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Diéssica Padilha Dalenogare, Paula Ronsani Ferro, Samira Dal Toé De Prá, Flávia Karine Rigo, Caren Tatiane de David Antoniazzi, Amanda Spring de Almeida, Adriani Paganini Damiani, Giulia Strapazzon, Thanielly Thais de Oliveira Sardinha, Nathália Coral Galvani, Aline Augusti Boligon, Vanessa Moraes de Andrade, Evelyne da Silva Brum, Sara Marchesan Oliveira, Gabriela Trevisan
Copaifera officinalis L. possesses traditional uses as an analgesic, anti-inflammatory, and antiseptic. However, until now the antinociceptive effect and the mechanism of action were not described for Copaifera officinalis L. oil and no compound present in this oil was identified to be responsible for its biological effects. The goal of this study was to identify the presence of kaurenoic acid in Copaifera officinalis oil and investigate its antinociceptive effect, mechanism of action, and possible adverse effects in mice...
May 16, 2019: Inflammopharmacology
Luiz Henrique Agra Cavalcante-Silva, Éssia de Almeida Lima, Deyse C M Carvalho, Sandra Rodrigues-Mascarenhas
Ouabain, a hormone that inhibits Na+ /K+ -ATPase, modulates many aspects of the inflammatory response. It has been previously demonstrated that ouabain inhibits neutrophil migration in several inflammation models in vivo, but little is known about the mechanisms underlying this effect. Thus, this work aimed to evaluate the effect of ouabain on molecules related to neutrophil migration. For this purpose, neutrophils obtained from mouse bone marrow were treated with ouabain (1, 10, and 100 nM) in vitro. Neutrophil viability was assessed by annexin V/propidium iodide staining...
May 13, 2019: Inflammopharmacology
Adnan Jehangir, Muhammad Shahzad, Khadija Shahid, Akbar Waheed, Farhana Ayub
Oleanolic acid (OA) is a hydroxyl pentacyclic triterpene acid (HTAs) used in various ailments. Inflammatory diseases may be profoundly influenced by iron (Fe) and zinc (Zn) status. We studied the anti-asthmatic effects of two metal complexes (Fe and Zn) of OA in the ovalbumin (OVA)-induced rat model. Delayed type hypersensitivity (DTH) was measured. Total and differential leucocyte count was done in blood as well as bronchoalveolar lavage fluid (BALF). The mRNA expression levels of pro-inflammatory cytokines were measured in lung tissue by reverse transcription polymerase chain reaction...
May 8, 2019: Inflammopharmacology
Anderson Rodrigues de Almeida, Andréa Tavares Dantas, Michelly Cristiny Pereira, Marina Ferraz Cordeiro, Rafaela Silva Guimarães Gonçalves, Moacyr Jesus Barreto de Melo Rêgo, Ivan da Rocha Pitta, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta
Glucocorticoids (GC) are widely used in the treatment of SSc, although there is not much evidence to prove the benefits offered by these drugs in this disease. In this study, we evaluated the effects of a GC on cytokine production in peripheral blood mononuclear cells (PBMC) of SSc patients. The effect of dexamethasone (DEX) was evaluated in PBMC of 21 SSc patients and 10 healthy volunteers after stimulation of cells with anti-CD3 and anti-CD28. Cytokines IL-2, IL-4, IL-6, IL-10, IL-17A, IL-17F, IFN-γ, TNF, and IL-1β were quantified in the culture supernatant by CBA or ELISA...
May 8, 2019: Inflammopharmacology
Ingvar Bjarnason, Guy Sission, Bu'Hussaine Hayee
BACKGROUND: There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports of their efficacy are conflicting. AIMS: To assess the efficacy of a multi-strain probiotic (Symprove™, Symprove Ltd, Farnham, United Kingdom) in quality of life issues and intestinal inflammation in patients with asymptomatic UC and CD...
May 3, 2019: Inflammopharmacology
Ammara Saleem, Mohammad Saleem, Muhammad Furqan Akhtar, Muhammad Shahzad, Shah Jahan
Moringa rivae is widely used as a traditional remedy against arthritis. The present research was designed to evaluate the anti-arthritic potential of Moringa rivae extracts. Treatment of rats with adjuvant-induced arthritis with methanolic and aqueous extracts of M. rivae (150, 300 or 600 mg/kg), and piroxicam (10 mg/kg) was started orally at day 8 post-administration of complete Freund's adjuvant and continued till 28th day. The therapeutic effect of the plant extracts was assessed in arthritic rats by arthritic index, body weight, and haematological and biochemical parameters...
