Fang Zhang, Jingjing Zhang, Weifen Zhang
Fungal keratitis (FK) is a serious pathogenic disease usually associated with serious ocular complications. The current mainstay of treatment for FK is topical eye drops; however, poor corneal penetration, low bioavailability of the drug and the need to administer high and frequent doses due to the presence of an effective clearance mechanism in the eye result in poor patient compliance. Nanocarriers can extend the duration of drug action through sustained and controlled release of the drug, protect the drug from ocular enzymes and help overcome ocular barriers...
May 17, 2023: European Journal of Ophthalmology
Alfonso Savastano, Matteo Mario Carlà, Gloria Gambini, Federico Giannuzzi, Francesco Boselli, Stanislao Rizzo
BACKGROUND: To discuss the efficacy of an inferior implant of XEN 63 gel stent in a patient with refractory glaucoma after trabeculectomy failure and vitreoretinal surgery with silicone oil tamponade. CASE DESCRIPTION: We report the case of a 73-year-old man with a history of refractory open glaucoma with trabeculectomy failure. He experienced recurrent retinal detachments with silicone oil tamponade, with uncontrolled intra-ocular pressure (IOP) after silicone oil removal...
May 16, 2023: European Journal of Ophthalmology
Ayşe Tüfekçi Balıkçı, Hafize Gökben Ulutaş
PURPOSE: To compare the visual and topographic results between patients who underwent epithelium-off cross-linking using riboflavin solutions compounds hydroxypropyl methylcellulose (HPMC) 1.1% and D-alpha-tocopheryl polyethylene-glycol 1000 succinate (VE-TPGS). METHODS: In this study, 37 eyes treated with HPMC and 29 eyes treated with VE-TPGS were evaluated retrospectively. Spherical equivalent (SE), refractive cylinder, corrected distance visual acuity tests (CDVA), corneal topography indices (flat and steep meridians' keratometry (K1 and K2)), maximum keratometry (K max), central, thinnest, and apical corneal thicknesses, the front and back keratoconus vertex index (KVf, KVb), and the surface asymmetry index of the front and back surface (SIf, SIb), and endothelial cell density were compared at baseline and postoperative follow-up visits (1, 3, 6, and 12months)...
May 16, 2023: European Journal of Ophthalmology
Miguel Leitão, Diogo Cabral
PURPOSE: To describe a case of ocular Lichen Planus, successfully managed using a multimodal evaulation, including Anterior Segment OCT (AS-OCT). OBSERVATIONS: A female patient in her forties with a history of cutaneous Lichen Planus presents with blurred vision and burning eye sensation. Anterior segment evaluation revealed bilateral punctate keratitis, stromal haze and subepithelial pigmented dots. AS-OCT was pivotal for diagnosis, showing anterior stromal hyperreflective dots...
May 16, 2023: European Journal of Ophthalmology
Walaa Alturkistany, Richard Allen, Aysha Aloqab, Silvana Schellini, Hunter Yuen, Diego Strianese, Rawan N Althaqib, Hamad M Alsulaiman
OBJECTIVE: To determine the preference for dacryocystorhinostomy (DCR), patient selection criteria for endoscopic DCR, endoscopic DCR technique, and barriers to adoption of endoscopic DCR. METHOD: Cross-sectional study conducted from May-December 2021. A survey was sent to oculoplastic surgeons. Questions on demographic characteristics, type of clinical practice, technique preferences, barriers and facilitators to adoption of endoscopic DCR were included. RESULTS: 245 participants completed the survey...
May 16, 2023: European Journal of Ophthalmology
Indu Govindaraj, Anju Kuriakose, Anand Rajendran
INTRODUCTION: Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a rare clinical entity affecting young healthy individuals. Treatment primarily involves pan retinal photocoagulation (PRP) to capillary non perfusion areas. Intravitreal anti-VEGF or steroids are given in the presence of macula edema. Oral steroids do not alter the course of the disease. Arterial occlusions have been reported in IRVAN. METHODS: Retrospective case review...
