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International Journal of Gynecological Cancer

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https://read.qxmd.com/read/30992329/role-of-human-epididymis-protein-4-he4-in-detecting-recurrence-in-ca125-negative-ovarian-cancer-patients
#1
Francesco Plotti, Federica Guzzo, Teresa Schirò, Corrado Terranova, Carlo De Cicco Nardone, Roberto Montera, Daniela Luvero, Giuseppe Scaletta, Salvatore Lopez, Stella Capriglione, Pierluigi Benedetti Panici, Roberto Angioli
OBJECTIVE: There are no current guidelines regarding evaluation of patients with normal CA125 at initial diagnosis during routine surveillance after completion of treatment. Thus, the purpose of this study was to evaluate the role of human epididymis protein 4 (HE4) in the detection of recurrence in patients with ovarian cancer and a negative CA125 at diagnosis. METHODS: All patients with ovarian cancer with a negative CA125 referred to the Division of Gynecologic Oncology of the University Campus Bio-Medico of Rome were included in the study...
April 16, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30992328/patients-experience-and-compliance-with-extended-low-molecular-weight-heparin-prophylaxis-post-surgery-for-gynecological-cancer-a-prospective-observational-study
#2
Zibi Marchocki, Lucy Norris, Sharon O'Toole, Noreen Gleeson, Feras Abu Saadeh
OBJECTIVE: Gynaecological cancer patients have a high risk of developing venous thromboembolism (VTE). There is limited information on patient experience and compliance with an extended low molecular weight heparin prophylaxis in this setting. The aim of this study was to assess patient compliance, satisfaction and experience with the extended low molecular weight heparin prophylaxis after major surgery for gynaecological cancer. METHODS: This was a prospective observational study conducted in a large tertiary center for gynaecological cancer between July 2017-March 2018...
April 16, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30992327/early-stage-mucinous-carcinoma-infiltrative-type-of-the-ovary-and-fertility-preservation
#3
Maria Platero, Inigo Espinosa, Victor Vega Suarez, Antonio Gonzalez Martin, Luis Chiva
No abstract text is available yet for this article.
April 16, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30948429/working-together-to-eliminate-cervical-cancer-a-partnership-across-three-countries-as-mudan%C3%A3-as-no-mundo-s%C3%A3-o-criadas-por-n%C3%A3-s
#4
Mila Pontremoli Salcedo, Cesaltina Lorenzoni, Kathleen M Schmeler
No abstract text is available yet for this article.
April 3, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30948428/central-vietnam-needs-you
#5
Joseph Ng
No abstract text is available yet for this article.
April 3, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30923082/a-prospective-randomized-assessment-of-quality-of-life-between-open-and-robotic-hysterectomy-in-early-endometrial-cancer
#6
Evelyn Serreyn Lundin, Ninnie Borendal Wodlin, Lena Nilsson, Preben Kjölhede
OBJECTIVE: There are limited prospective data on the evaluation of quality of life in patients undergoing robotic hysterectomy for endometrial cancer. Our objective was to determine whether post-operative recovery differs between robotic and abdominal hysterectomy. METHODS: At a Swedish tertiary referral university hospital, 50 women with low-risk endometrial cancer scheduled for surgery between February 2012 and May 2016 were included in a randomized trial. Surgery was performed according to principles for minimal invasive surgery...
March 28, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30923081/utility-of-18f-fdg-pet-ct-imaging-in-patients-with-recurrent-gynecological-malignancies-prior-to-pelvic-exenteration
#7
Soyoun Rachel Kim, Yoo-Young Lee, Harinder Brar, Arianne Albert, Allan Covens, Ur Metser, Taymaa May
BACKGROUND: In patients with recurrent gynecologic malignancies isolated to the pelvis, pelvic exenteration is a potential option. 18F-Fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT), is often used to confirm no evidence of metastatic disease. OBJECTIVE: To assess the impact of PET/CT on clinical management of patients with recurrent gynecologic malignancies being considered for pelvic exenteration. METHODS: Patients with recurrent gynecological malignancies who underwent PET/CT imaging between 2011 and 2014 were identified...
March 28, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30917999/extraperitoneal-radical-trachelectomy-with-pelvic-lymphadenectomy
#8
Kotaro Shimura, Seiji Mabuchi
Radical trachelectomy combined with pelvic lymphadenectomy has been used to treat patients with early-stage cervical cancer who wish to preserve their fertility. Vaginal, abdominal, laparoscopic, and robotic approaches have been employed during this procedure, but all cause peritoneal damage, which could result in periadnexal adhesion. As periadnexal adhesion can lead to female infertility due to restricted sweeping of the fimbria over the ovary, it is important to minimize peritoneal damage during the fertility-preserving surgery...
