journal
https://read.qxmd.com/read/38881301/climate-change-and-its-implications-for-kidney-health
#1
JOURNAL ARTICLE
David S Goldfarb, Anuj A Patel
PURPOSE OF REVIEW: Extremes of weather as a result of climate change are affecting social, economic and health systems. Kidney health is being threatened by global warming while treatment of kidney disease is contributing to increasing resource utilization and leaving a substantial carbon footprint. Improved physician awareness and patient education are needed to mitigate the risk. RECENT FINDINGS: Rising temperatures are changing kidney disease patterns, with increasing prevalence of acute kidney injury, chronic kidney disease and kidney stones...
June 13, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38881293/assessing-the-ripple-effects-of-natural-disasters-on-healthcare-systems-a-narrative-review
#2
JOURNAL ARTICLE
Filippo Dagnino, Zhiyu Qian, Edoardo Beatrici
PURPOSE OF REVIEW: Natural disasters are on the rise, driven by shifts in climatic patterns largely attributed to human-induced climate change. This relentless march of climate change intensifies the frequency and severity of these disasters, heightening the vulnerability of communities and causing significant harm to both lives and socio-economic systems. Healthcare services are particularly strained during extreme weather events, with impacts felt not only on infrastructure but also on patient care...
June 10, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38847801/footprints-in-the-scan-reducing-the-carbon-footprint-of-diagnostic-tools-in-urology
#3
JOURNAL ARTICLE
Alexandre Woernle, Caroline M Moore, Clare Allen, Francesco Giganti
PURPOSE OF REVIEW: There is an ever-growing focus on climate change and its impact on our society. With healthcare contributing a sizeable proportion of carbon emissions, the sector has a duty to address its environmental impact. We highlight the recent progress, current challenges, and future prospects for reducing the carbon footprint in diagnostic urology, specifically for imaging, without compromising patient care. RECENT FINDINGS: The review is separated into four key areas of recent research: the design of a green radiology department, considering both infrastructural as well as behavioural changes that promote sustainability; individual scanners, where we provide an update on recent technological advancements and changes in behaviour that may enhance sustainable use; responsible resource allocation, where it is important to derive the maximal benefit for patients through the smallest use of resources; the recent research regarding single versus reusable urologic endoscopes as a case example...
June 7, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38835180/extracellular-vesicles-as-novel-uro-oncology-biomarkers-insights-toward-clinical-applications
#4
JOURNAL ARTICLE
Fumihiko Urabe, Takaaki Tamura, Shinichi Sakamoto, Takahiro Kimura, Takahiro Ochiya
PURPOSE OF REVIEW: We discussed the challenges associated with the clinical application of extracellular vesicles and summarized their potential impact on oncological clinical practice in urology. RECENT FINDINGS: Despite extensive research on extracellular vesicles, their clinical applications remain limited; this is likely to be because of small study cohorts, a lack of large-scale analyses, and the impact of variable extraction and storage methods on analysis outcomes...
June 5, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38832408/plant-based-diets-animal-agriculture-and-the-connection-with-urological-and-planetary-health
#5
JOURNAL ARTICLE
Natasha Gupta, Michael S Leapman, Stacy Loeb
PURPOSE OF REVIEW: We summarize the latest evidence regarding the impact of plant-based diets on urological and planetary health to facilitate patient counseling and research regarding dietary intervention. RECENT FINDINGS: Studies have highlighted the association of plant-based diets with a lower risk of multiple urological conditions including prostate cancer, erectile dysfunction, benign prostatic hyperplasia, and nephrolithiasis, as well as benefits for planetary health...
June 3, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38813704/sustainable-practices-in-hospital-and-operating-theaters
#6
JOURNAL ARTICLE
Julien Anract, Benjamin Pradere, Ugo Pinar
PURPOSE OF REVIEW: This review aims to provide an update on the results of studies published in the last two years involving the development of sustainable practices in hospital and operating theaters (OT). RECENT FINDINGS: Recently, many studies evaluated various initiatives to better understand the environmental impact of the OT but also to minimize its environmental impact. Many trials evidenced the positive impact of the instrument's reuse using an appropriate reprocessing procedure...
May 30, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38757170/advances-in-preclinical-approaches-for-intravesical-therapy-of-bladder-cancer
#7
JOURNAL ARTICLE
Sreekanth Reddy Obireddy, Wing-Fu Lai
PURPOSE OF REVIEW: The purpose of this review is to explore new strategies to treat bladder cancer. This article addresses challenges and opportunities in intravesical therapy of bladder cancer. RECENT FINDINGS: The review examines the latest advances in the development of preclinical approaches for intravesical therapy of bladder cancer. It discusses strategies to improve drug delivery efficiency by using synthesized diverse carriers. Immunotherapy with protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride has been shown to be more effective than intravesical Bacillus Calmette-Guerin...
