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Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society

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https://read.qxmd.com/read/30683832/effects-of-phosphodiesterase-5-inhibitor-sildenafil-on-the-respiratory-parameters-inflammation-and-apoptosis-in-a-saline-lavage-induced-model-of-acute-lung-injury
#1
P Kosutova, P Mikolka, S Balentova, M Kolomaznik, M Adamkov, J Mokry, A Calkovska, D Mokra
Acute lung injury (ALI) is associated with deterioration of alveolar-capillary lining and transmigration and activation of inflammatory cells. Sildenafil, phosphodiesterase 5 (PDE5) inhibitor, inhibits degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5. Positive effects of sildenafil treatment result from influencing proliferation of regulatory T cells and production of proinflammatory cytokines and autoantibodies as well as from modulation of platelet activation, angiogenesis, and pulmonary vasoreactivity...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683831/oral-supplements-of-combined-fructo-and-xylo-oligosaccharides-during-perinatal-period-significantly-offsets-acrylamide-induced-oxidative-impairments-and-neurotoxicity-in-rats
#2
G Krishna, - Muralidhara
Fetal and early childhood exposure to low levels of chemicals formed in foods during heating, especially acrylamide (ACR) is of increased concern due to developmental neurotoxicity. The neurodevelopment during perinatal period is critical and evidence suggests that the gut microbiota plays a major role in shaping brain development and behavior. Pregnant Wistar rats provided with oral supplements a combination of fructo- and xylo-oligosaccharides (FOS + XOS, 3 g/kg/day) from gestation day 0 (GD 0) to postnatal day 21 (PND 21) were exposed to ACR (100 ppm, GD 6 to PND 21) in drinking water...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683830/characterization-and-biological-effects-of-hypericum-extracts-on-experimentally-induced-anxiety-oxidative-stress-and-inflammation-in-rats
#3
A C Sevastre-Berghian, V A Toma, B Sevastre, D Hanganu, L Vlase, D Benedec, I Oniga, I Baldea, D Olteanu, R Moldovan, N Decea, G A Filip, S V Clichici
Anxiety disorders can associate with oxidative stress and immune system alterations. Our study aimed to chemically analyze Hypericum maculatum (HM) and Hypericum perforatum (HP) dry extracts and to evaluate their effects along with quercetin (Q), on brain oxidative stress biomarkers: malondialdehyde (MDA), catalase (CAT) and superoxide dismutase (SOD), inflammatory cytokines: interleukin-1α, (IL-1α), IL-1β, regulated on activation normal T cell expressed and secreted (RANTES), interferon (IFN), monocyte chemoattractant protein-1 (MCP1), macrophage inflammatory protein (MIP) and serum corticosterone levels...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683829/cysteinyl-leukotrienes-predominantly-mediate-cisplatin-induced-acute-renal-damage-in-male-rats
#4
A A Hashim, M M Helmy, S M Mouneir
Previous studies, including ours, demonstrated that activation of 5-lipoxygenase pathway and its products play a role in mediating cisplatin nephrotoxicity. Here, we tested the hypothesis whether these products, namely cysteinyl (Cys-LTs) and non cyseinyl leukotrienes (non Cys-LTs), would differentially contribute to cisplatin-induced acute renal damage in rats. Male Sprague-Dawley rats were treated with a single intraperitoneal dose of cisplatin (5 mg/kg) alone or combined with montelukast (Cys-LT receptor blocker, 10 mg/kg/day, orally), or ONO-4057 (leukotriene B4 receptor blocker, 300 mg/kg/day, orally)...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683828/high-activity-of-the-endogenous-opioid-system-and-acute-but-not-chronic-stress-influence-experimental-colitis-development-in-mice
#5
M Zielinska, A Szymaszkiewicz, M Salaga, H Zatorski, J Wlodarczyk, D Jacenik, R Kordek, W M Krajewska, A Misicka, J Fichna, M Sacharczuk
Exposition to environmental factors is one of the major underlying causes in inflammatory bowel diseases (IBD), with several endogenous systems involved. Our aim was to characterize the impact of stress on the colitis development in relation to the endogenous opioid system (EOS) activity in mice. A unique mouse model of high and low activity of EOS (namely high (HA)/low (LA) stress-induced analgesia) was employed. Mice were bred using bidirectional selection and classified as HA or LA line based on the measurement of analgesia...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683827/host-nuclear-factor-erythroid-2-related-factor-2-defense-system-determines-the-outcome-of-dextran-sulfate-sodium-induced-colitis-in-mice
