Journals Cancer Epidemiology, Biomarker...

Cancer Epidemiology, Biomarkers & Prevention
Anna Gottschlich, Quan Hong, Lovedeep Gondara, Md Saiful Alam, Darrel A Cook, Ruth Elwood Martin, Marette Lee, Joy Melinikow, Stuart Peacock, Lily Proctor, Gavin Stuart, Eduardo L Franco, Mel Krajden, Laurie W Smith, Gina S Ogilvie
BACKGROUND: Growing use of primary HPV cervical cancer screening requires determining appropriate screening intervals to avoid overtreatment of transient disease. This study examined the long-term risk of cervical precancer after HPV screening to inform screening interval recommendations. METHODS: This longitudinal cohort study (British Columbia, Canada, 2008-2022) recruited women and individuals with a cervix (WIC) who received 1-2 negative HPV screen(s) (HPV1 cohort, N = 5,546, HPV2 cohort, N = 6,624) during a randomized trial and WIC with 1-2 normal cytology result(s) (BCS1 cohort, N = 782,297, BCS2 cohort, N = 673,778) extracted from the provincial screening registry...
May 22, 2024: Cancer Epidemiology, Biomarkers & Prevention
Patrick A Williams, Sayyed Kaleem Zaidi, Haleh Ramian, Rajarshi Sengupta
Advances in cancer prevention, early detection and treatments have led to unprecedented progress against cancer. However, these advances have not benefited everyone equally. Because of a long history of structural inequities and systemic injustices in the United States, many segments of the US population continue to shoulder a disproportionate burden of cancer. The American Association for Cancer Research (AACR) Cancer Disparities Progress Report 2024 ( outlines the recent progress against cancer disparities, the ongoing challenges faced by medically underserved populations, and emphasizes the vital need for further advances in cancer research and patient care to benefit all populations...
May 15, 2024: Cancer Epidemiology, Biomarkers & Prevention
Lindsay F Schwartz, Kayla L Stratton, Wendy M Leisenring, Stefania Marron Rodriguez, Shani Alston, Aaron McDonald, Chris Vukadinovich, Dayton Rinehart, Kevin C Oeffinger, Eric J Chow, Kevin R Krull, Tara M Brinkman, Paul C Nathan, Marcia M Tan, Julie S McCrae, Tiffany Burkhardt, Kirsten K Ness, Gregory T Armstrong, Tara O Henderson
BACKGROUND: The impact of Adverse Childhood Experiences (ACEs: e.g., abuse, neglect and/or household dysfunction experienced before age 18) and resilience on risk for cardiovascular disease (CVD) has not previously been investigated in adult survivors of childhood cancer. METHODS: We conducted a nested case-control study among long-term, adult-aged survivors of childhood cancer from the Childhood Cancer Survivor Study (CCSS). Self-report questionnaires ascertained ACEs and resilience, and scores were compared between cases with serious/life-threatening CVD and controls without CVD matched on demographic and cardiotoxic treatment factors...
May 13, 2024: Cancer Epidemiology, Biomarkers & Prevention
Stephanie C Melkonian, Melissa A Jim, Donald Haverkamp, Madeleine Lee, Amanda E Janitz, Janis E Campbell
Background Non-Hispanic American Indian and Alaska Native (NH-AI/AN) people experience a disproportionate incidence of kidney cancer. Nationally aggregated data does not allow for a comprehensive description of regional disparities in kidney cancer incidence among NH-AI/AN communities. This study describes kidney cancer incidence rates and trends among NH-AI/AN compared to non-Hispanic White (NHW) populations by geographic region. Methods Using the United States Cancer Statistics American Indian and Alaska Native (AI/AN) Incidence Analytic Database, we calculated age-adjusted incidence rates (per 100,000) of kidney cancers for NH-AI/AN and NHW people for the years 2011-2020 combined using SEER*stat software...
