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European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology

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https://read.qxmd.com/read/30773389/the-effect-of-genetic-vulnerability-and-military-deployment-on-the-development-of-post-traumatic-stress-disorder-and-depressive-symptoms
#1
Remmelt R Schür, Dick Schijven, Marco P Boks, Bart P F Rutten, Murray B Stein, Jan H Veldink, Marian Joëls, Elbert Geuze, Eric Vermetten, Jurjen J Luykx, Christiaan H Vinkers
Exposure to trauma strongly increases the risk to develop stress-related psychopathology, such as post-traumatic stress disorder (PTSD) or major depressive disorder (MDD). In addition, liability to develop these moderately heritable disorders is partly determined by common genetic variance, which is starting to be uncovered by genome-wide association studies (GWASs). However, it is currently unknown to what extent genetic vulnerability and trauma interact. We investigated whether genetic risk based on summary statistics of large GWASs for PTSD and MDD predisposed individuals to report an increase in MDD and PTSD symptoms in a prospective military cohort (N = 516) at five time points after deployment to Afghanistan: one month, six months and one, two and five years...
February 14, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30773388/increased-sensitivity-to-d9-thc-induced-rewarding-effects-after-seven-week-exposure-to-electronic-and-tobacco-cigarettes-in-mice
#2
Luisa Ponzoni, Milena Moretti, Daniela Braida, Michele Zoli, Francesco Clementi, Paola Viani, Mariaelvina Sala, Cecilia Gotti
Cigarette (CIG) smoking often precedes the use of illegal drugs. Electronic-cigarettes (e-CIGs) have been promoted as a means of stopping smoking and reducing the harmful effects of CIGs on the population. However, although e-CIGs eliminate some of the morbidity associated with combustible tobacco, they are still nicotine-delivery devices. In order to study whether the nicotine delivered via e-CIG acts as "a gateway drug" to the use of cannabis, we analysed the behavioural and molecular effects of 7 weeks' pre-exposure to air (AIR), e-CIGs or CIGs on addiction-related conditioned place preference (CPP) in mice using a sub-threshold (0...
February 14, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30773387/early-intervention-for-obsessive-compulsive-disorder-an-expert-consensus-statement
#3
Naomi A Fineberg, Bernardo Dell'Osso, Umberto Albert, Giuseppe Maina, Daniel Geller, Lior Carmi, Nick Sireau, Susanne Walitza, Giacomo Grassi, Stefano Pallanti, Eric Hollander, Vlasios Brakoulias, Jose M Menchon, Donatella Marazziti, Konstantinos Ioannidis, Annemieke Apergis-Schoute, Dan J Stein, Danielle C Cath, Dick J Veltman, Michael Van Ameringen, Leonardo F Fontenelle, Roseli G Shavitt, Daniel Costa, Juliana B Diniz, Joseph Zohar
Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD...
February 14, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30772118/anxiety-during-ketamine-infusions-is-associated-with-negative-treatment-responses-in-major-depressive-disorder
#4
Sabine Aust, Matti Gärtner, Laura Basso, Christian Otte, Katja Wingenfeld, Woo Ri Chae, Isabella Heuser-Collier, Francesca Regen, Nicoleta Carmen Cosma, Franziska van Hall, Simone Grimm, Malek Bajbouj
About 20 to 30 percent of patients with Major Depressive Disorder (MDD) do not respond to standard treatment and are considered treatment-resistant. The N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant MDD, but it is unknown whether its acute psychological effects are related to the later antidepressant effect. Therefore, we investigated the association between antidepressant responses to ketamine and the quality of ketamine-induced psychological experiences in MDD...
February 13, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30770235/long-acting-injectable-antipsychotics-lais-for-maintenance-treatment-of-bipolar-and-schizoaffective-disorders-a-systematic-review
#5
REVIEW
Isabella Pacchiarotti, Jari Tiihonen, Georgios D Kotzalidis, Norma Verdolini, Andrea Murru, José Manuel Goikolea, Marc Valentí, Alberto Aedo, Eduard Vieta
Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression)...