May 15, 2023: European Journal of Ophthalmology
Alessio Antropoli, Lorenzo Bianco, Alessandro Arrigo, Francesco Bandello, Maurizio Battaglia Parodi
PURPOSE: To study peripheral capillary non-perfusion (PCN-P) in branch retinal vein occlusion (BRVO) by means of ultra wide-field fluorescein angiography (UWFFA), and to correlate its extent and severity with optical coherence tomography (OCT) and OCT-angiography (OCTA) parameters and best corrected visual acuity (BCVA). METHODS: Prospective case series with 2 years of planned follow-up. We recruited patients from June 2019 to December 2019. Ophthalmologic examination included BCVA, UWFFA, OCT and OCTA...
May 11, 2023: European Journal of Ophthalmology
Adriano Carnevali, Andrea Taloni, Valentina Gatti, Luca Lamonica, Flavia Oliverio, Giorgio Randazzo, Vincenzo Scorcia
INTRODUCTION: Intravitreal dexamethasone (DEX) implant is indicated for the treatment of macular oedema due to diabetic retinopathy, retinal vein occlusion and uveitis. The most common complications are cataract and elevated intraocular pressure (IOP). Accidental injection of DEX implant into the lens is a rare complication and only few papers presented it. CASE PRESENTATION: A 40-year-old man was treated with DEX implant for diabetic macular oedema in both eyes...
May 10, 2023: European Journal of Ophthalmology
Sebastião Cronemberger, Daniel Vítor Vasconcelos-Santos, Clóvis Correia de Carvalho, José Herculano Carvalho, Júlia Calixto, Alberto Diniz-Filho
INTRODUCTION: Bilateral acute iris transillumination (BAIT) is a relatively new syndrome whose etiopathogenesis is still not fully understood. It is characterized by acute bilateral onset of intense pigment dispersion in the anterior chamber, iris depigmentation with severe transillumination defects, accentuated pigment deposition in the angle, and elevated intraocular pressure (IOP). In literature, the first case was of bilateral acute iris depigmentation (BADI) reported in 2004 in a 77-year-old woman...
May 9, 2023: European Journal of Ophthalmology
Sara García Caride, Federico Sáenz-Francés San Baldomero, Laura Morales Fernández, Lucia Perucho González, Julián García Feijoo, José María Martínez de la Casa
PURPOSE: The aim of this study is to analyze the distribution of visual field (VF) mean defect (MD) in six subgroups of glaucoma patients at baseline and follow-up. METHODS: We assessed glaucoma patients treated in a Spanish tertiary care setting with a follow-up of at least 10 months. We have included 1036 visual fields and the following glaucoma subtypes: open-Angle Glaucoma (OAG); Angle-Closure Glaucoma (ACG); Congenital Glaucoma (CG); Ocular hypertension (OHT); Pseudoexfoliative Glaucoma (PSXG); Pigmentary Glaucoma (PG)...
May 8, 2023: European Journal of Ophthalmology
Ana Filipa Moleiro, Joana Santos Oliveira, Ana Grangeia, Pedro Faria, Fernando Falcão-Reis, Augusto Magalhães, Sérgio Estrela Silva
BACKGROUND: Oculofaciocardiodental (OFCD) syndrome is a rare genetic disorder affecting ocular, facial, dental, and cardiac systems, being an X-linked condition caused by pathogenic variants in the BCL-6 corepressor gene ( BCOR ). We report a case series of three female patients with OFCD syndrome with severe glaucoma. RESULTS: Three female patients with OFCD syndrome with different variants involving BCOR gene, in heterozygosity: a seven-years-old girl with an insertion (c...
May 8, 2023: European Journal of Ophthalmology
Azyadeh Camacho-Ordonez, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante, Ana Jimena Hernandez-Medrano, Selma Alin Somilleda-Ventura, Hector J Pérez-Cano, Ángel Nava-Castañeda, Oscar Guerrero-Berger
PURPOSE: To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD). METHODS: Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified using a human total αSyn enzyme-linked immunosorbent assay (ELISA) kit. The retinal thickness was evaluated with spectral-domain optical coherence tomography...
May 7, 2023: European Journal of Ophthalmology
Alfredo Pece, Federica Fossataro, Giulio Maione, Raffaele Liuzzi
PURPOSE: To examine structural and clinical changes in previously treated type 1 macular neovascularization (MNV) in non-responder age-related macular degeneration (nAMD) eyes switched to brolucizumab. Subretinal hyper-reflective material (SHRM), intraretinal (IRF) and subretinal fluid (SRF) presence, fibrovascular-pigment epithelium detachment (PED) height and central macular thickness (CMT) variation were analyzed using optical coherence tomography (OCT). METHODS: In this prospective study all patients underwent a complete ophthalmological evaluation including structural OCT at baseline (T0), one month (T1), three (T2), four (T3) and six months after switching to brolucizumab treatment (T4)...