May 10, 2024: Cancer Epidemiology, Biomarkers & Prevention
Yann Ruffieux, Nathalie Veronica Fernandez Villalobos, Christiane Didden, Andreas D Haas, Chido Chinogurei, Morna Cornell, Matthias Egger, Gary Maartens, Naomi Folb, Eliane Rohner
BACKGROUND: Several studies have found lower prostate cancer diagnosis rates among men with HIV (MWH) than men without HIV, but reasons for this finding remain unclear. METHODS: We used claims data from a South African private medical insurance scheme (07/2017-07/2020) to assess prostate cancer diagnosis rates among men aged ≥18 years with and without HIV. Using flexible parametric survival models, we estimated hazard ratios (HR) for the association between HIV and incident prostate cancer diagnoses...
May 7, 2024: Cancer Epidemiology, Biomarkers & Prevention
Hanqing Zhang, Minghao He, Peng Zhang, Yang Gao, Ling Ouyang, Xianjun He, Na Han, Jinfeng Zhang, Mengshan Guan, Yueqi Feng, Yonghua Li
BACKGROUND: The objective of this study was to identify the risk of cardiovascular disease (CVD)-related death in older patients with major hematological malignancies (HM). METHODS: This study included 103,102 older patients diagnosed with 7 major types of HM between 1975 and 2018 (median follow-up: 2.7 years) from the Surveillance, Epidemiology, and End Result (SEER) database. The proportion of deaths, Fine-Gray sub-distribution hazards regression model, standardized mortality ratios (SMR) and absolute excess risk (AER) were used to evaluate the risk of CVD-related death...
May 7, 2024: Cancer Epidemiology, Biomarkers & Prevention
Ramkrishna Kumar Singh, Kayla R Getz, Joy K Kyeyune, Myung Sik Jeon, Chongliang Luo, Jingqin Luo, Adetunji T Toriola
BACKGROUND: Studies investigating the associations of self-reported aspirin use and mammographic breast density (MBD) have reported conflicting results. We, therefore, investigated the associations of aspirin metabolites, with MBD in premenopausal women. METHODS: We performed this study on 705 premenopausal women who had fasting blood draw for metabolomic profiling. We performed covariate-adjusted linear regression models to calculate the least squares means of volumetric measures of MBD (volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV)) by quartiles of aspirin metabolites (salicyluric glucuronide, 2-hydroxyhippurate (salicylurate), salicylate, and 2,6-dihydroxybenzoic acid)...
May 3, 2024: Cancer Epidemiology, Biomarkers & Prevention
Jacob Allen Miller, Zhiwei Liu, Benjamin A Pinsky, Quynh-Thu Le, Tong Li, Kelly J Yu, Allan Hildesheim, Su-Mei Cao
BACKGROUND: Screening with anti-Epstein-Barr Virus (EBV) serology and endoscopy decreased nasopharyngeal carcinoma (NPC) mortality in Guangdong in a randomized trial. We conducted a secondary analysis of this trial using local incidence and cost data to optimize screening programs, hypothesizing that screening could be cost-effective in southern China. METHODS: Screening costs and life-years after NPC diagnosis were obtained from the Guangdong trial's intent-to-screen population (men and women age 30-69)...
May 2, 2024: Cancer Epidemiology, Biomarkers & Prevention
Jing Wang, Qi Wang, Ziwei Shi, Xiaolong Yan, Zhiqun Lei, Wenmin Zhu
BACKGROUND: Previous studies usually focused on the separate association of metabolism or genetic factors with lung cancer risk and have largely ignored their combined effect. We aimed to examine the associations between serum lipid levels, genetic risk, and lung cancer risk. METHODS: 426,524 participants of the UK Biobank were included. The Cox proportional hazards models and restricted cubic splines were performed to assess the association between serum lipid and lung cancer risk...
