journal
https://read.qxmd.com/read/38512589/analysing-postprandial-amino-acid-responses-in-crossover-studies-with-the-aaresponse-package-for-r
#1
JOURNAL ARTICLE
Ron Wehrens, Jasper Engel, Jurriaan Mes, Aard de Jong, Diederik Esser
Nowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the uptake of proteins, usually from alternatives to animal-based sources, by healthy volunteers. The data analysis is complex and requires many decisions on the part of the scientists involved. Such a process can be streamlined and made more objective and reproducible through bespoke software. This paper describes such a software package, <mml:math xmlns:mml="https://www...
March 21, 2024: Amino Acids
https://read.qxmd.com/read/38506936/retraction-note-taurine-plays-a-beneficial-role-against-cadmium-induced-oxidative-renal-dysfunction
#2
Prasenjit Manna, Mahua Sinha, Parames C Sil
No abstract text is available yet for this article.
March 20, 2024: Amino Acids
https://read.qxmd.com/read/38506925/an-insight-into-role-of-amino-acids-as-antioxidants-via-nrf2-activation
#3
REVIEW
Melford C Egbujor, Olugbemi T Olaniyan, Chigbundu N Emeruwa, Sarmistha Saha, Luciano Saso, Paolo Tucci
Oxidative stress can affect the protein, lipids, and DNA of the cells and thus, play a crucial role in several pathophysiological conditions. It has already been established that oxidative stress has a close association with inflammation via nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway. Amino acids are notably the building block of proteins and constitute the major class of nitrogen-containing natural products of medicinal importance. They exhibit a broad spectrum of biological activities, including the ability to activate NRF2, a transcription factor that regulates endogenous antioxidant responses...
March 20, 2024: Amino Acids
https://read.qxmd.com/read/38483649/targeted-metabolomic-analysis-of-serum-amino-acids-in-heart-failure-patients
#4
JOURNAL ARTICLE
Chunjing Yang, Zhengyuan Shi, Li Bao, Xiqiao Xv, Dechun Jiang, Longtai You
Heart failure (HF) has been recognized as a global epidemic with high rates of morbidity, hospitalization, and mortality. The role of amino acids, which provide the body with energy, in the development of HF is still unclear. The aim of this study was to explore changes in serum amino acids in patients with HF and identify potential biomarkers. First, the serum amino acid metabolism profiles of 44 patients with HF and 30 healthy controls (Con) were quantitatively measured. Then, candidate markers were identified through the utilization of T test, multivariate statistical analysis, and receiver operating characteristic (ROC) curve analysis...
March 14, 2024: Amino Acids
https://read.qxmd.com/read/38461423/gc-ms-analysis-of-4-hydroxyproline-elevated-proline-hydroxylation-in-metformin-associated-lactic-acidosis-and-metformin-treated-becker-muscular-dystrophy-patients
#5
JOURNAL ARTICLE
Svetlana Baskal, Rene A Posma, Alexander Bollenbach, Willem Dieperink, Stephan J L Bakker, Maarten W Nijsten, Daan J Touw, Dimitrios Tsikas
Metformin (N,N-dimethylbiguanide), an inhibitor of gluconeogenesis and insulin sensitizer, is widely used for the treatment of type 2 diabetes. In some patients with renal insufficiency, metformin can accumulate and cause lactic acidosis, known as metformin-associated lactic acidosis (MALA, defined as lactate ≥ 5 mM, pH < 7.35, and metformin concentration > 38.7 µM). Here, we report on the post-translational modification (PTM) of proline (Pro) to 4-hydroxyproline (OH-Pro) in metformin-associated lactic acidosis and in metformin-treated patients with Becker muscular dystrophy (BMD)...
March 10, 2024: Amino Acids
https://read.qxmd.com/read/38460031/dietary-branched-chain-amino-acids-intake-and-new-onset-hypertension-a-nationwide-prospective-cohort-study-in-china
#6
LETTER
Lianlong Yu, Qianrang Zhu, Pengkun Song, Yuqian Li, Qingqing Man, Beibei Liu, Shanshan Jia, Jian Zhang
OBJECTIVE: This study aimed to investigate the relationship between dietary branched-chain amino acids (BCAAs) and the risk of developing hypertension. METHODS: A cohort study of 14,883 Chinese adults without hypertension at baseline with were followed for an average of 8.9 years. Dietary intakes of BCAAs, including Ile, Leu, and Val, were collected using 3-day 24-h meal recall and household condiment weighing. Cox proportional hazards regression, restricted cubic splines, interaction analysis, and sensitivity analysis were used to assess the relationship between dietary BCAAs and risk of developing self-reported hypertension, adjusting for age, gender, region, body mass index (BMI), smoking and drinking status, physical activity, energy intake, salt intake...