February 12, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30770234/functional-asymmetry-of-thalamocortical-networks-in-subjects-at-ultra-high-risk-for-psychosis-and-first-episode-schizophrenia
#6
Furong Zhu, Yi Liu, Feng Liu, Ru Yang, Huabing Li, Jindong Chen, David N Kennedy, Jingping Zhao, Wenbin Guo
Disrupted functional asymmetry has been implicated in schizophrenia. However, it remains unknown whether disrupted functional asymmetry originates from intra-hemispheric and/or inter-hemispheric functional connectivity (FC) in the patients, and whether it starts at very early stage of psychosis. Seventy-six patients with first-episode, drug-naive schizophrenia, 74 subjects at ultra-high risk for psychosis (UHR), and 71 healthy controls underwent resting-state functional magnetic resonance imaging. The 'Parameter of asymmetry' (PAS) metric was calculated and support vector machine (SVM) classification analysis was applied to analyze the data...
February 12, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30704794/high-occupational-level-is-associated-with-poor-response-to-the-treatment-of-depression-a-replication-study
#7
Laura Mandelli, Alessandro Serretti, Daniel Souery, Julien Mendlewicz, Siegfried Kasper, Stuart Montgomery, Joseph Zohar
Major depressive disorder (MDD) is a leading cause of disability and inability to work. There is evidence that occupational factors may precipitate a MDD episode and interfere with the recovery process. In a previous investigation, we found that those employed in high occupational levels had a worse outcome after treatment for depression (Mandelli et al., 2016). The aim of the present study was to further investigate response to treatments for depression according to occupational status on an independent sample of MDD patients...
January 28, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30686631/acute-and-subchronic-pcp-attenuate-d2-autoreceptor-signaling-in-substantia-nigra-dopamine-neurons
#8
Elisabeth Piccart, Christopher W Tschumi, Michael J Beckstead
Phencyclidine (PCP) administration is commonly used to model schizophrenia in laboratory animals. While PCP is well-characterized as an antagonist of glutamate-sensitive N-methyl-D-aspartate (NMDA) receptors, its effects on dopamine signaling are not well understood. Here we used whole-cell and cell-attached patch-clamp electrophysiology of substantia nigra dopamine neurons to determine the effects of acute and subchronic PCP exposure on both dopamine D2 autoreceptor-mediated currents and burst firing evoked by glutamate receptor activation...
January 24, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30658938/altered-striatal-reward-processing-in-abstinent-dependent-cannabis-users-social-context-matters
#9
Kaeli Zimmermann, Keith M Kendrick, Dirk Scheele, Wolfgang Dau, Markus Banger, Wolfgang Maier, Bernd Weber, Yina Ma, René Hurlemann, Benjamin Becker
Public perception of cannabis as relatively harmless, alongside claimed medical benefits, have led to moves towards its legalization. Yet, long-term consequences of cannabis dependence, and whether they differ qualitatively from other drugs, are still poorly understood. A key feature of addictive drugs is that chronic use leads to adaptations in striatal reward processing, blunting responsivity to the substance itself and natural (non-drug) rewards. Against this background, the present study investigated whether cannabis dependence is associated with lasting alterations in behavioral and neural responses to social reward in 23 abstinent cannabis-dependent men and 24 matched non-using controls...
January 15, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30654916/structural-changes-in-the-hippocampus-as-a-biomarker-for-cognitive-improvements-in-neuropsychiatric-disorders-a-systematic-review
#10
REVIEW
Caroline Vintergaard Ott, Claire Bergstrom Johnson, Julian Macoveanu, Kamilla Miskowiak
Cognitive impairments are a core feature of several neuropsychiatric disorders. A common biomarker for pro-cognitive effects may provide a much-needed tool to select amongst candidate treatments targeting cognition. The hippocampus is a promising biomarker for target-engagement due to the illness-associated morphological hippocampal changes across unipolar disorder (UD), bipolar disorder (BD) and schizophrenia (SCZ). Following the PRISMA guidelines, we searched PubMed and Embase, for clinical trials targeting cognition across neuropsychiatric disorders, with longitudinal structural magnetic resonance imaging (MRI) measures of the hippocampus...
January 14, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30635160/a-systematic-review-of-phytocannabinoid-exposure-on-the-endocannabinoid-system-implications-for-psychosis
#11
REVIEW
Maya R Jacobson, Jeremy J Watts, Isabelle Boileau, Junchao Tong, Romina Mizrahi
Cannabis, the most widely used illicit drug worldwide, produces psychoactive effects through its component cannabinoids, which act on the endocannabinoid system. Research on how cannabinoid exposure affects the endocannabinoid system is limited. Substantial evidence indicates cannabis use as a risk factor for psychosis, and the mechanism(s) by which this is occurring is/are currently unknown. Here, we conduct the first review of the effects of exogenous cannabinoids on the endocannabinoid system in humans with and without psychotic disorders...