#6
J S Lee, J M An, E A Kang, Y M Han, Y S Kim, H J Lee, K-J Kim, Y J Surh, K-B Hahm
Administration of dextran sulfate sodium (DSS) in drinking water led to significant bout of colitis simulating ulcerative colitis of human. However, colitis usually developed 5 - 7 days after DSS administration. Therefore, we hypothesized host defense system might protect colitis up to 5 days of DSS administration. 2.5% DSS-induced colitis were administered to C57BL/6 mice and sequential measurements of pathology, cyclooxygenase-2 (COX-2), nuclear factor-κB (NF-κB), heme oxygenase-1 (HO-1), NADPH quinone oxidoreductase-1 (NQO1), γ-glutamylcysteine synthetase (γ-GCS), nuclear factor erythroid 2-related factor-2 (Nrf2), and keap1 were done at 2, 6, 12, 24, 48, 96, 120, and 168 hour of DSS administration, respectively...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683826/local-regulators-of-seasonal-reproduction-processes-in-uterus-masculinus-of-an-adult-male-european-bison-bison-bonasus-linnaeus-1758
#7
A Tabecka-Lonczynska, J Mytych, P Solek, A Abrachamowicz, M Welz, M Koziorowski
Growth factors, hypoxia-inducible factor 1-alpha (HIF-1α) and klotho protein all have very important functions in the male reproduction; however their role in the regulation of seasonal reproductive processes in the male European bison remains unclear. Similarly, although the uterus masculinus is very frequently found in the bison, its importance and functions remain unknown. It is likely that, this organ may have secretory functions and thus be a target for various regulatory factors. Therefore, the aim of this study was to investigate expression and activity of several factors: vascular endothelial growth factor (VEGF-A), fibroblast growth factor (FGF-2), transforming growth factor β1 (TGF-β1), nerve growth factor (NGF), insulin-like growth factor receptor (IGF-IR β), hypoxia-inducible factor 1 alpha (HIF-1α), and klotho protein in the uterus masculinus, immediately after the season of the reproductive activity (November and December)...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683825/the-influence-of-orlistat-metformin-and-diet-on-serum-levels-of-insulin-like-growth-factor-1-in-obeses-women-with-and-without-insulin-resistance
#8
M Kujawska-Luczak, M Szulinska, D Skrypnik, K Musialik, E Swora-Cwynar, M Kregielska-Narozna, L Markuszewski, M Grzymislawska, P Bogdanski
A range of studies showed confusing data about the relationship between obesity, weight reduction and circulating total insulin-like growth factor -1 (IGF-1). The aim of the study was to compare the influence of orlistat (IO), metformin (IM), or calorie-restricted diet (LC) on IGF-1, with special respect to insulin-resistance status. One hundred and fourteen obese women aged from 18 to 40 years were divided into insulin sensitive (IS) and insulin resistant (IR) groups and received a low calorie diet (LC), or an isocaloric diet and 500 mg metformin twice daily (IM), or isocaloric diet with 120 mg orlistat three times daily (IO)...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683824/the-effect-of-selective-agonists-of-opioid-receptors-on-in-vitro-secretion-of-steroid-hormones-by-porcine-endometrium-during-the-estrous-cycle-and-early-pregnancy
#9
M Dziekonski, A Zmijewska, W Czelejewska, P Wojtacha, S Okrasa
Steroid hormones play an important role in the regulation of cyclic changes in the uterus and preparation of intrauterine environment for the egg fertilization, embryo implantation and maintenance of pregnancy. Their secretion by porcine uterus has been demonstrated. The present study aimed to establish the effect of opioid receptors (μ, δ and κ) activation by selective agonists (DAMGO, DPLPE and U 50.488, respectively) on in vitro secretion of steroid hormones (during 6-h and 24-h incubations) by the endometrial explants of gilts on days 2 - 3, 10 - 11, 12 - 3, 15 - 16, 18 - 20 of the estrous cycle and 10 - 11, 12 - 13, 15 - 16 of pregnancy...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683823/modulation-of-anterior-pituitary-cell-luteinizing-hormone-secretory-activity-by-neuropeptide-y-in-early-pregnant-pigs
#10
G Siawrys, H Buchowski
