Maria Pascual-García, Maurits Unkel, Johan A Slotman, Anne Bolleboom, Bibi Bouwen, Adriaan B Houtsmuller, Clemens Dirven, Zhenyu Gao, Sara Hijazi, Steven A Kushner
The axons of neocortical pyramidal neurons are frequently myelinated. Heterogeneity in the topography of axonal myelination in the cerebral cortex has been attributed to a combination of electrophysiological activity, axonal morphology, and neuronal-glial interactions. Previously, we showed that axonal segment length and caliber are critical local determinants of fast-spiking interneuron myelination. However, the factors that determine the myelination of individual axonal segments along neocortical pyramidal neurons remain largely unexplored...
April 1, 2024: Cerebral Cortex