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European Psychiatry: the Journal of the Association of European Psychiatrists

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https://read.qxmd.com/read/30769239/illness-representations-among-parents-of-children-and-adults-with-serious-mental-disorders-a-systematic-review-and-theoretical-model
#1
Ilanit Hasson-Ohayon, Gil Goldzweig, Adi Lavi-Rotenberg, David Roe, Gerdina Hendrika Maria Pijnenborg
OBJECTIVE: Cognitive representations of an illness have an important impact on psychological outcomes. The current systematic review explored 1) the characteristics of illness representations held by parents of children and adults with serious mental illness (SMI), and 2) the associations of these representations with both parents' and patients' psychological outcomes. METHOD: PSYINFO and PUBMED were screened for eligible studies published between January 2000 and August 2018...
February 12, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30763828/duration-of-untreated-illness-and-response-to-sri-treatment-in-obsessive-compulsive-disorder
#2
Umberto Albert, Francesca Barbaro, Stefano Bramante, Gianluca Rosso, Diana De Ronchi, Giuseppe Maina
BACKGROUND: The duration of untreated illness (DUI) is a potentially modifiable parameter associated with worst prognosis in several psychiatric disorders, but poorly investigated in Obsessive-Compulsive Disorder (OCD). Our aims were to estimate the mean DUI in a large sample of individuals with OCD and its impact on response to the first ever adequate SRI treatment. METHODS: We retrospectively examined records of 251 patients with OCD (SCID-I, DSM-IV) who referred to our Department and were prospectively and naturalistically treated according to International Guidelines...
February 11, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30743239/child-maltreatment-is-mediating-long-term-consequences-of-household-dysfunction-in-a-population-representative-sample
#3
Vera Clemens, Oliver Berthold, Andreas Witt, Cedric Sachser, Elmar Brähler, Paul L Plener, Bernhard Strauß, Jörg M Fegert
BACKGROUND: Adverse childhood experiences (ACE) exhibit long-lasting consequences on later life and are considered as a major public health problem. ACEs can be divided into household dysfunctions, which affect the child indirectly, and direct maltreatment. As a high correlation between ACEs in general is known, we assessed the risk for child maltreatment associated with the occurrence of household dysfunctions. To provide a better understanding for the mechanisms leading to the deleterious sequelae of ACEs, we furthermore assessed whether the long-term consequences of household dysfunction are mediated by child maltreatment and thereby might be targeted by effective child protection programs...
February 8, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30738380/the-efficacy-of-cariprazine-in-negative-symptoms-of-schizophrenia-post-hoc-analyses-of-panss-individual-items-and-panss-derived-factors
#4
Wolfgang Fleischhacker, Silvana Galderisi, István Laszlovszky, Balázs Szatmári, Ágota Barabássy, Károly Acsai, Erzsébet Szalai, Judit Harsányi, Willie Earley, Mehul Patel, György Németh
BACKGROUND: Negative symptoms in schizophrenia are heterogeneous and multidimensional; effective treatments are lacking. Cariprazine, a dopamine D3 -preferring D3 /D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, was significantly more effective than risperidone in treating negative symptoms in a prospectively designed trial in patients with schizophrenia and persistent, predominant negative symptoms. METHODS: Using post hoc analyses, we evaluated change from baseline at week 26 in individual items of the Positive and Negative Syndrome Scale (PANSS) and PANSS-derived factor models using a mixed-effects model for repeated measures (MMRM) in the intent-to-treat (ITT) population (cariprazine = 227; risperidone = 227)...
February 6, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30721802/the-pharmacological-management-of-agitated-and-aggressive-behaviour-a-systematic-review-and-meta-analysis
#5
Maarten Bak, Irene Weltens, Chris Bervoets, Jürgen De Fruyt, Jerzy Samochowiec, Andrea Fiorillo, Gaia Sampogna, Przemyslaw Bienkowski, W Ulrich Preuss, Blazej Misiak, Dorota Frydecka, Agnieszka Samochowiec, Emma Bak, Marjan Drukker, Geert Dom
INTRODUCTION: Non-pharmacological interventions preferably precede pharmacological interventions in acute agitation. Reviews of pharmacological interventions remain descriptive or compare only one compound with several other compounds. The goal of this study is to compute a systematic review and meta-analysis of the effect on restoring calmness after a pharmacological intervention, so a more precise recommendation is possible. METHOD: A search in Pubmed and Embase was done to isolate RCT's considering pharmacological interventions in acute agitation...