January 8, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30630651/neuroinflammation-in-the-dorsolateral-prefrontal-cortex-in-elderly-chronic-schizophrenia
#12
Irene López-González, Raquel Pinacho, Èlia Vila, Ana Escanilla, Isidre Ferrer, Belén Ramos
Cognitive deterioration and symptom progression occur in schizophrenia over the course of the disorder. A dysfunction of the immune system/neuroinflammatory pathways has been linked to schizophrenia (SZ). These altered processes in the dorsolateral prefrontal cortex (DLPFC) could contribute to the worsening of the deficits. However, limited studies are available in this brain region in elderly population with long-term treatments. In this study, we explore the possible deregulation of 21 key genes involved in immune homeostasis, including pro- and anti-inflammatory cytokines, cytokine modulators (toll-like receptors, colony-stimulating factors, and members of the complement system) and microglial and astroglial markers in the DLPFC in elderly chronic schizophrenia...
January 7, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30612854/a-randomized-double-blind-placebo-controlled-trial-of-lamotrigine-for-prescription-corticosteroid-effects-on-the-human-hippocampus
#13
E Sherwood Brown, Nasreen Sayed, Changho Choi, Nicholas Tustison, Jared Roberts, Michael A Yassa, Erin Van Enkevort, Alyson Nakamura, Elena I Ivleva, Prabha Sunderajan, David A Khan, Miguel Vazquez, Bruce McEwen, Alexandra Kulikova, Alan B Frol, Traci Holmes
In animals, stress and corticosteroid excess are associated with decreases in memory performance and hippocampal volume that may be prevented with agents that decrease glutamate release. Humans also demonstrate changes in memory and hippocampus with corticosteroids. In this report the effects of glutamate-release inhibitor lamotrigine on hippocampal structure and memory were examined in people receiving medically needed prescription corticosteroid therapy. A total of 54 outpatient adults (n = 28 women) receiving chronic (≥ 6 months) oral corticosteroid therapy were randomized to lamotrigine or placebo for 48 weeks...
January 3, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30600114/nucleus-accumbens-neurochemistry-in-human-anxiety-a-7-t-1-h-mrs-study
#14
Alina Strasser, Lijing Xin, Rolf Gruetter, Carmen Sandi
Individual differences in anxiety provide a differential predisposition to develop neuropsychiatric disorders. The neurochemical underpinnings of anxiety remain elusive, particularly in deep structures, such as the nucleus accumbens (NAc) whose involvement in anxiety is being increasingly recognized. We examined the associations between the neurochemical profile of human NAc metabolites involved in neural excitation and inhibition and inter-individual variation in temperamental and situational anxiety. Twenty-seven healthy 20-30 years-old human males were phenotyped with questionnaires for state and trait anxiety (State-Trait Anxiety Inventory, STAI), social anxiety (Liebowitz Social Anxiety Scale), negative mood (Beck Depression Inventory, BDI) and fatigue (Mental and Physical State Energy and Fatigue Scales, SEF)...
December 29, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30595354/combined-fluvoxamine-and-extended-release-methylphenidate-improved-treatment-response-compared-to-fluvoxamine-alone-in-patients-with-treatment-refractory-obsessive-compulsive-disorder-a-randomized-double-blind-placebo-controlled-study
#15
Huirong Zheng, Fujun Jia, Hongying Han, Shibin Wang, Guangquan Guo, Dongming Quan, Gang Li, Huiyan Huang
More effective, tolerable interventions for treatment-refractory obsessive-compulsive disorder (OCD) are needed. Preliminary findings encourage optimism that methylphenidate augmentation may be of benefit in the treatment of OCD. To test modulator methylphenidate (MPH) of extended-release formulations (MPH-ER) a safe and effective add-on therapy for refractory OCD, a pilot randomized, placebo-controlled, double-blind trial was conducted at an outpatient, single-center academic setting. Participants included 44 adults with serotonin reuptake inhibitor (SRI) treatment-refractory OCD and receiving a stable fluvoxamine pharmacotherapy with Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores higher than 20...
