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Nutrition, Metabolism, and Cardiovascular Diseases: NMCD

D-H Cho, M-N Kim, H J Joo, W J Shim, D-S Lim, S-M Park
BACKGROUND AND AIMS: Metabolic syndrome (MetS) is a cluster of multiple risk factors including central obesity that may lead to cardiac damage and cardiovascular events. We investigated whether visceral obesity induces cardiac structural and functional remodeling independently from central obesity and other risk factors in subjects with suspected MetS. METHODS AND RESULTS: We studied 229 participants with suspected MetS. Visceral fat area (VFA) was measured by bioelectrical impedance analysis...
January 29, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M Vinceti, R Chawla, T Filippini, C Dutt, S Cilloni, R Loomba, A Bargellini, N Orsini, K S Dhillon, P Whelton
BACKGROUND AND AIMS: Recent human and laboratory studies have suggested the possibility that selenium overexposure may increase blood pressure. We sought to ascertain whether adults living in a seleniferous area exhibit an association between selenium exposure and both blood pressure levels as well as prevalence of hypertension. METHODS AND RESULTS: We measured selenium levels in blood (serum), hair and nail samples obtained from 680 adult volunteers (267 men and 413 women), living in seven Punjabi villages in a seleniferous area and related them to health outcomes, including systolic and diastolic blood pressure and presence of hypertension...
January 24, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
H J Chen, S Y Chuang, H Y Chang, W H Pan
BACKGROUND AND AIMS: This study examined the association between macronutrient intake at different times of the day and blood lipid levels. METHODS AND RESULTS: The study was based on the Nutrition and Health Survey in Taiwan, a cross-sectional study of non-institutionalized and non-pregnant healthy adults (≥19-years-old). A one-day (24 h) dietary recall assessed participants' food intake. Fasting plasma triglycerides, total cholesterol, and high-density lipoprotein (HDL) cholesterol were determined...
January 14, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Massimo Sabbatini, L Ferreri, A Pisani, I Capuano, M Morgillo, A Memoli, E Riccio, B Guida
AIMS: The nutritional management of renal transplant recipients (RTR) represents a complex problem either because the recovery of renal function is not complete and for the appearance of "unavoidable" metabolic side effects of immunosuppressive drugs. Nevertheless, it remains a neglected problem, whereas an appropriate dietary intervention could favorably affect graft survival. DATA SYNTHESIS: Renal transplantation is associated with steroids and calcineurin inhibitors administration, liberalization of diet after dialysis restrictions, and patients' better quality of life...
January 12, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A W Willis, O N Brown, M W Greene
AIMS: To evaluate theory-based psychological approaches that have been effective in promoting behavior change in interventions promoting a Mediterranean style diet (MD) for the reduction of cardiovascular disease (CVD) risk. DATA SYNTHESIS: A systematic review of primary research articles using PRISMA recommendations was conducted. References were retrieved using keyword searches from MEDLINE via PUBMED and included studies targeted participants at high risk for CVD...
January 12, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
S Kim, M J Graham, R G Lee, L Yang, S Kim, V Subramanian, J D Layne, L Cai, R E Temel, D Shih, A J Lusis, J A Berliner, S Lee
BACKGROUND AND AIMS: Heparin-binding EGF-like growth factor (HB-EGF) is a representative EGF family member that interacts with EGFR under diverse stress environment. Previously, we reported that the HB-EGF-targeting using antisense oligonucleotide (ASO) effectively suppressed an aortic aneurysm in the vessel wall and circulatory lipid levels. In this study, we further examined the effects of the HB-EGF ASO administration on the development of hyperlipidemia-associated atherosclerosis using an atherogenic mouse model...
January 9, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
K Pertiwi, D E Kok, A J Wanders, J de Goede, P L Zock, J M Geleijnse
BACKGROUND AND AIMS: Population-based studies often use plasma fatty acids (FAs) as objective indicators of FA intake, especially for n-3 FA and linoleic acid (LA). The relation between dietary and circulating FA in cardiometabolic patients is largely unknown. We examined whether dietary n-3 FA and LA were reflected in plasma lipid pools in post-myocardial infarction (MI) patients. METHODS AND RESULTS: Patients in Alpha Omega Cohort filled out a 203-item food-frequency questionnaire from which eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and LA intake were calculated...
