journal
MENU ▼
Read by QxMD icon Read
search

Developmental Dynamics: An Official Publication of the American Association of Anatomists

journal
https://read.qxmd.com/read/30875130/expression-of-new-genes-in-vertebrate-tooth-development-and-p63-signaling
#1
Nasim Rostampour, Cassy M Appelt, Aunum Abid, Julia C Boughner
BACKGROUND: P63 is an evolutionarily ancient transcription factor essential to vertebrate tooth development. Our recent gene expression screen comparing wild-type and "toothless" p63-/- mouse embryos implicated in tooth development several new genes that we hypothesized act downstream of p63 in dental epithelium, where p63 is also expressed. RESULTS: Via in situ hybridization and immunohistochemistry, we probed mouse embryos (E10.5-E14.5) and spotted gar fish embryos (14 days post-fertilization) for these newly linked genes - Cbln1, Cldn23, Fermt1, Krt15, Pltp and Prss8 - which were expressed in mouse and gar dental epithelium...
March 15, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30859697/foxn3-is-necessary-for-the-development-of-the-interatrial-septum-the-ventricular-trabeculae-and-the-muscles-at-the-head-trunk-interface-in-the-african-clawed-frog-xenopus-laevis-lissamphibia-anura-pipidae
#2
Benjamin Naumann, Jennifer Schmidt, Lennart Olsson
BACKGROUND: Fox genes are a large family of transcription factors that play diverse roles in the immune system, metabolism, cancer, cell cycle and animal development. It has been shown that FoxN3 is indispensable for normal craniofacial development in the mouse and the African clawed frog, Xenopus laevis. Morpholino-mediated knockdown of FoxN3 in X. laevis delays overall development of early tadpole stages, causes eye defects, the absence of some cranial nerve branches and malformations of the cranial skeleton and some cranial muscles while the skeleton, nerves and muscles of the trunk are unaffected...
March 11, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30854720/limb-specific-acvr1-knockout-during-embryogenesis-in-mice-exhibits-great-toe-malformation-as-seen-in-fibrodysplasia-ossificans-progressiva-fop
#3
Laura Hildebrand, Mareen Schmidt-von Kegler, Maria Walther, Petra Seemann, Katja Stange
BACKGROUND: This study analyzes Prx1-specific conditional knockout of Acvr1 aiming to elucidate the endogenous role of Acvr1 during limb formation in early embryonic development. ACVR1 can exhibit activating and inhibiting function in BMP signaling. ACVR1 gain-of-function mutations can cause the rare disease Fibrodysplasia Ossificans Progressiva (FOP), where patients develop ectopic bone replacing soft tissue, tendons and ligaments. RESULTS: Whole mount in-situ hybridization (WISH) and skeletal preparations revealed that following limb-specific conditional knockout of Acvr1, metacarpals and proximal phalanges were shortened and additional cartilage and bone elements were formed...
March 10, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30847983/lpa-1-lpa-2-lpa-4-and-lpa-6-receptor-expression-during-mouse-brain-development
#4
Olga Suckau, Isabel Gross, Sandra Schrötter, Fan Yang, Jiankai Luo, Andreas Wree, Jerold Chun, David Baska, Jan Baumgart, Kuniyuki Kano, Junken Aoki, Anja U Bräuer
BACKGROUND: LPA is a small bioactive phospholipid that acts as an extracellular signaling molecule and is involved in cellular processes, including cell proliferation, migration, and differentiation. LPA acts by binding and activating at least six known G-protein-coupled receptors: LPA1-6 . In recent years, LPA has been suggested to play an important role in both normal neuronal development and under pathological conditions in the nervous system. RESULTS: We show the expression pattern of LPA receptors during mouse brain development, by using qRT-PCR, in situ hybridization and immunocytochemistry...
March 8, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30843624/the-platelet-derived-growth-factor-receptor-alpha-promoter-directed-expression-of-cre-recombinase-in-mouse-placenta
#5
Jean-Sebastien Wattez, Liping Qiao, Samuel Lee, David Renato Christopher Natale, Jianhua Shao
BACKGROUND: Numerous pathologies of pregnancy originate from placental dysfunction. It is essential to understand the functions of key genes in the placenta in order to discern the etiology of placental pathologies. A paucity of animal models that allow conditional and inducible expression of a target gene in the placenta is a major limitation for studying placental development and function. METHODOLOGY/PRINCIPAL FINDING: To study the platelet-derived growth factor receptor alpha-directed and tamoxifen-induced Cre recombinase expression in the placenta, PDGFRα-CreER mice were crossed with mT/mG dual fluorescent reporter mice...
