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Cancer Epidemiology, Biomarkers & Prevention

Lindsay A Williams, Jun J Yang, Betsy A Hirsch, Erin L Marcotte, Logan G Spector
While substantial advances in the identification of cytogenomic subtypes of childhood acute lymphoblastic leukemia (ALL) have been made in recent decades, epidemiologic research characterizing the etiologic heterogeneity of ALL by subtype has not kept pace. The purpose of this review is to summarize the current literature concerning subtype-specific epidemiologic risk factor associations with ALL subtype defined by immunophenotype (e.g. B-cell vs T-cell) and cytogenomics (including gross chromosomal events characterized by recurring numerical and structural abnormalities, along with cryptic balanced rearrangements, and focal gene deletions)...
February 15, 2019: Cancer Epidemiology, Biomarkers & Prevention
Eric Levesque, Patrick Caron, Louis Lacombe, Veronique Turcotte, David Simonyan, Yves Fradet, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Chantal Guillemette
BACKGROUND: In men with localized prostate cancer (PCa) who are undergoing radical prostatectomy (RP), it is uncertain whether their hormonal environment is associated with outcomes. The objective of the study was to examine the association between the steroid metabolome with prognostic factors and progression. PATIENTS AND METHODS: The prospective PROCURE cohort was recruited from 2007-2012, and comprises 1766 patients with localized PCa who provided blood samples prior to RP...
February 7, 2019: Cancer Epidemiology, Biomarkers & Prevention
Marlene Camacho Rivera, Samuel L Rice, Sehyun Oh, Manuel A Paris, Rosario Costas Muniz, Ezinne Akpara, Michael Obadina, Justen Molina, Shireene J Mcmillan, Joshua L Mendez Aracena, Jason Morency, Francesca Gany, Carol L Brown, Jason Gonsky, Joseph R Osborne
BACKGROUND: Bedford-Stuyvesant (BS) and Bushwick (BW) communities of Brooklyn, New York are the predominantly African-American and Hispanic neighborhoods within the main catchment area Memorial Sloan Kettering. Cancer is a leading cause of death, with a higher prostate (PCa) and colorectal cancer (CRC) mortality than New York City. Opportunity to design cancer interventions which leverage accessibility and acceptability of mobile health (mHealth) tools exists. METHODS: Cancer Health Impact Program (CHIP) was formed for this purpose...
February 7, 2019: Cancer Epidemiology, Biomarkers & Prevention
Lisa P Spees, Wendy R Brewster, Mahesh A Varia, Morris Weinberger, Christopher Baggett, Xi Zhou, Victoria M Petermann, Stephanie B Wheeler
BACKGROUND: While rural cancer patients encounter substantial barriers to care, they more often report receiving timely care than urban patients. We examined whether geographic distance, a contributor to urban-rural health disparities, differentially influences treatment initiation and completion among insured urban and rural cervical cancer patients. METHODS: We identified women diagnosed with cervical cancer from 2004-2013 from a statewide cancer registry linked to multi-payer, insurance claims...
February 7, 2019: Cancer Epidemiology, Biomarkers & Prevention
Brandilyn A Peters, Richard B Hayes, Chandra Goparaju, Christopher Reid, Harvey I Pass, Jiyoung Ahn
BACKGROUND: Human microbiota have many functions that could contribute to cancer initiation and/or progression at local sites, yet the relation of the lung microbiota to lung cancer prognosis has not been studied. METHODS: In a pilot study, 16S rRNA gene sequencing was performed on paired lung tumor and remote normal samples from the same lobe/segment in 19 non-small cell lung cancer patients. We explored associations of tumor or normal tissue microbiome diversity and composition with recurrence-free and disease-free survival, and compared microbiome diversity and composition between paired tumor and normal samples...
