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International Journal of Methods in Psychiatric Research

David Daniel Ebert, Philippe Mortier, Fanny Kaehlke, Ronny Bruffaerts, Harald Baumeister, Randy P Auerbach, Jordi Alonso, Gemma Vilagut, Kalina U Martínez, Christine Lochner, Pim Cuijpers, Ann-Marie Kuechler, Jennifer Green, Penelope Hasking, Coral Lapsley, Nancy A Sampson, Ronald C Kessler
BACKGROUND: Although mental disorders and suicidal thoughts-behaviors (suicidal thoughts and behaviors) are common among university students, the majority of students with these problems remain untreated. It is unclear what the barriers are to these students seeking treatment. AIMS: The aim of this study is to examine the barriers to future help-seeking and the associations of clinical characteristics with these barriers in a cross-national sample of first-year college students...
May 9, 2019: International Journal of Methods in Psychiatric Research
Astrid Chevance, Florian Naudet, Raphaël Gaillard, Philippe Ravaud, Raphaël Porcher
OBJECTIVE: To evaluate the impact of controllable design factors on the power of antidepressants trials. METHODS: Using clinical trial simulation (CTS), we analyzed the combined impact on the power of trials of controllable design factors (sample size, outcome metrics, and disease severity at inclusion) and uncontrollable parameters (heterogeneity of diseases labeled "depression" in the source population and selective effects of drugs on items of the Hamilton Depression Rating Scale [HDRS], the most used outcome measurement tool)...
April 17, 2019: International Journal of Methods in Psychiatric Research
Linus Jönsson, Jacob Simonsen, Cecilia Brain, Steven Kymes, Louise Watson
OBJECTIVES: Treatment-resistant schizophrenia (TRS) is clinically defined as failure to respond to two antipsychotics of adequate dose and duration. An algorithm (registry TRS) was developed, for identifying patients with TRS in claim datasets from Sweden and the United States. METHODS: Schizophrenia (SZ) patients aged ≥13 years were identified in both datasets and matched to controls. Patients were identified as having TRS by use of the registry TRS or ≥1 prescription for clozapine or use of other published criteria...
April 7, 2019: International Journal of Methods in Psychiatric Research
Véronique S Grazioli, Joseph Studer, Mary E Larimer, Melissa A Lewis, Simon Marmet, Mélissa Lemoine, Jean-Bernard Daeppen, Gerhard Gmel
OBJECTIVE: The Protective Behavioral Strategies Scale (PBSS-20) is one of the most commonly used measures of engagement in protective behavioral strategies (PBS). This research aimed to examine the psychometric properties of a French and German version of the PBSS-20 in a large sample of young males in Switzerland. METHOD: The sample included 5,017 young males (mean age = 25.44) participating in the Cohort Study on Substance Use Risk Factors in Switzerland. Measures of PBS use, total drinks per week, and alcohol-related consequences were used from a second follow-up assessment...
March 7, 2019: International Journal of Methods in Psychiatric Research
Kiersten L Johnson, Sarah L Desmarais, Stephen J Tueller, Richard A Van Dorn
OBJECTIVES: Methodological limitations of extant research hinder the development of effective violence risk screening, assessment, and management strategies for adults with mental illness. This study quantifies the effects of three common limitations: (a) insensitive measurement of violence that results in violence classification with high levels of information bias, (b) use of cross-sectional data, and (c) use of data lacking spatiotemporal contiguity. METHODS: We utilize secondary data (N = 3,000 participants; N = 10,017 observations) and parametric and nonparametric bootstrap simulation methodologies...
February 27, 2019: International Journal of Methods in Psychiatric Research
In Hee Shim, Jonghun Lee, Moon-Doo Kim, Young-Eun Jung, Kyung Joon Min, Young-Joon Kwon, Ji Sun Kim, Kwanghun Lee, Young Sup Woo, Beomwoo Nam, Jeong Seok Seo, Jung Goo Lee, Duk-In Jon, Inki Sohn, Sung-Yong Park, Bo-Hyun Yoon, Won-Myong Bahk
OBJECTIVES: The purpose of this study was to evaluate the prevalence of mixed features using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and to examine how patients with mixed states would be classified using the DSM-5. METHODS: In total, 12 hospitals participated in this study, and data on the demographic characteristics and clinical diagnoses of patients treated between October 2013 and September 2016 were obtained. We reviewed the data for opposite-polarity symptoms according to the DSM-5 criteria and the research-based diagnostic criteria...
February 20, 2019: International Journal of Methods in Psychiatric Research
Marina Zeldovich, Rainer W Alexandrowicz
OBJECTIVES: The Clinical Outcome in Routine Evaluation-Outcome Measure (CORE-OM) is a freely accessible self-assessment questionnaire with a total of 34 items measuring the progress of psychological or psychotherapeutic treatments according to four scales (well-being, problems, functioning, and risk). The CORE-OM originated in the United Kingdom and has been translated into 54 languages and dialects. The aim of this study is to systematically compare the translated versions. METHOD: A total of 21 translations were compared using methods of systematic review and meta-analysis...
