral Janus kinase (JAK) inhibitors were found to be effective for the treatment of severe AA variants. OBJECTIVE: The aim of this work was to evaluate and compare the efficacy, side effects, and durability of two oral JAK inhibitor medications (ruxolitinib and tofacitinib) in the treatment of severe AA...
December 19, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30566935/psoriasis-keratinocytes-or-immune-cells-which-is-the-trigger
#10
REVIEW
Farida Benhadou, Dillon Mintoff, Véronique Del Marmol
BACKGROUND: Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood. SUMMARY: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity...
December 19, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30554198/confocal-microscopy-and-lentigo-maligna-an-in-vivo-pilot-study-for-the-assessment-of-response-to-imiquimod-therapy
#11
Flurin L Brand, S Morteza Seyed Jafari, Robert E Hunger
BACKGROUND: Reflectance confocal microscopy (RCM) is a noninvasive technique that provides real-time in vivo images of the epidermal layer. Imiquimod has been recommended as an alternative treatment in lentigo maligna (LM) when surgical excision is not the treatment of choice. In the present study we compare the results of in vivo RCM to the histopathological examination before and after treatment of LM with topical imiquimod. METHODS: Thirty-four patients with confirmed LM were included...
December 14, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30544123/a-review-of-scabies-an-infestation-more-than-skin-deep
#12
REVIEW
David J Chandler, Lucinda C Fuller
Human scabies, a common infestation, has a worldwide distribution with a variable impact and presentation depending on the clinical situation. In developed, high-income settings, health institution and residential home outbreaks challenge health and social care services. In resource-poor settings, it is the downstream sequelae of staphylococcal and streptococcal bacteraemia, induced by scratching, which have a significant impact on the long-term health of communities. Over the past decade scabies has been recognised as a "neglected tropical disease" (NTD) by the World Health Organisation, has an accepted practical system of global diagnostic criteria and is being adopted into integrated programmes of mass drug administration for NTDs in field settings...
December 13, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30485847/dermatonutrigenomics-past-present-and-future
#13
LETTER
Joanna Jaros, Rajani Katta, Vivian Y Shi
No abstract text is available yet for this article.
November 28, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30466093/facial-and-extrafacial-lesions-in-an-ethnically-diverse-series-of-91-patients-with-frontal-fibrosing-alopecia-followed-at-a-single-center
#14
Joshua S Mervis, Luis J Borda, Mariya Miteva
BACKGROUND: Various facial and extrafacial lesions have been reported in frontal fibrosing alopecia (FFA). Facial papules have been associated with worse prognosis. OBJECTIVES: We sought to detect the prevalence of facial and extrafacial lesions and to analyze their relation to demographic and clinical variables in a large and ethnically diverse series of patients with FFA. METHODS: Charts of patients diagnosed with FFA between January 1, 2015, and December 31, 2017, at the Department of Dermatology, University of Miami, were reviewed retrospectively...
November 22, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30463069/potassium-iodide-for-cutaneous-inflammatory-disorders-a-monocentric-retrospective-study
#15
Florian Anzengruber, Caroline Mergenthaler, Carla Murer, Reinhard Dummer
OBJECTIVES: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. METHODS: The hospital information system was searched for patients treated with KI at the Department of Dermatology (University Hospital Zurich) in the last 20 years (January 1, 1998 to December 31, 2017)...
November 21, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30408786/depression-symptoms-predict-worse-clinical-response-to-etanercept-treatment-in-psoriasis-patients
#16
Waishu Jin, Shuqing Zhang, Yanjuan Duan
BACKGROUND/AIMS: This study aimed to investigate the predicting values of depression and anxiety symptoms for clinical response to etanercept treatment in psoriasis patients. METHODS: A total of 85 psoriasis patients who received 6 months of etanercept treatment were consecutively enrolled in this prospective cohort study. The Psoriasis Area and Severity Index (PASI) score was evaluated at month 0 (M0), M1, M3, and M6, and the corresponding PASI 75/90 response at each visit was assessed...
November 8, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30404090/body-piercing-a-national-survey-in-france
#17
Nicolas Kluger, Laurent Misery, Sophie Seité, Charles Taieb
BACKGROUND: There are no recent data available in France regarding body piercing (BP). OBJECTIVE: We examined the demographics, motivations, quality of life, cutaneous conditions, and cutaneous side effects after BP within the French population. METHODS: A representative sample of 5,000 individuals (aged 15 and over) from the general population responded to a survey online between April and August 2017. Data regarding demographics, BP characteristics (location, age at first piercing, hesitation, regrets, motivations, cutaneous side effects), tobacco, skin conditions (acne, contact eczema, atopic eczema, rosacea, psoriasis, vitiligo), and tattoos were collected...
November 7, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30404085/redesigning-skin-cancer-early-detection-and-care-using-a-new-mobile-health-application-protocol-of-the-skin-research-project-a-randomised-controlled-trial
#18
Monika Janda, Caitlin Horsham, Uyen Koh, Nicole Gillespie, Lois J Loescher, Dimitrios Vagenas, H Peter Soyer
Patients often detect melanoma themselves; therefore, regular skin self-examinations (SSEs) play an important role in the early detection and prompt treatment of melanoma. Mobile teledermoscopy is a technology that may facilitate consumer SSEs and rapid communication with a dermatologist. This paper describes the planned randomised controlled trial of an intervention to determine whether mobile technologies can help improve the precision of SSE in consumers. A randomised controlled trial will be conducted to evaluate mobile teledermoscopy-enhanced SSE versus naked-eye SSE...
November 7, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30404081/consumer-acceptance-and-expectations-of-a-mobile-health-application-to-photograph-skin-lesions-for-early-detection-of-melanoma
#19
Uyen Koh, Caitlin Horsham, H Peter Soyer, Lois J Loescher, Nicole Gillespie, Dimitrios Vagenas, Monika Janda
BACKGROUND: Mobile teledermoscopy may facilitate skin self-examinations (SSEs) and further improve monitoring and detection of melanoma. OBJECTIVE: To assess consumer acceptability and expectations of a mobile health app used to: (i) instruct SSE and (ii) conduct consumer-performed mobile teledermoscopy. METHODS: People aged 18 years and above were invited to participate in either (i) an online survey or (ii) focus group in Brisbane, Australia...
November 7, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/30404078/lesions-mimicking-melanoma-at-dermoscopy-confirmed-basal-cell-carcinoma-evaluation-with-reflectance-confocal-microscopy
#20
Francesca Peccerillo, Victor Desmond Mandel, Francesca Di Tullio, Silvana Ciardo, Johanna Chester, Shaniko Kaleci, Nathalie de Carvalho, Ester Del Duca, Luca Giannetti, Laura Mazzoni, Steven Paul Nisticò, Ignazio Stanganelli, Giovanni Pellacani, Francesca Farnetani
BACKGROUND: Atypical basal cell carcinoma (BCC), characterized by equivocal dermoscopic features typical of malignant melanoma (MM), can be difficult to diagnose. Reflectance confocal microscopy (RCM) enables in vivo imaging at nearly histological resolution. OBJECTIVES: To evaluate with RCM atypical melanocytic lesions identified in dermoscopy, according to common RCM criteria for the differential diagnosis of BCC, and to identify representative RCM parameters for superficial (sBCCs) and nonsuperficial (nsBCCs) basal cell carcinomas (BCCs)...
November 7, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
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