February 7, 2019: Cancer Epidemiology, Biomarkers & Prevention
Cindy M Chang, Brian L Rostron, Joanne T Chang, Catherine G Corey, Heather L Kimmel, Connie S Sosnoff, Maciej L Goniewicz, Kathryn C Edwards, Dorothy K Hatsukami, Yuesong Wang, Arseima Y Del Valle-Pinero, Maocheng Yang, Mark J Travers, Stephen Arnstein, Kristie Taylor, Kevin Conway, Bridget K Ambrose, Nicolette Borek, Andrew Hyland, Lanqing Wang, Benjamin C Blount, Dana M van Bemmel
BACKGROUND: Given the diverse cigar market and limited data on biomarker patterns by cigar type, we compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups. METHODS: Using Wave 1 urinary biomarker data from 5,604 adults in the Population Assessment of Tobacco and Health (PATH) Study, we compared geometric mean concentrations among cigar-only smokers (all cigars and separately for traditional, cigarillo, and filtered cigars), cigarette-only smokers, dual cigar/cigarette smokers, and never users of tobacco...
February 7, 2019: Cancer Epidemiology, Biomarkers & Prevention
Huiru Chang, Song Yao, David Tritchler, Meredith A Hullar, Johanna W Lampe, Lilian U Thompson, Susan E McCann
Background: Metabolism and excretion of the phytoestrogen enterolactone (ENL), which has been associated with breast cancer risk, may be affected by variation in steroid hormone and xenobiotic-metabolizing genes. Methods: We conducted a randomized, crossover flaxseed intervention study in 252 healthy, postmenopausal women [137 European ancestry (EA) and 115 African ancestry (AA)] from western New York. Participants were randomly assigned to maintain usual diet or consume 10 g/day ground flaxseed for 6 weeks...
February 1, 2019: Cancer Epidemiology, Biomarkers & Prevention
Seungho Ryu, Kyungeun Kim, Yoosoo Chang, Jiin Ahn, Hyo-Joon Yang, Ju Young Jung, Seokkyun Kim, Chong Il Sohn
BACKGROUND: We examined the association between body mass index (BMI) and development of endoscopic intestinal metaplasia (IM). METHODS: This retrospective cohort study included 142,832 Korean adults free of endoscopic IM and atrophic gastritis (AG) who underwent upper endoscopy at baseline and subsequent visits and were followed for up to 5 years. A parametric proportional hazards model was used to estimate the adjusted hazard ratio with 95% confidence interval (CI) for incident IM...
January 30, 2019: Cancer Epidemiology, Biomarkers & Prevention
Sonia A Cunningham, Robert Yu, Ya Chen Tina Shih, Sharon Giordano, Lorna H McNeill, Ruth Rechis, Susan K Peterson, Paul M Cinciripini, Lewis E Foxhall, Ernest T Hawk, Sanjay Shete
BACKGROUND: Cancer beliefs and perceptions of cancer risk affect the cancer continuum. METHODS: We developed a cancer-focused questionnaire and administered it online to a nonprobability sample of the Texas population. Weighted multivariable logistic regression analysis identified key factors associated with perceptions and beliefs about cancer. RESULTS: The study population comprised 2034 respondents (median age, 44.4 years) of diverse ethnicity: 45...
January 30, 2019: Cancer Epidemiology, Biomarkers & Prevention
Angeline S Andrew, Margaret R Karagas, Florian R Schroeck, Carmen J Marsit, Alan R Schned, Jason R Pettus, David A Armstrong, John D Seigne
BACKGROUND: The high rate of non-muscle invasive bladder cancer recurrence is a major challenge in patient management. microRNAs (miRNAs) functionally regulate tumor cell proliferation and invasion, and have strong potential as biomarkers, since they are robust to degradation. The objective of this project was to identify reproducible prognostic miRNAs in resected non-muscle invasive bladder tumor tissue that are predictive of the recurrent tumor phenotype. METHODS: We utilized patients diagnosed with primary non-muscle invasive bladder cancer in three independent cohorts for a biomarker discovery / validation approach...