February 2, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30721801/hippocampal-subfield-volumes-in-major-depressive-disorder-and-bipolar-disorder
#6
Kyu-Man Han, Aram Kim, Wooyoung Kang, Youbin Kang, June Kang, Eunsoo Won, Woo-Suk Tae, Byung-Joo Ham
BACKGROUND: The hippocampus is not a uniform structure, but rather consists of multiple, functionally specialized subfields. Few studies have explored hippocampal subfield volume difference in the same sample of major depressive disorder (MDD) and bipolar disorder (BD) cases. We aimed to investigate the difference of hippocampal subfield volume between patents with MDD and BD and healthy controls (HCs). METHODS: A total of 102 MDD and 55 BD patients and 135 HCs were recruited and underwent T1-weighted image...
February 2, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30677550/developmental-cascades-of-internalising-symptoms-externalising-problems-and-cognitive-ability-from-early-childhood-to-middle-adolescence
#7
Eirini Flouri, Efstathios Papachristou, Emily Midouhas, George B Ploubidis, Glyn Lewis, Heather Joshi
BACKGROUND: Cognitive ability and problem behaviour (externalising and internalising problems) are variable and inter-related in children. However, it is not known if they mutually influence one another, if difficulties in one cause difficulties in the other, or if they are related only because they share causes. METHODS: Random-intercept cross-lagged models adjusted for confounding were fitted to explore this in 17,318 (51% male) children of the UK's Millennium Cohort Study at ages 3, 5, 7, 11 and 14 years...
January 21, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30677549/the-research-domain-criteria-rdoc-and-the-historical-roots-of-psychopathology-a-viewpoint
#8
Drozdstoy Stoyanov, Diogo Telles Correia, Bruce N Cuthbert
In this article we aim at conceptual reconstruction of the historical background behind RDoC project. It incorporates some elements that have not heretofore been included in frameworks for psychopathology research. At the same time, however, RDoC - like any approach to mental illness - must grapple with longstanding challenges in addressing issues about the roles and relationships of mind, brain, and patients' reports in considering the nature of disorder. In this respect, the historical roots of psychopathology remain as relevant as ever...
January 21, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30677548/characterization-of-mood-instability-through-bipolar-disorders-a-cluster-analytic-approach-using-weekly-prospective-life-chart-methodology
#9
A G Szmulewicz, D J Martino, S A Strejilevich
BackgroundThe aim of this study was to characterize mood instability (MI) in Bipolar Disorder (BD) and to investigate potential differences between subtype I and II. MethodsLife-charts from weekly mood ratings of 90 patients were used to compute: weeks spent with symptoms, number of episodes, and MI. Regression analyses were conducted to assess the relationship between BD subtype and MI adjusting by all potential confounding factors. Hierarchical cluster analysis was performed to determine the appropriate number of clusters that described the data and to assign subjects to a specific cluster based on their MI...
January 21, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30677547/il-10-is-associated-with-increased-mu-opioid-receptor-levels-in-major-depressive-disorder
#10
Suhaer Zeki Al-Fadhel, Hussein Kadhem Al-Hakeim, Arafat Hussein Al-Dujaili, Michael Maes
OBJECTIVE: Activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) and aberrations in endogenous opioids play a role in the pathophysiology of major depressive disorder (MDD). There are no studies which examined the associations between both systems in MDD. The aim of the present study was to examine the relation between β-Endorphin (β-EP), Endomorphin-2, and their mu-opioid receptor (MOR) as well as interleukin (IL)-6 and IL-10, an anti-inflammatory cytokine, in MDD patients...
