journal
https://read.qxmd.com/read/38886179/human-immunodeficiency-virus-infection-challenges-current-therapeutic-limitations-and-strategies-for-improved-management-through-long-acting-injectable-formulation
#1
REVIEW
Tanushree, Aman Sharma, Monika, Rahul Pratap Singh, Vikas Jhawat
HIV infection has been a severe global health burden, with millions living with the virus and continuing new infections each year. Antiretroviral therapy can effectively suppress HIV replication but requires strict lifelong adherence to daily oral medication regimens, which presents a significant challenge. Long-acting formulations of antiretroviral drugs administered infrequently have emerged as a promising strategy to improve treatment outcomes and adherence to HIV therapy and prevention. Long-acting injectable (LAI) formulations are designed to gradually release drugs over extended periods of weeks or months following a single injection...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38886173/epidemiology-biosafety-and-biosecurity-of-avian-influenza-insights-from-the-east-mediterranean-region
#2
REVIEW
Laith Al-Eitan, Iliya Khair, Zaid Shakhatreh, Diana Almahdawi, Saif Alahmad
The World Organization for Animal Health defines Avian Influenza Virus as a highly infectious disease caused by diverse subtypes that continue to evolve rapidly, impacting poultry species, pet birds, wild birds, non-human mammals, and occasionally humans. The effects of Avian influenza viruses have been recognised as a precursor for serious health concerns among affected birds, poultry, and human populations in the Middle East. Furthermore, low and high pathogenic avian influenza viruses lead to respiratory illness with varying severity, depending on the virus subtype (e...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38878003/efficacy-and-safety-of-adoptive-t-cell-therapy-in-treating-cytomegalovirus-infections-post-haematopoietic-stem-cell-transplantation-a-systematic-review-and-meta-analysis
#3
REVIEW
Mohammad Reza Taherian, Pouya Azarbar, Maryam Barkhordar, Shahin Toufani, Leyla Sharifi Aliabadi, Tanaz Bahri, Mohammad Ahmadvand, Marjan Yaghmaie, Alireza Daneshvar, Mohammad Vaezi
Cytomegalovirus (CMV) infection poses significant risks in allogeneic haematopoietic stem cell transplant (allo-HSCT) recipients. Despite advances in antiviral therapies, issues such as drug resistance, side effects, and inadequate immune reconstitution remain. This systematic review and meta-analysis aim to evaluate the efficacy and safety of adoptive cell therapy (ATC) in managing CMV infections in allo-HSCT recipients. Adhering to preferred reporting items for systematic reviews and meta-analyses guidelines, we conducted a comprehensive database search through July 2023...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38877989/association-between-epstein-barr-virus-lmp-1-and-hodgkin-lymphoma-lmp-1-mechanisms-in-hodgkin-lymphoma-development
#4
REVIEW
Leonam Oliver Durval Oliveira, Igor Brasil Costa, Juarez Antônio Simões Quaresma
Hodgkin lymphoma is histologically characterised by the presence of Hodgkin (H) and Reed-Sternberg (RS) cells originating from germinal centre B-cells rearranged in the IgV gene. The formation of multinucleated RS cells is a product of telomere organisation in a process initiated by telomere aggregate accumulation in mononuclear H cells and may be mediated by latent membrane protein 1 (LMP-1) expression. LMP-1 is the main oncoprotein of EBV and supports several tumourigenic processes. LMP-1 may rescue proapoptotic B-cells through downregulation of B-cell receptor (BCR) components, mimicking and inducing multiple distinct B-cell signalling pathways to promote proliferation and survival, such as Janus kinase-signal transducer and activator of transcription (JAK-STAT), nuclear factor-kappa b (NF-кB), and cellular MYC (c-MYC), and inducing telomere instability mainly through Telomere repeat binding factor 2 (TRF2) downregulation to promote the formation of multinucleated RS cells...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38877365/blood-borne-viruses-and-neurological-manifestations-an-overview
#5
REVIEW
Yan Xu, Bo Yu
