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Trends in Cardiovascular Medicine

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https://read.qxmd.com/read/30956033/arson-in-the-artery-who-set-the-atheroma-aflame
#1
EDITORIAL
Peter Libby
Inflammation drives the formation, evolution, and complication of atherosclerotic plaques. Yet, we have not yet captured the culprits who light the fire that burns within the atherosclerotic plaque. The arsonist remains at large. A rigorous analysis exculpates many of the usual suspects. Low-density lipoprotein (LDL) itself engenders little inflammation. Clinical trials do not support an actionable role of oxidized LDL in atherothrombosis. In contrast, triglyceride-rich lipoproteins do promote inflammation, and provide a promising target for intervention...
March 28, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30952383/a-review-of-reversal-of-oral-anticoagulants-old-and-new-in-major-bleeding-and-the-need-for-urgent-surgery
#2
REVIEW
Truman J Milling, Christopher M Ziebell
Oral anticoagulants, old and new, are effective therapies for prevention and treatment of venous thromboembolism and reduction of stroke risk in patients with atrial fibrillation. However, blocking elements of the clotting cascade carries an inherent risk of bleeding. Also, anticoagulated patients sometimes require urgent surgery or invasive procedures. This has led to the emergence of a body of scientific literature on the reversal of anticoagulation in these two settings. Traditionally, vitamin K antagonists (VKAs), which indirectly inactivate clotting factors II, VII, IX and X (and natural anticoagulant proteins C and S), had been the mainstay of oral anticoagulation for half a century...
March 26, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30935726/harnessing-crispr-cas9-technology-in-cardiovascular-disease
#3
REVIEW
Hamzeh Rezaei, Saedeh Khadempar, Najmeh Farahani, Elaheh Zadeh Hosseingholi, Seyed Mohammad Gheibi Hayat, Thozhukat Sathyapalan, Amir Hossein Sahebkar
The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compared to other genome editing techniques such as zinc-finger nucleases and transcription activator-like effector nucleases (TALENS), the CRISPR/Cas9 system is much easier and more efficient. Most importantly, the multifunctional capacity of this technology allows simultaneous editing of several genes...
March 26, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30926237/new-approach-to-blood-pressure-control-triple-combination-pill
#4
REVIEW
Massimo Volpe, Giovanna Gallo, Giuliano Tocci
Blood pressure (BP) control remains insufficient worldwide, mostly due to poor adherence to treatments, clinical inertia, adverse effects and underuse of drug-combination strategies. Monotherapy and its uptitration have been long considered the first-line strategy in the treatment of hypertension, often leading to ineffective, time consuming and frustrating results. On the other hand, several studies have demonstrated that starting and continuing antihypertensive therapy based on a drug combination is associated with a greater reduction of BP, an earlier achievement of therapeutic goals and a higher proportion of patients achieving targets with favorable implications on cardiovascular events...
March 14, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30876793/statin-for-primary-prevention-of-atherosclerotic-cardiovascular-disease-in-young-adults-are-we-there-yet
#5
EDITORIAL
Joseph Yeboah
No abstract text is available yet for this article.
March 5, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30871865/subclinical-thyroid-dysfunction-and-cardiovascular-consequences-an-alarming-wake-up-call
#6
REVIEW
Antonis A Manolis, Theodora A Manolis, Helen Melita, Antonis S Manolis
Subclinical thyroid dysfunction (STD), presenting as subclinical hypothyroidism (SHypo) or subclinical hyperthyroidism (SHyper), defined as abnormal serum thyrotropin (TSH) and normal free thyroid hormones, is associated with increased cardiovascular (CV) risk and mortality. Depending on the degree of such dysfunction, atherosclerosis, coronary artery disease, heart failure and cardiac arrhythmias, predominantly atrial fibrillation, characterize both disorders and increase CV and total mortality compared to euthyroid persons...
March 5, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30833072/recommendations-on-stroke-prevention-for-patients-having-a-cha-2-ds-2-vasc-score-of-1-males-or-2-females-in-2019-atrial-fibrillation-guidelines
#7
LETTER
Tze-Fan Chao, Shih-Ann Chen, Gregory Y H Lip
No abstract text is available yet for this article.
February 25, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30833071/editorial-commentary-lessons-learned-and-unanswered-questions-about-weight-changes-throughout-the-life-course-and-cardiovascular-disease-in-response-to-change-in-body-mass-index-from-childhood-onwards-and-risk-of-adult-cardiovascular-disease
#8
EDITORIAL
https://read.qxmd.com/read/30928315/my-approach-to-stem-cell-therapy-for-heart-failure-patients-not-all-cells-are-created-equally
#9
Eugenio Cingolani
No abstract text is available yet for this article.