January 21, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30658278/effectiveness-of-cbt-for-children-and-adolescents-with-depression-a-systematic-review-and-meta-regression-analysis
#11
Matthijs Oud, Lars de Winter, Evelien Vermeulen-Smit, Denise Bodden, Maaike Nauta, Lisanne Stone, Marieke van den Heuvel, Reham Al Taher, Ireen de Graaf, Tim Kendall, Rutger Engels, Yvonne Stikkelbroek
BACKGROUND: Cognitive-behavioral therapy (CBT) is first choice of treatment for depressive symptoms and disorders in adolescents, however improvements are necessary because overall efficacy is low. Insights on CBT components and contextual and structural characteristics might increase the efficacy. The aim of our approach is to evaluate the efficacy of CBT for youth with depression and investigate the influence of specific components, contextual and structural factors that could improve effects...
January 15, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30658277/unmet-needs-in-patients-with-brief-psychotic-disorders-too-ill-for-clinical-high-risk-services-and-not-ill-enough-for-first-episode-services
#12
Amedeo Minichino, Grazia Rutigliano, Sergio Merlino, Cathy Davies, Dominic Oliver, Andrea De Micheli, Rashmi Patel, Philip McGuire, Paolo Fusar-Poli
BACKGROUND: Patients with acute and transient psychotic disorders (ATPDs) are by definition remitting, but have a high risk of developing persistent psychoses, resembling a subgroup of individuals at Clinical High Risk for Psychosis (CHR-P). Their pathways to care, treatment offered and long-term clinical outcomes beyond risk to psychosis are unexplored. We conducted an electronic health record-based retrospective cohort study including patients with ATPDs within the SLaM NHS Trust and followed-up to 8 years...
January 15, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30658276/prevalence-of-late-life-depression-and-gap-in-mental-health-service-use-across-european-regions
#13
Katerina Horackova, Miloslav Kopecek, Vendula Machů, Anna Kagstrom, Dag Aarsland, Lucie Bankovska Motlova, Pavla Cermakova
Background We aimed to determine the prevalence and gap in use of mental health services for late-life depression in four European regions (Western Europe, Scandinavia, Southern Europe and Central and Eastern Europe) and explore socio-demographic, social and health-related factors associated with it. Methods We conducted a cross-sectional study based on data from the Survey on Health, Ageing and Retirement in Europe. Participants were a population-based sample of 28 796 persons (53% women, mean age 74 years old) residing in Europe...
January 15, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30658275/cost-effectiveness-analysis-of-collaborative-treatment-of-late-life-depression-in-primary-care-germanimpact
#14
Thomas Grochtdreis, Christian Brettschneider, Frederike Bjerregaard, Christiane Bleich, Sigrid Boczor, Martin Härter, Lars P Hölzel, Michael Hüll, Thomas Kloppe, Wilhelm Niebling, Martin Scherer, Iris Tinsel, Hans-Helmut König
BACKGROUND: Late-life depression is a highly prevalent disorder that causes a large economic burden. A stepped collaborative care program was set up in order to improve care for patients with late-life depression in primary care in Germany: GermanIMPACT is the adaption of the Improving Mood-Promoting Access to Collaborative Treatment (IMPACT) program that has already been established in primary care in the USA. The aim of this study was to determine the cost-effectiveness of GermanIMPACT compared with treatment as usual from a societal perspective...
January 15, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30658274/awareness-and-perceptions-of-clinical-guidelines-for-the-diagnostics-and-treatment-of-severe-behavioural-problems-in-children-across-europe-a-qualitative-survey-with-academic-experts
#15
Alexandra-Raluca Gatej, Audri Lamers, Lieke van Domburgh, Matty Crone, Terje Ogden, Daniel Rijo, Eeva Aronen, Ricardo Barroso, Dorret I Boomsma, Robert Vermeiren
BACKGROUND: Severe behavioural problems (SBPs1 ) in childhood are highly prevalent, impair functioning, and predict negative outcomes later in life. Over the last decade, clinical practice guidelines for SBPs have been developed across Europe to facilitate the translation of scientific evidence into clinical practice. This study outlines the results of an investigation into academic experts' perspectives on the current prevalence, implementation, and utility of clinical guidelines for SBPs in children aged 6-12 across Europe...
