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Journals International Journal of Gynec...

International Journal of Gynecological Cancer

https://read.qxmd.com/read/36928097/poly-adp-ribose-polymerase-inhibitors-parpi-in-ovarian-cancer-lessons-learned-and-future-directions
#1
REVIEW
Giuseppe Caruso, Federica Tomao, Gabriella Parma, Mariateresa Lapresa, Francesco Multinu, Innocenza Palaia, Giovanni Aletti, Nicoletta Colombo
Poly (ADP-ribose) polymerase inhibitors (PARPi) represent a new standard of care in the upfront treatment of advanced epithelial ovarian cancer to the point that the vast majority of patients now receive a PARPi, alone or in combination with the anti-angiogenic bevacizumab, as part of their first-line maintenance therapy. The clinical benefit of PARPi is well established; however, much has changed since their introduction and several relevant questions have been raised and remain unresolved in the post-PARPi era...
March 16, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36918227/human-papillomavirus-hpv-vaccination-a-call-for-action-in-italy
#2
REVIEW
Giorgio Bogani, Alessandro Ghelardi, Francesco Sopracordevole, Marco Annoni, Andrea Ciavattini, Luca Giannella, Rosa De Vincenzo, Paolo Cattani, Maggiorino Barbero, Paolo Vercellini, Francesco Raspagliesi, Paolo Bonanni, Giovanni Scambia
Human papillomavirus (HPV) is the most common sexually transmitted infection. The implementation of primary prevention aims to reduce the burden of HPV infection and HPV-related disease. However, HPV-related diseases are still a concern, even in high-income countries. Approximately 570 000 new cervical cancer cases are diagnosed in Italy every year. Prophylactic HPV vaccines have been developed to minimize the spread of HPV. Growing evidence supports the administration of HPV vaccines (even just one dose) in reducing the prevalence of HPV infection and HPV-related disease including cancers...
March 14, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36914172/predictive-factors-of-sentinel-lymph-node-failed-mapping-in-endometrial-carcinoma-patients-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Antonio Raffone, Francesco Fanfani, Diego Raimondo, Giulia Rovero, Federica Renzulli, Antonio Travaglino, Umberto De Laurentiis, Angela Santoro, Gian Franco Zannoni, Paolo Casadio, Giovanni Scambia, Renato Seracchioli, Antonio Mollo
OBJECTIVE: In endometrial carcinoma patients, sentinel lymph node bilateral mapping fails in 20-25% of cases, with several factors affecting the likelihood of detection. However, pooled data about predictive factors of failure are lacking. The aim of this systematic review and meta-analysis was to assess the predictive factors of sentinel lymph node failed mapping in endometrial cancer patients undergoing sentinel lymph node biopsy. METHODS: A systematic review and a meta-analysis was performed searching all studies assessing predictive factors of sentinel lymph node failed mapping in apparent uterine-confined endometrial cancer patients undergoing sentinel lymph node biopsy through the cervical injection of indocyanine green...
March 13, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36914171/quality-assurance-in-human-papillomavirus-testing-for-primary-cervical-screening
#4
REVIEW
Kate Cuschieri, María Dolores Fellner, Laila Sara Arroyo Mühr, Elizaveta Padalko, Rita Mariel Correa, Joakim Dillner, Murat Gultekin, Maria Alejandra Picconi
The recommendation for cervical screening is that it should be based on human papillomavirus (HPV) molecular testing. For all screening programs, attention to quality assurance is required to fully realize the benefits. Internationally recognized quality assurance recommendations for HPV-based screening are needed that are ideally applicable for a variety of settings, including in low- and middle-income countries. We summarize the main points of quality assurance for HPV screening, with a focus on the selection, implementation, and use of an HPV screening test, quality assurance systems (including internal quality control and external quality assessment), and staff competence...