April 25, 2024: Cancer Epidemiology, Biomarkers & Prevention
Humberto Parada, Tianying Wu, Eunha Hoh, Cheryl L Rock, Maria Elena Martinez
BACKGROUND: Intake of polyunsaturated fatty acids (PUFAs) may impact mortality following breast cancer (BC); however, epidemiological studies have relied on self-reported assessment of PUFA intake. Herein, we examined the associations between red blood cell (RBC) PUFAs and mortality. METHODS: This nested case-control study included 1,104 women from, the Women's Healthy Eating and Living Study, a multi-site randomized controlled trial. Cases (n=290) were women who died from 1995-2006...
April 24, 2024: Cancer Epidemiology, Biomarkers & Prevention
Jie Chen, Jaime E Hart, Trang VoPham, Elise G Elliott, Brenda M Birmann, Francine Laden
BACKGROUND: Certain hazardous air pollutants (HAPs) are known or suspected to pose immunological or cancer risk to humans, but evidence is limited from the general population. METHODS: We assessed associations between residential exposure to HAPs at the Census tract level and incident non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) in the Nurses' Health Study (NHS, 1986-2012) and NHSII (1989-2019). We used covariate-adjusted proportional hazards models to estimate hazard ratios (HRs) of NHL, major NHL subtypes, and MM per interquartile range increase in exposure to a given HAP and pooled the cohort-specific estimates using fixed-effects meta-analyses...
April 24, 2024: Cancer Epidemiology, Biomarkers & Prevention
David Cheng, Meghan L Rieu-Werden, Jacquelyn M Lykken, Claudia L Werner, Sarah Feldman, Michelle I Silver, Steven J Atlas, Jasmin A Tiro, Jennifer S Haas, Aruna Kamineni
BACKGROUND: Follow-up of abnormal results is essential to cervical cancer screening, but data on adherence to follow-up are limited. We describe patterns of follow-up after screening abnormalities and identify predictors of guideline-concordant follow-up. METHODS: We identified the index screening abnormality (positive human papillomavirus [HPV] test or atypical squamous cells of undetermined significance [ASC-US] or more severe cytology) among women 25-65 years old at three U...
April 23, 2024: Cancer Epidemiology, Biomarkers & Prevention
Hannah Oh, Lusine Yaghjyan, Yujing J Heng, Bernard Rosner, Matt B Mahoney, Divya Murthy, Gabrielle M Baker, Rulla M Tamimi
BACKGROUND: According to the stem cell hypothesis, breast carcinogenesis may be related to the breast stem cell pool size. However, little is known about associations of breast cancer risk factors, such as anthropometric measures, with the expression of stem cell markers in non-cancerous breast tissue. METHODS: The analysis included 414 women with biopsy-confirmed benign breast disease (BBD) in the Nurses' Health Study (NHS) and NHSII. Birthweight, weight at age 18, current weight, and current height were reported via self-administered questionnaire...
April 23, 2024: Cancer Epidemiology, Biomarkers & Prevention
Yiwen Zhang, Xiaotong Feng, Edward L Giovannucci
BACKGROUND: Appendectomy is a common surgical procedure to treat appendicitis. Limited studies examined its association on prostate cancer, with one large cohort study suggesting significant increased risk of overall and advanced prostate cancer, especially among younger men. METHODS: A total of 49,104 men in the Health Professionals Follow-up Study were followed from 1986 to 2016. Cox proportional hazards models were applied to evaluate the association between self-reported history of appendectomy and risk of overall and subtype specific prostate cancer, adjusted for multiple risk factors...
April 23, 2024: Cancer Epidemiology, Biomarkers & Prevention
Danielle Novetsky Friedman, Joanne F Chou, Jeanne M Clark, Chaya S Moskowitz, Jennifer S Ford, Gregory T Armstrong, Nidha Z Mubdi, Aaron McDonald, Paul C Nathan, Charles A Sklar, Lakshmi V Ramanathan, Leslie L Robison, Kevin C Oeffinger, Emily S Tonorezos
BACKGROUND: Obesity is prevalent in childhood cancer survivors and interacts with cancer treatments to potentiate risk for cardiovascular (CV) death. We tested a remote weight-loss intervention that was effective among adults with CV risk factors in a cohort of adult survivors of childhood acute lymphoblastic leukemia (ALL) with overweight/obesity. METHODS: In this phase 3 efficacy trial, survivors of ALL enrolled in the Childhood Cancer Survivor Study with body mass index (BMI)≥25 kg/m2 were randomized to a remotely-delivered weight-loss intervention versus self-directed weight loss, stratified by history of cranial radiotherapy (CRT)...