January 15, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30654319/the-utility-of-outpatient-commitment-reduced-risks-of-victimization-and-crime-perpetration
#16
Steven P Segal, Lachlan Rimes, Stephania L Hayes
BACKGROUND: Outpatient civil commitment (OCC) provisions, community treatment orders (CTOs) in Australia and Commonwealth nations, are part of mental health law worldwide. This study considers whether and by what means OCC provides statutorily required "needed-treatment" addressing two aspects of its legal mandate to protect the safety of self (exclusive of deliberate-self-harm) and others. METHOD: Over a 12.4-year period, records of hospitalized-psychiatric-patients, 11,424 with CTO-assignment and 16,161 without CTO-assignment were linked to police-records...
January 14, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30654318/attention-deficit-hyperactivity-disorder-symptoms-and-perceived-mental-health-discrimination-in-adults-in-the-general-population
#17
Andrew Stickley, Mall Leinsalu, Vladislav Ruchkin, Hans Oh, Zui Narita, Ai Koyanagi
BACKGROUND: The experience of discrimination is common in individuals with mental health problems and has been associated with a range of negative outcomes. As yet, however, there has been an absence of research on this phenomenon in adults with attention-deficit/hyperactivity disorder (ADHD). The current study examined the association between ADHD symptoms and mental health discrimination in the general adult population. METHODS: The analytic sample comprised 7274 individuals aged 18 and above residing in private households in England that were drawn from the Adult Psychiatric Morbidity Survey, 2007...
January 14, 2019: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30599337/the-mediating-role-of-borderline-personality-features-in-the-relationship-between-childhood-trauma-and-psychotic-like-experiences-in-a-sample-of-help-seeking-non-psychotic-adolescents-and-young-adults
#18
Mary Sengutta, Łukasz Gawęda, Steffen Moritz, Anne Karow
OBJECTIVE: Psychotic-like experiences (PLEs) often occur across different non-psychotic disorders in adolescent and young adult population and are related to early trauma. However, the mechanisms of how exposure to early trauma shapes the risk of PLEs are unclear. In our study, we investigated whether borderline personality features and further non-psychotic symptoms, i.e. factors related to both PLEs and childhood trauma, may mediate the relationship between childhood trauma and PLEs...
December 29, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30583254/predictors-of-personal-continuity-of-care-of-patients-with-severe-mental-illness-a-comparison-across-five-european-countries
#19
Pierre Smith, Pablo Nicaise, Domenico Giacco, Victoria Jane Bird, Michael Bauer, Mirella Ruggeri, Marta Welbel, Andrea Pfennig, Antonio Lasalvia, Jacek Moskalewicz, Stefan Priebe, Vincent Lorant
BACKGROUND: In Europe, at discharge from a psychiatric hospital, patients with severe mental illness may be exposed to one of two main care approaches: personal continuity, where one clinician is responsible for in- and outpatient care, and specialisation, where various clinicians are. Such exposure is decided through patient-clinician agreement or at the organisational level, depending on the country's health system. Since personal continuity would be more suitable for patients with complex psychosocial needs, the aim of this study was to identify predictors of patients' exposure to care approaches in different European countries...
December 21, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/30530103/predicting-suicidal-ideation-by-interpersonal-variables-hopelessness-and-depression-in-real-time-an-ecological-momentary-assessment-study-in-psychiatric-inpatients-with-depression
#20
N Hallensleben, H Glaesmer, T Forkmann, D Rath, M Strauss, A Kersting, L Spangenberg
OBJECTIVE: To extend evidence on the short-term variability of passive and active suicidal ideation (SI) and the association with suggested proximal risk factors such as interpersonal variables (perceived burdensomeness [PB], thwarted belongingness [TB], hopelessness, and depression) in real-time. METHODS: This is an observational study using a prospective design applying ecological momentary assessments (EMA). Eligible for study inclusion were inpatients with unipolar depression, current or lifetime suicidal ideation, and fluent German...
December 5, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
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