February 19, 2019: International Journal of Methods in Psychiatric Research
Krishnan Radhakrishnan, Mihaela Aslan, Kelly M Harrington, Robert H Pietrzak, Grant Huang, Sumitra Muralidhar, Kelly Cho, Rachel Quaden, David Gagnon, Saiju Pyarajan, Ning Sun, Hongyu Zhao, Michael Gaziano, John Concato, Murray B Stein, Joel Gelernter
OBJECTIVES: Heritability in the risk for developing posttraumatic stress disorder (PTSD) has been established, but most genome-wide association studies (GWASs) of PTSD involve relatively small sample sizes and limited identification of associated genetic loci. This report describes the methodology of a Veterans Affairs (VA) Cooperative Studies Program GWAS of PTSD among combat-exposed U.S. veterans. METHODS: Probable cases (with PTSD) and probable controls (without PTSD) were identified from among veterans enrolled in the VA Million Veteran Program (MVP) with an algorithm developed using questionnaire responses and electronic health record information...
February 14, 2019: International Journal of Methods in Psychiatric Research
Anna C Domen, Sjors C F van de Weijer, Monique W Jaspers, Damiaan Denys, Dorien H Nieman
OBJECTIVES: Cognitive impairment affects many psychiatric patients, influences daily functioning, and should be an important treatment focus. Assessment of cognitive status is crucial in cognitive remediation studies. However, current test batteries have limitations. A new, online tool, the MyCognition Quotient (MyCQ), was developed to assess cognition within 30 min. We present the psychometric properties and aim to determine the validity of the MyCQ by comparing it with the Cambridge Neuropsychological Automated Test Battery (CANTAB)...
February 13, 2019: International Journal of Methods in Psychiatric Research
Alvin Kuowei Tay, Susan Rees, Natalino Tam, Moses Kareth, Derrick Silove
OBJECTIVES: We report the testing and refinement of the Adaptive Stress Index (ASI), a psychosocial assessment tool designed to measure the longer terms stressors of adapting to the psychosocial disruptions experienced by refugees. METHODS: The ASI is based on a theoretical model, the Adaptation and Development After Persecution and Trauma (ADAPT), which postulates that five psychosocial domains are disrupted by conflict and displacement, namely, safety and security, attachment, access to justice, roles and identities, and existential meaning...
February 11, 2019: International Journal of Methods in Psychiatric Research
Emine R Ayvaci, David E Pollio, Jeffrey Sonis, Saira M Bhatti, Carol S North
OBJECTIVE: This study used mixed methods to investigate satisfaction with justice and desire for revenge in a sample of employees from New York City agencies affected by the 9/11 attacks on the World Trade Center. METHODS: A volunteer sample of 196 employees of eight affected agencies provided a short essay about what justice means to them in relation to the 9/11 attacks, followed by 20 quantitative questions covering personal experiences and perceptions of 9/11-related justice...
February 11, 2019: International Journal of Methods in Psychiatric Research
Cody Ding
OBJECTIVES: Multiple-item measuring instruments are frequently used in a wide range of disciplines for the purpose of research in substantive areas. The quality of items in these instruments determine to a large extent whether the results are trustworthy. In this paper, we suggested to use property fitting analysis to evaluate the appropriateness of items content validity based on explicit item property criteria. METHODS: Using Center for Epidemiologic Studies Depression scale as an example, item property fitting analyses via multidimensional scaling model was used to quantitatively evaluate the properties of items based on rating data from 12 counselors...
February 7, 2019: International Journal of Methods in Psychiatric Research
Mohammadali Nikoo, Ehsan Moazen-Zadeh, Nooshin Nikoo, Sanam Javidanbardan, Alireza Kazemi, Fiona Choi, Marc Vogel, Ali Gholami, Saeed Tavakoli, Reza Givaki, Majid Jazani, Fatemeh Mohammadian, Nader Markazi Moghaddam, Nasser Goudarzi, Christian Schutz, Kerry Jang, Shahin Akhondzadeh, Michael Krausz
OBJECTIVES: This is the first study to compare the safety and efficacy of opium tincture (OT) with methadone for treatment of opioid use disorder. METHODS: In this multicenter, double-blind, noninferiority controlled trial, a stratified sample of 204 participants with opioid use disorder were recruited from community outreach, drop-in centers, and triangular clinics. Participants were excluded in case of active participation in another treatment program for opioid use disorder, hypersensitivity to trial medications, pregnancy, and certain serious medical conditions...
February 4, 2019: International Journal of Methods in Psychiatric Research
Eriko Tani, Tohru Ohnuma, Hitoki Hirose, Ken Nakayama, Wanyi Mao, Mariko Nakadaira, Narihiro Orimo, Hiroki Yamashita, Yuto Takebayashi, Yasue Miki, Narimasa Katsuta, Shohei Nishimon, Toshio Hasegawa, Etsuko Komiyama, Yasushi Suga, Shigaku Ikeda, Heii Arai
OBJECTIVES: Photosensitivity to ultraviolet A (UVA) radiation from sunlight is an important side effect of treatment with antipsychotic agents. However, the pathophysiology of drug-induced photosensitivity remains unclear. Recent studies demonstrated the accumulation of advanced glycation end products (AGEs), annotated as carbonyl stress, to be associated with the pathophysiology of schizophrenia. In this study, we investigated the relationship among skin AGE levels, minimal response dose (MRD) with UVA for photosensitivity, and the daily dose of antipsychotic agents in patients with schizophrenia and healthy controls...
