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Romanian Journal of Morphology and Embryology

Daniel Alin Olimid, Anca Parmena Olimid, Feng Ifrim Chen
PURPOSE: The paper focuses on the ethical appraisal of the clinical investigations (CIs) and the informed consent within the new European Union (EU) legislation on medical devices (MDs). The Regulation (EU) 2017∕745 of the European Parliament and of the Council was adopted on 5 April 2017 and entered into force on 25 May 2017, repealing the Council Directives concerning Medical Devices 93∕42∕EEC and the Active Implantable Medical Devices 90∕385∕EEC. BACKGROUND: For the past thirty years, the EU legislation on MDs has been updated by several directives: Council Directive 90∕385∕EEC on Active Medical Devices (1990); Council Directive 93∕42∕EEC on Medical Devices (1993) and Council Directive 98∕79∕EC on In vitro Medical Devices (1998) aiming to frame the MDs market development...
2018: Romanian Journal of Morphology and Embryology
Aurel George Mohan, Mircea Vicenţiu Săceleanu, Andrei Alexandru Marinescu, Mihai Popescu, Alexandru Vlad Ciurea
Neurosurgery is one of the newest medical specialties in the world, having less than 100 years since its definition as a stand-alone surgical specialty by Harvey Cushing (1869-1939). Its emergence required several special prerequisites, which were met only in the mid-19th century: knowledge of neuroanatomy, function of nervous centers and main cortical area topography, standard asepsis-antisepsis rules, neuroimaging, safe and longer general anesthesia, hemostasis and coagulation techniques and of course knowledgeable, skillful and bold surgeons...
2018: Romanian Journal of Morphology and Embryology
Pompiliu Horaţiu Petrescu, Dana Cristina Bratu, Marius Octavian Pricop, Delia Mira Berceanu-Văduva, Marcel Mihai Berceanu-Văduva, Jenel Marian Pătraşcu, Venera Margareta Bucur, Gabriel Ovidiu Dinu, Dorela Codruţa Lăzureanu
Although osteochondral fractures of the lateral femoral condyle are uncommon, fixation of the fragments is recommended, mostly when is about young athletes with such post-traumatic pathology. We present a case of a professional handball player teenager female, with a lateral femur condylar osteochondral fracture after a fall with the right knee in extension and in internal rotation. Magnetic resonance imaging (MRI) showed an osteochondral fracture of the lateral femoral condyle, 34.6 mm on long axis, impossible to manage arthroscopically, because of the size and the location of the detached fragment...
2018: Romanian Journal of Morphology and Embryology
Cristina Elena Singer, Laura Daniela Marinău, Carmen Simona Coşoveanu, Liliana Streba, Ileana Octavia Petrescu, Mioara Desdemona Stepan, George Alin Stoica, Diana Maria Traşcă
The nephroblastoma or Wilms tumor (WT) is the most common renal tumor in childhood, representing approximately 6-7% of all pediatric cancers, with a yearly incidence of 10 cases in one million children less than 15 years old, and continues to arouse interest by remarkable actual therapeutic successes, consecutive to the multidisciplinary approach. Its maximum incidence is around the age of 3-3.5 years old, having an equal frequency in males and females. We present the case of a child, aged three years and five months, who was diagnosed with WT (nephroblastoma) with triphasic pattern, stage II tumor, and admitted to the Department of Oncopediatry for chemotherapeutic treatment and clinico-biological investigations...
2018: Romanian Journal of Morphology and Embryology
Dragoş Cătălin Jianu, Silviana Nina Jianu, Graţian Dragoslav Miclăuş, Georgiana Munteanu, Traian Flavius Dan, Claudia Bârsan, Mihnea Munteanu, Horia Tudor Stanca, Andrei Gheorghe Marius Motoc, Octavian Marius Creţu
The congenital anomalies of the supra-aortic arteries and their branches as potential risk factors for cerebrovascular insufficiency are not yet fully investigated and clarified. This report describes the case of a 68-year-old man who was admitted in our Clinic for an acute ischemic stroke in the vertebrobasilar territory. Extracranial color-coded duplex sonography (CCDS) and computed tomography angiography revealed a combination of congenital anomalies of the neck arteries: left internal carotid artery hypoplasia, left common carotid artery hypoplasia, right vertebral artery hypoplasia and the emergence of the left vertebral artery directly from the aortic arch...
