Ultrasound in Obstetrics & Gynecology

OBJECTIVE: To compare the performance of two-dimensional ultrasound (2D-US) three-dimensional ultrasound (3D-US) and magnetic resonance imaging (MRI) at 36 weeks of gestation (WG) in the prediction of Large-for-Gestational-Age (LGA) fetuses defined as birthweight > 95th percentile in a high- and low-risk groups for macrosomia. METHODS: This was a prospective observational study conducted between January 2017 and February 2019. Women with singleton pregnancy at 36 WG underwent simultaneously 2D-US, 3D-US, and MRI...

OBJECTIVE: To determine the diagnostic test accuracy of transvaginal ultrasound (TVS) using a standardized technique for the diagnosis of deep endometriosis (DE) of the uterosacral ligaments (USLs) and adjacent torus uterinus (TU). METHODS: This was a prospective diagnostic test accuracy study conducted at the McMaster University Medical Center Tertiary Endometriosis Clinic. Consecutive participants were enrolled if they successfully underwent TVS and surgery with our team from August 10, 2020 - October 31, 2021...

OBJECTIVE: Primarily to determine the incremental yield of Whole Genome Sequencing (WGS) over Chromosome Microarray Assessment (CMA) and/or Exome Sequencing (ES) in fetuses and infants with a congenital anomaly that was or could have been detectable on ultrasound prenatally. Secondly, to evaluate the turnaround time (TAT) and quantity of DNA required for testing using these pathways. METHODS: OVID MEDLINE(R), EMBASE, Medline (Web of Science), Cochrane Library, and ClinicalTrials...

OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the performance of existing externally validated prediction models for pre-eclampsia (specifically for any- early- late-onset and preterm pre-eclampsia). METHODS: A systematic search was conducted in five databases (MEDLINE, Embase, Emcare, CINAHL, and Maternity and Infant Care Database) to identify studies based on Population, Index model, Comparator, Outcome, Timing, and Setting (PICOTS) approach until May 20, 2023...

OBJECTIVES: To investigate the overall and type-specific prenatal detection rates (DRs) of orofacial clefts in a national cohort in Denmark. METHODS: This study was based on data from the Danish Fetal Medicine Database (DFMD) and included all fetuses and children from singleton pregnancies diagnosed with an orofacial cleft pre- and/or postnatally between 2009 and 2018. The types of clefts included uni-, bilateral or median cleft lip (CL); uni-, bilateral or median cleft lip with secondary cleft palate (CLP); and cleft palate (CP)...

No abstract text is available yet for this article.

OBJECTIVE: There are four objectives in this study investigating the predictive performance of screening for delivery with preeclampsia (PE) and gestational hypertension (GH) at ≥37 weeks' gestation. First, to examine the performance of maternal serum glycosylated fibronectin (GlyFn) at 35+0 to 36+6 weeks' gestation in screening for delivery with PE and GH within 3 weeks and at any time after the examination. Second, to compare the predictive performance for delivery with PE and GH of various combinations of biomarkers, including GlyFn, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFLT-1)...

OBJECTIVES: Mitochondrial complex I deficiency, nuclear type 16 is a rare autosomal recessive disorder caused by biallelic pathogenic variants in NDUFAF5 (C20orf7) [OMIM 618238]. This entity belongs to a genetically and clinically heterogenic group of complex I deficiency which accounts for up to 30% of childhood mitochondrial disorders presenting as Leigh syndrome, leukoencephalopathy, fatal infantile lactic acidosis, and other early-onset neurodegenerative disorders. We present very early, unique, and severe prenatal manifestation of this disorder, previously considered to manifest post-natally...

No abstract text is available yet for this article.

OBJECTIVE: Effective first-trimester screening for preeclampsia(PE) can be achieved with the use of a competing risks model that combines risk factors from the maternal history with multiple of the median (MoM) values of biomarkers. A new model with the use of artificial intelligence (AI) through machine-learning methods has been shown to achieve a similar performance of screening without the need for conversion of raw data of biomarkers to MoMs. We aimed to show how this model can be used across populations without specific adaptations...

OBJECTIVE: To measure the association of detecting a perforated cavum septi pellucidi (CSP) seen on brain imaging of fetuses referred to a large Fetal Center for open neural tube defect (ONTD) repair at the time of referral and six weeks postoperatively, with the eventual need for hydrocephalus treatment by 1 year of age. In utero repair of ONTD reduces the risk of developing severe hydrocephalus requiring treatment by 1 year of age. Additional studies have shown that the presence of severe fetal lateral ventriculomegaly (> 15 mm) before in utero repair significantly increases the risk of requiring postnatal treatment for hydrocephalus...

OBJECTIVES: To report the rate and the outcomes of unplanned caesarean delivery (CD) delivery in women with placenta accreta spectrum disorders (PAS) and placenta previa without PAS, and to elucidate the diagnostic accuracy of ultrasound in predicting this outcome. METHODS: Secondary analysis of a multicenter prospective study involving 14 referral hospital in Italy (ADoPAD Study). Inclusion criteria were women with a low-lying placenta (< 20 mm from the internal cervical os) or placenta previa (covering the os), aged ≥ 18 years, who underwent trans-abdominal and transvaginal ultrasound assessment at ≥ 26 + 0 weeks of gestation...

OBJECTIVES: To describe the distributional properties and assess the performance of placental growth factor (PlGF) measured in blood samples collected before 11 weeks' gestation in prediction of preeclampsia. METHODS: The study population consisted of pregnant women included in the PRESIDE study (Preeclampsia Screening in Denmark) with a PlGF measurement from the routine combined first trimester screening (cFTS) blood sample collected at 8-14 weeks' gestation...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVE: A short corpus callosum (SCC) is defined as a generalized hypoplasia with intact morphology. In the absence of any associated fetal anomaly, its management remains challenging because there is no consensus definition or biometric charts upon which to base the diagnosis, and data regarding outcomes of SCC are scarce. Diffusion Tensor Imaging (DTI) evaluation of corpus callosum (CC) has suggested that the presence of Probst bundles in SCC could help to differentiate between callosal dysplasia and variant of normal CC development...

OBJECTIVE: To compare the predictive performance for delivery with preeclampsia (PE) within 2 weeks of assessment in women with chronic hypertension at 24-41 weeks' gestation between serum glycosylated fibronectin (GlyFn) concentration, serum placental growth factor (PlGF) concentration and soluble fms-like tyrosine kinase-1 (sFLT-1) / PlGF concentration ratio. METHODS: This was a prospective study in 104 women with singleton pregnancies and chronic hypertension presenting at 24-41 weeks' gestation...

OBJECTIVE: The maternal cardiovascular system of women with hypertensive disorders of pregnancy (HDP) can be impaired, with higher rates of left ventricular (LV) remodelling and diastolic dysfunction compared to normotensive pregnancies. The primary objective of this prospective study was to correlate cardiac indices obtained by transthoracic echocardiography (TTE) and circulating angiogenic markers, such as soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF)...

OBJECTIVES: Low dose aspirin has been shown to reduce the risk of preterm pre-eclampsia and it has been suggested that it should be recommended for all pregnancies. However, some studies have reported an association between low dose aspirin and an increased risk of bleeding complications in pregnancy. Our aim was to evaluate the risk of placental abruption and postpartum hemorrhage (PPH) in patients for whom their healthcare provider had recommended prophylactic aspirin. METHODS: This multicenter cohort study included 72,598 singleton births at 19 U...