March 9, 2024: Amino Acids
https://read.qxmd.com/read/38460024/prediction-of-matrilineal-specific-patatin-like-protein-governing-in-vivo-maternal-haploid-induction-in-maize-using-support-vector-machine-and-di-peptide-composition
#7
JOURNAL ARTICLE
Suman Dutta, Rajkumar U Zunjare, Anirban Sil, Dwijesh Chandra Mishra, Alka Arora, Nisrita Gain, Gulab Chand, Rashmi Chhabra, Vignesh Muthusamy, Firoz Hossain
The mutant matrilineal (mtl) gene encoding patatin-like phospholipase activity is involved in in-vivo maternal haploid induction in maize. Doubling of chromosomes in haploids by colchicine treatment leads to complete fixation of inbreds in just one generation compared to 6-7 generations of selfing. Thus, knowledge of patatin-like proteins in other crops assumes great significance for in-vivo haploid induction. So far, no online tool is available that can classify unknown proteins into patatin-like proteins...
March 9, 2024: Amino Acids
https://read.qxmd.com/read/38427104/applications-of-biaryl-cyclization-in-the-synthesis-of-cyclic-enkephalin-analogs-with-a-highly-restricted-flexibility
#8
JOURNAL ARTICLE
Maria Różanowska, Gabriela Szczupaj, Michał Nowakowski, Priyadharshni Rajagopal, Piotr F J Lipiński, Joanna Matalińska, Aleksandra Misicka, Marek Lisowski, Łukasz Jaremko, Mariusz Jaremko
A series of 10 cyclic, biaryl analogs of enkephalin, with Tyr or Phe residues at positions 1 and 4, were synthesized according to the Miyaura borylation and Suzuki coupling methodology. Biaryl bridges formed by side chains of the two aromatic amino acid residues are of the meta-meta, meta-para, para-meta, and para-para configuration. Conformational properties of the peptides were studied by CD and NMR. CD studies allowed only to compare conformations of individual peptides while NMR investigations followed by XPLOR calculations provided detailed information on their conformation...
March 1, 2024: Amino Acids
https://read.qxmd.com/read/38393495/snat2-mediated-regulation-of-estrogen-and-progesterone-in-the-proliferation-of-goat-mammary-epithelial-cells
#9
JOURNAL ARTICLE
Tingting Jiang, Xiaoyue Ma, Hanling Liu, Qianqian Jia, Jianguo Chen, Yi Ding, Ming Sun, Hongmei Zhu
The development of the goat mammary gland is mainly under the control of ovarian hormones particularly estrogen and progesterone (P4 ). Amino acids play an essential role in mammary gland development and milk production, and sodium-coupled neutral amino acid transporter 2 (SNAT2) was reported to be expressed in the mammary gland of rats and bovine mammary epithelial cells, which may affect the synthesis of milk proteins or mammary cell proliferation by mediating prolactin, 17β-estradiol (E2 ) or methionine function...
February 23, 2024: Amino Acids
https://read.qxmd.com/read/38358574/hybrid-2d-3d-quantitative-structure-activity-relationship-studies-on-the-bioactivities-and-molecular-mechanism-of-antibacterial-peptides
#10
JOURNAL ARTICLE
Qingguo Yan, Fangfang Wang, Bo Zhou, Xiangna Lin
Antimicrobial peptide (AMP) is the polypeptide, which protects the organism avoiding attack from pathogenic bacteria. Studies have shown that there were some antimicrobial peptides with molecular action mechanism involved in crossing the cell membrane without inducing severe membrane collapse, then interacting with cytoplasmic target-nucleic acid, and exerting antibacterial activity by interfacing the transmission of genetic information of pathogenic microorganisms. However, the relationship between the antibacterial activities and peptide structures was still unclear...