May 17, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38712633/liquid-biomarkers-in-prostate-cancer-recent-advancements-and-future-directions
#8
JOURNAL ARTICLE
Chris Ho-Ming Wong, Ivan Ching-Ho Ko, Chi Fai Ng
PURPOSE OF REVIEW: Traditional diagnostic approaches of prostate cancer like PSA are limited by high false-positive rates and insufficient capture of tumour heterogeneity, necessitating the development of more precise tools. This review examines the latest advancements in liquid biomarkers for prostate cancer, focusing on their potential to refine diagnostic accuracy and monitor disease progression. RECENT FINDINGS: Liquid biomarkers have gained prominence because of their minimally invasive nature and ability to reflect the molecular characteristics of prostate cancer...
May 7, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38704827/defining-oligometastatic-state-in-uro-oncological-cancers
#9
JOURNAL ARTICLE
Tamás Fazekas, Marcin Miszczyk, Akihiro Matsukawa, Péter Nyirády, Shahrokh F Shariat, Pawel Rajwa
PURPOSE OF REVIEW: Oligometastatic tumors illustrate a distinct state between localized and systematic disease and might harbor unique biologic features. Moreover, these tumors represent a different clinical entity, with a potential of long-term disease control or even cure, therefore they receive growing attention in the field of urologic oncology. RECENT FINDINGS: Currently, there is no consensus on the definition of oligometastatic prostate cancer, most experts limit it to a maximum of three to five lesions and involvement of no more than two organs, excluding visceral metastases...
May 3, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38650456/recent-contributions-of-single-cell-and-spatial-profiling-to-the-understanding-of-bladder-cancer
#10
JOURNAL ARTICLE
Reinhard Grausenburger, Paula Herek, Shahrokh F Shariat, Bernhard Englinger
PURPOSE OF REVIEW: Current risk stratification and treatment decision-making for bladder cancer informed by histopathology as well as molecular diagnostics face limitations. This review summarizes recent advancements in single-cell and spatial omics methodologies for understanding bladder cancer biology and their potential impact on development of novel therapeutic strategies. RECENT FINDINGS: Single-cell RNA sequencing and spatial omics techniques offer unprecedented insights into various aspects of tumor microenvironment (TME), bladder cancer heterogeneity, cancer stemness, and cellular plasticity...
April 23, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38630912/preclinical-models-for-bladder-cancer-therapy-research
#11
JOURNAL ARTICLE
Iris Ertl, Shahrokh F Shariat, Walter Berger, Bernard Englinger
PURPOSE OF REVIEW: Bladder cancer (BC) is a highly heterogenous disease comprising tumours of various molecular subtypes and histologic variants. This heterogeneity represents a major challenge for the development of novel therapeutics. Preclinical models that closely mimic in vivo tumours and reflect their diverse biology are indispensable for the identification of therapies with specific activity in various BC subtypes. In this review, we summarize efforts and progress made in this context during the last 24 months...
April 17, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38607277/molecular-research-in-bladder-cancer
#12
JOURNAL ARTICLE
Bernhard Englinger
No abstract text is available yet for this article.
April 12, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38602053/advances-in-preclinical-assessment-of-therapeutic-targets-for-bladder-cancer-precision-medicine
#13
JOURNAL ARTICLE
Christoph Nössing, Paula Herek, Shahrokh F Shariat, Walter Berger, Bernhard Englinger
PURPOSE OF REVIEW: Bladder cancer incidence is on the rise, and until recently, there has been little to no change in treatment regimens over the last 40 years. Hence, it is imperative to work on strategies and approaches to untangle the complexity of intra and inter-tumour heterogeneity of bladder cancer with the aim of improving patient-specific care and treatment outcomes. The focus of this review is therefore to highlight novel targets, advances, and therapy approaches for bladder cancer patients...
April 11, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38595170/antegrade-ejaculation-preservation-in-surgical-treatment-for-benign-prostatic-hyperplasia-quest-for-balance-between-voiding-and-sexual-function
#14
JOURNAL ARTICLE
Diana M Lopategui, Hemendra N Shah, Thomas R W Herrmann
PURPOSE OF REVIEW: Surgical treatment of benign prostatic hyperplasia (BPH) carries a significant risk of ejaculation dysfunction. Preservation of antegrade ejaculation while providing effective, well tolerated, and durable treatment of BPH is a paramount component of physical and sexual well being for significant number of men. We reviewed available literature with an aim of providing status on antegrade ejaculation preserving BPH surgical therapies. RECENT FINDINGS: Minimally invasive surgical therapies for BPH have been developed over the last decade, with significant marketing emphasis on their potential for preservation of antegrade ejaculation...
