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Journals Dermatology : International Jo...

Dermatology : International Journal for Clinical and Investigative Dermatology

https://read.qxmd.com/read/38772345/cutaneous-reactions-in-pediatric-patients-treated-with-mek-inhibitors-a-retrospective-single-center-study
#1
JOURNAL ARTICLE
Rivka Friedland, Mirit Glick, Iris Amitay-Laish, Helen Toledano
Introduction MEK inhibitors are in use for several indications for adults and children. Cutaneous toxicities are among the most common adverse effects. We aimed to describe the spectrum of cutaneous adverse events, its frequency and severity in a cohort of pediatric patients. Methods We reviewed all records of patients in our tertiary treatment center treated with MEK inhibitors between January 2016 and January 2023 for all indications. Results Among 33 patients, 76% reported cutaneous adverse effects. The highest prevalence was in the group of patients treated with trametinib (90%), followed by the group treated with selumetinib (50%) and the group treated with combination of trametinib and BRAF inhibitor (dabrafenib, 34%)...
May 21, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38768566/preoperative-mapping-biopsies-with-local-excision-in-the-treatment-of-extramammary-paget-disease-a-retrospective-cohort-study-systematic-review-and-individual-patient-data-analysis
#2
LETTER
Sophie Soyeon Lim, Ji Su Lee, Hyun Jeong Ju, Jung Min Bae, Seong Jin Jo, Je-Ho Mun
BACKGROUND: Surgical excision of extramammary Paget disease (EMPD) is associated with a high local recurrence rate. OBJECTIVES: This study aimed to assess the local recurrence rate of EMPD after preoperative mapping biopsy (PMB) with local excision. METHODS: This retrospective study included patients with EMPD who were treated at our dermatosurgery clinic between January 2016 through May 2022. In addition, we retrieved individual patient data of EMPD cases from articles published in PubMed, Cochrane, Embase, and Scopus to compare recurrence rates between patients with or without PMB using Cox's proportional hazard model...
May 20, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38735287/rare-med12l-variants-is-associated-with-susceptibility-to-guttate-psoriasis-in-the-han-chinese-population
#3
JOURNAL ARTICLE
Kejia Wu, Wanrong Wang, Qianhui Cheng, Duncheng Xiao, Yunxiao Li, Mengyun Chen, Xiaodong Zheng
INTRODUCTION: According to the common disease/rare variant (CDRV) hypothesis, it is important to study the role of rare variants in complex diseases. The association of rare variants with psoriasis has been demonstrated, but the association between rare variants and specific clinical subtypes of psoriasis has not been investigated. METHODS: Gene-based and gene-level meta-analyses were performed on data extracted from our previous study data sets(2,483 patients with guttate psoriasis and 8,292 patients with non-guttate psoriasis) for genotyping...
May 10, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38697027/clinical-use-of-super-bioavailable-itraconazole-for-the-management-of-dermatophytosis-consensus-statement-by-dermatologists-from-india-via-the-modified-delphi-technique
#4
JOURNAL ARTICLE
Abir Saraswat, Sunil Dogra, Manjunath Shenoy, Shyam Verma, Seetharam K, Sunil Ghate, Anil Ganjoo, Sanjeev Aurangabadkar, Anurag Tiwari, Shital Poojary, Arun Inamdar, Imran Majid, Mukesh Girdhar, Bela Shah, Sachin Varma, Ramkumar Ramamoorthy, Dhiraj Dhoot, Hanmant Barkate
INTRODUCTION: Super bioavailable itraconazole (SB ITZ) overcomes the limitations of conventional itraconazole (CITZ) such as inter-individual variability and reduced bioavailability. It has been approved for systemic mycoses in Australia and Europe as 50mg and the United States as 65mg and in India as 50mg, 65mg, 100mg, and 130mg. However, data on the ideal dose and duration of SB ITZ treatment in managing dermatophytosis is insufficient. This consensus discusses the suitability, dosage, duration of treatment, and relevance of using SB ITZ in managing dermatophytosis in different clinical scenarios...
