Lorenzo Bianco, Alessandro Arrigo, Alessio Antropoli, Alessandro Berni, Andrea Saladino, Manuel Ap Vilela, Ahmad M Mansour, Francesco Bandello, Maurizio Battaglia Parodi
Best Vitelliform Macular Dystrophy (BVMD) is a dominantly inherited retinal disease caused by dominant variants in the BEST1 gene. The original classification of BVMD is based on biomicroscopy and color fundus photography (CFP); however, advancements in retinal imaging provided unique structural, vascular, and functional data and novel insights on disease pathogenesis. Quantitative fundus autofluorescence studies informed us that lipofuscin accumulation, the hallmark of BVMD, is unlikely to be a primary effect of the genetic defect...
March 27, 2023: European Journal of Ophthalmology
Ana Orive Bañuelos, Alaitz Santamaría Carro, Raquel Feijóo Lera, Jaime Etxebarria Ecenarro
Purpose: To report sterile corneal necrosis as a severe and rare complication after Bowman Layer Transplantation (BTL). Methods: A 35-year-old woman with Down syndrome and advanced progressive keratoconus in her left eye was scheduled for a BLT. The patient rubbed her eyes and did not tolerate contact lenses. Following standard technique, a 8mm Bowman layer graft was placed into a intrastromal pocket with no intraoperative complications. Results: Postoperatively, the patient remained stable and topography showed notable central flattening but 17 days after the BTL was performed she developed a sterile corneal necrosis...
March 21, 2023: European Journal of Ophthalmology
Rhea Narang, Priya Narang
PURPOSE: To describe Reverse four-throw (RFT) technique for pupilloplasty. METHODS: The technique involves making a single pass through the anterior chamber that helps achieve a posteriorly directed suture knot. A single arm 9-0 polypropylene suture attached to long arm needle engages the iris defects with the tip of the needle piercing the iris tissue from the posterior surface and emerging from the anterior aspect. The suture end is passed from the loop with four throws taken consecutively in the same direction that create a self-sealing and self-retaining lock like single-pass four-throw technique but with the difference that the knot slides on the posterior surface of the iris tissue...
March 20, 2023: European Journal of Ophthalmology
Pasquale Viggiano, Maria Oliva Grassi, Giulia Bisceglia, Giacomo Boscia, Enrico Borrelli, Maria Giovanna Malerba, Antonio Fracchiolla, Giovanni Alessio, Francesco Boscia
PURPOSE: To evaluate short-term peripapillary structural and vascular changes in DME after treatment with dexamethasone implant (DEX-I) and anti-VEGFs using OCT-A. METHODS: Sixty-five patients with naïve center-involving DME were enrolled. 33 of sixty five patients (group 1) underwent with single DEX-I 0.7 mg (Ozurdex, Allergan, Inc., USA), 32 of sixty-five (group 2) underwent with intravitreal injection of aflibercept 0.5 mg (Eylea, Bayer, Genentech, San Francisco, USA)...
March 20, 2023: European Journal of Ophthalmology
Ahmet Kaan Gündüz, Diğdem Tetik
PURPOSE: To report RetCam fluorescein angiographic (FA) changes and correlation with clinical findings in the follow-up of retinoblastoma (RB) after frontline intravenous chemotherapy and other treatments. METHODS: Patients having RB who underwent post-treatment RetCam fundus photography and FA under general anesthesia between February 2020 and February 2022 were retrospectively analyzed. RESULTS: 78 eyes of 70 patients with RB were included...
March 20, 2023: European Journal of Ophthalmology
Ali Nouraeinejad
The management of acute acquired comitant esotropia (AACE) is controversial, and no clear guidelines exist to guide its treatment options. Therefore, the author proposes his idea that treatment options for AACE should be prioritized to achieve optimal outcomes with fewer potential complications for this type of esotropia. In this manner, treatment should be started with less invasive, muscle-sparing procedures while the patient is regularly checked for improvement in esotropia and diplopia. This is also a good scheme because the patient can go through vital neurological and ophthalmological assessments while he/she is spared from invasive interventions in the beginning...
March 20, 2023: European Journal of Ophthalmology
Christopher Robert Giles Arthur, Chuen Yen Hong, Saghir Ahmed Sadiq
BACKGROUND: Currently there is no universally agreed schema for predicting ocular morbidity in facial nerve palsy. The House Brackmann Scale has limitations in assessing ocular morbidity from facial nerve palsy. Our aim was to create a scoring system to help quantify ocular morbidity to aid in decision making regarding the need for corneal protective oculoplastic surgery. METHODS: We conducted a large cohort study observing 606 patients attending the specialist facial palsy clinic in Manchester UK between March 2002 and October 2017...
