Elizabeth S Barrie, Julia K Pinsonneault, Wolfgang Sadee, Jill A Hollway, Benjamin L Handen, Tristram Smith, L Eugene Arnold, Eric Butter, Emily Hansen-Kiss, Gail E Herman, Michael G Aman
Background: Frequent non-pathogenic genetic variants may act as moderators of phenotypic severity for complex disorders such as autism spectrum disorder (ASD). We previously identified polymorphisms affecting mRNA expression of candidate genes, including tryptophan hydroxylase 2 ( TPH2 ), dopamine beta hydroxylase ( DBH ), and dopamine transporter ( DAT, SLC6A3 ). Method: We compare genotypes and (1) clinical response to atomoxetine, (2) scores from the Autism Diagnostic Interview-Revised (ADI-R), and (3) severity of Attention Deficit Hyperactivity Disorder (ADHD) symptoms in a cohort of patients with ASD from multiple study sites...
June 2018: Journal of Developmental and Physical Disabilities