April 29, 2019: Inflammopharmacology
Philipp Guenthoer, Kerstin Fuchs, Gerald Reischl, Leticia Quintanilla-Martinez, Irene Gonzalez-Menendez, Stefan Laufer, Bernd J Pichler, Manfred Kneilling
BACKGROUND: Mitogen-activated protein kinase (MAPK) signaling plays an important role in inflammatory diseases such as rheumatoid arthritis (RA).The aim of our study was to elucidate the therapeutic potential of the highly selective p38 MAPK inhibitor Skepinone-L and the dual inhibitor LN 950 (p38 MAPK and JNK 3) in the K/BxN serum transfer model of RA. Additionally, we aimed to monitor MAPK treatment non-invasively in vivo using the hypoxia tracer [18 F]fluoromisonidazole ([18 F]FMISO) and positron emission tomography (PET)...
April 29, 2019: Inflammopharmacology
Xiaobo Zhu, Jiankun Liu, Ou Chen, Jiang Xue, Shanying Huang, Weiwei Zhu, Yibiao Wang
Epileptogenesis is a complex pathological process that occurs after an initial brain injury and involves a series of molecular events. Isoliquiritigenin (ISL), a flavonoid in licorice, is reported to have anti-inflammatory and antioxidant effects in various experimental models, but its specific roles and molecular mechanisms in the epileptogenic process following kainic acid (KA) treatment remain unclear. The purpose of this study was to explore the effects of ISL pretreatment in KA-induced epileptic rats and the underlying mechanisms...
April 29, 2019: Inflammopharmacology
Nara L M Quintão, Lilian W Rocha, Gislaine F da Silva, Ana F Paszcuk, Marianne N Manjavachi, Allisson F Bento, Kathryn Ana B S da Silva, Maria M Campos, João B Calixto
Unfortunately, the Fig. 7 was wrongly downloaded in the original publication.
April 6, 2019: Inflammopharmacology
Gurjit Singh, Anudeep Kaur, Jashanpreet Kaur, Manpreet S Bhatti, Palwinder Singh, Rajbir Bhatti
In continuation with our previous studies on osthole, bergapten, a closely related furanocoumarin was investigated for its ameliorative effect on chemically induced neurogenic and inflammatory hyperalgesia and inflammation in mice. Chemical hyperalgesia and inflammation was induced by administration of formalin (intraplantar), acetic acid (intraperitoneal) and carrageenan (intraplantar) to different groups of animals. Pain responses were quantified and median effective dose (ED50 ) of bergapten was calculated...
April 5, 2019: Inflammopharmacology
Thacyana T Carvalho, Sandra S Mizokami, Camila R Ferraz, Marília F Manchope, Sergio M Borghi, Victor Fattori, Cassia Calixto-Campos, Doumit Camilios-Neto, Rubia Casagrande, Waldiceu A Verri
Rutin is a glycone form of the flavonol quercetin and it reduces inflammatory pain in animal models. Therapy with granulocyte colony-stimulating factor (G-CSF) is known by the pain caused as its main side effect. The effect of rutin and its mechanisms of action were evaluated in a model of hyperalgesia induced by G-CSF in mice. The mechanical hyperalgesia induced by G-CSF was reduced by treatment with rutin in a dose-dependent manner. Treatment with both rutin + morphine or rutin + indomethacin, at doses that are ineffectual per se, significantly reduced the pain caused by G-CSF...
April 3, 2019: Inflammopharmacology
Mohammad Alsalem, Mansour Haddad, Sara A Aldossary, Heba Kalbouneh, Ahmad Altarifi, Sahar M Jaffal, Manal A Abbas, Nour Aldaoud, Khalid El-Salem
Osteoarthritis (OA) is characterized by cartilage degeneration, subchondral sclerosis, and pain. Cannabinoids have well-established anti-nociceptive properties in animal models of chronic pain. The aim of this study is to evaluate the anti-nociceptive effects of synthetic cannabinoids (WIN-55,212 and HU210) and the cannabinoid-like compound palmitoylethanolamide (PEA) in rat models of OA and to assess the role of cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor α (PPARα) in mediating these effects...
April 3, 2019: Inflammopharmacology
Zhenjiang Zhao, Guoguo Jin, Yinghui Ge, Zhiping Guo
BACKGROUND: Naringenin, a flavonoid compound, has a wide variety of uses in the pharmaceutical industry for its antioxidant and anti-inflammatory potential. OBJECTIVES: The current experiment aimed to investigate the anticancer effect of naringenin in triple-negative human breast cancer cells (MDA-MR-231) and an animal model with 7,12-dimethylbenz[a] anthracene (DMBA)-induced breast cancer in female rats to determine the mechanisms and molecular targets. METHODS: The cytotoxic effects of naringenin against MDA-MB-231 cells were assessed by MTT assay...
