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Acta Diabetologica

Christoph Werner, Nicolle Müller, Ulrich Alfons Müller
AIMS: Agonistic autoantibodies directed against adrenergic, endothelin, and angiotensin receptors are known as pathogenic factors in disease-causing vascular impairments such as Buergers' disease, dilatative cardiomyopathy, dementia, and preeclampsia. Diabetes mellitus also causes micro- and macrovascular damages, but pathogenesis is still not fully understood. Following indications for a pathogenic role of the mentioned antibodies from our preliminary investigations, we investigated the prevalence in a bigger cohort of patients with longstanding diabetes with or without diabetic complications...
February 15, 2019: Acta Diabetologica
L Bertoccini, F Sentinelli, M Incani, D Bailetti, F A Cimini, I Barchetta, A Lenzi, M G Cavallo, E Cossu, M G Baroni
No abstract text is available yet for this article.
February 13, 2019: Acta Diabetologica
Taichi Kanzawa, Toshihito Hirai, Hironori Fukuda, Haruki Katsumata, Rumi Ishii, Masako Ikemiyagi, Yasuyuki Ishii, Kan Saiga, Masayoshi Okumi, Kazunari Tanabe
AIMS: Islet transplantation is an effective therapeutic option for type 1 diabetes. Although maintenance immunosuppression therapy is required to prevent allogeneic rejection and recurrence of autoimmunity, long-term allograft survival has not yet been achieved partly because of its adverse effects. The induction of donor-specific immunotolerance is a promising approach for long-term allograft survival without maintenance immunosuppression therapy. We previously reported that combination therapy using a liposomal ligand for invariant natural killer T cells, RGI-2001, and anti-CD154 antibody established mixed hematopoietic chimerism for the induction of donor-specific immunotolerance...
February 13, 2019: Acta Diabetologica
Giovanni Sartore, Nino Cristiano Chilelli, Roberta Seraglia, Eugenio Ragazzi, Raffaella Marin, Marco Roverso, Chiara Cosma, Olga Vaccaro, Silvia Burlina, Annunziata Lapolla
AIMS: Type 2 diabetes (DM2) is associated to oxidative modifications of high-density lipoproteins (HDL), which can interfere with their function. Pioglitazone has proved effective in raising HDL cholesterol (HDL-C) and lowering small dense low-density lipoprotein (LDL), but no clinical studies have examined its effect on lipoprotein oxidation in patients with DM2. METHODS: We assessed the effect of pioglitazone vs glimepiride after 1 year on HDL oxidation, expressed as relative abundance of peptides containing Met112 O in ApoA-I (oxApoA-I) estimated by mass spectrometry (MALDI/TOF/TOF), in 95 patients with DM2...
February 10, 2019: Acta Diabetologica
Laure Alexandre-Heymann, Amal Y Lemoine, Samir Nakib, Nathalie Kapel, Séverine Ledoux, Etienne Larger
AIMS: Altered pancreatic exocrine function can be observed in patients with type 1 or type 2 diabetes. In the present study, we evaluated the potential nutritional consequences of this dysfunction. METHODS: Serum concentrations of nutritional markers, including albumin, cholesterol, triacylglycerol, vitamins A, D, and E, were assessed in a cohort of 468 patients (137 with type 1 diabetes and 331 with type 2 diabetes), after exclusion of the patients with a CRP > 10 mg/l...
February 10, 2019: Acta Diabetologica
K Pafili, N Papanas
No abstract text is available yet for this article.
February 8, 2019: Acta Diabetologica
G Bax, F Bellavere
No abstract text is available yet for this article.