Numerous reports indicate that neuropeptide Y (NPY) is implicated in the regulation of anterior pituitary (AP) gonadotropin secretion in prepuberal and cyclic females. This study was performed to explain whether NPY directly affects basal and gonadotropin-releasing hormone- (GnRH-) induced luteinizing hormone (LH) secretion and intracellular accumulation by AP cells and whether NPY and its receptor (Y1 and Y2) mRNAs are expressed in the AP gland in pregnant pigs (days 14 - 16). Additionally, the expression of genes encoding β subunit of luteinizing hormone (β-LH) and GnRH receptor (GnRH-R) was determined in porcine AP gland...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683822/lipopolysaccharide-induced-redistribution-of-myocardial-connexin43-is-associated-with-increased-macrophage-infiltration-in-both-normotensive-and-spontaneously-hypertensive-rats
#11
L Okruhlicova, Z Cicakova, K Frimmel, P Weismann, J Krizak, R Sotnikova, V Knezl, J Slezak
We investigated whether changes in gap junction alpha-1 protein (Cx43) expression may be associated with macrophage-induced inflammation in the heart of spontaneously hypertensive rats (SHR). To examine mutual interactions of macrophage infiltration with Cx43 expression and redistribution, we applied a bolus of bacterial lipopolysaccharide (LPS) to SHR and age-matched normotensive Wistar rats. The results demonstrated association of Cx43 downregulation with increased infiltration of cardiac CD-68 macrophages and upregulation of nuclear factor-κB (NFκB) and tumor necrosis factor-α (TNF-α) expression in the heart of SHR...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683821/controlled-aerobic-training-improves-endothelial-function-and-modifies-vascular-remodeling-in-healthy-adults-with-high-normal-blood-pressure
#12
J Glodzik, K Rewiuk, J Adamiak, J Marchewka, A Salakowski, M Mazur, J Brudecki, T P Mikolajczyk, T Guzik, P Aleksander-Szymanowicz, T Grodzicki
The aim of the study was to assess endothelial function in adults with high normal blood pressure (HNBP) undergoing controlled aerobic training. The study was conducted among 31 volunteers with HNBP. Subjects underwent supervised cycle ergometer training for 12 weeks. Exercise intensity was assessed by monitoring the pulse with intention to keep the heart rate increase within the range of 40% to 65% of the heart rate reserve. The control group consisted of 14 healthy adults, not subjected to any intervention...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683820/hypercholesterolemia-antagonized-heart-adaptation-and-functional-remodeling-of-the-mitochondria-observed-in-acute-diabetes-mellitus-subjected-to-ischemia-reperfusion-injury
#13
M Ferko, V Farkasova, M Jasova, I Kancirova, T Ravingerova, A Duris Adameova, N Andelova, I Waczulikova
Intrinsic cardioprotective mechanisms become activated in the early diabetes mellitus (DM) and this may protect the heart from ischemia/reperfusion (I/R) similarly as in case of ischemic preconditioning. However, this protection may by blunted in the presence of cardiovascular risk factors. Assuming that hypercholesterolemia (HCH) frequently accompanies DM, this study extends findings from separate models of DM and HCH by investigation the impact of HCH on DM-induced changes, including those of compensatory nature, in rat heart and its mitochondria...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683819/the-role-of-low-calorie-diets-and-intermittent-fasting-in-the-treatment-of-obesity-and-type-2-diabetes
#14
REVIEW
A Zubrzycki, K Cierpka-Kmiec, Z Kmiec, A Wronska
Obesity is a condition associated with an increased risk of metabolic disorders, and in particular of type-2 diabetes (T2D). The treatment and prevention of obesity and associated metabolic disorders present great medical challenges. A major therapeutic goal in T2D is to control blood glucose levels, which can be achieved by pharmacological and nonpharmacological measures. The latter include increased physical activity and reduction of body fat mass by limiting dietary caloric content. Low-calorie diets (LCDs) involve a reduction in daily caloric intake by 25% to 30%...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30683818/the-cyclooxygenase-2-prostaglandin-e-2-pathway-and-its-role-in-the-pathogenesis-of-human-and-dog-hematological-malignancies
#15
M Zmigrodzka, A Rzepecka, M Krzyzowska, O Witkowska-Pilaszewicz, A Cywinska, A Winnicka
The overexpression of cyclooxygenase-2 (COX-2) has been documented in many types of cancer occurring in humans and animals. Increasing evidences have shown that the overexpression of COX-2 and increased production of prostaglandin E2 (PGE2 ) correlate with poor prognosis in human solid tumours and hematological malignancies. Both, in vitro and in vivo studies have demonstrated that increased proliferation of cancer cells as well as an impairment of anti-tumour immunity are influenced by the overexpression of this enzyme...