March 17, 2023: European Journal of Ophthalmology
Sudipta Chakraborty, Anshul Sharma, Soumen Pal, Arundhati Sharma, Ramanjit Sihota, Samsiddhi Bhattacharjee, Moulinath Acharya
PURPOSE: PACG is one of the leading causes of blindness where lens thickness is a major risk factor for narrow-angle individuals. To our knowledge, no literature has been reported on candidate gene for lens thickness as a quantitative trait (QT)...
March 17, 2023: European Journal of Ophthalmology
Jingwen Ding, Yang Zhang, Hui Feng, Hua Sun
OBJECTIVE: Ocular actinomycosis is an uncommon progressive infection. The study aims to investigate the predisposing factors, clinical characteristics and treatment outcomes of culture-proven cases of Actinomycotic primary canaliculitis. METHODS: Single-center, retrospective, interventional case series. Culture-proven cases of Actinomyces -associated primary canaliculitis diagnosed and treated between January 2017 and December 2021 at the Beijing Tongren Eye Center, Capital Medical University were identified and reviewed for ocular and systemic risk factors, clinical presentations, microbiological profile, treatment modalities and outcomes...
March 16, 2023: European Journal of Ophthalmology
M J Crespo Carballés, M Sastre-Ibáñez, M Prieto Del Cura, R De Hoz, M C Garcia-Saenz
AIM: To describe the efficacy of a modification of the superior inverted flap technique, with maculorrhexis, in vitrectomy for full-thickness macular hole (MH) surgery compared to internal limiting membrane peeling (ILM). METHODS: Retrospective and comparative study of patients with MH. In group A, a superior ILM flap is created to cover the macular hole, and in group B conventional ILM peeling was performed. RESULTS: A total of 80 eyes were included (44 group A and 36 group B)...
March 15, 2023: European Journal of Ophthalmology
Jesse Panthagani, Elizabeth M Law, Caroline Wong, Chimwemwe Chipeta, Harry Roberts, James Myerscough
BACKGROUND/OBJECTIVES: To describe the visual and clinical outcomes of patients with post endothelial keratoplasty (EK) cystoid macular oedema (CMO) refractory to topical treatment with intravitreal sustained-release dexamethasone implant (Ozurdex). SUBJECTS/METHODS: 131 eyes from 111 patients undergoing solitary or combined EK (52 DSAEK (40.0%) and 79 DMEK (60.0%)) at Southend University Hospital between January 2020 and February 2022 with a minimum follow-up of 6 months were evaluated...
March 14, 2023: European Journal of Ophthalmology
Lin Zhou, Ganghua Wang, Bin Hu, Hui Jiang, Fanwen Jiang, Zhuping Xu
INTRODUCTION: To report a family with severe ocular disorder caused by double gene variants in causative genes of autosomal dominant cataracts, GJA8 and CRYGC . CASE PRESENTATION: A 5-month-old boy with poor vision and enophthalmos was referred to our hospital. Further ocular examination showed horizontal nystagmus, iris abnormalities with pinpoint pupils, and extreme microphthalmia with axial right and left eye lengths of 13.48 mm and 13.75 mm, respectively. Digenic heterozygous variants (c...
March 14, 2023: European Journal of Ophthalmology
Samuel Goulart Nacácio E Silva, Marcelo Luís Occhiutto, Vital Paulino Costa
Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells (RGCs), which leads to progressive visual field loss and may result in blindness. Currently, the only available treatment to avoid or delay progression in glaucoma patients is to decrease intraocular pressure (IOP). However, despite adequate IOP control, approximately 25% of the patients continue to progress. To delay or prevent optic nerve damage in glaucoma, two forms of vitamin B3, nicotinamide (NAM) and nicotinamide riboside (NR) are emerging as viable adjuvant therapies...
March 14, 2023: European Journal of Ophthalmology
Srishti Raksheeth Ramamurthy, Joveeta Joseph, Vivek Pravin Dave
PURPOSE: To report the clinical settings, management and factors affecting outcomes in multi-drug resistant (MDR) and extensively-drug resistant (XDR) Pseudomonas endophthalmitis. SETTINGS: Retrospective, consecutive, non-comparative interventional case series. Cases of MDR and XDR Pseudomonas endophthalmitis from January 2012 to December 2020 treated at our tertiary eye care center were included. Data collected included clinical data, anatomic and functional outcome, isolated micro-organisms, and culture sensitivity...