March 13, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36914170/impact-of-lymphadenectomy-and-intra-operative-tumor-rupture-on-survival-in-early-stage-mucinous-ovarian-cancers
#5
JOURNAL ARTICLE
Soyoun Rachel Kim, Ainhoa Madariaga, Liat Hogen, Danielle Vicus, Allan Covens, Carlos Parra-Herran, Stephanie Lheureux, Lilian T Gien
OBJECTIVE: Mucinous ovarian carcinoma is a rare subtype of epithelial ovarian cancer with scarce literature guiding its management. We aimed to investigate the optimal surgical management of clinical stage I mucinous ovarian carcinoma by examining the prognostic significance of lymphadenectomy and intra-operative rupture on patient survival. METHODS: We conducted a retrospective cohort study of all pathology-reviewed invasive mucinous ovarian carcinomas diagnosed between 1999 and 2019 at two tertiary care cancer centers...
March 13, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36914169/the-asia-pacific-gynecologic-oncology-trials-group-apgot-building-a-pan-asian-and-oceania-women-s-cancer-research-organization
#6
JOURNAL ARTICLE
David Tan, Noriko Fujiwara, Keiichi Fujiwara, Philip Beale, Jae-Weon Kim, Joseph Ng, Se Ik Kim, Alison Evans, Byoung-Gie Kim
No abstract text is available yet for this article.
March 13, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36898701/can-simple-hysterectomy-replace-radical-hysterectomy-as-treatment-of-early-stage-cervical-cancer
#7
JOURNAL ARTICLE
Andreas Obermair, Rene Pareja
No abstract text is available yet for this article.
March 10, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36898700/the-necessity-to-adhere-to-evidence-based-indications-for-hyperthermic-intraperitoneal-chemotherapy-hipec-in-patients-with-ovarian-cancer
#8
JOURNAL ARTICLE
Donal J Brennan, Willemien J van Driel, Oliver Zivanovic
No abstract text is available yet for this article.
March 10, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36898699/uterine-smooth-muscle-tumors-with-uncertain-malignant-potential-analysis-following-fertility-saving-procedures
#9
JOURNAL ARTICLE
Adela Richtarova, Barbora Boudova, Pavel Dundr, Zdenka Lisa, Kristyna Hlinecka, Zdenek Zizka, Filip Fruhauf, David Kuzel, Jiri Slama, Michal Mara
OBJECTIVE: The aim of this study was to analyze the clinical and reproductive outcomes of patients treated with myomectomy who were histologically diagnosed with uterine smooth muscle tumor of uncertain malignant potential (STUMP). METHODS: Patients who were diagnosed with STUMP and underwent a myomectomy at our institution between October 2003 and October 2019 were identified. Variables of interest obtained from the institution's database included patient age, relevant medical history, pre-operative appearance of the tumor on ultrasound, parameters of the surgical procedure, histopathological analysis of the tumor, post-operative clinical course, and course of follow-up, including reinterventions and fertility outcomes...
March 10, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36898698/the-modified-5-item-frailty-index-is-a-predictor-of-post-operative-complications-in-vulvar-cancer-a-national-surgical-quality-improvement-program-nsqip-analysis
#10
JOURNAL ARTICLE
Monica D Levine, Ashley S Felix, Caitlin E Meade, Kristin L Bixel, Laura M Chambers
OBJECTIVE: To determine whether frailty is associated with post-operative complications following surgery for vulvar cancer. METHODS: This retrospective study used a multi-institutional dataset from the National Surgical Quality Improvement Program (NSQIP) database (2014-2020) to analyze the relationship between frailty, procedure type, and post-operative complications. Frailty was determined using the modified frailty index-5 (mFI-5). Univariate and multivariable-adjusted logistic regression analyses were performed...