Infections caused by blood-borne viruses, such as human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis C virus (HCV), and hepatitis B virus (HBV), are systemic diseases that can lead to a wide range of pathological manifestations. Besides causing severe immune and hepatic disorders, these viral pathogens can also induce neurological dysfunctions via both direct and indirect mechanisms. Neurological dysfunctions are one of the most common manifestations caused by these viruses that can also serve as indicators of their infection, impacting the clinical presentation of the disease...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38866595/potential-relationship-between-cytomegalovirus-and-immunosenescence-evidence-from-observational-studies
#6
REVIEW
Adva Gadoth, Kevork Ourfalian, Sandeep Basnet, Colin Kunzweiler, Rhonda L Bohn, Tamas Fülöp, John Diaz-Decaro
Immunosenescence (IS) occurs as a natural outcome of ageing and may be described as a decline in immune system flexibility and adaptability to sufficiently respond to new, foreign antigens. Potential factors that may precipitate IS include persistent herpesvirus infections, such as cytomegalovirus (CMV). Here, we conducted a review of the literature evaluating the potential association between CMV and IS. Twenty-seven epidemiologic studies that included direct comparisons between CMV-seropositive and CMV-seronegative immunocompetent individuals were analysed...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38862398/varicella-zoster-virus-related-neurological-complications-from-infection-to-immunomodulatory-therapies
#7
REVIEW
Mohammed Ageeli Hakami, Farhan R Khan, Osama Abdulaziz, Khalid Alshaghdali, Ali Hazazi, Awad F Aleissi, Adil Abalkhail, Bader S Alotaibi, Abdulfattah Yahya M Alhazmi, Neelima Kukreti, Abdulkarim S Binshaya
The Varicella-zoster virus (VZV), classified as a neurotropic member of the Herpesviridae family, exhibits a characteristic pathogenicity, predominantly inducing varicella, commonly known as chickenpox, during the initial infectious phase, and triggering the reactivation of herpes zoster, more commonly recognized as shingles, following its emergence from a latent state. The pathogenesis of VZV-associated neuroinflammation involves a complex interplay between viral replication within sensory ganglia and immune-mediated responses that contribute to tissue damage and dysfunction...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38853706/a-comprehensive-updated-systematic-review-and-meta-analysis-of-epidemiologic-evidence-on-the-connection-between-herpes-zoster-infection-and-the-risk-of-stroke
#8
REVIEW
Mohammad Heiat, Mahmood Salesi, Mohammad Hossein Peypar, Ali Ramazani, Mahdi Abdorrashidi, Amin Vesal Yeganeh
Stroke is a common worldwide cause of death and disability, resulting from an obstruction or reduction in blood flow to the brain. Research has demonstrated that systemic infection such as herpes zoster (HZ) / ophthalmicus herpes zoster (HZO) can potentially trigger stroke. This study includes an updated systematic review and meta-analysis of the epidemiologic data on the connection between HZ/HZO infection and the risk of stroke. A meticulous search of different database yielded 905 studies. Furthermore, an additional 14 studies from a previous meta-analysis were incorporated...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38849982/azvudine-versus-paxlovid-in-covid-19-a-systematic-review-and-meta-analysis
#9
REVIEW
Behnam Amani, Bahman Amani
This systematic review and meta-analysis aimed to compare the effectiveness and safety of azvudine versus nirmatrelvir/ritonavir (Paxlovid) in treating coronavirus disease 2019 (COVID-19). The researchers conducted searches on PubMed, Cochrane Library, Web of Science, medRxiv, and Google Scholar until January 2024. The Cochrane risk of bias tool was utilised to evaluate the quality of the included studies, and data analysis was performed using Comprehensive Meta-Analysis software. Thirteen studies, including 4949 patients, were analysed...
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38825753/fluvoxamine-and-long-covid-post-acute-recovery
#10
LETTER
Angela M Reiersen, Charles F Zorumski, Eric J Lenze
No abstract text is available yet for this article.