January 31, 2019: International Journal of Methods in Psychiatric Research
Fanny Kählke, Thomas Berger, Ava Schulz, Harald Baumeister, Matthias Berking, Randy P Auerbach, Ronny Bruffaerts, Pim Cuijpers, Ronald C Kessler, David Daniel Ebert
OBJECTIVES: Internet- and mobile-based interventions (IMIs) offer the opportunity to deliver mental health treatments on a large scale. This randomized controlled trial evaluated the efficacy of an unguided IMI (StudiCare SAD) for university students with social anxiety disorder (SAD). METHODS: University students (N = 200) diagnosed with SAD were randomly assigned to an IMI or a waitlist control group (WLC) with full access to treatment as usual. StudiCare SAD consists of nine sessions...
January 27, 2019: International Journal of Methods in Psychiatric Research
Ronny Bruffaerts, Philippe Mortier, Randy P Auerbach, Jordi Alonso, Alicia E Hermosillo De la Torre, Pim Cuijpers, Koen Demyttenaere, David D Ebert, Jennifer Greif Green, Penelope Hasking, Dan J Stein, Edel Ennis, Matthew K Nock, Stephanie Pinder-Amaker, Nancy A Sampson, Gemma Vilagut, Alan M Zaslavsky, Ronald C Kessler
OBJECTIVES: Mental disorders and suicidal thoughts and behaviors (STB) are common and burdensome among college students. Although available evidence suggests that only a small proportion of the students with these conditions receive treatment, broad-based data on patterns of treatment are lacking. The aim of this study is to examine the receipt of mental health treatment among college students cross-nationally. METHODS: Web-based self-report surveys were obtained from 13,984 first year students from 19 colleges in eight countries across the world as part of the World Health Organization's World Mental Health-International College Student Initiative...
January 20, 2019: International Journal of Methods in Psychiatric Research
Gerhard Gmel, Yasser Khazaal, Joseph Studer, Stéphanie Baggio, Simon Marmet
OBJECTIVES: The study aims to develop a short form of the compulsive internet use scale (CIUS), which can be used in multitopic and general population health surveys and is invariant across different sexes, linguistic regions, and ages. METHODS: Two general population surveys from 2013 and 2015 were used as learning (n = 1,371) and validation samples (n = 1,550), respectively. Reducing items from the original CIUS was based on the following: (a) correlated errors between items, (b) differential item functioning, and (c) measurement invariance...
January 16, 2019: International Journal of Methods in Psychiatric Research
Alka Sabharwal, Gurprit Grover, Sakshi Kaushik, K E Sadanandan Unni
OBJECTIVES: Schizophrenia is a chronic mental condition. The objective of this study is to apply time series modelling to Positive and Negative Syndrome Scale scores of outpatients with schizophrenia, observed at regular intervals of time, and hence forecast the number of visits required to reach remission. METHODS: A retrospective data of outpatients diagnosed with chronic paranoid-type schizophrenia were extracted from the records of outpatient department of a tertiary hospital in New Delhi, India...
January 16, 2019: International Journal of Methods in Psychiatric Research
Pim Cuijpers, Randy P Auerbach, Corina Benjet, Ronny Bruffaerts, David Ebert, Eirini Karyotaki, Ronald C Kessler
Most mental disorders have their first onset in early adulthood. Epidemiological research, as well as research on preventive and early interventions, is therefore very important. This thematic issue focuses on one of the first systematic attempts to develop such services for college students. The WHO World Mental Health International College Student (WMH-ICS) initiative is based on the largest and continuously growing epidemiological dataset ever collected in college students. Based on these results, the initiative has now started to implement internet-based interventions for common mental disorders and emotional problems...
January 9, 2019: International Journal of Methods in Psychiatric Research
Diana Guertler, Anne Moehring, Kristian Krause, Sandra Eck, Anil Batra, Jean-François Chenot, Jennis Freyer-Adam, Sabina Ulbricht, Hans-Jürgen Rumpf, Gallus Bischof, Ulrich John, Christian Meyer
OBJECTIVES: Real world implementation of proactive screening and brief intervention in health care is threatened by high cost. Using e-health interventions and screening for multiple health risk factors may provide more efficiency. We describe methodological details of a proactive multipurpose health risk screening in health care settings and report on participation rates, participants' characteristics, and participation factors. METHODS: Patients between 18 and 64 years from ambulatory practices and hospitals were proactively approached by study assistants at three sites for a computerized screening on harmful alcohol and tobacco consumption, depressive symptoms, insufficient fruit/vegetable consumption, physical inactivity and overweight...
January 7, 2019: International Journal of Methods in Psychiatric Research
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