May 2, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38679001/dermatology-life-quality-index-dlqi-in-patients-with-atopic-dermatitis-are-not-relevant-responses-relevant
#5
Anna Langenbruch, Valerie Andrees, Matthias Augustin
INTRODUCTION: According to the DLQI user manual, the patients´ answers 'not relevant' (NR) and 'not at all' (affected in this aspect of life by the skin problem) are treated equally and interpreted as no impairment in health related quality of life (HRQoL). The aim of this study was to gain more insights about 'not relevant' responders with atopic dermatitis (AD). METHODS: 3,353 patients with AD, recruited from dermatological offices and a patient organisation, were surveyed in three cross-sectional studies...
April 27, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38679004/topical-corticosteroid-phobia-among-danish-pharmacy-staff
#6
JOURNAL ARTICLE
Jakob Maarbjerg Toft-Hansen, Line Brok Nørreslet, Ida Vittrup, Jacob Pontoppidan Thyssen, Tove Agner, Yasemin Topal Yüksel
BACKGROUND: Topical corticosteroid (TCS) phobia may negatively impact treatment adherence. Currently, there are few studies exploring trust and knowledge of TCS use among pharmacy staff. OBJECTIVE: To examine TCS knowledge and possible phobia among Danish pharmacy staff. METHODS: A questionnaire, based on Topical Corticosteroid Phobia (TOPICOP©) questionnaire, was developed and rephrased to fit pharmacy staff. The questions were Likert scales and numerical rating scales (NRS) (0-10)...
April 26, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38648732/erratum
#7
(no author information available yet)
No abstract text is available yet for this article.
April 22, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38631324/quality-of-life-impact-in-patients-with-cutaneous-toxicities-caused-by-egfr-inhibitors-and-immunotherapy
#8
JOURNAL ARTICLE
Maria Mannino, Pietro Sollena, Alessandro Di Stefani, Ernesto Rossi, Ettore D'Argento, Giovanni Schinzari, Giampaolo Tortora, Ketty Peris
BACKGROUND: novel oncologic therapies, including epidermal growth factor receptor inhibitors (EGFR-Is) and immune checkpoint inhibitors (ICIs), are associated with a new spectrum of adverse reactions, with prominent cutaneous toxicities. The impact of cutaneous adverse events (cAEs) on patients' quality of life (QoL) represents an unmet clinical need. OBJECTIVES: 1) to assess whether cutaneous toxicities directed therapies are effective in reducing the QoL burden via the submission of two patient reported outcome measures (PROMs); 2) to investigate whether class of oncologic therapy, type of cAE and toxicity severity differently impact on patients' QoL...
April 17, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38621365/belgian-patients-of-the-european-registry-for-hidradenitis-suppurativa-erhs-be-data-scores-and-phenotypes-since-2015
#9
JOURNAL ARTICLE
Stephanie Heudens, Anne-Sophie Sarkis, Mathieu Daoud, Mathilde Daxhelet, Farida Benhadou, Mariano Suppa, Laura Nobile, Jalila Karama, Hassane Njimi, Jonathan M White, Veronique Del Marmol
Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease, characterized by painful and recurrent lesions in apocrine gland-bearing skin areas. It is a heterogeneous disease, which makes assessment and data collection difficult. Questionnaires with detailed items, such as the Belgian European Registry for Hidradenitis Suppurativa (ERHS-Be), are useful to study HS and its associated comorbidities. The aim of this registry is to uncover new factors associated with HS, understand HS patients' clinical profiles and efficacy of treatments...
April 15, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38599206/response-to-a-bibliometrics-of-the-treatment-of-alopecia-areata-in-the-past-twenty-years
#10
LETTER
Ambika Nohria, Deesha Desai, Kristen Lo Sicco, Jerry Shapiro
No abstract text is available yet for this article.