February 8, 2019: Acta Diabetologica
Engy Shokry, Linda Marchioro, Olaf Uhl, Mercedes G Bermúdez, Jose Antonio García-Santos, Mª Teresa Segura, Cristina Campoy, Berthold Koletzko
AIMS: Maternal obesity and gestational diabetes mellitus (GDM) were frequently reported to be risk factors for obesity and diabetes in offspring. Our goal was to study the impact of maternal prepregnancy BMI (pBMI) and GDM on both maternal and cord blood metabolic profiles. METHODS: We used LC-MS/MS to measure 201 metabolites comprising phospholipids (PL), amino acids, non-esterified fatty acids (NEFA), organic acids, acyl carnitines (AC), and Krebs cycle metabolites in maternal plasma at delivery and cord plasma obtained from 325 PREOBE study participants...
February 6, 2019: Acta Diabetologica
Giuseppe Seghieri, Laura Policardo, Elisa Gualdani, Roberto Anichini, Paolo Francesconi
AIMS: Diabetic foot syndrome (DFS) increases the risk for atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), or mortality. The present study aims at ascertaining whether such DFS-related excess risk differs between genders, retrospectively investigating a population with diabetes from Tuscany, Italy, followed-up for 6 years (2011-2016). METHODS: People with diabetes living in Tuscany on January 1st 2011 identified by administrative databases, were divided by baseline history of prior DFS hospitalizations, stratified by presence/absence of peripheral vascular disease and evaluating, by Cox regression analysis, whether adjusted DFS-related excess risk of incident ASCVD, CKD or mortality differed between genders...
February 5, 2019: Acta Diabetologica
Iori Kawata, Tomomichi Koshi, Kazuko Hirabayashi, Hideo Koike, Yuka Sato, Koh Yamashita, Tomomasa Oguchi, Toru Aizawa
AIMS: To clarify if prediabetes defined by the International Expert Committee (PrediabetesIEC ) and/or the American Diabetes Society (PrediabetesADA ) is a risk for incident glomerular hyperfiltration (GH). METHODS: 24,524 health examinees without diabetes, chronic kidney disease (CKD), GH and antihypertensive treatment at baseline, and repeated examinations at least twice during a mean of 5.3 years were retrospectively analysed. Diabetes was defined as fasting plasma glucose (FPG) ≥ 7...
February 1, 2019: Acta Diabetologica
Paul B Higgins, Franco Folli, Marcia C R Andrade, Jaydee Foster, Vicki Mattern, Rita Paroni, Natalia Schlabritz-Loutsevitch, V Saroja Voruganti, Shyamesh Kumar, Rodolfo Guardado-Mendoza, Gaetano Bulfamante, Paolo Fiorina, Antonio E Pontiroli, Gene B Hubbard, Michael Owston, Edward J Dick, Anthony G Comuzzie
AIMS: Ectopic fat is a recognized contributor to insulin resistance and metabolic dysfunction, while the role of fat deposition inside intestinal wall tissue remains understudied. We undertook this study to directly quantify and localize intramural fat deposition in duodenal tissue and determine its association with adiposity. METHODS: Duodenal tissues were collected from aged (21.2 ± 1.3 years, 19.5 ± 3.1 kg, n = 39) female baboons (Papio sp.). Fasted blood was collected for metabolic profiling and abdominal circumference (AC) measurements were taken...
January 23, 2019: Acta Diabetologica
Lucie Meillet, Alfred Penfornis, Pierre-Yves Benhamou, Thierry Berney, Sophie Borot
No abstract text is available yet for this article.
January 20, 2019: Acta Diabetologica
Natalia Zubkova, Fatima Burumkulova, Margarita Plechanova, Vasily Petrukhin, Vasily Petrov, Evgeny Vasilyev, Anton Panov, Ekaterina Sorkina, Victoria Ulyatovskaya, Nina Makretskaya, Anatoly Tiulpakov
AIMS: Diabetes in pregnancy may be associated with monogenic defects of beta-cell function, frequency of which depends on ethnicity, clinical criteria for selection of patients as well as methods used for genetic analysis. The aim was to evaluate the contribution and molecular spectrum of mutations among genes associated with monogenic diabetes in non-obese Russian patients with diabetes in pregnancy using the next-generation sequencing (NGS). METHODS: 188 non-obese pregnant women with diabetes during pregnancy were included in the study; among them 57 subjects (30...