February 15, 2024: Amino Acids
https://read.qxmd.com/read/38351332/a-novel-lncrna-hidden-polypeptide-regulates-malignant-phenotypes-and-pemetrexed-sensitivity-in-a549-pulmonary-adenocarcinoma-cells
#11
JOURNAL ARTICLE
Xiaobing Han, Liangxin Chen, Peng Sun, Xiuqing Wang, Qian Zhao, Lingfeng Liao, Dejin Lou, Nan Zhou, Yujun Wang
The advance of high-throughput sequencing enhances the discovery of short ORFs embedded in long non-coding RNAs (lncRNAs). Here, we uncovered the production and biological activity of lncRNA-hidden polypeptides in lung adenocarcinoma (LUAD). In the present study, bioinformatics was used to screen the lncRNA-hidden polypeptides in LUAD. Analysis of protein expression was done by western blot or immunofluorescence assay. The functions of the polypeptide were determined by detecting its effects on cell viability, proliferation, migration, invasion, and pemetrexed (PEM) sensitivity...
February 13, 2024: Amino Acids
https://read.qxmd.com/read/38340233/intersubunit-communication-in-glycogen-phosphorylase-influences-substrate-recognition-at-the-catalytic-sites
#12
JOURNAL ARTICLE
Nahori Kamada, Ayato Ikeda, Yasushi Makino, Hiroshi Matsubara
Glycogen phosphorylase (GP) is biologically active as a dimer of identical subunits, each activated by phosphorylation of the serine-14 residue. GP exists in three interconvertible forms, namely GPa (di-phosphorylated form), GPab (mono-phosphorylated form), and GPb (non-phosphorylated form); however, information on GPab remains scarce. Given the prevailing view that the two GP subunits collaboratively determine their catalytic characteristics, it is essential to conduct GPab characterization to gain a comprehensive understanding of glycogenolysis regulation...
February 10, 2024: Amino Acids
https://read.qxmd.com/read/38340185/lateralization-of-the-5-ht-1a-receptors-in-the-basolateral-amygdala-in-metabolic-and-anxiety-responses-to-chronic-restraint-stress
#13
JOURNAL ARTICLE
Habib Valipour, Gholam Hossein Meftahi, Gila Pirzad Jahromi, Alireza Mohammadi
Behavioral and functional studies describe hemispheric asymmetry in anxiety and metabolic behaviors in responses to stress. However, no study has reported serotonergic receptor (the 5-HT1A receptor) lateralization in the basolateral amygdala (BLA) in vivo on anxiety and metabolic behaviors under stress. In the present study, the effect of unilateral and bilateral suppression of the 5-HT1A receptor in the BLA on anxiety, and metabolic responses to chronic restraint stress was assessed. Male Wistar rats 7 days after cannulation into the BLA received chronic restraint stress for 14 consecutive days...
February 10, 2024: Amino Acids
https://read.qxmd.com/read/38319435/antimicrobial-and-antitumor-properties-of-anuran-peptide-temporin-shf-induce-apoptosis-in-a549-lung-cancer-cells
#14
JOURNAL ARTICLE
Anet Antony, Anupama Kizhakke Purayil, Shilpa Olakkaran, Shweta Dhannura, Shamasoddin Shekh, Konkallu Hanumae Gowd, Hunasanahally Puttaswamygowda Gurushankara
Temporin-SHf is a linear, ultra-short, hydrophobic, α-helix, and phe-rich cationic antimicrobial peptide. The antitumor activities and mechanism of temporin-SHf-induced cancer cell death are unknown. The temporin-SHf was synthesized by solid-phase Fmoc chemistry and antimicrobial and antitumor activities were investigated. Temporin-SHf was microbiocidal, non-hemolytic, and cytotoxic to human cancer cells but not to non-tumorigenic cells. It affected the cancer cells' lysosomal integrity and caused cell membrane damage...
February 6, 2024: Amino Acids
https://read.qxmd.com/read/38319413/identification-and-characterization-of-endogenous-biomarkers-for-hepatic-vectorial-transport-oatp1b3-p-gp-function-using-metabolomics-with-serum-pharmacology
#15
JOURNAL ARTICLE
Yong-Wen Jin, Yan-Rong Ma, Ming-Kang Zhang, Wen-Bin Xia, Pei Yuan, Bo-Xia Li, Yu-Hui Wei, Xin-An Wu
The organic anion-transporting polypeptide 1B3 and P-glycoprotein (P-gp) provide efficient directional transport (OATP1B3-P-gp) from the blood to the bile that serves as a key determinant of hepatic disposition of the drug. Unfortunately, there is still a lack of effective means to evaluate the disposal ability mediated by transporters. The present study was designed to identify a suitable endogenous biomarker for the assessment of OATP1B3-P-gp function in the liver. We established stably transfected HEK293T-OATP1B3 and HEK293T-P-gp cell lines...