April 10, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38599196/efficacy-of-combinational-treatment-versus-nicotinamide-monotherapy-in-the-prevention-of-ultraviolet-radiation-induced-skin-cancer
#11
JOURNAL ARTICLE
Celina Pihl, Flemming Andersen, Peter Bjerring, Merete Haedersdal, Catharina Margrethe Lerche
INTRODUCTION: Ultraviolet radiation (UVR) is the primary risk factor for keratinocyte carcinomas (KC). Oral supplementation with nicotinamide (NAM; NAM-mono) is reported to reduce the formation of new KCs. NAM's photoprotection is mediated by enhanced DNA repair. We wanted to explore whether NAM in combination with anti-proliferative (Metformin; Met) or antioxidant (Phloroglucinol; PG) compounds could potentially enhance its photoprotective effects. METHODS: Hairless mice (C3...
April 10, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38599182/clinical-and-pathological-features-of-pilomatrixoma-in-children-a-retrospective-study
#12
JOURNAL ARTICLE
Hongyang Fu, Changbing Shen, Bo Wu, Tingting Wang, Jiutong Wu, Yaqin Li, Juan Ding, Jing Gao
Introduction Pilomatrixoma is a benign skin neoplasm that is common in children and is often misdiagnosed. This study aimed to summarize the clinical and pathological features of pilomatrixoma in children. Methods Data on demographic information, clinical and pathological features, diagnosis, and treatment of 171 patients with pilomatrixoma from Shenzhen Baoan Women's and Children's Hospital were collected and analyzed retrospectively. Results The mean age of the patients was 5.7 (standard deviation (SD) = 3...
April 10, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38588653/cross-sectional-study-on-autosomal-recessive-congenital-ichthyoses-association-of-genotype-with-disease-severity-phenotypic-and-ultrastructural-features-in-74-italian-patients
#13
JOURNAL ARTICLE
Andrea Diociaiuti, Marialuisa Corbeddu, Sabrina Rossi, Elisa Pisaneschi, Claudia Cesario, Angelo Giuseppe Condorelli, Tonia Samela, Simona Giancristoforo, Adriano Angioni, Giovanna Zambruno, Antonio Novelli, Rita Alaggio, Damiano Abeni, May El Hachem
BACKGROUND: Autosomal recessive congenital ichthyoses (ARCI) are a clinically heterogeneous group of keratinization disorders characterized by generalized skin scaling due to mutations in at least 12 genes. The aim of our study was to assess disease severity, phenotypic and ultrastructural features and to evaluate their association with genetic findings in ARCI patients. METHODS: Clinical signs and symptoms, and disease severity were scored in a single-center series of patients with a genetic diagnosis of ARCI...
April 8, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38574470/exploring-remission-dynamics-and-prognostic-factors-in-lichen-planopilaris-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
A Lyakhovitsky, T Zilberminz, Z Segal, E Galili, A Shemer, B Jaworowsk, S Baum, V Hermush, B Kaplan, A Barzilai
INTRODUCTION: Lichen planopilaris (LPP) is a common type of primary cicatricial alopecia. Previous studies focused on the epidemiology, clinical characteristics, and treatment of LPP. A lack of knowledge regarding LPP outcomes and prognostic factors remained. METHODS: To delineate the rate and timing of remission in LPP, as well as the prognostic factors for achieving remission, a retrospective cohort study was conducted. The study included 126 patients, from a single tertiary center, diagnosed with LPP between January 2010 and December 2022, who were followed up for a minimum of 6 months...
April 4, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38522421/does-the-diagnostic-accuracy-and-rates-of-face-to-face-visits-occurring-shortly-after-an-asynchronized-tele-dermatology-consultations-justify-its-implementation-an-18-month-cohort-study
#15
JOURNAL ARTICLE
Jonathan Shapiro, Izana Kaplan Lavi, Daniel Kun, Arieh Ingber, Tamar Freud, Orly Grunfeld
INTRODUCTION: In 2019, Maccabi Health Services (MHS), rolled out the store-and-forward "Dermadetect" teledermatology consultation (TC) application. Study goal was to analyze MHS records of TCs (August 2019-February 2021) for the rate and reasons for face to face consultations (FTFC) occurring shortly after a TC with emphasis on FTFCs resulting in a different diagnosis for the same indication. METHODS: The records of FTFCs held up shortly after TCs were reviewed and classified into cases marked as unsuited for tele-dermatology, cases which the indication differed and cases with the same indication which were analyzed for concordance of diagnoses...