2018: Romanian Journal of Morphology and Embryology
Dimitrios Sfoungaris, Mitroudi Magdalini, Ioannis Patoulias, Christina Panteli, Ioannis Valioulis
Duplications of the gastrointestinal tract are rare malformations, most commonly presenting as cystic structures growing within the smooth muscle wall. Very rarely, they are completely detached from the tract. Several theories have been proposed regarding their embryological development, but no single one has been able to account for all of the described variants. The most common type of duplication is related to the small bowel and develops at its mesenteric border, assuming a spherical or tubular shape. Their clinical manifestations vary, depending mainly on their localization and size...
2018: Romanian Journal of Morphology and Embryology
Konstantinos Sapalidis, Dimitrios Giannakidis, Stella Laskou, Georgia Karayannopoulou, Triantafyllia Koletsa, Vasileios Rafailidis, Katerina Zarampouka, Sotiris Sotiriou, Konstantina Spyridaki, Isidora Stamenitou, Isaak Kesisoglou, Ion Păun
Double functioning adrenocortical adenomas, occurring in the same gland is an extremely rare condition. This paper presents two cases of double functioning adrenocortical adenomas within the same adrenal gland, causing primary aldosteronism. Diagnosis was set histopathologically in one case since magnetic resonance imaging (MRI) failed to distinguish the two entities. In each case, a laparoscopic adrenalectomy was conducted. When preoperative imaging studies fail to report the presence of double adrenocortical adenomas, histopathology reports should be comprehensive enough so as to reveal such rare lesions...
2018: Romanian Journal of Morphology and Embryology
Ioana Delia Horhat, Nicolae Constantin Balica, Horaţiu Constantin Urechescu, Flavia Baderca, Mărioara Poenaru, Caius Ion Doroş, Ion Cristian Moţ, Eugen Radu Boia, Carmen Aurelia Mogoantă, Alexandru Chioreanu, Alexandru Nicolae Vlăescu, Cristian Andrei Sarău
We report a case of rare benign tumor of the larynx - amyloidosis of larynx - in a 52-year-old female who presented to the Department of Ear, Nose and Throat (ENT), Timişoara Municipal Hospital, Romania, with dysphonia. The patient's first presentation was in June 2012, with a polypoid formation localized on left vocal cord. The patient underwent a suspended microlaryngoscopy (SM) with tumor removal followed by histopathological examination, which revealed a laryngeal amyloidosis. The tumor recurred in 2013, 2014, 2016, 2017 and 2018...
2018: Romanian Journal of Morphology and Embryology
Dana Maria Albulescu, Andreea Elena Ceauşescu, Lorena Mihaela Sas, Maria Cristina Comănescu, Cristian Constantin, Ştefania Tudorache
The Herlyn-Werner-Wunderlich syndrome (HWWS) is a complex congenital malformation, originally described as a triad of symptoms: didelphys uterus, low genital obstruction and unilateral renal anomaly. The term OHVIRA is an acronym (obstructed hemivagina/hemicervix with ipsilateral renal anomaly) and refers to the same syndrome. It gained acceptance in recent years, due to reports of cases having a non-didelphys uterus (normal, septated or having other abnormalities). In the following, we report two cases with good pregnancy outcome and we provide a short discussion on published literature...
2018: Romanian Journal of Morphology and Embryology
Daniel Laurenţiu Pop, Gheorghe Nodiţi, Ahmed Abu-Awwad, Daniel Claudiu Maliţa, Carmen Lăcrămioara Zamfir, Mirela Loredana Grigoraş, Dinu Vermeşan, Radu Prejbeanu, Horia George Hărăguş, Anca Laura Boşcu, Bogdan Cătălin Ciupe, Bogdan Nicolae Deleanu, Cosmin Ioan Faur, Roxana Folescu
Alveolar rhabdomyosarcoma (RMS) is a common pediatric malignant mesenchymal tumor, representing half of soft tissue sarcomas and approximately 5% of all cancers. We present the case of an adolescent male patient treated in our Department for a tumoral mass located in the middle third of the forearm. Magnetic resonance imaging (MRI) and angiography-computed tomography (angio-CT) showed a large mass located in the muscles of the anterior compartment of the forearm. Surgical treatment consisted of tumor ablation including segmental resection of the radial and ulnar arteries and of the median nerve, followed by saphenous autograft vascular bypass...