October 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30552308/hypoglycemic-side-effects-of-sulfonylureas-and-repaglinide-in-ageing-patients-knowledge-and-self-management
#16
I A Harsch, R H Kaestner, P C Konturek
Insulinotropic oral antidiabetics (OAD) such as sulfonylureas and (SU) glinides are among the frequently prescribed OAD. Side effects are the potential to induce hypoglycemias and weight gain. The aim was to assess the self-managing skills in case of a hypoglycemic event in an elderly type 2 diabetic patient population. In a 2-year period, 160 hospitalized patients (mean age 77.4 years) under insulinotrophic OAD were interviewed using a standardized questionnaire. Additionally, possible dementia was evaluated by using the Mini-Mental State Examination (MMSE) and the Clock-Drawing Test (CDT)...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30552307/drug-adherence-and-drug-related-problems-in-pharmacotherapy-for-lower-urinary-tract-symptoms-related-to-benign-prostatic-hyperplasia
#17
T Zabkowski, M Saracyn
Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) is one of the most common urinary disorders in elderly men. In recent years, pharmacotherapy of BPH has increased the efficacy, including combination treatment mostly with two drug classes, namely, 5-α-reductase inhibitors and α-1-adrenolytics (alpha blockers) with a different pharmacological activity. Although pharmacological treatment of BPH is a success story in urology, daily practice suggests that several medical needs remain unmet...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30552306/urinary-neutrophil-gelatinase-associated-lipocalin-kidney-injury-molecule-1-uromodulin-and-cystatin-c-concentrations-in-an-experimental-rat-model-of-ascending-acute-kidney-injury-induced-by-pyelonephritis
#18
B Skowron, A Baranowska, L Dobrek, K Ciesielczyk, J Kaszuba-Zwoinska, G Wiecek, A Malska-Wozniak, M Strus, K Gil
Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), cystatin C (CysC), uromodulin (UMOD), and some interleukins (IL-6 and IL-18) can be considered as diagnostic markers of acute kidney injury (AKI). The aim of this study was to verify the applicability of four urinary (u) markers, namely uNGAL, uKIM-1, uCysC, and uUMOD, for the diagnosis of ascending AKI induced by bacterial pyelonephritis. The study included 30 female rats that were divided into three groups (n = 10 each) and were inoculated transurethrally with various doses of Escherichia coli to induce isolated pyelonephritis (group 1, 105 CFU/ml), pyelonephritis-induced AKI (group 2, 107 CFU/ml), or AKI and urosepsis (group 3, 109 CFU/ml)...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30552305/serum-rantes-transforming-growth-factor-%C3%AE-1-and-interleukin-6-levels-correlate-with-cardiac-muscle-fibrosis-in-patients-with-aortic-valve-stenosis
#19
J Podolec, J Baran, M Siedlinski, M Urbanczyk, M Krupinski, K Bartus, L Niewiara, M Podolec, T Guzik, L Tomkiewicz-Pajak, M Komar, A Kablak-Ziembicka
Regulated on Activation Normal T Expressed and Secreted (RANTES) chemokine is involved in the initiation of inflammation and immune-cell recruitment. Interleukin -6 (IL-6) is used as a general index of severity of the chronic inflammatory process. Finally, transforming growth factor-β (TGF-β) is an immune biomarker potentially involved in the regulation of valve fibrosis and calcification. The aim of this study was to analyze selected biomarkers associated with the different stages of immune-pathogenesis in aortic stenosis...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30552304/interleukin-6-deficiency-modifies-the-effect-of-high-fat-diet-on-myocardial-expression-of-fatty-acid-transporters-and-myocardial-lipids
#20
P Mysliwiec, B Choromanska, M M Winnicka, K Kaminski, H Mysliwiec, J Dadan, E Supruniuk, A Chabowski
Chronic inflammation is a critical feature of obesity in the development of myocardial dysfunction. The observations that interleukin-6 (IL-6) is implicated in lipid and glucose homeostasis as well as its connection with the pathogenesis of insulin resistance might suggest the involvement of this cytokine in metabolic disorders of the failing heart. In the present study we aimed to assess the effects of IL-6 ablation in mice fed with normal and high fat diet on the myocardial expression of glucose and fatty acid transporting proteins, and to evaluate the paralleled alterations in lipid content...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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