journal

Trends in Cardiovascular Medicine | Page 2

journal
https://read.qxmd.com/read/32205034/wearable-cardioverter-defibrillators-a-review-of-evidence-and-indications
#21
REVIEW
Christopher C Cheung, Jeffrey E Olgin, Byron K Lee
The wearable cardioverter-defibrillator (WCD) was first approved for clinical use in 2002, and is routinely used in select populations at high risk for sudden cardiac death. WCDs are frequently considered as a bridge to definitive therapy or in circumstances where insertion of conventional implantable cardioverter-defibrillators (ICD) is temporarily contraindicated. In this review, we summarize the literature on WCDs. From prospective trials to the first randomized controlled trial with WCD, there is a growing body of evidence that suggests that the WCD is safe and effective...
March 12, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32205033/why-patients-with-familial-hypercholesterolemia-are-at-high-cardiovascular-risk-beyond-ldl-c-levels
#22
REVIEW
Vanessa Bianconi, Maciej Banach, Matteo Pirro
Familial hypercholesterolemia (FH) is a common genetic cause of elevated low-density lipoprotein cholesterol (LDL-C) due to defective clearance of circulating LDL particles. All FH patients are at high risk for premature cardiovascular disease (CVD) events due to their genetically determined lifelong exposure to high LDL-C levels. However, different rates of CVD events have been reported in FH patients, even among those with the same genetic mutations and comparable LDL-C levels. Hence, additional CVD risk modifiers, beyond LDL-C, may contribute to increase CVD risk in the FH population...
March 12, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32192823/editorial-commentary-on-the-role-of-periodontal-microorganisms-in-the-pathogenesis-of-myocardial-infarction-from-pcr-techniques-to-microbiome-sequencing
#23
EDITORIAL
Antonio Magan-Fernandez, Giuseppa Castellino, Francesco Cappello, Francisco Mesa
No abstract text is available yet for this article.
February 29, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32192822/editorial-commentary-sickle-cell-disease-diagnosing-the-heart-of-the-matter
#24
EDITORIAL
Melissa C Caughey, Enrico M Novelli
No abstract text is available yet for this article.
February 28, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32146016/editorial-commentary-paradigm-shift-in-the-circadian-and-septadian-patterns-of-sudden-cardiac-death-fact-or-fiction
#25
EDITORIAL
Heikki V Huikuri, M Juhani Junttila
No abstract text is available yet for this article.
February 18, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32122731/editorial-commentary-challenges-in-the-diagnosis-and-management-of-pulmonary-artery-stenosis
#26
EDITORIAL
Meghan M Cirulis, Tim Lahm
No abstract text is available yet for this article.
February 18, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32115339/editorial-commentary-cardiac-arrest-and-the-young-will-we-ever-be-able-to-predict-the-unpredictable
#27
EDITORIAL
Jason S Bradfield
No abstract text is available yet for this article.
February 14, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32139143/cardiovascular-complications-of-sickle-cell-disease
#28
REVIEW
Vandana Sachdev, Douglas R Rosing, Swee Lay Thein
Sickle cell disease (SCD) is the most common inherited blood disorder in the United States, and a global health problem. Pathological features of the abnormal hemoglobin (HbS) result in 2 hallmarks of the disease - recurrent episodes of acute microvascular occlusion and chronic hemolytic anemia - that inflict continuous and insidious damage to multiple organs. With improved childhood survival, SCD in adults has evolved into a chronic degenerative disease with underlying damage to multiple organs including the heart and lungs...
February 11, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32081565/treatment-approach-to-unilateral-branch-pulmonary-artery-stenosis
#29
REVIEW
Gurumurthy Hiremath, Athar M Qureshi, Jeffery Meadows, Varun Aggarwal
Unilateral proximal pulmonary artery stenosis is often seen in the setting of postoperative congenital heart disease. Accurate assessment of the hemodynamic significance of such a lesion is important so as to determine "When to intervene?" A thorough evaluation should include symptom assessment, anatomical assessment through detailed imaging, functional assessment using differential pulmonary blood flow measurement and cardiopulmonary exercise testing. Symptoms of exertional dyspnea or intolerance, decreased pulmonary blood flow to stenosed lung, and abnormal exertional performance would be factors to pursue therapy in the setting of significant anatomical narrowing...
February 10, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32088067/do-peak-times-exist-for-sudden-cardiac-arrest
#30
REVIEW
Archana Ramireddy, Sumeet S Chugh
Sudden cardiac arrest remains an unexpected and dynamic cardiovascular disease process that continues to present challenges for accurate risk prediction and prevention. The notion of a circadian pattern in the occurrence of sudden cardiac arrest had long been supported by the presence of an early morning peak; however, more recent studies are calling this observation into question. This likely paradigm shift in the presentation and mechanisms of sudden cardiac arrest has major implications and needs to be carefully considered...
February 6, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/31003756/familial-chylomicronemia-syndrome-a-rare-but-devastating-autosomal-recessive-disorder-characterized-by-refractory-hypertriglyceridemia-and-recurrent-pancreatitis
#31
REVIEW
Vadzim Chyzhyk, Alan S Brown
Familial Chylomicronemia Syndrome (FCS) is a rare autosomal recessive lipid disorder characterized by severe hypertriglyceridemia and recurrent pancreatitis. Because the disorder is often misdiagnosed or not diagnosed and because traditional triglyceride lowering medications are often ineffective, the disease leads to a tremendous physical, social and emotional burden on afflicted patients and their caretakers. Mutations in 5 different genes have been implicated in the development of FCS, all of which have an effect on the activity of lipoprotein lipase...