February 22, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30824163/recent-paradigm-shifts-in-molecular-cardiac-imaging-establishing-precision-cardiology-through-novel-18-f-labeled-pet-radiotracers
#10
REVIEW
Rudolf A Werner, Xinyu Chen, Steven P Rowe, Constantin Lapa, Mehrbod S Javadi, Takahiro Higuchi
In nuclear cardiology, numerous single-photon emission computed tomography radiotracers have been advocated to reflect various cardiac metabolic and functional conditions, but positron emission tomography (PET) may offer a more thorough evaluation, mainly due to superior characteristics associated with the latter imaging modality. This shift in recent years has been fueled by the introduction of 18 F-labeled PET radiotracers. Due to physical and chemical key properties, these imaging agents allow for more flexibility of imaging protocols and a better employment in the clinic...
February 20, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30808553/statin-therapy-for-young-adults-a-long-term-investment-worth-considering
#11
REVIEW
Michael D Miedema, Victor D Nauffal, Avinainder Singh, Ron Blankstein
HMG coenzyme A reductase inhibitors (statins) significantly decrease low-density lipoprotein-cholesterol, resulting in stabilization, and in some cases regression, of atherosclerotic plaque with subsequent reduction in atherosclerotic cardiovascular disease (ASCVD) events. To date, there remains a paucity of data to guide the use of statins in young adults (20-49 years old). We herein aim to summarize the potential benefits and risks for statin therapy in younger adults, outlining a possible approach to statin use in young adults...
February 19, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30808552/promising-findings-on-the-role-of-endothelin-1-and-related-peptides-in-primary-cardiovascular-prevention
#12
Federico Carbone, Fabrizio Montecucco, Amirhossein Sahebkar
No abstract text is available yet for this article.
February 19, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30797696/editorial-commentary-searching-for-the-sweet-spot-of-cardioprotection-in-cancer-treatment-related-cardiotoxicity-who-will-benefit
#13
EDITORIAL
Richard K Cheng, Eric H Yang
No abstract text is available yet for this article.
February 15, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30797695/editorial-commentary-the-public-physician-in-cardiology-the-solution-to-information-pollution
#14
EDITORIAL
Samira Farouk, Matthew A Sparks
No abstract text is available yet for this article.
February 14, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30770174/the-pleiotropic-effect-of-statins-on-the-atherosclerotic-plaque-and-coronary-heart-disease
#15
Antonis I Sakellarios, Dimitrios I Fotiadis
No abstract text is available yet for this article.
February 10, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30878294/editorial-commentary-pericardiocentesis-no-more-a-subspecialty-technique
#16
EDITORIAL
Massimo Imazio, Gaetano Maria De Ferrari
No abstract text is available yet for this article.
February 5, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30773326/the-role-of-social-media-in-cardiology
#17
REVIEW
John Mandrola, Piotr Futyma
Digital and social media are transforming society and Medicine. In this review, we discuss how social media speeds the translation of medical evidence, disrupts peer review, changes the path to leadership, improves lifelong learning, connects colleagues and may even transform cardiovascular research. Despite some downsides, we make the case that social media will be a net positive for Medicine.
February 5, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30772134/change-in-body-mass-index-from-childhood-onwards-and-risk-of-adult-cardiovascular-disease
#18
REVIEW
Lise G Bjerregaard, Kasper Adelborg, Jennifer L Baker
Childhood obesity adversely affects the structure and function of the cardiovascular system, but the relationship between excessive weight gain during childhood and adult cardiovascular disease (CVD) is not fully understood. This review summarizes evidence for associations of change in body mass index (BMI) from childhood onwards with CVD outcomes. We found that excessive gain in BMI from childhood onwards was consistently associated with the presence of CVD risk factors, with increased risks of coronary heart disease, and there were suggestions of associations with stroke, atrial fibrillation and heart failure, but a lack of evidence precludes firm conclusions...
February 5, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30770175/editorial-commentary-imaging-the-aorta-for-inflammation-informing-practice-on-emerging-molecular-techniques
#19
EDITORIAL
Patrick Veit-Haibach, Hassan Ellaban, Michael E Farkouh
No abstract text is available yet for this article.
February 5, 2019: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/30765295/endothelin-1-levels-and-cardiovascular-events
#20
REVIEW
Matthew Jankowich, Gaurav Choudhary
Circulating plasma levels of endothelin-1 and related peptides generated during the synthesis of endothelin-1 from its precursor molecule pre-proendothelin-1 have been widely studied as potential risk markers for cardiovascular events. The associations of endothelin-1 with aging, blood pressure, lung function, and chronic kidney disease have been described, as have relations between endothelin-1 levels and evidence of cardiac remodeling, including increased left atrial diameter and increased left ventricular mass...
February 1, 2019: Trends in Cardiovascular Medicine
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