March 7, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30843293/kidney-organoids-in-translational-medicine-disease-modeling-and-regenerative-medicine
#6
REVIEW
Tomoya Miyoshi, Ken Hiratsuka, Edgar Garcia Saiz, Ryuji Morizane
The kidney is one of the most complex organs composed of multiple cell types, functioning to maintain homeostasis via the filtering of metabolic wastes, balancing of blood electrolytes, and adjustment of blood pressure. Recent advances in 3D culture technologies in vitro enabled the generation of 'organoids' which mimic the structure and function of in vivo organs. Organoid technology has allowed for new insights into human organ development and human pathophysiology, with great potential for translational research...
March 6, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30839129/the-transcriptome-of-the-veiled-chameleon-chamaeleo-calyptratus-a-resource-for-studying-the-evolution-and-development-of-vertebrates
#7
Brendan J Pinto, Daren C Card, Todd A Castoe, Raul E Diaz, Stuart V Nielsen, Paul A Trainor, Tony Gamble
BACKGROUND: The Veiled Chameleon (Chamaeleo calyptratus) is an emerging model system for studying functional morphology and evolutionary developmental biology (evo-devo). Chameleons possess body plans that are highly adapted to an arboreal life style, featuring laterally compressed bodies, split hands/feet for grasping, a projectile tongue, turreted independently-moving eyes, and a prehensile tail. Despite being one of the most phenotypically divergent clades of tetrapods, genomic resources for chameleons are severely lacking...
March 6, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30801852/myosin-vb-is-required-for-correct-trafficking-of-n-cadherin-and-cardiac-chamber-ballooning
#8
Daniela R Grassini, Jason Da Silva, Thomas E Hall, Gregory J Baillie, Cas Simons, Robert G Parton, Benjamin M Hogan, Kelly A Smith
BACKGROUND: During heart morphogenesis, the cardiac chambers undergo ballooning: a process involving regionalized elongation of cardiomyocytes. Cardiomyocyte shape changes require reorganisation of the actin cytoskeleton however the genetic regulation of this process is not well understood. RESULTS: From a forward genetic screen, we identified the zebrafish uq23ks mutant which manifests chamber ballooning defects. Whole-genome sequencing-mapping identified a truncating mutation in the gene, myo5b...
February 25, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30741457/aggregation-segregation-and-dispersal-of-homotypic-germ-plasm-rnps-in-the-early-zebrafish-embryo
#9
C Eno, C L Hansen, F Pelegri
BACKGROUND: In zebrafish and many other organisms, specification of primordial germ cells (PGCs) requires the transmission of maternally-derived germ plasm. Zebrafish germ plasm ribonucleoparticles (RNPs) aggregate along the cleavage furrows during the first several cell cycles, segregate asymmetrically during the cleavage stages, and undergo cytoplasmic dispersal in the late blastula. RESULTS: For all tested germ plasm RNAs [carbonic anhydrase 15b (ca15b), deleted in azoospermia-like (dazl), dead end (dnd), nanos 3 (nos3), regulator of G-protein signaling14a (rgs14a), and vasa/DEAD box polypeptide 4 (vasa/ddx4)], RNPs are homotypic (containing a single RNA type), with RNPs packing tightly yet remaining distinct within germ plasm aggregates...
February 11, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30698914/development-and-organization-of-the-zebrafish-intestinal-epithelial-stem-cell-niche
#10
Jianlong Li, Morgan Prochaska, Lea Maney, Kenneth N Wallace
BACKGROUND: Development of the vertebrate intestinal epithelial stem cell niche begins during embryogenesis but maturation occurs post-embryonic. The intestinal mammalian crypt contains stem cells interspersed by secretory cells that play a role in regulation of proliferation. Epithelial cells are specified as either secretory or enterocytes as they migrate up the villi in mammals or fold in zebrafish. Zebrafish forms a functional intestine by the end of embryogenesis but takes another four weeks to develop the adult proliferation pattern...