April 23, 2024: Cancer Epidemiology, Biomarkers & Prevention
Gabriel Tchuente Kamsu, Eugene Jamot Ndebia
Tobacco is usually cited among the well-known risk factors of esophageal cancer, nevertheless, the extent of the contribution of the type of smoking and its intensity to the disease has not been comprehensively elucidated in Africa. We searched Medline/PubMed, Embase, Web of Science, Scopus, Cochrane Library, and African Journals Online studies published before September 2023. The quality of the studies was assessed using the Newcastle-Ottawa scale and the funnel plot was used for assessing potential publication bias...
April 23, 2024: Cancer Epidemiology, Biomarkers & Prevention
Jussi Niemelä, Joel Nuotio, Tomi T Laitinen, Mika Kähönen, Nina Hutri, Terho Lehtimäki, Eero Jokinen, Päivi Tossavainen, Tomi P Laitinen, Olli J Heinonen, Terence Dwyer, Katja Pahkala, Suvi P Rovio, Jorma Viikari, Olli Raitakari, Markus Juonala
BACKGROUND: Lifestyle factors may affect cancer risk. This study aimed to identify whether American Heart Association (AHA) Ideal Cardiovascular Health (ICH) score and its individual variables in youth associate with subsequent cancer incidence. METHODS: Study comprised of participants of the Cardiovascular Risk in Young Finns Study free of cancer at analysis baseline in 1986 (n=1873). Baseline age was 12-24 years and the follow-up occurred between 1986-2018. RESULTS: Among 1873 participants (mean age 17...
April 19, 2024: Cancer Epidemiology, Biomarkers & Prevention
Ashly C Westrick, Monica Ospina-Romero, Philippa Clarke, Kenneth M Langa, Lindsay C Kobayashi
BACKGROUND: Neighborhood disadvantage has been linked to cognitive impairment, but little is known about the effect of neighborhood disadvantage on long-term cancer-related memory decline. METHODS: Incident cancer diagnosis and memory (immediate and delayed recall, combined with proxy-reported memory) were assessed at biennial interviews in the U.S. Health and Retirement Study (N=13,293, 1998-2016). Neighborhood disadvantage was measured using the National Neighborhood Data Archive disadvantage index, categorized into tertiles (T1: least disadvantaged - T3: most disadvantaged)...
April 19, 2024: Cancer Epidemiology, Biomarkers & Prevention
Jennifer A Collister, Xiaonan Liu, Thomas J Littlejohns, Jack Cuzick, Lei Clifton, David J Hunter
BACKGROUND: Previous studies have demonstrated that incorporating a polygenic risk score (PRS) to existing risk prediction models for breast cancer improves model fit, but to determine its clinical utility the impact on risk categorisation needs to be established. We add a PRS to two well-established models and quantify the difference in classification using the net reclassification improvement (NRI). METHODS: We analysed data from 126,490 post-menopausal women of "White British" ancestry, aged 40-69 years at baseline from the UK Biobank prospective cohort...
April 17, 2024: Cancer Epidemiology, Biomarkers & Prevention
Bruna Pellini, Aadel A Chaudhuri
Non-small cell lung cancer (NSCLC) is associated with a 5-year survival rate of only 28%, however, when caught at an early stage, it can be cured with surgery or stereotactic body radiotherapy (SBRT). Unfortunately, racial disparities may result in limited access to care for some patients. Liu et al. analyzed 64,999 cases of early-stage NSCLC treated between 2005 and 2017 from the Florida cancer registry and showed that Black patients had 36% lower odds of receiving curative-intent surgery compared to their White counterparts...
April 8, 2024: Cancer Epidemiology, Biomarkers & Prevention
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