January 20, 2019: Acta Diabetologica
Krzysztof Jeziorny, Arleta Waszczykowska, Dobromiła Baranska, Wojciech Mlynarski, Agnieszka Zmyslowska
No abstract text is available yet for this article.
January 20, 2019: Acta Diabetologica
Hamza Dallali, Serena Pezzilli, Meriem Hechmi, Om Kalthoum Sallem, Sahar Elouej, Haifa Jmel, Yosra Ben Halima, Mariem Chargui, Mariem Gharbi, Luana Mercuri, Federica Alberico, Tommaso Mazza, Afaf Bahlous, Melika Ben Ahmed, Henda Jamoussi, Abdelmajid Abid, Vincenzo Trischitta, Sonia Abdelhak, Sabrina Prudente, Rym Kefi
AIMS: Maturity Onset Diabetes of the Young (MODY) is a monogenic form of diabetes with autosomal dominant inheritance pattern. The diagnosis of MODY and its subtypes is based on genetic testing. Our aim was investigating MODY by means of next-generation sequencing in the Tunisian population. METHODS: We performed a targeted sequencing of 27 genes known to cause monogenic diabetes in 11 phenotypically suspected Tunisian patients. We retained genetic variants passing filters of frequency in public databases as well as their probable effects on protein structures and functions evaluated by bioinformatics prediction tools...
January 17, 2019: Acta Diabetologica
Zijing Li, Xin Wen, Peng Zeng, Yunru Liao, Shuxian Fan, Yichi Zhang, Yuanjun Li, Jianhui Xiao, Yuqing Lan
AIMS: To evaluate the microvascular and neural differences of the optic nerve head (ONH) between type 2 diabetes mellitus (T2DM) subjects and controls. METHODS: This was a cross-sectional observational study. One hundred and eight eyes of 108 T2DM subjects with or without diabetic retinopathy (DR) (54 preclinical DR and 54 mild-to-moderate DR) were included. Fifty-two eyes of 52 healthy subjects were included as controls. The 4.5-mm Angio Disc scan mode and the ganglion cell complex scan mode were performed with all participants using AngioVue software 2...
January 17, 2019: Acta Diabetologica
Emilia Hagman, Omri Besor, Karen Hershkop, Nicola Santoro, Bridget Pierpont, Mariana Mata, Sonia Caprio, Ram Weiss
AIMS: In this study, we investigated whether adipose tissue insulin resistance (IR) is affected by the degree of obesity during the fasting and post-prandial state, independent of glucose tolerance among obese children and adolescents. We also tested whether systemic subclinical inflammation is associated with adipose tissue IR. METHODS: Subjects were recruited to the Yale Pathophysiology of Type 2 Diabetes in Youth Study (NCT01967849). An oral glucose-tolerance test was performed to establish glucose-tolerance status and blood samples were drawn for measurement of free fatty acids (FFAs), to calculate the area under the curve (AUC) of FFA...
January 12, 2019: Acta Diabetologica
Maddalena De Bernardo, Giovanni Cembalo, Nicola Rosa
No abstract text is available yet for this article.
January 12, 2019: Acta Diabetologica
Evaline Cheng, Raquel Burrows, Paulina Correa, Carmen Gloria Güichapani, Estela Blanco, Sheila Gahagan
AIMS: Metabolic syndrome (MetS) is a cluster of risk factors for cardiometabolic diseases. While cigarette smoking is associated with MetS in adults, young adulthood is an under-studied, susceptible period for developing long-term morbidity from MetS. We examined associations between cigarette smoking and MetS risk factors. METHODS: We studied 430 participants in Santiago, Chile who have been followed in a longitudinal cohort since infancy and assessed in adolescence for MetS...
January 11, 2019: Acta Diabetologica
Andrea Latini, Vincenza Spallone, Cinzia D'Amato, Giuseppe Novelli, Paola Borgiani, Cinzia Ciccacci
No abstract text is available yet for this article.
January 11, 2019: Acta Diabetologica
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