March 22, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38493762/epidemiology-characteristics-of-disease-and-unmet-needs-of-patients-with-generalized-pustular-psoriasis-a-large-italian-delphi-consensus
#16
JOURNAL ARTICLE
Francesca Prignano, Laura Atzori, Francesco Bellinato, Giovanni Damiani, Carlotta Galeone, Paolo Mariani, Concetta Potenza, Annalisa Scopinaro, Stefano Piaserico, Gabriella Fabbrocini
INTRODUCTION: Generalized pustular psoriasis (GPP) is a rare and chronic, debilitating skin condition characterised, in its acute flare phase, by clinically severe and potentially life-threatening systemic manifestations. Data on GPP are still scanty, particularly in Europe and at a national level. To provide expert indications on several disease-related and patient-related aspects of GPP, with specific focus to the Italian context. METHODS: We conducted an iterative eDelphi study following the recommended criteria for reporting methods and results...
March 17, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38442697/associations-of-digital-ulcers-in-patients-with-systemic-sclerosis-an-8-year-retrospective-study
#17
JOURNAL ARTICLE
Miaomiao Chi, Qi An, Xiuyuan Feng, Lan He, Ying Pan
INTRODUCTION: This study aimed to investigate the associations of digital ulcers (DUs) in patients with systemic sclerosis (SSc). METHODS: This retrospective study investigated the demographic characteristics, specific autoantibodies, organ involvement, and laboratory tests in patients with SSc from our hospital. RESULTS: This study enrolled 144 patients with SSc. The DU+ group consisted of 15 (10.4%) patients. Patients with SSc having DUs have longer disease duration, higher fibrinogen, higher fibrin degradation product, and lower cholesterol...
March 5, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38422999/early-organ-metastasis-in-granulomatous-mycosis-fungoides-a-systematic-review
#18
Melika Motamedi, Maggie Zx Xiao, Jean Deschenes, Jori Hardin, Russell Sterrett, Lesley Street, Minakshi Taparia, Etienne Mahe, Giovanni Ferrara, James R Barrie, Robert Gniadecki
BACKGROUND: Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate. OBJECTIVE: The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there are both favorable and unfavorable outcomes documented. METHODS: We performed a systematic review of 116 GMF cases previously described in the literature. RESULTS: In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course...
February 29, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38417409/bridging-molecular-mechanism-and-clinical-practice-in-vitiligo-treatment-an-updated-review
#19
REVIEW
Hyun Jeong Ju, Jung Min Bae
BACKGROUND: In recent years, a great advance has been made in the area of pathogenesis of vitiligo and the understanding of vitiligo treatment is also expanding. SUMMARY: Treatment of vitiligo seeks to achieve three goals: cessation of disease progression, regeneration of pigmentation, and prevention of recurrence. To achieve these goals, a number of non-surgical interventions are available that suppress the autoimmune response and regenerate the remaining melanocytes from the reservoir, and optimal treatment outcome can be achieved when each modality is used properly...
February 28, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38402858/tattoo-pigment-biokinetics-in-vivo-in-a-28-day-porcine-model-elements-undergo-fast-distribution-to-lymph-nodes-and-reach-steady-state-after-7-days
#20
JOURNAL ARTICLE
Janos Cambiaso-Daniel, Hanna Luze, Silvia Meschnark, Julia Fink, Ines Schreiver, Thomas Rappl, Walter Goessler, Petra Kotzbeck, Lars-Peter Kamolz
INTRODUCTION: Pigments of tattoo inks may over time migrate to other parts of the body. Inks kinetics are still poorly understood and little studied. The aim of this first study was to investigate the kinetics of tattoo inks pigment in tattooed porcine skin, which is closer to human skin than mouse skin studied in the past. METHODS: Three animals were tattooed on the inner thigh and one animal served as untreated control. Skin biopsies were taken on days 7, 14, and 28 after tattooing...
February 23, 2024: Dermatology: International Journal for Clinical and Investigative Dermatology
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