2018: Romanian Journal of Morphology and Embryology
Daniel Mihai Teleanu, Andreea Ilieşiu, Adrian Florian Bălaşa, Raluca Ioana Teleanu, Nicolae Ştefan Bogaciu
BACKGROUND: Astroblastoma is a poorly defined central nervous system (CNS) tumor, included along with polar spongioblastoma and gliomatosis cerebri in the group of neuroepithelial tumors of uncertain origin in the June 2016 World Health Organization (WHO) Classification of tumors of the CNS. They are rare neoplasms that affect primarily patients of young ages. The purpose of this research is to highlight the uniqueness and rareness of this pathology and to emphasize on the particularities of one case managed in our Clinic...
2018: Romanian Journal of Morphology and Embryology
Cătălin Gabriel Herghelegiu, Adrian Neacşu, Nuţi Daniela Oprescu, Ana Elena Cărbunaru, Anca Daniela Brăila, Fabiana Georgiana Curea, Mădălina Lucia Marcu, Raluca Gabriela Ioan, Roxana Elena Bohîlţea
Clear cell carcinoma (CCC) of the female genital tract usually arises in the ovary, endometrium, cervix and vagina. A rare site for CCC is the vulva, and moreover even rarer are the cases involving the Bartholin gland. A 54-year-old female was admitted for a 1.5×2 cm tumor at the level of the right Bartholin gland. The magnetic resonance imaging (MRI) exam revealed enlarged inguinal, pelvic and para-aortic lymph nodes but no other primary tumor. Microscopic examination revealed CCC. The tumor was positive for cytokeratin 7 (CK7), paired-box 8 (Pax8), napsin A and vimentin, negative for estrogen receptor (ER), progesterone receptor (PR), calretinin, cluster of differentiation 10 (CD10), carcinoembryonic antigen (CEA), p16 and p63...
2018: Romanian Journal of Morphology and Embryology
Alin Dragoş Demetrian, Mihai Olteanu, Ion Mîndrilă, Adrian Macovei, Dumitru Sandu Râmboiu, Monalisa Elena Enache, Violeta Serenada Bălă, Camelia Demetrian, Mihai Popescu, Costin Teodor Streba
Unique sternal metastasis is an uncommon finding in the follow-up of operated breast cancer. We present a case of massive sternal metastasis occurred few years after radical resection of a right mammary cancer, that we solved by total sternal resection and reconstruction of sternum with acrylic cement and Vicryl mesh. The patient is disease-free five years after the operation.
2018: Romanian Journal of Morphology and Embryology
Marian Valentin Zorilă, Răzvan Ştefan Ţolescu, George Lucian Zorilă, Magdalena Diaconu, Bogdan Silviu Ungureanu, Roxana Eugenia Zăvoi, Oana Mariana Cristea, Feng Ifrim Chen
Liver hydatid cyst represents one of the most frequent localizations of Echinococcus granulosus tapeworm in humans. The disease progresses symptom-free in most patients, due to a slow growth rhythm of the cyst. When it reaches large sizes, the hydatid cyst causes discomfort or pain in the liver bed, low appetite, phenomena of hepatitis or cholangitis. The patients are most often diagnosed with liver hydatid cyst after imagistic investigations (radiological or ultrasound) for symptoms that, most commonly, are not related to a hydatid cyst...
2018: Romanian Journal of Morphology and Embryology
Corneliu Toader, Marian Stroi, Andrei Kozma, Dorel Eugen Arsene
Esthesioneuroblastoma (ENB), also called olfactory neuroblastoma, is a cancerous tumor originating from the olfactory neuroepithelial cells frequently invading the brain through the cribriform plate. The optimal therapy is the multimodality treatment involving a group of physicians trained in different medical specialties. Establishing a careful histopathological diagnostic and treatment planning based on a multidisciplinary approach is of paramount importance. The treatment of ENB correlates with the extent of the lesion, with surgery being the mainstay of therapy followed by postoperative irradiation...