March 26, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30898938/senticol-iii-an-international-validation-study-of-sentinel-node-biopsy-in-early-cervical-cancer-a-gineco-engot-gcig-and-multicenter-study
#9
Fabrice R Lecuru, Mary McCormack, Peter Hillemanns, Amelie Anota, Mario Leitao, Patrice Mathevet, Ronald Zweemer, Keiichi Fujiwara, Vanna Zanagnolo, Ane Gerda Zahl Eriksson, Emma Hudson, Gwenael Ferron, Marie Plante
BACKGROUND: Radical hysterectomy and complete pelvic lymphadenectomies are the most commonly performed procedures for women with early-stage cervical cancer. Sentinel lymph node (SLN) mapping could be an alternative to routine pelvic lymphadenectomy, aiming to diagnose accurately nodal extension and decrease lymphatic morbidity. PRIMARY OBJECTIVE: To compare 3-year disease-free survival and health-related quality of life after SLN biopsy or SLN biopsy + pelvic lymphadenectomy in early cervical cancer...
March 20, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30898937/compliance-with-enhanced-recovery-after-surgery-program-in-gynecology-are-all-items-of-equal-importance
#10
Basile Pache, Jonas Jurt, Fabian Grass, Martin Hübner, Nicolas Demartines, Patrice Mathevet, Chahin Achtari
INTRODUCTION: Enhanced recovery after surgery (ERAS) guidelines in gynecologic surgery are a set of multiple recommendations based on the best available evidence. However, according to previous studies, maintaining high compliance is challenging in daily clinical practice. The aim of this study was to assess the impact of compliance to individual ERAS items on clinical outcomes. METHODS: Retrospective cohort study of a prospectively maintained database of 446 consecutive women undergoing gynecologic oncology surgery (both open and minimally invasive) within an ERAS program from 1 October 2013 until 31 January 2017 in a tertiary academic center in Switzerland...
March 20, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30898936/american-society-of-anesthesiologists-physical-status-score-as-a-predictor-of-long-term-outcome-in-women-with-endometrial-cancer
#11
Anne Maarit Kolehmainen, Annukka Pasanen, Taru Tuomi, Riitta Koivisto-Korander, Mikko Loukovaara, Ralf Butzow
OBJECTIVE: To study the association of the American Society of Anesthesiologists (ASA) physical status score with long-term outcome in endometrial cancer. METHODS: Overall, disease-specific and non-cancer-related survival were estimated using simple and multivariable Cox regression analyses and the Kaplan-Meier method. RESULTS: A total of 1166 patients were included in the study. Median follow-up time was 76 (range 1-136) months. All-cause and non-cancer-related mortality were increased in patients whose ASA physical status score was III (HRs 2...
March 20, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30898935/characteristics-of-patients-with-cervical-cancer-during-pregnancy-a-multicenter-matched-cohort-study-an-initiative-from-the-international-network-on-cancer-infertility-and-pregnancy
#12
Michael J Halaska, Catherine Uzan, Sileny N Han, Robert Fruscio, Karina Dahl Steffensen, Ben Van Calster, Hana Stankusova, Martina Delle Marchette, Astrid Mephon, Roman Rouzier, Petronella O Witteveen, Patrizia Vergani, Kristina Van Calsteren, Lukas Rob, Frederic Amant
No abstract text is available yet for this article.
March 20, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30877144/guidelines-for-perioperative-care-in-gynecologic-oncology-enhanced-recovery-after-surgery-eras-society-recommendations-2019-update
#13
Gregg Nelson, Jamie Bakkum-Gamez, Eleftheria Kalogera, Gretchen Glaser, Alon Altman, Larissa A Meyer, Jolyn S Taylor, Maria Iniesta, Javier Lasala, Gabriel Mena, Michael Scott, Chelsia Gillis, Kevin Elias, Lena Wijk, Jeffrey Huang, Jonas Nygren, Olle Ljungqvist, Pedro T Ramirez, Sean C Dowdy
BACKGROUND: This is the first updated Enhanced Recovery After Surgery (ERAS) Society guideline presenting a consensus for optimal perioperative care in gynecologic/oncology surgery. METHODS: A database search of publications using Embase and PubMed was performed. Studies on each item within the ERAS gynecologic/oncology protocol were selected with emphasis on meta-analyses, randomized controlled trials, and large prospective cohort studies. These studies were then reviewed and graded according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system...
March 15, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30850437/therapeutic-value-of-selective-lymphadenectomy-in-interval-debulking-surgery-for-stage-iiic-and-iv-epithelial-ovarian-cancer
#14
Nan Song, Yunong Gao
OBJECTIVE: The role of selective lymphadenectomy at the time of interval debulking surgery in patients with advanced ovarian cancer remains a topic of debate. This study aimed to evaluate the value of selective lymphadenectomy during interval debulking surgery in patients with radiologic evidence of lymph node metastasis at initial diagnosis that ultimately become negative on imaging after neoadjuvant chemotherapy. METHODS: A retrospective analysis including patients with stage IIIC-IV epithelial ovarian cancer and suspicious pelvic or para-aortic lymph node metastasis by imaging at diagnosis that resolved after neoadjuvant chemotherapy...