July 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38801246/alzheimer-s-disease-and-herpes-viruses-current-events-and-perspectives
#11
REVIEW
Pinchera Biagio, Di Filippo Isabella, Cuccurullo Federica, Salvatore Elena, Gentile Ivan
Alzheimer's disease (AD) is a real and current scientific and societal challenge. Alzheimer's disease is characterised by a neurodegenerative neuroinflammatory process, but the etiopathogenetic mechanisms are still unclear. The possible infectious aetiology and potential involvement of Herpes viruses as triggers for the formation of extracellular deposits of amyloid beta (Aβ) peptide (amyloid plaques) and intraneuronal aggregates of hyperphosphorylated and misfold could be a possible explanation. In fact, the possible genetic interference of Herpes viruses with the genome of the host neuronal cell or the stimulation of the infection to a continuous immune response with a consequent chronic inflammation could constitute those mechanisms underlying the development of AD, with possible implications in the understanding and management of the disease...
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38782605/sars-cov-2-periodontal-pathogens-and-host-factors-the-trinity-of-oral-post-acute-sequelae-of-covid-19
#12
REVIEW
Joel Schwartz, Kristelle J Capistrano, Joseph Gluck, Armita Hezarkhani, Afsar R Naqvi
COVID-19 as a pan-epidemic is waning but there it is imperative to understand virus interaction with oral tissues and oral inflammatory diseases. We review periodontal disease (PD), a common inflammatory oral disease, as a driver of COVID-19 and oral post-acute-sequelae conditions (PASC). Oral PASC identifies with PD, loss of teeth, dysgeusia, xerostomia, sialolitis-sialolith, and mucositis. We contend that PD-associated oral microbial dysbiosis involving higher burden of periodontopathic bacteria provide an optimal microenvironment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38747622/global-seroprevalence-and-prevalence-of-infection-of-influenza-in-dogs-canis-familiaris-a-systematic-review-and-meta-analysis
#13
REVIEW
Char Leung, Amy Nishio King, Phoebe Rosemary Alice Barker, Abdulwahab Dhari Alshallal, Jia Yi Lee, Li Su
Influenza in dogs holds considerable public health significance due to their close companionship with humans, yet several facets of this phenomenon remain largely unexplored. This study undertook a systematic review and meta-analysis of observational studies to gauge the global seroprevalence of influenza in dogs. We also assessed whether pet dogs exhibited a higher seroprevalence of influenza compared to non-pet dogs, explored seasonal variations in seroprevalence, scrutinised the design and reporting standards of existing studies, and elucidated the geographical distribution of canine influenza virus (cIV)...
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38743385/transmission-dynamics-complications-and-mitigation-strategies-of-the-current-mpox-outbreak-a-comprehensive-review-with-bibliometric-study
#14
REVIEW
Ranjan K Mohapatra, Puneet K Singh, Francesco Branda, Snehasish Mishra, L V Simhachalam Kutikuppala, Tarun K Suvvari, Venkataramana Kandi, Azaj Ansari, Dhruv N Desai, Mubarak Alfaresi, Nawal A Al Kaabi, Mona A Al Fares, Mohammed Garout, Muhammad A Halwani, Mohammed Alissa, Ali A Rabaan
As the mankind counters the ongoing COVID-19 pandemic by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), it simultaneously witnesses the emergence of mpox virus (MPXV) that signals at global spread and could potentially lead to another pandemic. Although MPXV has existed for more than 50 years now with most of the human cases being reported from the endemic West and Central African regions, the disease is recently being reported in non-endemic regions too that affect more than 50 countries...
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38719789/potential-therapeutic-strategies-to-halt-viral-neuroinvasion
#15
REVIEW
Luping Zhang, Usama Ashraf, Huanchun Chen, Shengbo Cao, Jing Ye
The viral infection of the central nervous system is a significant public health concern. So far, most clinical cases of viral neuroinvasion are dealt with supportive and/or symptomatic treatments due to the unavailability of specific treatments. Thus, developing specific therapies is required to alleviate neurological symptoms and disorders. In this review, we shed light on molecular aspects of viruses' entry into the brain which upon targeting with specific drugs have shown promising efficacy in vitro and in preclinical in vivo model systems...