April 10, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38595192/definitions-and-unmet-needs-in-the-management-of-oligomestatic-renal-cell-carcinoma-in-the-modern-era
#15
JOURNAL ARTICLE
Giulio Francolini, Riccardo Campi, Chiara Ciccarese
PURPOSE OF REVIEW: Oligometastatic renal cell carcinoma (RCC) is a complex entity, potentially leading to a specific clinical management of these patients. Recent and ongoing trials have raised several unresolved questions that could impact clinical routine practice, advocating for the integration of novel treatment options (systemic treatment, cytoreductive surgery, or stereotactic body radiotherapy - SBRT) with varied modalities and objectives. RECENT FINDINGS: Immunotherapy represents a breakthrough in the systemic treatment of mRCC...
April 9, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38587018/role-of-cytoreductive-radical-prostatectomy-in-men-with-oligometastatic-prostate-cancer-on-molecular-imaging
#16
JOURNAL ARTICLE
Daniele Robesti, Andrea Gallina, Francesco Montorsi, Alberto Briganti, Nicola Fossati
PURPOSE OF REVIEW: The implementation of PET with prostate-specific membrane antigen (PSMA) tracer as primary staging tool occurred recently. Since its introduction, a novel category of patients emerged, with negative staging at conventional imaging, and positive molecular imaging. Local treatment in these patients might be associated with improved oncological outcomes when combined with systemic therapy. However, its impact on oligometastatic prostate cancer (omPCa) remains unknown. In this review, we aimed at investigating the role of cytoreductive radical prostatectomy (cRP) in oligometastatic disease at molecular imaging...
April 8, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38587010/is-there-a-role-for-metastasis-directed-therapy-in-bladder-cancer
#17
JOURNAL ARTICLE
Mohammad Abufaraj, Joud Al Karmi, Adan Bdeir
PURPOSE OF REVIEW: This article aims to comprehensively review and critique the existing literature on the role of metastatic-directed therapy in patients with metastatic bladder cancer, particularly in oligometastatic disease state. RECENT FINDINGS: The role of metastasectomy in metastatic bladder cancer is still controversial. Several studies have demonstrated improved outcomes, particularly in a highly selected patients with small metastatic lesions or with lung or brain metastases, whereas others show no significant survival benefit...
April 5, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38587022/radioguided-surgery-for-lymph-node-metastases-in-prostate-cancer
#18
JOURNAL ARTICLE
Sophie Knipper, Fabian Falkenbach, Tobias Maurer
PURPOSE OF REVIEW: This review highlights recent advancements in radioguided surgery (RGS) for prostate cancer. Our objective is to provide expert insights into the state of research, as reflected in the selected articles, and to offer perspectives on the clinical implications and future directions that emerge from this rapidly evolving domain. RECENT FINDINGS: Key findings include the potential of PSMA-RGS surgery to improve the detection of lymph node invasion in primary prostate cancer, to guide successful removal of metastatic lesions in oligorecurrent patients with acceptable complications, and the feasibility of robot-assisted PSMA-RGS using a miniaturized gamma probe...
April 4, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38587028/metastasis-directed-therapy-in-testicular-cancer
#19
JOURNAL ARTICLE
Kshitij Pandit, Kit Yuen, Dhruv Puri, Nuphat Yodkhunnatham, Frederick Millard, Aditya Bagrodia
PURPOSE OF REVIEW: This review highlights the importance of addressing testicular cancer metastasizing beyond the retroperitoneum, focusing on multidisciplinary approaches and advances in treatment. RECENT FINDINGS: Recent literature emphasizes on the evolving landscape of metastasis-directed therapy, including surgical interventions, chemotherapy regimens, and radiation therapy. The effectiveness of these treatments varies depending on the site of metastasis, with various approaches improving survival rates and quality of life for patients...
April 3, 2024: Current Opinion in Urology
https://read.qxmd.com/read/38835186/metastasis-directed-therapy-among-urological-malignancies-where-do-we-stand
#20
EDITORIAL
Chiara Re, Grant D Stewart, Umberto Capitanio
No abstract text is available yet for this article.
July 1, 2024: Current Opinion in Urology
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