February 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30952383/a-review-of-oral-anticoagulants-old-and-new-in-major-bleeding-and-the-need-for-urgent-surgery
#32
REVIEW
Truman J Milling, Christopher M Ziebell
Oral anticoagulants, old and new, are effective therapies for prevention and treatment of venous thromboembolism and reduction of stroke risk in patients with atrial fibrillation. However, blocking elements of the clotting cascade carries an inherent risk of bleeding. Also, anticoagulated patients sometimes require urgent surgery or invasive procedures. This has led to the emergence of a body of scientific literature on the reversal of anticoagulation in these two settings. Traditionally, vitamin K antagonists (VKAs), which indirectly inactivate clotting factors II, VII, IX and X (and natural anticoagulant proteins C and S), had been the mainstay of oral anticoagulation for half a century...
February 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32014369/editorial-commentary-drug-dosing-optimization-in-heart-failure-need-of-a-multidimensional-approach-and-skilled-heart-failure-specialists
#33
EDITORIAL
Gabriele Fragasso
No abstract text is available yet for this article.
January 24, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32008837/atrial-fibrillation-in-obstructive-sleep-apnea-neural-mechanisms-and-emerging-therapies
#34
REVIEW
Bing Huang, Huafen Liu, Benjamin J Scherlag, Lihua Sun, Shifeng Xing, Jie Xu, Mei Luo, Yankai Guo, Guiqiu Cao, Hong Jiang
Obstructive sleep apnea (OSA) has been reproducibly identified as a risk factor for initiation and progression of atrial fibrillation (AF) and reduces the efficacy of antiarrhythmic drugs, electrical cardioversion, and catheter ablation in AF. It is still controversial whether continuous positive airway pressure ventilation (CPAP) could improve the successful rate of AF treatment in OSA patients. Besides, CPAP has shown relative low compliance in patients with OSA. Therefore, novel optional therapies might be needed to improve the control of AF associated with OSA...
January 22, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32008836/editorial-commentary-every-cardiologist-should-know-diabetes-by-heart
#35
EDITORIAL
Ahmet Afşin Oktay, Hüseyin Şenocak
No abstract text is available yet for this article.
January 22, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32008835/editorial-commentary-is-there-a-cardiopulmonary-continuum-is-there-also-a-link
#36
EDITORIAL
Berne Eriksson
No abstract text is available yet for this article.
January 22, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32007383/editorial-commentary-are-men-really-from-mars-and-women-from-venus-the-survival-paradox-in-the-treatment-of-aortic-stenosis
#37
EDITORIAL
Daniela R Crousillat, Evin Yucel, Sammy Elmariah
No abstract text is available yet for this article.
January 18, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/32008834/body-surface-area-and-medication-dosing-in-patients-with-heart-failure-with-reduced-ejection-fraction
#38
REVIEW
Jeremy A Brooksbank, Stephen J Greene, Tracy A DeWald, Robert J Mentz
Multiple medications are proven to reduce morbidity and mortality in patients with heart failure with reduced ejection fraction (HFrEF), but data regarding personalized approaches to optimize medication dosing remain limited. Current treatment guidelines recommend up-titration to target or maximally tolerated doses of these medications, yet use and dosing remain suboptimal in clinical practice. Body surface area (BSA) is a readily available clinical metric, used for dosing many medications, closely associated with blood pressure, renal function, and vascular congestion, and may influence efficacy, safety, and tolerability of HFrEF medications...
January 15, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/31987774/symptoms-and-healthcare-contact-preceding-sudden-cardiac-death-in-persons-aged-1-49-years
#39
REVIEW
Tobias Skjelbred, Thomas Hadberg Lynge, Jakob Nielsen, Bo Gregers Winkel, Jacob Tfelt-Hansen
Sudden Cardiac Death (SCD) is a leading cause of death among persons in their youth and early middle-age. To prevent SCD it is crucial to identify persons at high-risk of SCD. Knowledge of symptoms and medical contact prior to SCD could potentially aid in the identification of high-risk persons in the general population who would benefit from further investigation. This review aims to summarize the current knowledge of symptoms and healthcare contact preceding SCD in persons aged 1-49 years, and to explore how the symptoms differ according to SCD cause and age of the deceased...
January 15, 2020: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/31983535/pluripotent-stem-cell-derived-cardiomyocytes-for-treatment-of-cardiomyopathic-damage-current-concepts-and-future-directions
#40
REVIEW
Jessica C Garbern, Gabriela O Escalante, Richard T Lee
Today, cell replacement therapy using pluripotent stem cell-derived cardiomyocytes (PSC-CMs) remains a research endeavor, with several hurdles that must be overcome before delivery of PSC-CMs can become a therapeutic reality. In this review, we highlight major findings to date from pre-clinical studies involving delivery of PSC-CMs and consider remaining challenges that must be addressed for successful clinical translation. Our goal is to provide an overview of the current status of cardiomyocyte replacement therapy and what challenges must be addressed before successful clinical translation of such therapies will be possible...
January 14, 2020: Trends in Cardiovascular Medicine
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