May 7, 2023: European Journal of Ophthalmology
Anthony C Oganov, Ian Seddon, Mike Zein, Ghasem Yazdanpanah, Hossein Fonoudi, Sayena Jabbehdari
The gut microbiome is a complex ecosystem in the gastrointestinal tract composed of trillions of bacteria, viruses, fungi, and protozoa. Disruption of this delicate ecosystem, formally called "dysbiosis", has been linked to a variety of metabolic and inflammatory pathologies. Several studies have focused on abnormal microbiome composition and correlated these findings with the development of type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR). However, given the complexity of this ecosystem, the current studies are narrow in design and present variable findings...
May 7, 2023: European Journal of Ophthalmology
Metehan Simsek, Sehnaz Ozcaliskan, Seren Pehlivanoglu, Ozgur Artunay
INTRODUCTION: Alexandrite laser is generally used for hair removal and treatment of hyperpigmented skin lesions. It is important to use protective equipment during treatment. In previous cases, complications such as conjunctival hyperemia, anterior uveitis, and choroidal neovascularization were reported. We report a case who developed chorioretinal anastomosis secondary to inadvertent alexandrite laser exposure. CASE DESCRIPTION: A 44 year-old woman presented with decrease of vision in the left eye...
May 7, 2023: European Journal of Ophthalmology
Edoardo Villani, Anton Giulio Catania, Saverio Vincenzo Luccarelli, Fabrizio Magnani, Gianluca Martone, Emma Zanzottera, Neil Lagali
Cataract surgery is the most frequently performed surgical procedure in the elderly in Western countries and patients' expectations for postoperative outcomes are very high.Dry eye disease (DED) is a common multifactorial symptomatic disease of the ocular surface with a complex etiopathogenesis and a prevalence significantly increasing with age.Cataract surgery and DED have a complex relationship, which needs to be acknowledged, understood, and properly managed, as suggested by daily clinical experience and growing scientific evidence...
May 7, 2023: European Journal of Ophthalmology
Mehrdad Mohammadpour, Mohsen Heirani, Narges Khoshtinat, Masoud Khorrami-Nejad
PURPOSE: to compare five-year outcomes of two complete intracorneal implants (MyoRing versus annular-shaped intracorneal implant [AICI]) combined with accelerated corneal cross-linking (A-CXL) in progressive KCN. METHODS: In this historical cohort study, preoperative and postoperative visual, refractive, tomographic, biomechanical, and aberrometric parameters of 27 eyes of 27 patients who underwent implantation of two complete rings (13 AICI and 14 MyoRing) combined with A-CXL were recorded...
May 4, 2023: European Journal of Ophthalmology
Luís Bernardes, João Gil, Esmeralda Costa, Cristina Tavares, Andreia Rosa, Maria João Quadrado, Joaquim Murta
PURPOSE: The purpose of this study was to assess the use of topical tacrolimus ointment in preventing rejection in high-risk corneal grafts, when added to the standard immunosuppressive regimen. METHODS: We conducted an observational, retrospective study using clinical data of high-risk patients subjected to penetrating keratoplasty, who were treated with topical tacrolimus ointment 0.2 mg/g twice a day plus topical dexamethasone 0.1 mg/ml 6 id and compared it with a similar control group treated with topical dexamethasone 0...
May 1, 2023: European Journal of Ophthalmology
Annegret Dahlmann-Noor
No abstract text is available yet for this article.
May 1, 2023: European Journal of Ophthalmology
Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Haleh Kangari, Azar Moradi, Reyhaneh Akbarzadeh, Shehzad A Naroo
OBJECTIVES: To compare changes in corneal biomechanical parameters one year after corneal cross-linking (CXL) in keratoconus (KCN) eyes of different severities. METHODS: Seventy-five eyes with mild, moderate, and severe grades of KCN (n = 24, 31, and 20 eyes, respectively) that were treated with CXL, based upon the standard Dresden protocol, were included. The corneal biomechanical assessment was performed using Corvis ST and Ocular Response Analyzer (ORA)...
April 27, 2023: European Journal of Ophthalmology
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