January 9, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
G De Pergola, V A Giagulli, E Guastamacchia, N Bartolomeo, R Tatoli, L Lampignano, F Silvestris, V Triggiani
BACKGROUND AND AIMS: A significant increase in platelet count may be a risk factor for atherosclerotic cardiovascular disease. This study investigates the association between platelet number and glucose metabolism, evaluated by glycated hemoglobin (HbA1c) levels, in a apparently healthy population represented by overweight and obese subjects with normal glucose and HbA1c levels. METHODS AND RESULTS: As many as 240 subjects, 177 women and 63 men, aged 18-70 years, were enrolled...
January 3, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M H Schernthaner-Reiter, B K Itariu, M Krebs, M Promintzer-Schifferl, T M Stulnig, A Tura, C H Anderwald, M Clodi, B Ludvik, G Pacini, A Luger, G Vila
BACKGROUND AND AIMS: Growth differentiation factor 15 (GDF15) is a strong predictor of cardiovascular morbidity and mortality found to be both marker and target of impaired glucose metabolism. GDF15 increases following glucose administration and is up-regulated in obesity and diabetes. We investigate here the relationship between GDF15 and beta cell function. METHODS AND RESULTS: In this cross-sectional study we evaluated GDF15 concentrations in 160 obese subjects (BMI 35-63 kg/m2 , age 39...
January 3, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
I Dicembrini, M Monami, E Mannucci
Dypeptidylpeptidase-4 (DPP-4) inhibitors are a therapeutic option for improving glucose control in patients with type 2 diabetes. They can be prescribed at different stages of the natural history of the disease because of their low risk for hypoglycemia and associated weight gain. For all new drugs for diabetes, the US Food and Drug Administration requires the demonstration of the cardiovascular (CV) safety profile through pooled analyses of phase 3 studies or specifically designed trials. A significant superiority over placebo has been observed with a sodium-dependent glucose transporter-2 inhibitor, empagliflozin, and two glucagon-like peptide-1 receptor agonists, liraglutide and semaglutide, thus suggesting cardioprotective effects for some antidiabetic drugs...
January 3, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
C Sayon-Orea, M Bes-Rastrollo, M Song, D Hang, F B Hu, L Ruiz-Estigarribia, M A Martinez-Gonzalez
AIMS: Our aim was to assess the association between trajectories of body-shape across the first 40 years of life and subsequent development of hypertension in a Mediterranean cohort. METHODS AND RESULTS: We used a group-based modeling approach to assess body shape trajectories from age 5 to 40 years, among 7514 participants included in the SUN study (1999-2016), and assessed the subsequent incidence of hypertension. To create the trajectories, we used a censored normal model as a polynomial function of age...
December 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Y Zhao, M Zhang, Y Liu, Z Yin, H Li, H Sun, C Wang, Y Ren, D Liu, C Cheng, F Liu, X Chen, L Liu, Q Zhou, Y Xiong, Q Xu, J Liu, S Hong, Z You, J Li, J Cao, J Huang, X Sun, D Hu
BACKGROUND AND AIMS: Elevated resting heart rate (RHR) is associated with risk of type 2 diabetes mellitus (T2DM). However, the association of change in RHR (ΔRHR) and incident T2DM is not fully elucidated. We aimed to assess the dose-response association between 6-year ΔRHR and T2DM. METHODS AND RESULTS: A total of 12155 non-T2DM participants ≥18 years old were enrolled during 2007-2008 and followed up during 2013-2014. ΔRHR was calculated by subtracting the baseline RHR from the RHR value at 6-year follow-up...
December 14, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
L Spatola, E Dozio
No abstract text is available yet for this article.
December 14, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
C Pelusi, P Altieri, A Gambineri, A Repaci, C Cavazza, F Fanelli, A M Morselli-Labate, U Pagotto, R Pasquali
BACKGROUND AND AIMS: Excess body weight (EBW) is the most prevalent nutritional disorder among adolescents worldwide. Identifying determinants of EBW may help find new intervention strategies. Behavioral, socio-economic, educational and demographic correlates of EBW were examined in a population of Italian adolescents, separately for males and females. METHODS AND RESULTS: As many as 1039 male and 2052 female students (aged 16-19 ys) attending the last three years of different types of high-school of the Emilia-Romagna region in Italy were offered participation, with 552 males and 841 females being finally evaluated...