April 2, 2019: Inflammopharmacology
Anja Dullius, Claudia Monfroni Rocha, Stefan Laufer, Claucia Fernanda Volken de Souza, Márcia Inês Goettert
While the inactivation mutations that eliminate JAK3 function lead to the immunological disorders such as severe combined immunodeficiency, activation mutations, causing constitutive JAK3 signaling, are known to trigger various types of cancer or are responsible for autoimmune diseases, such as rheumatoid arthritis, psoriasis, or inflammatory bowel diseases. Treatment of hyperactivated JAK3 is still an obstacle, due to different sensibility of mutation types to conventional drugs and unwanted side effects, because these drugs are not absolutely specific for JAK3, thus inhibiting other members of the JAK family, too...
March 30, 2019: Inflammopharmacology
Mohammad Sheibani, Hedyeh Faghir-Ghanesefat, Saman Dehpour, Hedieh Keshavarz-Bahaghighat, Mohammad Reza Sepand, Mohammad Hossein Ghahremani, Yaser Azizi, Nastaran Rahimi, Ahmad Reza Dehpour
Ischemic heart disease is a leading cause of death on a global scale, placing major socio-economic burdens on health systems worldwide. Myocardial ischaemia and reperfusion (I/R)-induced tissue injury is associated with alteration in activity of inflammatory system and nitric oxide pathway. Sumatriptan, which is mainly used to relieve migraine headache, has recently been shown to exert anti-inflammatory properties. In this study, we aimed to assess the possible cardioprotective effect of sumatriptan in a rat model of I/R injury...
March 30, 2019: Inflammopharmacology
Elizabeth Steels, Ruchitha Venkatesh, Eleanor Steels, Gemma Vitetta, Luis Vitetta
BACKGROUND: The aim of the study was to assess the safety, tolerability and efficacy of palmitoylethanolamide (PEA) when dosed at 300 mg and 600 mg per day on symptoms of knee osteoarthritis. METHODS: This was a single site, comparative, double-blind placebo controlled study in adults with mild to moderate knee osteoarthritis with 111 participants randomized to receive 300 mg PEA, 600 mg PEA or placebo each day, in divided doses b.i.d, for 8 weeks. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)...
March 29, 2019: Inflammopharmacology
Hossein Omidi-Ardali, Zahra Lorigooini, Amin Soltani, Shima Balali-Dehkordi, Hossein Amini-Khoei
Pathogenesis of the inflammatory bowel disease (IBD) involves the combination of immunological and inflammatory factors. IBD is associated with several extra-intestinal manifestations. The exact underlying bridge between the probable cardiac diseases in IBD patients is undetermined. Trigonelline is an alkaloid with several therapeutic potential properties. In this study, we aimed to assess the probable underlying mechanisms of this comorbidity as well as protective effect of trigonelline focusing inflammatory response and oxidative state in mouse model of colitis...
March 28, 2019: Inflammopharmacology
Feilong Lu, Haimei Lu, Meijuan Xie, Shan Li, Yunyun Zu, Jia Zhou, Jie Yu, Shuang Wang, Yeping Ruan, Chengping Wen, Zhenghao Xu
OBJECTIVE: To investigate whether glucocorticoids, the hallmark medication for systemic lupus erythematosus (SLE), could prevent the development of neuropsychiatric SLE (NPSLE). METHODS: The protective effects of prednisone on NPSLE were tested using the open field, object recognition/placement, forced swim, tail suspension, and sucrose preference tests in MRL/lpr mice. Auto-antibody titres and the weight of lymph nodes were also measured. RESULTS: MRL/lpr mice exhibited mild depression at the age of 8 weeks before progressing with spatial cognitive impairment and severe depression-like behaviour at the age of 16 weeks...
March 25, 2019: Inflammopharmacology
Mohsen Chamanara, Alireza Abdollahi, Seyed Mahdi Rezayat, Mamoud Ghazi-Khansari, Ahmadreza Dehpour, Ehsan Nassireslami, Amir Rashidian
AIM: The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS: Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in Wistar rats. Colitis was induced on the first day and all treatments were applied 5 days after the induction of colitis. Thymol was dissolved in 0...
March 21, 2019: Inflammopharmacology
Darshpreet Kaur, Vivek Sharma, Rahul Deshmukh
Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is usually observed in AD and could implicate both beneficial or detrimental effects depending on the severity of the disease. During initial AD pathology, microglia and astrocyte activation is beneficial since they are involved in amyloid-beta clearance. However, with the progression of the disease, activated microglia elicit detrimental effects by the overexpression of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) bringing forth neurodegeneration in the surrounding brain regions...
March 14, 2019: Inflammopharmacology
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