March 7, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30839285/brca1-associated-and-sporadic-ovarian-carcinomas-outcomes-of-primary-cytoreductive-surgery-or-neoadjuvant-chemotherapy
#15
Tatyana Gorodnova, Anna Sokolenko, Valeria Ni, Alexandr Ivantsov, Khristina Kotiv, Sergey Petrik, Inna Amelina, Igor Berlev, Evgeny Imyanitov
OBJECTIVE: Tumors arising in BRCA1/2 mutation carriers are characterized by increased platinum sensitivity; however, it is unknown whether this feature should be considered while choosing between primary surgical versus systemic treatment. This study aimed to compare outcomes of ovarian cancer patients undergoing either primary surgery or interval cytoreduction based on BRCA1/2 status. METHODS: The study included consecutive ovarian cancer patients, who were treated at the N...
March 5, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30839284/oncologic-outcomes-after-secondary-surgery-in-recurrent-clear-cell-carcinoma-of-the-ovary
#16
Hiroaki Kajiyama, Shiro Suzuki, Nobuhisa Yoshikawa, Michiyasu Kawai, Kiyosumi Shibata, Tetsuro Nagasaka, Fumitaka Kikkawa
OBJECTIVE: Complete tumor resection is considered essential in the management of patients with ovarian clear-cell carcinoma. There is a debate regarding whether patients with recurrent ovarian clear-cell carcinoma benefit from secondary cytoreductive surgery. METHODS: Details of patients with clear-cell carcinoma were collected by the Tokai Ovarian Tumor Study Group (Nagoya University Hospital and 13 affiliated institutions) and evaluated between January 1990 and December 2015...
March 5, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30826750/impact-of-treatment-duration-in-fertility-preserving-management-of-endometrial-cancer-or-atypical-endometrial-hyperplasia
#17
Yiqin Wang, Rong Zhou, Haibo Wang, Huixin Liu, Jianliu Wang
OBJECTIVE: Fertility preservation is an option for selected patients with endometrial hyperplasia or cancer. This study aimed to evaluate whether duration of treatment impacts the oncologic and reproductive outcomes. METHODS: We retrospectively reviewed patients diagnosed with endometrial cancer/atypical endometrial hyperplasia who underwent fertility-sparing treatment from January 2012 to December 2016. As the duration of treatment required by the patients was different, the patients who achieved a complete response were grouped according to the treatment duration as groups A (≤6 months), B (6-9 months), and C (>9 months)...
March 1, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30772826/impact-of-gene-specific-germline-pathogenic-variants-on-presentation-of-endometrial-cancer-in-lynch-syndrome
#18
Giorgio Bogani, Maria Teresa Ricci, Marco Vitellaro, Antonino Ditto, Valentina Chiappa, Francesco Raspagliesi
OBJECTIVE: Lynch syndrome is a risk factor for developing endometrial carcinoma. Our aim was to evaluate the impact of gene-specific germline pathogenic variants on clinical features of patients affected by endometrial cancer. METHODS: Patients with a diagnosis of endometrial cancer and with a germline pathogenic variant in mismatch repair genes were reviewed. Patients were classified on the basis of classes of risk according to the ESGO-ESGO-ESTRO (European Society of Medical Oncology/European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology) guidelines...
February 16, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30772825/localized-high-grade-endometrial-stromal-sarcoma-and-localized-undifferentiated-uterine-sarcoma-a-retrospective-series-of-the-french-sarcoma-group
#19
Marie Meurer, A Floquet, I Ray-Coquard, F Bertucci, M Auriche, A Cordoba, S Piperno-Neumann, S Salas, M Delannes, T Chevalier, A Italiano, J Y Blay, Julien Mancini, P Pautier, F Duffaud
OBJECTIVE: High grade endometrial stromal sarcoma and undifferentiated uterine sarcomas are associated with a very poor prognosis. Although large surgical resection is the standard of care, the optimal adjuvant strategy remains unclear. METHODS: A retrospective analysis of patients with localized high grade endometrial stromal sarcoma and undifferentiated uterine sarcomas (stages I-III) treated in 10 French Sarcoma Group centers was conducted. RESULTS: 39 patients with localized high grade endometrial stromal sarcoma and undifferentiated uterine sarcomas treated from 2008 to 2016 were included...
February 16, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30765489/international-radical-trachelectomy-assessment-irta-study
#20
Gloria Salvo, Pedro T Ramirez, Mario Leitao, David Cibula, Christina Fotopoulou, Ali Kucukmetin, Gabriel Rendon, Myriam Perrotta, Reitan Ribeiro, Marcelo Vieira, Glauco Baiocchi, Henrik Falconer, Jan Persson, Xiaohua Wu, Mihai Emil Căpilna, Nicolae Ioanid, Berit Jul Mosgaard, Igor Berlev, Dilyara Kaidarova, Alexander Babatunde Olawaiye, Kaijiang Liu, Silvana Pedra Nobre, Roman Kocian, Srdjan Saso, Stuart Rundle, Florencia Noll, Audrey Tieko Tsunoda, Kolbrun Palsdottir, Xiaoqi Li, Elena Ulrikh, Zhijun Hu, Rene Pareja
BACKGROUND: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy. PRIMARY OBJECTIVE: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy...
February 13, 2019: International Journal of Gynecological Cancer
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