December 27, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30594344/activation-of-the-immune-inflammatory-response-system-and-the-compensatory-immune-regulatory-system-in-antipsychotic-naive-first-episode-psychosis
#16
Mariane Nunes Noto, Michael Maes, Sandra Odebrecht Vargas Nunes, Vanessa Kiyomi Ota, Ana C Rossaneis, Waldiceu A Verri, Quirino Cordeiro, Sintia Iole Belangero, Ary Gadelha, Rodrigo Affonseca Bressan, Cristiano Noto
Psychotic disorders are accompanied by activation of the immune inflammatory response system (IRS). The compensatory immune-regulatory system (CIRS) is a regulatory immune response that is induced by the IRS but exerts negative feedback through increased levels of anti-inflammatory cytokines such as interleukin (IL)-4, IL-13 and IL-10. This study aims to examine the IRS and CIRS components, including macrophagic M1, T-helper (Th)-1, Th-2, Th-17 and T-regulatory (Treg) phenotypes, in antipsychotic-naïve first episode psychosis (AN-FEP) before and after risperidone treatment...
December 26, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30591345/rubiscolins-are-naturally-occurring-g-protein-biased-delta-opioid-receptor-peptides
#17
Robert J Cassell, Kendall L Mores, Breanna L Zerfas, Amr H Mahmoud, Markus A Lill, Darci J Trader, Richard M van Rijn
The impact that β-arrestin proteins have on G protein-coupled receptor trafficking, signaling and physiological behavior has gained much appreciation over the past decade. A number of studies have attributed the side effects associated with the use of naturally occurring and synthetic opioids, such as respiratory depression and constipation, to excessive recruitment of β-arrestin. These findings have led to the development of biased opioid small molecule agonists that do not recruit β-arrestin, activating only the canonical G protein pathway...
December 24, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30587400/smoking-moderates-association-of-5-httlpr-and-in-vivo-availability-of-serotonin-transporters
#18
Michael N Smolka, Matthias Reimold, Andrea Kobiella, Gerald Reischl, Marcella Rietschel, Andreas Heinz
Although preclinical studies clearly indicate an effect of 5-HTTLPR genotype on 5-HT transporter (5-HTT) expression, studies in humans provided inconclusive results, hypothetically due to environmental factors and differences in individual behavior. For example, nicotine and other constituents of tobacco smoke elevate serotonin (5-HT) levels in the brain and may thereby cause homeostatic adaptations in 5-HTT availability that moderate effects of 5-HTTLPR genotype. To test whether 5-HTT availability in the midbrain is affected by smoking status and 5-HTTLPR genotype, we pooled data from prior studies on in vivo 5-HTT availability (BPND ) measured with positron emission tomography (PET) and [11 C]DASB...
December 23, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30579654/european-mental-health-research-resources-picture-and-recommendations-of-the-roamer-project
#19
Jean-Baptiste Hazo, Matthias Brunn, Til Wikes, David McDaid, Maya Dorsey, Jacques Demotes-Mainard, Christina M van der Feltz-Cornelis, Kristian Wahlbeck, Susanne Knappe, Andreas Meyer-Lindenberg, Carla Obradors-Tarragó, Josep Maria Haro, Marion Leboyer, Karine Chevreul
As part of the Roamer project, we sought to have a picture of the available mental health research (MHR) funding, capacity-building and infrastructures resources and to establish consensus-based recommendations that would allow an increase of European MHR resources and enable better use and accessibility to them. The methods fell into three sections (i) a review of the literature, (ii) a mental health-related keywords search within the Cordis® , On-Course® and Meril® databases which contain information on European research funding, training and infrastructures...
December 19, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30563719/chronic-dietary-changes-in-n-6-n-3-polyunsaturated-fatty-acid-ratios-cause-developmental-delay-and-reduce-social-interest-in-mice
#20
Kim van Elst, Jos F Brouwers, Jessica E Merkens, Mark H Broekhoven, Barbara Birtoli, J Bernd Helms, Martien J H Kas
Polyunsaturated fatty acids (PUFAs) are one of the main cellular building blocks, and dietary changes in PUFA composition are proposed as a potential route to influence brain development. For example, initial studies indicated that there is a relation between blood omega-6(n-6)/omega-3(n-3) PUFA ratios and neurodevelopmental disease diagnosis. To study the consequences of dietary n-6/n-3 PUFA ratio changes, we investigated the impact of a n-3 supplemented and n-3 deficient diet in developing BTBR T + Itpr3tf/J (BTBR) - a mouse inbred strain displaying Autism Spectrum Disorder (ASD)-like symptomatology - and control C57BL/6J mice...
December 15, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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