March 10, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36898697/prehabilitation-in-an-eras-program-for-endometrial-cancer-patients-impact-on-post-operative-recovery
#11
JOURNAL ARTICLE
Ester Miralpeix, Berta Fabregó, Cristina Rodriguez-Cosmen, Josep-Maria Solé-Sedeño, Sonia Gayete, David Jara-Bogunya, Marta Corcoy, Gemma Mancebo
OBJECTIVES: Enhanced recovery after surgery (ERAS) and prehabilitation programs are multidisciplinary care pathways that aim to reduce stress response and improve perioperative outcomes. However, literature is limited regarding the impact of ERAS and prehabilitation in gynecologic oncology surgery. The aim of this study was to assess the impact of implementing an ERAS and prehabilitation program on post-operative outcomes of endometrial cancer patients undergoing laparoscopic surgery...
March 10, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36889817/esgo-prevention-committee-opinion-is-a-single-dose-of-hpv-vaccine-good-enough
#12
JOURNAL ARTICLE
Mustafa Onur Kamani, Maria Kyrgiou, Elmar Joura, Ignacio Zapardiel, Mihaela Grigore, Marc Arbyn, Mario Preti, François Planchamp, Murat Gultekin
No abstract text is available yet for this article.
March 8, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36889816/frequency-of-actionable-germline-pathogenic-variants-identified-through-tumor-next-generation-sequencing-in-a-gynecologic-cancer-cohort
#13
JOURNAL ARTICLE
Hannah Karpel, Elizabeth Manderski, Bhavana Pothuri
BACKGROUND: Tumor next-generation sequencing can identify potential germline pathogenic variants associated with cancer susceptibility. OBJECTIVE: To describe the frequency of tumor sequencing results that met European Society of Medical Oncology (ESMO) recommendations for further germline genetic testing, and the frequency of germline variants among a cohort with gynecologic cancer. METHODS: Patients with gynecologic cancer who underwent tumor sequencing between September 2019 and February 2022 in a large healthcare system in New York City were retrospectively identified...
March 8, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36863760/secondary-validation-of-an-ovarian-cancer-specific-comorbidity-index-in-a-us-population
#14
JOURNAL ARTICLE
Chelsey Vranes, Hui Zhao, Mette Calundann Noer, Shuangshuang Fu, Charlotte C Sun, Ross Harrison, Pedro T Ramirez, Claus Kim Høgdall, Sharon H Giordano, Larissa A Meyer
OBJECTIVES: The Ovarian Cancer Comorbidity Index (OCCI) is an age-specific index developed and previously found to be more predictive of overall and cancer-specific survival than the Charlson Comorbidity Index (CCI). The objective was to perform secondary validation of the OCCI in a US population. METHODS: A cohort of ovarian cancer patients undergoing primary or interval cytoreductive surgery from January 2005 to January 2012 was identified in SEER-Medicare. OCCI scores were calculated with the regression coefficients determined from the original developmental cohort for five comorbidities...
March 2, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36822657/pet-mri-for-evaluation-of-response-to-radiochemotherapy-in-patients-with-locally-advanced-cervical-cancer
#15
JOURNAL ARTICLE
Ariane Weyl, Charlotte Chollet, Erwan Gabiache, Valérie Cancès-Lauwers, Franklin Gallo, Alejandra Martinez, Frederic Courbon, Pierre Leguevaque, Isabelle Brenot Rossi, Aurélie Jalaguier, Eric Lambaudie, Elodie Chantalat, Stephanie Motton
OBJECTIVE: We aimed to analyze the diagnostic test accuracy of positron emission tomography and a magnetic resonance imaging scan (PET-MRI) fusion in evaluating tumor response after radiochemotherapy in patients with locally advanced cervical cancer. METHODS: Patients treated at two institutes between January 2008 and December 2016 were studied retrospectively. Re-evaluation by positron emission tomography (PET) and magnetic resonance imaging (MRI) was performed in a non-concurrent way 4-8 weeks after treatment...
February 23, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36822656/an-advantageous-technique-for-fertility-sparing-staging-surgery-of-epithelial-ovarian-cancer-with-a-single-umbilical-incision
#16
JOURNAL ARTICLE
Yu Chen, Ying Zheng, Sijing Chen, Shiyi Peng
No abstract text is available yet for this article.