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38708846/prevalence-and-factors-associated-with-viral-non-suppression-in-people-living-with-hiv-receiving-antiretroviral-therapy-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#16
REVIEW
Idda H Mosha, Goodluck G Nyondo, Castory G Munishi, Belinda J Njiro, George M Bwire
Despite advances in HIV treatment, the burden of viral non-suppression (VNS) remains a treatment success concern, particularly in Sub-Saharan African (SSA) countries. We determined the prevalence and factors associated with VNS for people living with HIV (PLHIV) receiving antiretroviral therapy (ART). This review, registered with PROSPERO (CRD42023470234), conducted an extensive search for evidence, focusing on PLHIV living in SSA on ART from the year 2000 to 19th October 2023, across databases including PubMed/MEDLINE, Embase, Web of Science, and Scopus...
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38666757/human-papillomavirus-infection-epidemiology-biology-host-interactions-cancer-development-prevention-and-therapeutics
#17
REVIEW
Jonas Wolf, Lucas Felipe Kist, Samanta Brangel Pereira, Marilze Alves Quessada, Helena Petek, Arthur Pille, Juçara Gasparetto Maccari, Mohamed Parrini Mutlaq, Luiz Antonio Nasi
Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections worldwide. It is caused by the HPV, a DNA virus that infects epithelial cells in various mucous membranes and skin surfaces. HPV can be categorised into high-risk and low-risk types based on their association with the development of certain cancers. High-risk HPV types, such as HPV-16 and HPV-18, are known to be oncogenic and are strongly associated with the development of cervical, anal, vaginal, vulvar, penile, and oropharyngeal cancers...
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38658176/serious-neurological-adverse-events-in-immunocompetent-children-and-adolescents-caused-by-viral-reactivation-in-the-years-following-varicella-vaccination
#18
REVIEW
Prashanth Ramachandran, Charles Grose
Serious adverse events following vaccination include medical complications that require hospitalisation. The live varicella vaccine that was approved by the Food and Drug Administration in the United States in 1995 has an excellent safety record. Since the vaccine is a live virus, adverse events are more common in immunocompromised children who are vaccinated inadvertently. This review includes only serious adverse events in children considered to be immunocompetent. The serious adverse event called varicella vaccine meningitis was first reported in a hospitalised immunocompetent child in 2008...
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38635404/passive-immunotherapies-for-the-next-influenza-pandemic
#19
REVIEW
Daniele Focosi, Massimo Franchini, Jonathon W Senefeld, Michael J Joyner, David J Sullivan, Andrew Pekosz, Fabrizio Maggi, Arturo Casadevall
Influenzavirus is among the most relevant candidates for a next pandemic. We review here the phylogeny of former influenza pandemics, and discuss candidate lineages. After briefly reviewing the other existing antiviral options, we discuss in detail the evidences supporting the efficacy of passive immunotherapies against influenzavirus, with a focus on convalescent plasma.
May 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38610091/modulation-of-immune-responses-in-the-central-nervous-system-by-zika-virus-west-nile-virus-and-dengue-virus
#20
REVIEW
Shuhui Wu, Ting Zhang, Weidong Qiang, Yang Yang
Arthropod-borne viruses (arboviruses) pose significant threats to global public health by causing a spectrum of diseases ranging from mild febrile illnesses to severe neurological complications. Understanding the intricate interplay between arboviruses and the immune system within the central nervous system is crucial for developing effective strategies to combat these infections and mitigate their neurological sequelae. This review comprehensively explores the mechanisms by which arboviruses such as Zika virus, West Nile virus, and Dengue virus manipulate immune responses within the CNS, leading to diverse clinical manifestations...
May 2024: Reviews in Medical Virology
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