December 8, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
F P Cappuccio, M Beer, P Strazzullo
The publication in the last few years of a number of prospective observational studies suggesting a J-shaped association between levels of salt (sodium) consumption and cardiovascular outcomes has opened a debate on the pertinence of population-wide salt reduction policies to reduce cardiovascular disease burden, and some have even questioned the global World Health Organization guidelines, that recommend a 30% reduction in salt consumption by 2025, aiming at an ideal target of no more than 5 g of salt consumption per day...
December 7, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M F Suárez-Ortegón, E Blanco, S McLachlan, J M Fernandez-Real, R Burrows, S H Wild, B Lozoff, S Gahagan
BACKGROUND AND AIM: Increased ferritin levels have been widely associated with cardiovascular risk in adults. Whether ferritin levels and their changes during childhood are related to metabolic syndrome (MetS) at adolescence is unknown. We aimed to evaluate these associations using levels of ferritin at 5, 10 and 16 years and their linear increases and patterns of sustained increased levels across childhood. METHODS AND RESULTS: There were four samples evaluated according to non-missing values for study variables at each stage (5 years: 562; 10 years: 381; and 16 years: 567 children; non-missing values at any stage: 379)...
December 4, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
E P B Dopona, V F Rocha, L N S Furukawa, I B Oliveira, J C Heimann
BACKGROUND AND AIMS: Although many studies have reported the effects of AT1 receptor on dietary salt overload, the role of AT2 receptor in this model is far from completely elucidated. The present study aimed to better understand the role of AT2 receptor in cardiac structure alterations in response to chronic high salt intake in rats. METHODS AND RESULTS: Male Wistar rats were fed a normal or high salt diet from weaning until 18 weeks of age. Both groups were subdivided into two groups...
December 2, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
H C G Nabuco, C M Tomeleri, P Sugihara Junior, R R Fernandes, E F Cavalcante, D Venturini, D S Barbosa, A M Silva, L B Sardinha, E S Cyrino
BACKGROUND AND AIM: Protein supplementation and resistance training (RT) are interventions that may counteract decline in muscle mass and increase in fat mass, thus reducing the risk of developing chronic diseases during the aging process. The objective of this study was to investigate the effect of whey protein (WP) pre- or post-RT on metabolic and inflammatory profile in pre-conditioned older women. METHODS AND RESULTS: Seventy older women participated in this investigation and were randomly assigned to one of three groups: WP pre-RT and placebo post-RT (WP-PLA, n = 24), placebo pre-RT and WP post-RT (PLA-WP, n = 23) and placebo pre and post-RT (PLA-PLA, n = 23)...
November 29, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A Tönjes, S Kralisch, A Hoffmann, D Schleinitz, J Kratzsch, M Blüher, M Stumvoll, P Kovacs, M Fasshauer, T Ebert
BACKGROUND AND AIMS: Pro-Neurotensin (NT), a stable surrogate parameter of NT, has recently been introduced as a peptide predicting the development of obesity, diabetes mellitus, cardiovascular diseases, and cardiovascular mortality. However, regulation of Pro-NT in gestational diabetes mellitus (GDM) remains uninvestigated. METHODS AND RESULTS: Pro-NT was quantified in 74 women with GDM, 74 healthy, gestational age-matched, pregnant controls, as well as in a second cohort comprising of 74 healthy, non-pregnant control women, using a chemiluminometric sandwich immunoassay...
January 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
C Chen, H Zhai, G Huang, J Cheng, F Xia, L Zhao, Y Chen, Y Chen, B Han, Q Li, B Jiang, N Wang, Y Lu
BACKGROUND AND AIMS: Therapeutic possibilities now exist to lower low-density lipoprotein cholesterol (LDL-C) to very low levels. However, substantial controversy remains in clinical practice with regard to its safety, and the question of whether low LDL-C levels per se may provoke adverse effects in humans arises. We aimed to explore the association of LDL-C with androgen and erectile dysfunction (ED) in a general population of men. METHODS AND RESULTS: A total of 4203 men without hormone replacement therapy were enrolled from 22 sites in East China...
December 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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