January 30, 2019: Cancer Epidemiology, Biomarkers & Prevention
Ying Zhu, Yongyue Wei, Ruyang Zhang, Xuesi Dong, Sipeng Shen, Yang Zhao, Jianling Bai, Demetrius Albanes, Neil E Caporaso, Maria Teresa Landi, Bin Zhu, Stephen J Chanock, Fangyi Gu, Stephen Lam, Ming-Sound Tsao, Frances A Shepherd, Adonina Tardon, Ana Fernández-Somoano, Guillermo Fernandez-Tardon, Chu Chen, Matthew J Barnett, Jennifer Doherty, Stig E Bojesen, Mattias Johansson, Paul Brennan, James D McKay, Robert Carreras-Torres, Thomas Muley, Angela Risch, Heunz-Erich Wichmann, Heike Bickeboeller, Albert Rosenberger, Gad Rennert, Walid Saliba, Susanne M Arnold, John K Field, Michael P A Davies, Michael W Marcus, Xifeng Wu, Yuanqing Ye, Loic Le Marchand, Lynne R Wilkens, Olle Melander, Jonas Manjer, Hans Brunnström, Rayjean J Hung, Geoffrey Liu, Yonathan Brhane, Linda Kachuri, Angeline S Andrew, Eric J Duell, Lambertus A Kiemeney, Erik H F M van der Heijden, Aage Haugen, Shanbeh Zienolddiny, Vidar Skaug, Kjell Grankvist, Mikael Johansson, Penella J Woll, Angela Cox, Fiona Taylor, Dawn M Teare, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Richard S Houlston, John McLaughlin, Victoria L Stevens, Hongbing Shen, Zhibin Hu, Juncheng Dai, Christopher I Amos, Younghun Han, Dakai Zhu, Gary E Goodman, Feng Chen, David C Christiani
BACKGROUND: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. METHODS: We performed single and combined multiple instrumental variable Mendelian Randomization(MR) analysis by an inverse-weighted (IVW) method, in addition to a series of sensitivity analyses. Summary data for associations between single nucleotide polymorphisms (SNPs) and platelet count is from a recent publication including 48,666 Caucasian Europeans and International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls analyze associations between candidate single nucleotide polymorphisms and lung cancer risk...
January 30, 2019: Cancer Epidemiology, Biomarkers & Prevention
Monica D'Arcy, Donna R Rivera, Andrew Grothen, Eric A Engels
BACKGROUND: Allergic conditions may prevent some cancers by promoting immune surveillance. We examined associations of allergic rhinitis, asthma, and eczema with cancer risk among elderly Americans. METHODS: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data to perform a case-control study. Cases were individuals with first cancer diagnosed in SEER registries (1992-2013, ages 66-99; N=1,744,575). Cancer-free controls (N=100,000) were randomly selected from Medicare, matched on sex, age and selection year...
January 30, 2019: Cancer Epidemiology, Biomarkers & Prevention
Ana F Best, Margaret A Tucker, Megan N Frone, Mark H Greene, June A Peters, Hormuzd A Katki
Background: Eligibility guidelines for genetic testing may be revisited, given technological advances, plummeting costs, and proposals for population mutation screening. A key property of eligibility criteria is the tradeoff between the number of mutation carriers identified versus population members tested. We assess the fractions of mutation carriers identified, versus women undergoing mutation testing, for BRCA1/2 founder mutation screening in U.S. Ashkenazi-Jewish women. Methods: BRCA1/2 carrier probabilities, based on personal/family history, were calculated using the risk-prediction tool BRCAPRO for 4,589 volunteers (102 mutation carriers) in the population-based Washington Ashkenazi Study...
January 28, 2019: Cancer Epidemiology, Biomarkers & Prevention
Elizabeth A Gage-Bouchard, Susan M Rawl
In recent years, the National Cancer Institute (NCI) has focused on the impact that NCI-designated cancer centers have in reducing the cancer burden in their defined catchment areas. In 2016, NCI funded 15 cancer center support grant supplements to support cancer centers' abilities to better define and describe their catchment areas and needs to enhance cancer prevention and control. As part of this initiative, a working group developed standardized measures to capture demographic, social, knowledge, attitude, and behavioral factors to be included in the surveys fielded by all 15 cancer centers...