January 30, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30687996/embryonic-and-post-embryonic-development-of-the-ornamental-twin-tail-goldfish
#11
Ing-Jia Li, Shu-Hua Lee, Gembu Abe, Kinya G Ota
BACKGROUND: Twin-tail ornamental goldfish have 'bifurcated median fins,' and this peculiar morphology is known to be caused by a mutation in the chdA gene. However, several ambiguities regarding the development of the phenotype still remain due to a paucity of detailed observations covering the entire developmental timeframe. RESULTS: Here, we report a detailed comparative description of embryonic and post-embryonic development for two representative twin-tail ornamental goldfish strains and single-tail common goldfish...
January 27, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30684382/a-cleft-lip-and-palate-gene-irf6-is-involved-in-osteoblast-differentiation-of-craniofacial-bone
#12
Jake Thompson, Fabian Mendoza, Ethan Tan, Jessica Wildgrube Bertol, Arju S Gaggar, Goo Jun, Claudia Biguetti, Walid D Fakhouri
BACKGROUND: Interferon Regulatory Factor 6 (IRF6) plays a critical role in embryonic tissue development including differentiation of epithelial cells. Besides orofacial clefting due to haploinsufficiency of IRF6, recent human genetic studies indicated that mutations in IRF6 are linked to small mandible and digit abnormalities. The function of IRF6 has been well studied in oral epithelium, however its role in craniofacial skeletal formation remains unknown. In this study, we investigated the role of Irf6 in craniofacial bone development using comparative analyses between wild-type and Irf6-null littermate mice...
January 26, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30682232/characterization-of-xenopus-laevis-guanine-deaminase-reveals-new-insights-for-its-expression-and-function-in-the-embryonic-kidney
#13
Paula G Slater, Garrett M Cammarata, Connor Monahan, Jackson T Bowers, Oliver Yan, Sangmook Lee, Laura Anne Lowery
The mammalian guanine deaminase (GDA), called cypin, is important for proper neural development, by regulating dendritic arborization through modulation of microtubule (MT) dynamics. Additionally, cypin can promote MT assembly in vitro. However, it has never been tested whether cypin (or other GDA orthologs) binds to MTs or modulates MT dynamics. Here, we address these questions and characterize Xenopus laevis GDA (Gda) for the first time during embryonic development. We find that exogenously-expressed human cypin and Gda both display a cytosolic distribution in primary embryonic cells...
January 25, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30653275/heparanase-1-activity-and-the-early-postnatal-prostate-development
#14
Guilherme Oliveira Barbosa, Alexandre Bruni-Cardoso, Maria Aparecida da Silva Pinhal, Taize Machado Augusto, Hernandes F Carvalho
Ventral prostate (VP) morphogenesis starts during embryonic development and continues for the first three postnatal weeks. Heparan sulfate (HS) affects paracrine signaling. Heparanase-1 (HPSE) is the only enzyme capable of cleaving HS. HPSE releases the HS bioactive fragment and mobilizes growth factors. Little is known, however, about HS turnover and HPSE function during VP morphogenesis. In this study, we measured HSPG expression and analyzed the expression and distribution of HPSE in the rat VP. HPSE was predominantly expressed by the VP epithelium...
January 17, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30620790/nuclear-fgfr2-regulates-musculoskeletal-integration-within-the-developing-limb
#15
Joanna E Salva, Ryan R Roberts, Taylor S Stucky, Amy E Merrill
BACKGROUND: Bent Bone Dysplasia Syndrome (BBDS), a congenital skeletal disorder caused by dominant mutations in Fibroblast growth factor receptor 2 (FGFR2), is characterized by bowed long bones within the limbs. We previously showed that the FGFR2 mutations in BBDS enhance nuclear and nucleolar localization of the receptor; however, exactly how shifts in subcellular distribution of FGFR2 affect limb development remained unknown. RESULTS: Targeted expression of the BBDS mutations in the lateral plate mesoderm of the developing chick induced angulated hindlimbs, a hallmark feature of the disease...