March 12, 2023: European Journal of Ophthalmology
George J Manayath, Rohan Suresh Ninan, Shishir Verghese, Venkatapathy Narendran
PURPOSE: To report a case of type 3 macular neovascularization presenting with an epiretinal neovascularization. METHODS: Case report. RESULTS: A 65-year-old gentleman presented with complaints of reduced vision in the left eye (LE) having a best corrected visual acuity (BCVA) of 20/200. Based on fundus examination and multimodal imaging findings he was diagnosed with type 3 macular neovascularization (MNV). An additional unusual finding was the presence of an epiretinal membrane (ERM) and epiretinal neovascularization (ERN), with the latter finding being confirmed on optical coherence tomography angiography (OCTA)...
March 12, 2023: European Journal of Ophthalmology
Pankaj Dongre, Nandini Bothra, Sunita Chaurasia
PURPOSE: To describe a previously unreported association of keratoconus in congenital distichiasis. METHODS: Observational case series of ocular findings in 2 siblings with congenital distichiasis. RESULTS: A 17-year-old male presented with tearing and photophobia in both eyes. His parents revealed that he was photophobic since birth. He had a lid surgery previously in both eyes. Clinical examination revealed a central scar with Descemet membrane tear suggestive of healed hydrops in the right eye...
March 8, 2023: European Journal of Ophthalmology
Prasanna Venkatesh Ramesh, Prajnya Ray, Tensingh Joshua, Aji Kunnath Devadas, Prakash Michael Raj, Shruthy Vaishali Ramesh, Meena Kumari Ramesh, Ramesh Rajasekaran
In this manuscript, we have reported an augmented reality (AR) application named, 'Eye MG AR' innovated by us, to show different anatomical/pathological parts of the eyeball pertaining to glaucoma, from multiple customized angles of the user's choice to simplify glaucoma learning and clinical counseling. It is available free of cost from the Google Play Store for Android users. Procedures ranging from a simple outpatient department procedure (yttrium aluminium garnet peripheral iridotomy) to a complex surgical technique (trabeculectomy/tube surgery) can be explained and counseled with this Android application...
March 7, 2023: European Journal of Ophthalmology
Rishi Swarup, Samip Mehta
PURPOSE: To report two cases of deep anterior lamellar keratoplasty (DALK) rejection occurring in association with SARS-CoV-2 vaccination. METHODS: Two patients with prior history of DALK developed immunologic rejection after SARS-CoV-2 vaccination. The first patient, a 15-year-old girl, had a stromal and sub-epithelial rejection nine days after receiving the first dose of the SARS-CoV-2 vaccine BBV152(COVAXINTM , Bharat Biotech, India). The second patient, an 18-year-old male, had a stromal rejection 13 days after receiving the second dose of the ChAdOx1 SARS-CoV-2 vaccine (COVISHIELDTM , Serum Institute of India, India)...
March 5, 2023: European Journal of Ophthalmology
Munirah Alafaleq, Jaime Garrido, Francis Ferrari
AIM: to assess the feasibility of performing a screening of ocular pathologies after Femtosecond laser Assisted Keratopigmentation (FAK) procedure in normal eyes with the aid of multimodal imaging technologies. DESIGN: A Retrospective cohort study. PARTICIPANTS: Thirty consecutive international patients (60 eyes) who underwent FAK for purely aesthetic reasons were chosen for this study. METHODS: Data from medical records of 30 consecutive patients were retrieved after performing tests 6 months after surgery...
March 5, 2023: European Journal of Ophthalmology
Rui-Heng Zhang, Qiong Yang, Li Dong, Yi-Fan Li, Wen-Da Zhou, Hao-Tian Wu, He-Yan Li, Lei Shao, Chuan Zhang, Ya-Xing Wang, Wen Bin Wei
PURPOSE: Studies have indicated that the observed association between vitamin D and myopia was confounded by time spent outdoors. This study aimed to elucidate this association using a national cross-sectional dataset. METHODS: Participants with 12 to 25 years who participated in non-cycloplegic vision exam from National Health and Nutrition Examination Survey (NHANES) 2001 to 2008 were included in the present study. Myopia was defined as spherical equivalent of any eyes ≤ -0...
March 3, 2023: European Journal of Ophthalmology
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