February 6, 2024: Amino Acids
https://read.qxmd.com/read/38315260/the-muscle-protein-synthetic-response-following-corn-protein-ingestion-does-not-differ-from-milk-protein-in-healthy-young-adults
#16
RANDOMIZED CONTROLLED TRIAL
Philippe J M Pinckaers, Michelle E G Weijzen, Lisanne H P Houben, Antoine H Zorenc, Imre W K Kouw, Lisette C P G M de Groot, Lex B Verdijk, Tim Snijders, Luc J C van Loon
Plant-derived proteins are generally believed to possess lesser anabolic properties when compared with animal-derived proteins. This is, at least partly, attributed to the lower leucine content of most plant-derived proteins. Corn protein has a leucine content that is highest among most plant-derived proteins and it even exceeds the levels observed in animal-derived proteins such as whey protein. Therefore, this study aimed to compare muscle protein synthesis rates following the ingestion of 30 g corn protein and a 30 g blend of corn plus milk protein with 30 g milk protein...
February 5, 2024: Amino Acids
https://read.qxmd.com/read/38315232/investigating-metabolic-dysregulation-in-serum-of-triple-transgenic-alzheimer-s-disease-male-mice-implications-for-pathogenesis-and-potential-biomarkers
#17
JOURNAL ARTICLE
Hongbin Zhuang, Xueshan Cao, Xiaoxiao Tang, Yongdong Zou, Hongbo Yang, Zhiyuan Liang, Xi Yan, Xiaolu Chen, Xingui Feng, Liming Shen
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease that lacks convenient and accessible peripheral blood diagnostic markers and effective drugs. Metabolic dysfunction is one of AD risk factors, which leaded to alterations of various metabolites in the body. Pathological changes of the brain can be reflected in blood metabolites that are expected to explain the disease mechanisms or be candidate biomarkers. The aim of this study was to investigate the changes of targeted metabolites within peripheral blood of AD mouse model, with the purpose of exploring the disease mechanism and potential biomarkers...
February 5, 2024: Amino Acids
https://read.qxmd.com/read/38315214/investigation-of-encapsulated-water-wire-within-self-assembled-hydrophilic-nanochannels-in-a-modified-%C3%AE-4-amino-acid-crystals-tracking-thermally-induced-changes-of-intermolecular-interactions-within-a-crystalline-hydrate
#18
JOURNAL ARTICLE
Krishnayan Basuroy, Jose de Jesus Velazquez-Garcia, Simone Techert
Nanostructures formed by the self-assembly of modified/unmodified amino acids have the potential to be useful in several biological/nonbiological applications. In that regard, the greater conformational space provided by γ-amino acids, owing to their additional backbone torsional degrees of freedom and enhanced proteolytic stability, compared to their α-counterparts, should be explored. Though, modified single amino acid-based nanomaterials such as nanobelts or hydrogels are developed by utilizing the monosubstituted γ-amino acids derived from the backbone homologation of phenylalanine (Phe)...
February 5, 2024: Amino Acids
https://read.qxmd.com/read/38310598/the-dual-role-of-autophagy-in-the-regulation-of-cancer-treatment
#19
REVIEW
Louis Boafo Kwantwi
As a catabolic process, autophagy through lysosomes degrades defective and damaged cellular materials to support homeostasis in stressful conditions. Therefore, autophagy dysregulation is associated with the induction of several human pathologies, including cancer. Although the role of autophagy in cancer progression has been extensively studied, many issues need to be addressed. The available evidence suggest that autophagy shows both cytoprotective and cytotoxic mechanisms. This dual role of autophagy in cancer has supplied a renewed interest in the development of novel and effective cancer therapies...
February 4, 2024: Amino Acids
https://read.qxmd.com/read/38310167/d-amino-acids-differentially-trigger-an-inflammatory-environment-in-vitro
#20
JOURNAL ARTICLE
Siew Hwei Yap, Cheng Siang Lee, Nur Diyana Zulkifli, Darshinie Suresh, Kenji Hamase, Kumitaa Theva Das, Reena Rajasuriar, Kok Hoong Leong
Studies in vivo have demonstrated that the accumulation of D-amino acids (D-AAs) is associated with age-related diseases and increased immune activation. However, the underlying mechanism(s) of these observations are not well defined. The metabolism of D-AAs by D-amino oxidase (DAO) produces hydrogen peroxide (H2 O2 ), a reactive oxygen species involved in several physiological processes including immune response, cell differentiation, and proliferation. Excessive levels of H2 O2 contribute to oxidative stress and eventual cell death, a characteristic of age-related pathology...
February 3, 2024: Amino Acids
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