January 8, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30653268/the-micrornas-control-eyelid-development-through-regulating-wnt-signaling
#16
Takahiro Nagai, Supaluk Trakanant, Maiko Kawasaki, Katsushige Kawasaki, Yurie Yamada, Momoko Watanabe, James Blackburn, Yoko Otsuka-Tanaka, Mitsue Hishinuma, Atsushi Kitatmura, Fumiya Meguro, Akane Yamada, Yasumitsu Kodama, Takeyasu Maeda, Qiliang Zhou, Yasuo Saijo, Akihiro Yasue, Paul T Sharpe, Robert Hindges, Ritsuo Takagi, Atsushi Ohazama
BACKGROUND: The timing, location, and level of gene expression are crucial for normal organ development, since morphogenesis requires strict genetic control. MicroRNAs (miRNAs) are noncoding small single-stranded RNAs that play a critical role in regulating gene expression level. Although miRNAs are known to be involved in many biological events, the role of miRNAs in organogenesis is not fully understood. Mammalian eyelids fuse and separate during development and growth. In mice, failure of this process results in the eye-open at birth (EOB) phenotype...
January 4, 2019: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30576023/a-systematic-review-of-hormonal-and-genetic-factors-involved-in-the-nonsyndromic-disorders-of-the-lower-jaw
#17
REVIEW
Srishti Manocha, Nadia Farokhnia, Sepideh Khosropanah, Jessica W Bertol, Joel Santiago Junior, Walid D Fakhouri
Mandibular disorders are among the most common birth defects in humans, yet the etiological factors are largely unknown. Most of the neonates affected by mandibular abnormalities have a sequence of secondary anomalies including airway obstruction and feeding problems that reduce the quality of life. In the event of lacking corrective surgeries, patients with mandibular congenital disorders suffer from additional lifelong problems like sleep apnea and temporomandibular disorders among others. The goal of this systematic review is to gather evidence on hormonal and genetic factors that are involved in signaling pathways and interactions that are potentially associated with the nonsyndromic mandibular disorders...
December 21, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30569660/amputation-induced-ros-signaling-is-required-for-axolotl-tail-regeneration
#18
Nour W Al Haj Baddar, Adarsh Chithrala, S Randal Voss
BACKGROUND: Among vertebrates, salamanders are unparalleled in their ability to regenerate appendages throughput life. However, little is known about early signals that initiate regeneration in salamanders. RESULTS: Ambystoma mexicanum embryos were administered tail amputations to investigate the timing of reactive oxygen species (ROS) production and the requirement of ROS for regeneration. ROS detected by dihydroethidium (DHE) increased within minutes of axolotl tail amputation and levels remained high for 24 hours...
December 20, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30566266/foxa-expression-pattern-in-two-polychaete-species-alitta-virens-and-platynereis-dumerilii-examination-of-the-conserved-key-regulator-of-the-gut-development-from-cleavage-through-larval-life-post-larval-growth-and-regeneration
#19
Roman P Kostyuchenko, Vitaly V Kozin, Nadezhda A Filippova, Ekaterina V Sorokina
BACKGROUND: foxA orthologs are involved in various processes from embryo patterning to regulation of metabolism. Since foxA conserved role in the development of the gut of errant annelids has never been thoroughly studied, we used a candidate gene approach to unravel the molecular profile of the alimentary canal in two closely related nereid worms with a trochophore-type lecithotrophic larva. RESULTS: The character of foxA expression in the two polychaetes was similar but not identical...
December 19, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://read.qxmd.com/read/30394653/anteroposterior-molecular-registries-in-ectoderm-of-the-echinus-rudiment
#20
Shinya Adachi, Iyo Niimi, Yui Sakai, Fuminori Sato, Takuya Minokawa, Makoto Urata, Atsuko Sehara-Fujisawa, Isao Kobayashi, Masaaki Yamaguchi
BACKGROUND: Echinoderms and hemichordates are sister taxa that both have larvae with tripartite coeloms. Hemichordates inherit the coelom plan and ectoderm from larvae, whereas echinoderms form the adult rudiment comprising rearranged coeloms and a vestibule that then develops into adult oral ectoderm. Molecular networks that control patterns of the ectoderm and the central nervous system along the anteroposterior (AP) axis are highly conserved between hemichordates and chordates, respectively...
December 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
journal
journal
30931
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"