2018: Romanian Journal of Morphology and Embryology
Gabriela Camelia Roşu, Dan Nechita, Cristina Jana Busuioc, Anca Maria Istrate-Ofiţeru, Otilia Clara Mărgăritescu, Iulia Diana Stanca, Daniel Pirici, Dan Bondari
Meningitis and encephalitis are inflammatory diseases in which acute and chronic inflammatory cells infiltrate leptomeninges, especially the arachnoid, and migrate through the subarachnoid space and by diapedesis, in order to extend around blood vessels and into the brain parenchyma. To what extent migrated/resident inflammatory cells participate to these interactions, or what are exactly the initial steps by which these cells reach the brain interstitium, it is not yet completely known. Recent years have brought new insights into the description of water flow circuits in the brain, suggesting that the cerebrospinal fluid enters the brain within the perivascular spaces of arteries, while interstitial fluid drains along perivascular venous sector...
2018: Romanian Journal of Morphology and Embryology
Cristian Adrian Raţiu, Mihaela Mirela Zdrîncă, Adina Bianca Boşca, Flavia Ruxanda, Viorel Miclăuş, Aranka Ilea
The case report describes a sinus membrane elevation procedure, where the augmentation was performed exclusively with plasma rich in growth factors (PRGF) and fibrin clot, followed by osseous regeneration at eight months. The patient exhibited a marked osseous atrophy in the premolar-molar area of the left superior alveolar process. Initially, we performed a sinus membrane elevation, with autologous bone on the sinus floor and bovine bone, followed by horizontal augmentation with autologous bone harvested from the mandibular ramus...
2018: Romanian Journal of Morphology and Embryology
Alex Emilian Stepan, Claudiu Mărgăritescu, Lucian Eugen Stoica, Mioara Desdemona Stepan, Cristiana Eugenia Simionescu
Clear cell renal cell carcinomas (CCRCCs) are the most common kidney tumors that despite current advances in diagnosis continue to have high rates of metastasis and mortality. In this study, we analyzed the cytokeratin (CK) AE1∕AE3 and vimentin immunoexpression in 26 CCRCCs in relation to histopathological prognostic parameters. Immunoreactions were positive and heterogeneous in all analyzed cases. CK AE1∕AE3 immunoexpression was associated with low grade and early stage lesions, while vimentin immunoexpression was associated with high grade and advanced lesions...
2018: Romanian Journal of Morphology and Embryology
Ruxandra Mihaela Florescu-Ţenea, Adina Maria Kamal, Paul Mitruţ, Radu Mitruţ, Daniel Sorin Ilie, Andrei Cristian Nicolaescu, Silviu Adrian Marinescu
Although in developed countries the incidence of colorectal cancer is decreasing through the introduction of well-designed screening systems, the worrying worldwide increase of the mortality rate by colorectal neoplasm indicates the need for a thorough characterization of this pathology. Clinical, endoscopic, histopathological and immunohistochemical data provide important information for creating categories of patients that can benefit from intensive screening methods and for establishing the prognosis based on these data...
2018: Romanian Journal of Morphology and Embryology
Gheorghe Adrian Bumbu, Mihail Claudius Berechet, Karim Nacer, Gheorghe Bumbu, Octavian Adrian Maghiar, Ovidiu Gabriel Bratu, Răzvan Marius Vicaş, Ovidiu Ţica, Bogdan Andrei Bumbu
Obstruction of the pyeloureteral junction (PUJ) is by far the most common cause of hydronephrosis in children, with an incidence of one in 1000-2000 newborns. Also, the obstruction of the PUJ is the most common cause of prenatal hydronephrosis, accounting for 80% of the cases. The aim of this study is to observe and discuss first the efficacy of described surgery procedures and second the microscopic modifications of the PUJ (abnormalities of smooth muscle tissue, inflammation and fibrosis). One hundred and eleven children with a diverse urological pathology with an average age of 11...
2018: Romanian Journal of Morphology and Embryology
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