February 23, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36810232/opioid-and-benzodiazepine-use-in-gynecologic-oncology-patients
#17
JOURNAL ARTICLE
Khrystyna Levytska, Savannah R Pena, Jubilee Brown, Ziqing Yu, Meghan K Wally, Joseph R Hsu, Rachel B Seymour, Wendel Naumann
OBJECTIVE: The goals of this study were to describe opioid and benzodiazepine prescribing practices in the gynecologic oncology patient population and determine risks for opioid misuse in these patients. METHODS: Retrospective study of opioid and benzodiazepine prescriptions for patients treated for cervical, ovarian (including fallopian tube/primary peritoneal), and uterine cancers within a single healthcare system from January 2016 to August 2018. RESULTS: A total of 7643 prescriptions for opioids and/or benzodiazepines were dispensed to 3252 patients over 5754 prescribing encounters for cervical (n=2602, 34...
February 21, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36808044/beyond-post-operative-readmissions-analysis-of-the-impact-of-unplanned-readmissions-during-primary-treatment-of-advanced-stage-epithelial-ovarian-cancer-on-long-term-oncology-outcome
#18
JOURNAL ARTICLE
Dandi Huang, Ross Harrison, Erin Curtis, Nina Mirabadi, Grace Yi Chen, Roxana Alexandridis, Lisa Barroilhet, Stephen Rose, Ellen Hartenbach, Ahmed Al-Niami
BACKGROUND: Multiple studies have assessed post-operative readmissions in advanced ovarian cancer. OBJECTIVE: To evaluate all unplanned readmissions during the primary treatment period of advanced epithelial ovarian cancer, and the impact of readmission on progression-free survival. METHODS: This was a single institution retrospective study from January 2008 to October 2018. Χ2 /Fisher's exact and t-test, or Kruskal-Wallis test were used...
February 17, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36796862/oncological-outcomes-among-young-women-with-non-epithelial-ovarian-cancer-the-yoc-care-study-young-ovarian-cancer-care
#19
JOURNAL ARTICLE
Lucas Minig, Myriam Gracia Segovia, Octavio Arencibia, Cristina Zorrero, Lola Marti, Virginia García Pineda, Juan Cespedes, Isabel Niguez, Blanca Gil-Ibanez, Berta Diaz-Feijoo, Soledad Fidalgo, Irene Valencia, Teodora Alonso-Gutierrez, Lorena Gonzalez, Amanda Veiga-Fernandez, Enrique Chacon, Isabel Negredo, Leticia Azcona Sutil, Mikel Gorostidi, Ignacio Zapardiel
OBJECTIVE: To determine oncological outcomes and associated prognostic factors in women younger than 45 years diagnosed with non-epithelial ovarian cancer. METHODS: A retrospective, multicenter Spanish study was performed including women with non-epithelial ovarian cancer younger than 45 years between January 2010 and December 2019. All types of treatments and stages at diagnosis with at least 12 months of follow-up were collected. Women with missing data, epithelial cancers, borderline or Krukenberg tumors, and benign histology, as well as patients with previous or concomitant cancer, were excluded...
February 16, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/36792167/adverse-postoperative-outcomes-associated-with-perioperative-blood-transfusion-in-gynecologic-oncology-surgery
#20
JOURNAL ARTICLE
Brenna E Swift, Azusa Maeda, Geneviève Bouchard-Fortier
OBJECTIVE: To examine the incidence of perioperative blood transfusion and association with 30 day postoperative outcomes in gynecologic cancer surgery. METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was queried to identify all gynecologic oncology cases from 2013 to 2019. Clinical and surgical characteristics and 30 day postoperative complications were retrieved. The primary outcome was 30 day composite morbidity, based on the occurrence of one or more of the 18 adverse events...
February 15, 2023: International Journal of Gynecological Cancer
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