Chen Wang, Matthew S Block, Julie M Cunningham, Mark E Sherman, Bryan M McCauley, Sebastian M Armasu, Robert A Vierkant, Nadia Traficante, Aline Talhouk, Susan J Ramus, Nadja Pejovic, Martin Köbel, Brooke D Jorgensen, Dale W Garsed, Sian Fereday, Jennifer A Doherty, Dinuka Ariyaratne, Michael S Anglesio, Martin Widschwendter, Tanja Pejovic, Jesus Gonzalez Bosquet, David D Bowtell, Stacey J Winham, Ellen L Goode
BACKGROUND: Better understanding of prognostic factors in tubo-ovarian high-grade serous carcinoma (HGSC) is critical, as diagnosis confers an aggressive disease course. Variation in tumor DNA methylation shows promise predicting outcome, yet prior studies were largely platform-specific and unable to evaluate multiple molecular features. METHODS: We analyzed genome-wide DNA methylation in 1,040 frozen HGSC, including 325 previously reported upon, seeking a multi-platform quantitative methylation signature that we evaluated in relation to clinical features, tumor characteristics, time to recurrence/death, extent of CD8+ tumor-infiltrating lymphocytes (TIL), gene expression molecular subtypes, and gene expression of the ATP-binding cassette transporter TAP1...
February 15, 2023: Cancer Epidemiology, Biomarkers & Prevention