January 22, 2019: Cancer Epidemiology, Biomarkers & Prevention
Natalie C DuPre, Jaime E Hart, Michelle D Holmes, Elizabeth M Poole, Peter James, Peter Kraft, Francine Laden, Rulla M Tamimi
BACKGROUND: While particulate matter (PM) has not been consistently associated with breast cancer risk, two studies have reported harmful associations for breast cancer survival. We examined PM exposures and breast cancer survival in two US-based prospective cohort studies. METHODS: The Nurses' Health Study (NHS) and NHSII are cohorts with detailed data on medical history, lifestyle factors, and causes of death. Women with Stage I-III breast cancer (n=8,936) were followed through June 2014...
January 15, 2019: Cancer Epidemiology, Biomarkers & Prevention
Kelly D Blake, Henry P Ciolino, Robert T Croyle
In May 2016, the National Cancer Institute (NCI) announced supplemental funding for NCI-designated cancer centers to conduct research to better characterize populations within cancer center catchment areas. The initiative was intended to support primary data collection efforts to better define and describe cancer center catchment areas using a multilevel population health framework. The long-term goal was to facilitate collaborations in which researchers, providers, public health practitioners, and nonprofit organizations could utilize the data to develop or expand applied cancer control research, planning, and implementation, with an emphasis on local health disparities and communication inequalities...
January 15, 2019: Cancer Epidemiology, Biomarkers & Prevention
Min-Hyung Kim, Sang Min Park, Young Ho Yun, In Cheol Hwang
BACKGROUND: Evidence has suggested that aspirin reduces the incidence of several cancers, but these benefits may not occur with pancreatic cancer. METHODS: A 12-year nationwide longitudinal cohort merged with health checkup data were divided into "exposure ascertainment period" and "outcome ascertainment period" to avoid immortal time bias. The Daily Defined Dose system was used to indicate the drug exposure. RESULTS: We found no significant association between aspirin use and incident pancreatic cancer based on hazard ratio...
January 14, 2019: Cancer Epidemiology, Biomarkers & Prevention
Johan F Arendt, Henrik Toft Sorensen, Laura J Horsfall, Irene Petersen
BACKGROUND: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. However, the implications for early cancer detection in primary care have not been assessed. METHODS: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, United Kingdom. Persons with low B12 levels were excluded together with persons with cancer or B12 treatment before date of B12 measurement. Incident cancer was the outcome of interest and was identified through Read codes...
January 14, 2019: Cancer Epidemiology, Biomarkers & Prevention
Ronaldo Iachan, Lewis Berman, Tonja M Kyle, Kelly J Martin, Yangyang Deng, Davia N Moyse, Deirdre Middleton, Audie A Atienza
BACKGROUND: The Population Health Assessment initiative by National Cancer Institute (NCI) sought to enhance cancer centers' capacity to acquire, aggregate and integrate data from multiple sources, as well as to plan, coordinate, and enhance catchment area analysis activities. METHODS: Key objectives of this initiative are pooling data and comparing local data with national data. A novel aspect of analyzing data from this initiative is the methodology used to weight datasets from sites that collected both probability and non-probability samples...
January 14, 2019: Cancer Epidemiology, Biomarkers & Prevention
Chandra Sekhar Amara, Chandrashekar R Ambati, Venkatrao Vantaku, Danthasinghe Waduge Badrajee Piyarathna, Sri Ramya Donepudi, Shiva Shankar Ravi, James M Arnold, Vasanta Putluri, Gurkamal Chatta, Khurshid A Guru, Hoda Badr, Martha K Terris, Roni J Bollag, Arun Sreekumar, Andrea B Apolo, Nagireddy Putluri
BACKGROUND: The current system to predict the outcome of smokers with Bladder cancer (BLCA) is insufficient due to complex genomic and transcriptomic heterogeneities. This study aims to identify serum metabolite associated genes related to survival in this population. METHODS: We performed liquid chromatography-mass spectrometry (LC-MS) based targeted metabolomic analysis for >300 metabolites in serum obtained from two independent cohorts of BLCA never smokers, smokers, healthy smokers, and healthy never smokers...
January 14, 2019: Cancer Epidemiology, Biomarkers & Prevention
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